解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases, bioenergetics demand increases and becomes reliant upon fatty acid oxidation as a source of energy. Defective fatty acid oxidation and mitochondrial dysfunctions correlate with hippocampal neurodegeneration and memory deficits in ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23534
更新日期:2019-01-01 00:00:00
abstract::Microglia undergo dynamic structural and transcriptional changes during the immune response to traumatic brain injury (TBI). For example, TBI causes microglia to form rod-shaped trains in the cerebral cortex, but their contribution to inflammation and pathophysiology is unclear. The purpose of this study was to determ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23523
更新日期:2018-12-01 00:00:00
abstract::NG2 is a type 1 integral membrane glycoprotein encoded by the Cspg4 gene. It is expressed on glial progenitor cells known as NG2 glial cells or oligodendrocyte precursor cells that exist widely throughout the developing and mature central nervous system and vascular mural cells but not on mature oligodendrocytes, astr...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23521
更新日期:2018-12-01 00:00:00
abstract::Microglia are known to regulate several aspects of the development of the central nervous system. When microglia colonize the spinal cord, from E11.5 in the mouse embryo, they interact with growing central axons of dorsal root ganglion sensory neurons (SNs), which suggests that they may have some functions in SN devel...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23499
更新日期:2018-11-01 00:00:00
abstract::To study the role of L-type voltage-gated Ca++ channels in oligodendrocyte development, we used a mouse model of Timothy syndrome (TS) in which a gain-of-function mutation in the α1 subunit of the L-type Ca++ channel Cav1.2 gives rise to an autism spectrum disorder (ASD). Oligodendrocyte progenitor cells (OPCs) isolat...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23468
更新日期:2018-11-01 00:00:00
abstract::Microglia contribute to pathophysiology at all stages of multiple sclerosis. Colony-stimulating factor-1 (CSF1) is crucial for microglial proliferation and activation. In this study we measured the CSF1 levels and studied its cellular expression in the mouse spinal cords with experimental autoimmune encephalomyelitis ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23464
更新日期:2018-10-01 00:00:00
abstract::Nogo-A is a potent glial-derived inhibitor of axon growth in the injured CNS and acts as a negative regulator of developmental angiogenesis by inhibiting vascular endothelial cell migration. However, its function in pathological angiogenesis has never been studied after ischemic injury in the CNS. Using the mouse mode...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23462
更新日期:2018-10-01 00:00:00
abstract::Microglia show a rich repertoire of activation patterns regulated by a complex ensemble of surface ion channels, receptors, and transporters. We and others have investigated whether microglia vary their K+ channel expression as a means to achieve functional diversity. However, most of the prior studies were conducted ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23457
更新日期:2018-09-01 00:00:00
abstract::Spinocerebellar ataxia type 1 (SCA1) is a fatal, dominantly inherited neurodegenerative disease caused by the expansion of CAG repeats in the Ataxin-1 (ATXN1) gene. SCA1 is characterized by balance and coordination deficits due to the predominant loss of Purkinje neurons in the cerebellum. We previously demonstrated t...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23451
更新日期:2018-09-01 00:00:00
abstract::The prospects of achieving regeneration in the central nervous system (CNS) have changed, as most recent findings indicate that several species, including humans, can produce neurons in adulthood. Studies targeting this property may be considered as potential therapeutic strategies to respond to injury or the effects ...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23282
更新日期:2018-07-01 00:00:00
abstract::Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) play a critical role in immune-mediated demyelinating diseases, including multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE), by regulating the viability of oligodendrocytes. Our previous studies show th...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23307
更新日期:2018-07-01 00:00:00
abstract::Microglia have diverse actions, ranging from synapse pruning in development to cytotoxic effects in disease. Brain energy metabolism and substrate availability vary under normal and disease states, but how these variations influence microglial function is relatively unknown. Microglia, like most other cell types, expr...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23271
更新日期:2018-06-01 00:00:00
abstract::Microglial cells have a double life as the immune cells of the brain in times of stress but have also specific physiological functions in homeostatic conditions. In pathological contexts, microglia undergo a phenotypic switch called "reaction" that promotes the initiation and the propagation of neuro-inflammation. Rea...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23295
更新日期:2018-05-01 00:00:00
abstract::Radial glial cells play an essential role through their function as guides for neuronal migration during development. Disruption of metabotropic glutamate receptor 5 (mGluR5) function retards the growth of radial glial processes in vitro. Neuregulins (NRG) are activated by proteolytic cleavage and regulate (radial) gl...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23230
更新日期:2018-01-01 00:00:00
abstract::VEGF is an important factor in tumor vascularization and used as target for anti-angiogenic treatment strategies in glioma. In this study, we demonstrate for the first time that VEGF is a modulator of the innate immune response with suppressive effects on the immunologic and pro-angiogenic function of microglia/macrop...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23234
更新日期:2018-01-01 00:00:00
abstract::Type I interferons (IFNs), IFN-α and IFN-β, represent the major effector cytokines of the host immune response against viruses and other intracellular pathogens. These cytokines are produced via activation of numerous pattern recognition receptors, including the Toll-like receptor signaling network, retinoic acid-indu...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23154
更新日期:2017-09-01 00:00:00
abstract::Activation of microglia resulting in exacerbated inflammation expression plays an important role in degeneration of dopaminergic (DA) neurons in the pathogenesis of Parkinson's disease (PD). However, how this enhanced inflammation is induced in microglia remains largely unclear. Here, in the mouse PD model induced by ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23153
更新日期:2017-08-01 00:00:00
abstract::Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage. Although remyelination is considered beneficial in the long term, it is not known, whether this is also the case early in lesion formation. Additionally...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23167
更新日期:2017-08-01 00:00:00
abstract::Astrocytes are the most abundant cell type of the central nervous system and cover a broad range of functionalities. We report here the generation of a novel monoclonal antibody, anti-astrocyte cell surface antigen-2 (Anti-ACSA-2). Flow cytometry, immunohistochemistry and immunocytochemistry revealed that Anti-ACSA-2 ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23140
更新日期:2017-06-01 00:00:00
abstract::Extracellular purines are signaling molecules in the neurogenic niches of the brain and spinal cord, where they activate cell surface purinoceptors at embryonic neural stem cells (NSCs) and adult neural progenitor cells (NPCs). Although mRNA and protein are expressed at NSCs/NPCs for almost all subtypes of the nucleot...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.23056
更新日期:2017-02-01 00:00:00
abstract::In previous work, we demonstrated that NF-κB p50 acts as crucial regulator of adult hippocampal neural progenitor cells (ahNPC). Indeed, NF-κB p50 knockout (KO) mice are characterized by remarkably reduced hippocampal neurogenesis. As a follow up to that work, herein we show that when cultured in vitro, ahNPC from wil...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23085
更新日期:2017-01-01 00:00:00
abstract::Emerging evidence shows that hypothalamic astrocytes react to and counteract energy surfeit produced by high-fat diet (HFD) feeding. However, the functional role of astrocytes in the control of energy states and the underlying molecular mechanism(s) during physiological conditions remain largely underexplored. In the ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23073
更新日期:2016-12-01 00:00:00
abstract::In the brain, glycogen metabolism has been implied in synaptic plasticity and learning, yet the distribution of this molecule has not been fully described. We investigated cerebral glycogen of the mouse by immunohistochemistry (IHC) using two monoclonal antibodies that have different affinities depending on the glycog...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23020
更新日期:2016-09-01 00:00:00
abstract::Activated microglia, astrogliosis, expression of pro-inflammatory cytokines, blood brain barrier (BBB) leakage and peripheral immune cell infiltration are features of mesial temporal lobe epilepsy. Numerous studies correlated the expression of pro-inflammatory cytokines with the activated morphology of microglia, attr...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23008
更新日期:2016-08-01 00:00:00
abstract::The G protein-coupled receptor 17 (GPR17) plays crucial roles in myelination. It is highly expressed during transition of oligodendrocyte progenitor cells to immature oligodendrocytes, but, after this stage, it must be down-regulated to allow generation of mature myelinating cells. After endocytosis, GPR17 is sorted i...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.23015
更新日期:2016-08-01 00:00:00
abstract::Integrins are transmembrane receptors that mediate cell-extracellular matrix and cell-cell interactions. The β1-integrin subunit is highly expressed by embryonic neural stem cells (NSCs) and is critical for NSC maintenance in the developing nervous system, but its role in the adult hippocampal niche remains unexplored...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22996
更新日期:2016-07-01 00:00:00
abstract::Retinoic acid (RA), a metabolite of vitamin A, is required for the regulation of growth and development. Aberrant expression of molecules involved in RA signaling has been reported in various cancer types including glioblastoma multiforme (GBM). Cellular retinoic acid-binding protein 2 (CRABP2) has previously been sho...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22976
更新日期:2016-06-01 00:00:00
abstract::Inflammation has been linked to the induction of apneas and Sudden Infant Death Syndrome, whereas proinflammatory mediators inhibit breathing when applied peripherally or directly into the CNS. Considering that peripheral inflammation can activate microglia in the CNS and that this cell type can directly release all p...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22951
更新日期:2016-04-01 00:00:00
abstract::Myelination in corpus callosum plays important role for normal brain functions by transferring neurological information between various brain regions. However, the factors controlling expression of myelin genes in myelination are poorly understood. Here, CXXC5, a recently identified protein with CXXC-type zinc finger ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22932
更新日期:2016-03-01 00:00:00
abstract::Astroglial dysfunction plays an important role in neurodegenerative diseases otherwise attributed to neuronal loss of function. Here we focus on the role of astroglia in ataxia-telangiectasia (A-T), a disease caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A hallmark of A-T pathology is progressiv...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22925
更新日期:2016-02-01 00:00:00
abstract::Multiple sclerosis (MS) frequently starts near the lateral ventricles, which are lined by subventricular zone (SVZ) progenitor cells that can migrate to lesions and contribute to repair. Because MS-induced inflammation may decrease SVZ proliferation and thus limit repair, we studied the role of galectin-3 (Gal-3), a p...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22906
更新日期:2016-01-01 00:00:00
abstract::Long-term, persistent central nervous system inflammation is commonly seen following brain infection. Using a murine model of viral encephalitis (murine cytomegalovirus, MCMV) we have previously shown that post-encephalitic brains are maintained in an inflammatory state consisting of glial cell reactivity, retention o...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22868
更新日期:2015-11-01 00:00:00
abstract::Inefficient lysosomal degradation is central in the development of various brain disorders, but the underlying mechanisms and the involvement of different cell types remains elusive. We have previously shown that astrocytes effectively engulf dead cells, but then store, rather than degrade the ingested material. In th...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22873
更新日期:2015-11-01 00:00:00
abstract::Hepatic encephalopathy (HE) is a neuropsychiatric syndrome frequently accompanying liver cirrhosis and reflects the clinical manifestation of a low grade cerebral edema associated with cerebral oxidative/nitrosative stress. The multidrug resistance-associated protein (Mrp) 4 is an export pump which transports metaboli...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22879
更新日期:2015-11-01 00:00:00
abstract::Enteric glial cells were first described at the end of the 19th century, but they attracted more interest from researchers only in the last decades of the 20th. Although, they have a different embryological origin, the enteric GLIA share many characteristics with astrocytes, the main glial cell type of the central ner...
journal_title:Glia
pub_type: 杂志文章,评审
doi:10.1002/glia.22795
更新日期:2015-06-01 00:00:00
abstract::Although the peripheral anti-inflammatory effect of norepinephrine (NE) is well documented, the mechanism by which this neurotransmitter functions as an anti-inflammatory/neuroprotective agent in the central nervous system (CNS) is unclear. This article aimed to determine the anti-inflammatory/neuroprotective effects ...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22801
更新日期:2015-06-01 00:00:00
abstract::Under pathological conditions, activated microglia play paradoxical roles and could have neurotoxic or neuroprotective effects. However, the signal determining how activated microglia affects the fate of neuronal cells remains largely unknown. Here we demonstrate that DNAX-activating protein of 12 kDa (DAP12), a trans...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22802
更新日期:2015-06-01 00:00:00
abstract::The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and include the PYHIN family members AIM2, IFI16, and p204 as well as the enzyme, cGAS. Activation of th...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22786
更新日期:2015-05-01 00:00:00
abstract::Expression profiling of distinct central nervous system (CNS) cell populations has been employed to facilitate disease classification and to provide insights into the molecular basis of brain pathology. One important cell type implicated in a wide variety of CNS disease states is the resident brain macrophage (microgl...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22754
更新日期:2015-04-01 00:00:00
abstract::The substantia nigra pars reticulata (SNr) is a major output nucleus of the basal ganglia circuitry particularly sensitive to pathological dopamine depletion. Indeed, hyperactivity of SNr neurons is known to be responsible for some motor disorders characteristic of Parkinson's disease. The neuronal processing of basal...
journal_title:Glia
pub_type: 杂志文章
doi:10.1002/glia.22777
更新日期:2015-04-01 00:00:00