abstract：:Pathological cardiac remodeling, characterized by excessive deposition of extracellular matrix proteins and cardiac hypertrophy, leads to the development of heart failure. Meprin α (Mep1a), a zinc metalloprotease, previously reported to participate in the regulation of inflammatory response and fibrosis, may also cont...

journal_title：Journal of molecular and cellular cardiology

authors： Ge W,Hou C,Zhang W,Guo X,Gao P,Song X,Gao R,Liu Y,Guo W,Li B,Zhao H,Wang J

更新日期：2020-12-08 00:00:00

abstract：:Ca2+ serves as a ubiquitous second messenger mediating a variety of cellular processes including electrical excitation, contraction, gene expression, secretion, cell death and others. The identification of the molecular components of the mitochondrial Ca2+ influx and efflux pathways has created a resurgent interest in...

journal_title：Journal of molecular and cellular cardiology

authors： O'Rourke B,Ashok D,Liu T

更新日期：2020-12-05 00:00:00

abstract：:Identification of proteins that interact with Cx43 has been instrumental in the understanding of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein tyrosine kinase 2 beta (Pyk2) phosphorylated purified Cx43CT and this led us to characterize the impact of this phosphorylation on Cx...

journal_title：Journal of molecular and cellular cardiology

authors： Zheng L,Trease AJ,Katsurada K,Spagnol G,Li H,Shi W,Duan B,Patel KP,Sorgen PL

更新日期：2020-12-01 00:00:00

abstract：:The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein complex with the actin and myosin filaments at its core. Assembling the sarcomere constituents into this organized structure in development, and with muscle growth as new sarcomeres are built, is a complex process coordinate...

journal_title：Journal of molecular and cellular cardiology

authors： Martin TG,Kirk JA

更新日期：2020-11-01 00:00:00

abstract：AIMS:One unaddressed aspect of healing after myocardial infarction (MI) is how non-myocyte cells that survived the ischemic injury, keep withstanding additional cellular damage by stress forms typically arising during the post-infarction inflammation. Here we aimed to determine if cell survival is conferred by expressi...

journal_title：Journal of molecular and cellular cardiology

authors： Razin T,Melamed-Book N,Argaman J,Galin I,Lowy Y,Anuka E,Naftali-Shani N,Kandel-Kfir M,Garfinkel BP,Brielle S,Granot Z,Apte RN,Conway SJ,Molkentin JD,Kamari Y,Leor J,Orly J

更新日期：2020-10-30 00:00:00

abstract：AIMS:In response to vascular injury, vascular smooth muscle cells (VSMC) may change from a contractile phenotype to a proliferative phenotype and consequently become conducive to neointima formation. Apoptosis repressor with caspase recruitment domain (ARC) was initially discovered as an endogenous apoptosis inhibitor,...

journal_title：Journal of molecular and cellular cardiology

authors： Liu M,Yu T,Li M,Fang X,Hou B,Liu G,Wang J

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Cardiac injury, as measured by troponin elevation, has been reported among hospitalized coronavirus disease 2019 (COVID-19) patients and portends a poor prognosis. However, how the dynamics of troponin elevation interplay with inflammation and coagulation biomarkers over time is unknown. We assessed longitud...

journal_title：Journal of molecular and cellular cardiology

authors： Li C,Jiang J,Wang F,Zhou N,Veronese G,Moslehi JJ,Ammirati E,Wang DW

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Rodent cardiomyocytes (CM) undergo mitotic arrest and decline of mononucleated-diploid population post-birth, which are implicated in neonatal loss of heart regenerative potential. However, the dynamics of postnatal CM maturation are largely unknown in swine, despite a similar neonatal cardiac regenerative c...

journal_title：Journal of molecular and cellular cardiology

authors： Velayutham N,Alfieri CM,Agnew EJ,Riggs KW,Baker RS,Ponny SR,Zafar F,Yutzey KE

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular condition. Despite being strongly associated with genetic alterations, wide variation of disease penetrance, expressivity and hallmarks of progression complicate treatment. We aimed to characterize different human isogenic cellular m...

journal_title：Journal of molecular and cellular cardiology

authors： Bhagwan JR,Mosqueira D,Chairez-Cantu K,Mannhardt I,Bodbin SE,Bakar M,Smith JGW,Denning C

更新日期：2020-08-01 00:00:00

abstract：:The mitochondrial permeability transition, an established mechanism for heart diseases, is a long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection. Several hypotheses about its molecular nature have been put forward over the years, and the prevailing view is that permeabilization ...

journal_title：Journal of molecular and cellular cardiology

authors： Carraro M,Carrer A,Urbani A,Bernardi P

更新日期：2020-07-01 00:00:00

abstract：:COVID-19, caused by the SARS-CoV-2 virus, is a major source of morbidity and mortality due to its inflammatory effects in the lungs and heart. The p38 MAPK pathway plays a crucial role in the release of pro-inflammatory cytokines such as IL-6 and has been implicated in acute lung injury and myocardial dysfunction. The...

journal_title：Journal of molecular and cellular cardiology

authors： Grimes JM,Grimes KV

更新日期：2020-07-01 00:00:00

abstract：:Cardiac troponin I (cTnI), the inhibitory-unit, and cardiac troponin T (cTnT), the tropomyosin-binding unit together with the Ca-binding unit (cTnC) of the hetero-trimeric troponin complex signal activation of the sarcomeres of the adult cardiac myocyte. The unique structure and heart myocyte restricted expression of ...

journal_title：Journal of molecular and cellular cardiology

authors： Solaro CR,Solaro RJ

更新日期：2020-06-01 00:00:00

abstract：AIMS:During embryogenesis, the onset of circulatory blood flow generates a variety of hemodynamic forces which reciprocally induce changes in cardiovascular development and performance. It has been known for some time that these forces can be detected by as yet unknown mechanosensory systems which in turn promote cardi...

journal_title：Journal of molecular and cellular cardiology

authors： Faucherre A,Moha Ou Maati H,Nasr N,Pinard A,Theron A,Odelin G,Desvignes JP,Salgado D,Collod-Béroud G,Avierinos JF,Lebon G,Zaffran S,Jopling C

更新日期：2020-06-01 00:00:00

abstract：:There is currently a growing global burden of valvular heart diseases due to aging populations and changing lifestyles. Valvular heart diseases mainly include the malfunctioning of aortic and mitral valves and are characterized by extensive tissue remodeling, which includes calcification, endothelial dysfunction, and ...

journal_title：Journal of molecular and cellular cardiology

authors： Gupta SK,Kumari S,Singh S,Barthwal MK,Singh SK,Thum T

更新日期：2020-05-01 00:00:00

abstract：:Mitochondria are the major source of cellular energy (ATP), as well as critical mediators of widespread functions such as cellular redox balance, apoptosis, and metabolic flux. The organelles play an especially important role in the maintenance of cardiac homeostasis; their inability to generate ATP following impairme...

journal_title：Journal of molecular and cellular cardiology

authors： Stotland AB,Spivia W,Orosco A,Andres AM,Gottlieb RA,Van Eyk JE,Parker SJ

更新日期：2020-05-01 00:00:00

abstract：:Cardiomyocyte (CM) proliferative potential varies considerably across species. While lower vertebrates and neonatal mammals retain robust capacities for CM proliferation, adult mammalian CMs lose proliferative potential due to cell-cycle withdrawal and polyploidization, failing to mount a proliferative response to reg...

journal_title：Journal of molecular and cellular cardiology

authors： Cutie S,Payumo AY,Lunn D,Huang GN

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Cardiac troponins are the preferred biomarkers of acute myocardial infarction. Despite superior sensitivity, serial testing of Troponins to identify patients suffering acute coronary syndromes is still required in many cases to overcome limited specificity. Moreover, unstable angina pectoris relies on report...

journal_title：Journal of molecular and cellular cardiology

authors： Kayvanpour E,Gi WT,Sedaghat-Hamedani F,Lehmann DH,Frese KS,Haas J,Tappu R,Samani OS,Nietsch R,Kahraman M,Fehlmann T,Müller-Hennessen M,Weis T,Giannitsis E,Niederdränk T,Keller A,Katus HA,Meder B

更新日期：2020-04-17 00:00:00

abstract：:Pyroptosis is a pro-inflammatory form of programmed cell death, whose genesis directly depended on caspase-1 activation. Pulmonary hypertension (PH) is a disease characterized, in part, by vascular fibrosis. Up to now, there is no report on the relationship between pyroptosis and vascular fibrosis in PH. Here, we conf...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang M,Xin W,Yu Y,Yang X,Ma C,Zhang H,Liu Y,Zhao X,Guan X,Wang X,Zhu D

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) is established as a central intracellular trigger for various cardiac pathologies such as hypertrophy, heart failure or arrhythmias in animals and humans suggesting CaMKII as a promising target protein for future medical treatments. However, ...

journal_title：Journal of molecular and cellular cardiology

authors： Baier MJ,Klatt S,Hammer KP,Maier LS,Rokita AG

更新日期：2020-01-01 00:00:00

abstract：:There is increasing momentum toward the development of gene therapy for heart failure (HF) that is defined by impaired calcium (Ca2+) transport and reduced contractility. We have used FRET (fluorescence resonance energy transfer) between fluorescently-tagged SERCA2a (the cardiac Ca2+ pump) and PLB (phospholamban, vent...

journal_title：Journal of molecular and cellular cardiology

authors： Stroik DR,Ceholski DK,Bidwell PA,Mleczko J,Thanel PF,Kamdar F,Autry JM,Cornea RL,Thomas DD

更新日期：2020-01-01 00:00:00

abstract：:Cardiac fibrosis is a common feature of various cardiovascular diseases. Previous studies showed that acetaldehyde dehydrogenase 2 (ALDH2) deficiency exacerbated pressure overload-induced heart failure. However, the role and mechanisms of cardiac fibrosis in this process remain largely unknown. This study aimed to inv...

journal_title：Journal of molecular and cellular cardiology

authors： Li X,Weng X,Shi H,Gao R,Wang P,Jia D,Zhang S,Dong Z,Sun X,Yang J,Wang Z,Liu R,Li Y,Qiu Z,Hu K,Sun A,Ge J

更新日期：2019-12-01 00:00:00

abstract：:Heart failure is the leading cause of death among diabetic people. Cellular and molecular entities leading to diabetic cardiomyopathy are, however, poorly understood. Coupling of cardiac carbonic anhydrase II (CAII) and Na+/H+ exchanger 1 (NHE1) to form a transport metabolon was analyzed in obese type 2 diabetic mice ...

journal_title：Journal of molecular and cellular cardiology

authors： Jaquenod De Giusti C,Blanco PG,Lamas PA,Carrizo Velasquez F,Lofeudo JM,Portiansky EL,Alvarez BV

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Cardiovascular fibrosis is a major contributor to cardiovascular disease, the primary cause of death in patients with chronic kidney disease (CKD). We previously reported expression of endogenous Klotho in human arteries, and that CKD is a state of Klotho deficiency, resulting in vascular calcification, but ...

journal_title：Journal of molecular and cellular cardiology

authors： Liu Q,Zhu LJ,Waaga-Gasser AM,Ding Y,Cao M,Jadhav SJ,Kirollos S,Shekar PS,Padera RF,Chang YC,Xu X,Zeisberg EM,Charytan DM,Hsiao LL

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Cultured adult mouse and rat cardiomyocytes are the best and low-cost cell model for cardiac cellular physiology, pathology, drug toxicity screening, and intervention. The functions of mouse cardiomyocytes decline faster than rat cardiomyocytes in culture conditions. However, little is known about the differ...

journal_title：Journal of molecular and cellular cardiology

authors： Liu B,Li A,Qin Y,Tian X,Gao M,Jiang W,Gong G

更新日期：2019-11-01 00:00:00

abstract：:The mitral valve is a complex multilayered structure populated by fibroblast-like cells, valvular interstitial cells (VIC) which are embedded in an extracellular matrix (ECM) scaffold and are submitted to the mechanical deformations affecting valve at each heartbeat, for an average of 40 million times per year. Myxoma...

journal_title：Journal of molecular and cellular cardiology

authors： Blomme B,Deroanne C,Hulin A,Lambert C,Defraigne JO,Nusgens B,Radermecker M,Colige A

更新日期：2019-10-01 00:00:00

abstract：:Atrial fibrillation (AF) is associated with oxidative stress and Ca2+-handling abnormalities in atrial myocytes. Our prior study has demonstrated the involvement of CD44, a membrane receptor for hyaluronan (HA), in the pathogenesis of AF. This study further evaluated whether CD44 and its related signaling mediate atri...

journal_title：Journal of molecular and cellular cardiology

authors： Chen WJ,Chang SH,Chan YH,Lee JL,Lai YJ,Chang GJ,Tsai FC,Yeh YH

更新日期：2019-10-01 00:00:00

abstract：:(±)-Sodium5-bromo-2-(α-hydroxypentyl) benzoate (brand name: brozopine, BZP, 1a), derived from L-3-n-butylphthalide (L-NBP), has been reported to protect the brain from stoke and has been approved by CFDA in Phase I-II clinical trials. However, it remains to be investigated whether 1a may exhibit any cardioprotective e...

journal_title：Journal of molecular and cellular cardiology

authors： Xiao Y,Song C,Lin Q,Shi X,Yu W,Huang X,Wang H,Chen Y,Wang R,Geng X,Qin M,Hu K,Fan Y,Qiao Y,Gao E,Zhao W,Chang J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Inflammatory serine proteases (ISPs) play an important role in cardiac repair after injury through hydrolysis of dead cells and extracellular matrix (ECM) debris. Evidence also suggests an important role of ISPs in the coordination of the inflammatory response. However, the effect of ISPs on inflammation is ...

journal_title：Journal of molecular and cellular cardiology

authors： Miller SA,Kolpakov MA,Guo X,Du B,Nguyen Y,Wang T,Powel P,Dell'Italia LJ,Sabri A

更新日期：2019-09-01 00:00:00

abstract：AIMS:Cyclic AMP phosphodiesterases (PDEs) are important modulators of the cardiac response to β-adrenergic receptor (β-AR) stimulation. PDE3 is classically considered as the major cardiac PDE in large mammals and human, while PDE4 is preponderant in rodents. However, it remains unclear whether PDE4 also plays a functio...

journal_title：Journal of molecular and cellular cardiology

authors： Mika D,Bobin P,Lindner M,Boet A,Hodzic A,Lefebvre F,Lechène P,Sadoune M,Samuel JL,Algalarrondo V,Rucker-Martin C,Lambert V,Fischmeister R,Vandecasteele G,Leroy J

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Phosphoinositide 3-kinase α (PI3Kα) is a proto-oncogene with high activity in the heart. BYL719 (BYL) is a PI3Kα-selective small molecule inhibitor and a prospective drug for advanced solid tumors. We investigated whether acute pharmacological inhibition of PI3Kα has pro-arrhythmic effects. METHODS & RESULT...

journal_title：Journal of molecular and cellular cardiology

authors： Zhabyeyev P,McLean B,Chen X,Vanhaesebroeck B,Oudit GY

更新日期：2019-07-01 00:00:00

abstract：:The leading cause of genetic dilated cardiomyopathy (DCM) is due to mutations in the TTN gene, impacting approximately 15-20% of familial and 18% of sporadic DCM cases. Currently, there is potential for a personalized RNA-based therapeutic approach in titin-based DCM, utilizing antisense oligonucleotide (AON) mediated...

journal_title：Journal of molecular and cellular cardiology

authors： Hahn JK,Neupane B,Pradhan K,Zhou Q,Testa L,Pelzl L,Maleck C,Gawaz M,Gramlich M

更新日期：2019-06-01 00:00:00

abstract：:Arrhythmogenic right ventricular cardiomyopathy (ARVC) has been linked to variants in the coding sequence of desmosomal genes. The potential contribution of non-coding desmoglein-2 (DSG2) variants for development of ARVC is undescribed. We sequenced 1450 base pairs upstream of ATG in the DSG2 gene in 65 unrelated pati...

journal_title：Journal of molecular and cellular cardiology

authors： Christensen AH,Andersen CB,Wassilew K,Svendsen JH,Bundgaard H,Brand SM,Schmitz B

更新日期：2019-06-01 00:00:00

abstract：AIMS:The FDA-approved histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt ischemia/reperfusion (I/R) injury when administered at the time of reperfusion. However, the precise mechanisms underlying the cardioprotective activi...

journal_title：Journal of molecular and cellular cardiology

authors： Yang J,He J,Ismail M,Tweeten S,Zeng F,Gao L,Ballinger S,Young M,Prabhu SD,Rowe GC,Zhang J,Zhou L,Xie M

更新日期：2019-05-01 00:00:00

abstract：:Calmodulin (CaM) is a Ca-binding protein that binds to, and can directly inhibit cardiac ryanodine receptor calcium release channels (RyR2). Animal studies have shown that RyR2 hyperphosphorylation reduces CaM binding to RyR2 in failing hearts, but data are lacking on how CaM regulates human RyR2 and how this regulati...

journal_title：Journal of molecular and cellular cardiology

authors： Walweel K,Gomez-Hurtado N,Rebbeck RT,Oo YW,Beard NA,Molenaar P,Dos Remedios C,van Helden DF,Cornea RL,Knollmann BC,Laver DR

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Duchenne muscular dystrophy (DMD) is an X-linked disease characterized by skeletal muscle degeneration and a significant cardiomyopathy secondary to cardiomyocyte damage and myocardial loss. The molecular basis of DMD lies in the absence of the protein dystrophin, which plays critical roles in mechanical mem...

journal_title：Journal of molecular and cellular cardiology

authors： Meyers TA,Heitzman JA,Krebsbach AM,Aufdembrink LM,Hughes R,Bartolomucci A,Townsend D

更新日期：2019-03-01 00:00:00

abstract：RATIONALE:Truncation mutations in the MYBPC3 gene, encoding for cardiac myosin-binding protein C (MyBP-C), are the leading cause of hypertrophic cardiomyopathy (HCM). Whole heart, fiber and molecular studies demonstrate that MyBP-C is a potent modulator of cardiac contractility, but how these mutations contribute to HC...

journal_title：Journal of molecular and cellular cardiology

authors： O'Leary TS,Snyder J,Sadayappan S,Day SM,Previs MJ

更新日期：2019-02-01 00:00:00

abstract：:Human vascular connexins (Cx37, Cx40, Cx43, and Cx45) can form various types of gap junction channels to synchronize vasodilation/constriction to control local circulation. Most of our knowledge on heterotypic gap junctions of these vascular connexins was from studies on rodent connexins. In human vasculature, the sam...

journal_title：Journal of molecular and cellular cardiology

authors： Kim NK,Santos-Miranda A,Chen H,Aoyama H,Bai D

更新日期：2019-02-01 00:00:00

abstract：:The sympathetic nervous system is the main stimulator of cardiac function. While acute activation of the β-adrenoceptors exerts positive inotropic and lusitropic effects by increasing cAMP and Ca2+, chronically enhanced sympathetic tone with changed β-adrenergic signaling leads to alterations of gene expression and re...

journal_title：Journal of molecular and cellular cardiology

authors： Morhenn K,Quentin T,Wichmann H,Steinmetz M,Prondzynski M,Söhren KD,Christ T,Geertz B,Schröder S,Schöndube FA,Hasenfuss G,Schlossarek S,Zimmermann WH,Carrier L,Eschenhagen T,Cardinaux JR,Lutz S,Oetjen E

更新日期：2019-02-01 00:00:00

abstract：:The Raf/MAPK/ERK kinase (Mek)/extracellular signal-regulated kinases (Erk) pathway is activated in cardiac hypertrophy after a myocardial infarction. Although heat-shock protein 90 (Hsp90) may regulate the Raf/Mek/Erk signal pathway, the role of Hsp90 in pathophysiological cardiac hypertrophy remains unclear. In this ...

journal_title：Journal of molecular and cellular cardiology

authors： Tamura S,Marunouchi T,Tanonaka K

更新日期：2019-02-01 00:00:00

abstract：:The mitochondrial calcium uniporter (MCU) relays cytosolic Ca2+ transients to the mitochondria. We examined whether energy metabolism was compromised in hearts from mice with a cardiac-specific deficiency of MCU subjected to an isoproterenol (ISO) challenge. Surprisingly, isolated working hearts from cardiac MCU-defic...

journal_title：Journal of molecular and cellular cardiology

authors： Altamimi TR,Karwi QG,Uddin GM,Fukushima A,Kwong JQ,Molkentin JD,Lopaschuk GD

更新日期：2019-02-01 00:00:00