Heterotypic docking compatibility of human connexin37 with other vascular connexins.

abstract：:The sarcomere is the basic contractile unit of striated muscle and is a highly ordered protein complex with the actin and myosin filaments at its core. Assembling the sarcomere constituents into this organized structure in development, and with muscle growth as new sarcomeres are built, is a complex process coordinate...

journal_title：Journal of molecular and cellular cardiology

authors： Martin TG,Kirk JA

更新日期：2020-11-01 00:00:00

abstract：:Reoxygenation of isolated rat cardiac myocytes following a period of hypoxia and substrate deprivation resulted in a 1.5-2-fold increase in the total Ca2+ content which could be inhibited by 1 microM antimycin A or ruthenium red (50% inhibition at 2.5 microM). This increase in Ca2+ content was not accompanied by any r...

journal_title：Journal of molecular and cellular cardiology

authors： Stone D,Darley-Usmar V,Smith DR,O'Leary V

更新日期：1989-10-01 00:00:00

abstract：:We investigated the effects of viral infection on Tissue Factor (TF) expression and activity in mice within the myocardium to understand increased thrombosis during myocarditis. Mice were infected with coxsackie virus B3 (CVB3) and the hearts were collected at day 4, 8 and 28 post infection (p.i.). Myocardial TF expre...

journal_title：Journal of molecular and cellular cardiology

authors： Antoniak S,Boltzen U,Riad A,Kallwellis-Opara A,Rohde M,Dörner A,Tschöpe C,Noutsias M,Pauschinger M,Schultheiss HP,Rauch U

更新日期：2008-07-01 00:00:00

abstract：:The relationship between reperfusion-induced arrhythmias and the size of the occluded zone was examined. The isolated perfuse rat heart was used because its negligible collateral flow maximizes susceptibility to arrhythmias and reduces variability. Ischemia lasting 10 min was followed by 10 min of reperfusion. A const...

journal_title：Journal of molecular and cellular cardiology

authors： Curtis MJ,Hearse DJ

更新日期：1989-06-01 00:00:00

abstract：:The heart responds to increased haemodynamic load with growth of the ventricles. The rise in ventricle mass is due to increasing mass of the myocytes and proliferation of fibroblasts and smooth muscle cells. The accompanying adaptation and remodelling of the interstitium, e.g. production and composition of the extrace...

journal_title：Journal of molecular and cellular cardiology

authors： Simm A,Nestler M,Hoppe V

更新日期：1997-01-01 00:00:00

abstract：:The key information processing units within gene regulatory networks are enhancers. Enhancer activity is associated with the production of tissue-specific noncoding RNAs, yet the existence of such transcripts during cardiac development has not been established. Using an integrated genomic approach, we demonstrate that...

journal_title：Journal of molecular and cellular cardiology

authors： Ounzain S,Pezzuto I,Micheletti R,Burdet F,Sheta R,Nemir M,Gonzales C,Sarre A,Alexanian M,Blow MJ,May D,Johnson R,Dauvillier J,Pennacchio LA,Pedrazzini T

更新日期：2014-11-01 00:00:00

abstract：:Cardiomyocyte (CM) proliferative potential varies considerably across species. While lower vertebrates and neonatal mammals retain robust capacities for CM proliferation, adult mammalian CMs lose proliferative potential due to cell-cycle withdrawal and polyploidization, failing to mount a proliferative response to reg...

journal_title：Journal of molecular and cellular cardiology

authors： Cutie S,Payumo AY,Lunn D,Huang GN

更新日期：2020-05-01 00:00:00

abstract：:Cardiac hypertrophy has been well-characterized at the level of transcription. During cardiac hypertrophy, genes normally expressed primarily during fetal heart development are re-expressed, and this fetal gene program is believed to be a critical component of the hypertrophic process. Recently, alternative splicing o...

journal_title：Journal of molecular and cellular cardiology

authors： Ames EG,Lawson MJ,Mackey AJ,Holmes JW

更新日期：2013-09-01 00:00:00

abstract：:We studied peripheral skeletal muscle metabolism in monocrotaline-treated rats. Two distinct groups emerged: a percentage of the animals developed ventricular hypertrophy, with no signs of heart failure (compensated group), whilst others, besides ventricular hypertrophy, developed the syndrome of congestive heart fail...

journal_title：Journal of molecular and cellular cardiology

authors： Bernocchi P,Ceconi C,Pedersini P,Pasini E,Curello S,Ferrari R

更新日期：1996-11-01 00:00:00

abstract：:Connexin40 (Cx40) and connexin45 (Cx45) are involved in both cardiac morphogenesis and propagation of electrical activity. We found that Cx40/Cx45 double deficiency (Cx40(-/-)/Cx45(+/-)) causes a variety of cardiac defects leading to high mortality during embryonic development and at birth. The majority of Cx40(-/-)/C...

journal_title：Journal of molecular and cellular cardiology

authors： Krüger O,Maxeiner S,Kim JS,van Rijen HV,de Bakker JM,Eckardt D,Tiemann K,Lewalter T,Ghanem A,Lüderitz B,Willecke K

更新日期：2006-11-01 00:00:00

abstract：:The purpose of this study was to investigate whether vitamin D3 deficiency affects the cardiac function of chick hearts directly or whether the influence is secondary through the hormone's effect on serum calcium levels. To this end, three experimental groups were studied: (a) the control group of vitamin D3 supplemen...

journal_title：Journal of molecular and cellular cardiology

authors： Hochhauser E,Kushnir T,Navon G,Rehavi M,Barak J,Edelstein S,Vidne B

更新日期：1993-01-01 00:00:00

abstract：:To establish new treatment for cardiovascular disease, the development of safe and highly efficient vectors is necessary. Especially, non-viral vectors are considered to be ideal for human gene therapy, since recent adverse events with retroviral or adenoviral vectors have highlighted the issue of safety. Although we ...

journal_title：Journal of molecular and cellular cardiology

authors： Tashiro H,Aoki M,Isobe M,Hashiya N,Makino H,Kaneda Y,Ogihara T,Morishita R

更新日期：2005-09-01 00:00:00

abstract：AIMS:Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role in stabilizing fibrotic scars after experimental myocardial infarction. However, the role of biglycan in the development and regression of cardiomyocyte hypertrophy and fibrosis during cardiac pressure overload and unloading rema...

journal_title：Journal of molecular and cellular cardiology

authors： Beetz N,Rommel C,Schnick T,Neumann E,Lother A,Monroy-Ordonez EB,Zeeb M,Preissl S,Gilsbach R,Melchior-Becker A,Rylski B,Stoll M,Schaefer L,Beyersdorf F,Stiller B,Hein L

更新日期：2016-12-01 00:00:00

abstract：:ADP-ribosylation factors (ARFs) are approximately 20-kDa, guanine nucleotide-binding proteins, initially discovered as stimulators of cholera toxin ADP-ribosyltransferase activity and subsequently shown to participate in vesicular trafficking. Five of the six mammalian ARFs have been identified in human tissues by mol...

journal_title：Journal of molecular and cellular cardiology

authors： Lee CM,Stevens LA,Hsu HC,Tsai SC,Lee YT,Moss J,Vaughan M

更新日期：1996-09-01 00:00:00

abstract：:Despite advances in the treatment of acute tissue ischemia significant challenges remain in effective cytoprotection from ischemic cell death. It has been documented that injected stem cells, such as mesenchymal stem cells (MSCs), can confer protection to ischemic tissue through the release of paracrine factors. The s...

journal_title：Journal of molecular and cellular cardiology

authors： Huang J,Guo J,Beigi F,Hodgkinson CP,Facundo HT,Zhang Z,Espinoza-Derout J,Zhou X,Pratt RE,Mirotsou M,Dzau VJ

更新日期：2014-01-01 00:00:00

abstract：:COVID-19, caused by the SARS-CoV-2 virus, is a major source of morbidity and mortality due to its inflammatory effects in the lungs and heart. The p38 MAPK pathway plays a crucial role in the release of pro-inflammatory cytokines such as IL-6 and has been implicated in acute lung injury and myocardial dysfunction. The...

journal_title：Journal of molecular and cellular cardiology

authors： Grimes JM,Grimes KV

更新日期：2020-07-01 00:00:00

abstract：:The possible involvement of protein kinase C in modulating membrane currents was investigated in isolated guinea-pig ventricular cells. In a Na(+)-and K(+)-free external solution, the delayed rectifier K+ current (IK) was increased by the activator of protein kinase C (PKC), 12-O-tetradecanoylphorbol-13-acetate (TPA)....

journal_title：Journal of molecular and cellular cardiology

authors： Tohse N,Kameyama M,Sekiguchi K,Shearman MS,Kanno M

更新日期：1990-06-01 00:00:00

abstract：:A decade ago, stem or progenitor cells held the promise of tissue regeneration in human myocardium, with the expectation that these therapies could rescue ischemic myocyte damage, enhance vascular density and rebuild injured myocardium. The accumulated evidence in 2014 indicates, however, that the therapeutic success ...

journal_title：Journal of molecular and cellular cardiology

authors： Pavo N,Charwat S,Nyolczas N,Jakab A,Murlasits Z,Bergler-Klein J,Nikfardjam M,Benedek I,Benedek T,Pavo IJ,Gersh BJ,Huber K,Maurer G,Gyöngyösi M

更新日期：2014-10-01 00:00:00

abstract：:The transcription factor Wilms' Tumor-1 (WT1) is essential for cardiac development. Deletion of Wt1 in mice results in disturbed epicardial and myocardial formation and lack of cardiac vasculature, causing embryonic lethality. Little is known about the role of WT1 in the human fetal heart. Therefore, as a first step, ...

journal_title：Journal of molecular and cellular cardiology

authors： Duim SN,Smits AM,Kruithof BP,Goumans MJ

更新日期：2016-01-01 00:00:00

abstract：:Application of ultrasound-mediated destruction of microbubbles (US + Bubble) to skeletal muscle creates capillary ruptures leading to leakage of the cell components. We studied whether US + Bubble combined with bone-marrow-derived mononuclear cells (BM-MNCs) infusion enables the targeted delivery of endothelial-lineag...

journal_title：Journal of molecular and cellular cardiology

authors： Zen K,Okigaki M,Hosokawa Y,Adachi Y,Nozawa Y,Takamiya M,Tatsumi T,Urao N,Tateishi K,Takahashi T,Matsubara H

更新日期：2006-06-01 00:00:00

abstract：:Hypothermic cardioplegic solutions are currently used to preserve cardiac function during transportation. However, it has been shown that end-diastolic compliance decreases in donor hearts during reperfusion. Excessively cold temperatures may affect membrane-bound enzymes (Ca2+ ATPase and Ca2+ uptake) which are necess...

journal_title：Journal of molecular and cellular cardiology

authors： Labow RS,Hendry PJ,Meek E,Keon WJ

更新日期：1993-10-01 00:00:00

abstract：:Previous studies have demonstrated that in different cardiac preparations action potential duration (APD) increases with age. As in various species, thyroid hormone levels increase developmentally, and since hyperthyroidism shortens APD while hypothyroidism prolongs it, we hypothesized that developmental changes in AP...

journal_title：Journal of molecular and cellular cardiology

authors： Felzen B,Rubinstein I,Lotan R,Binah O

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:Dilated cardiomyopathy (DCM) could be caused by mutations in more than 40 different genes. However, the pathogenic impact of specific mutations is in most cases unknown complicating the genetic counseling of affected families. Therefore, functional studies could contribute to distinguish pathogenic mutations...

journal_title：Journal of molecular and cellular cardiology

authors： Brodehl A,Dieding M,Biere N,Unger A,Klauke B,Walhorn V,Gummert J,Schulz U,Linke WA,Gerull B,Vorgert M,Anselmetti D,Milting H

更新日期：2016-02-01 00:00:00

abstract：:The two-pore domain potassium (K(+)) channel TWIK-1 (or K2P1.1) contributes to background K(+) conductance in diverse cell types. TWIK-1, encoded by the KCNK1 gene, is present in the human heart with robust expression in the atria, however its physiological significance is unknown. To evaluate the cardiac effects of T...

journal_title：Journal of molecular and cellular cardiology

authors： Christensen AH,Chatelain FC,Huttner IG,Olesen MS,Soka M,Feliciangeli S,Horvat C,Santiago CF,Vandenberg JI,Schmitt N,Olesen SP,Lesage F,Fatkin D

更新日期：2016-08-01 00:00:00

abstract：:The kappa-opioid receptor exerts a negative modulatory action on the beta-adrenoceptor and the action is blunted in adult spontaneously hypertensive rats (SHR). In order to determine whether the blunted negative modulation of the beta-adrenoceptor by the kappa-opioid receptor contributes to the development of hyperten...

journal_title：Journal of molecular and cellular cardiology

authors： Yu XC,Wang HX,Zhang WM,Wong TM

更新日期：1999-03-01 00:00:00

abstract：:Biglycan, a small dermatan sulphate proteoglycan, has been postulated to interact with other components of the extracellular matrix (ECM), specifically collagens. We hypothesized that biglycan messenger ribonucleic acid (mRNA) is increased in the myocardial infarct zone. Biglycan mRNA expression after acute myocardial...

journal_title：Journal of molecular and cellular cardiology

authors： Yamamoto K,Kusachi S,Ninomiya Y,Murakami M,Doi M,Takeda K,Shinji T,Higashi T,Koide N,Tsuji T

更新日期：1998-09-01 00:00:00

abstract：:Nkx2.5 and serum response factor (SRF) are critically important transcription factors in cardiac morphogenesis. They are also widely expressed in adult cardiomyocytes, but there is little data to indicate their possible role in adult cardiac cells. In this paper we demonstrate that the interaction of Nkx2.5 and SRF in...

journal_title：Journal of molecular and cellular cardiology

authors： Müller JG,Thompson JT,Edmonson AM,Rackley MS,Kasahara H,Izumo S,McQuinn TC,Menick DR,O'Brien TX

更新日期：2002-07-01 00:00:00

abstract：:We evaluated whether phospholemman (PLM) regulates L-type Ca(2+) current (ICa) in mouse ventricular myocytes. Expression of α1-subunit of L-type Ca(2+) channels between wild-type (WT) and PLM knockout (KO) hearts was similar. Compared to WT myocytes, peak ICa (at -10 mV) from KO myocytes was ~41% larger, the inactivat...

journal_title：Journal of molecular and cellular cardiology

authors： Zhang XQ,Wang J,Song J,Rabinowitz J,Chen X,Houser SR,Peterson BZ,Tucker AL,Feldman AM,Cheung JY

更新日期：2015-07-01 00:00:00

abstract：:Previous studies have shown that p53 plays an important role in maintaining cell cycle arrest of cardiomyocytes, which might account for the inability of human hearts to regenerate adequately after injury. Therefore, inhibition of p53 represents an attractive strategy to restore cell cycle progression in cardiomyocyte...

journal_title：Journal of molecular and cellular cardiology

authors： Ebelt H,Zhang Y,Köhler K,Xu J,Gajawada P,Boettger T,Hollemann T,Müller-Werdan U,Werdan K,Braun T

更新日期：2008-09-01 00:00:00

abstract：:Under conditions of mitochondrial calcium overload, especially when accompanied by oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a non-specific pore, the mitochondrial permeability transition pore (MPTP), opens in the inner mitochondrial membrane. MPTP opening enables free passa...

journal_title：Journal of molecular and cellular cardiology

authors： Halestrap AP

更新日期：2009-06-01 00:00:00