当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Developmental changes in ventricular action potential properties in guinea-pigs are modulated by age-related changes in the thyroid state.

Developmental changes in ventricular action potential properties in guinea-pigs are modulated by age-related changes in the thyroid state.

Abstract：

:Previous studies have demonstrated that in different cardiac preparations action potential duration (APD) increases with age. As in various species, thyroid hormone levels increase developmentally, and since hyperthyroidism shortens APD while hypothyroidism prolongs it, we hypothesized that developmental changes in APD result from age-related variations in the thyroid state. The hypothesis was tested by analysing ventricular action potentials and total T4 (TT4) levels in guinea-pigs in the age range of 0 days to 3 months (adult), and in hyperthyroid and hypothyroid newborns (0-5 days old). We found that APD50 increased exponentially with age with a time constant of 6.7 days, from 100.6 +/- 3.4 ms in newborns (0-5 days old) to 147.4 +/- 5.2 ms in adults (P less than 0.001). TT4 decreased exponentially with age with a time constant of 4.8 days, from 3.9 +/- 0.4 micrograms/dl in newborns to less than 1.0 microgram/dl in adults. In the age range studied, APD50 and TT4 were linearly correlated: Y = -12.13X + 142, r - 0.865. In contrast to the marked changes in APD, resting potential and action potential amplitude were age-independent, and Vmax only slightly increased with age. Alterations in the thyroid state in newborns affected ventricular action potentials as predicted by the hypothesis. In euthyroid (TT4 = 3.9 +/- 0.4 micrograms/dl), hypothyroid (TT4 = 1.6 +/- 0.4 micrograms/dl) and hyperthyroid (TT4 = 39.8 +/- 10.8 micrograms/dl) newborns, APD50 was: 100.6 +/- 3.4 ms, 117.7 +/- 4.2 ms and 63.7 +/- 7.4 ms, respectively (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Felzen B,Rubinstein I,Lotan R,Binah O

doi

10.1016/0022-2828(91)90212-5

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

787-94

issue

7

eissn

0022-2828

issn

1095-8584

pii

0022-2828(91)90212-5

journal_volume

23

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • Identification, localization and interaction of SNARE proteins in atrial cardiac myocytes.

    abstract：:Atrial cardiac myocytes secrete the vasoactive hormone atrial natriuretic peptide (ANP) by both constitutive and regulated exocytotic fusion of ANP-containing large dense core vesicles (LDCV) with the sarcolemma. Detailed information, however, regarding the identity and function of specific membrane fusion proteins (S...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.12.007

    authors： Peters CG,Miller DF,Giovannucci DR

    更新日期：2006-03-01 00:00:00

  • Implications of the complex biology and micro-environment of cardiac sarcomeres in the use of high affinity troponin antibodies as serum biomarkers for cardiac disorders.

    abstract：:Cardiac troponin I (cTnI), the inhibitory-unit, and cardiac troponin T (cTnT), the tropomyosin-binding unit together with the Ca-binding unit (cTnC) of the hetero-trimeric troponin complex signal activation of the sarcomeres of the adult cardiac myocyte. The unique structure and heart myocyte restricted expression of ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2020.05.010

    authors： Solaro CR,Solaro RJ

    更新日期：2020-06-01 00:00:00

  • Regulation of post-translationally modified microtubule populations during neonatal cardiac development.

    abstract：:Microtubules have been implicated in a number of muscle-specific functions, including sarcomerogenesis and the regulation of heart cell beating rate. Post-translationally modified microtubules (MTs) have been correlated, in other cell types, with MTs of increased stability and possibly distinct functions. This study w...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0421

    authors： Webster DR

    更新日期：1997-06-01 00:00:00

  • Myocyte growth and cardiac repair.

    abstract：:Introduced several decades ago, the dogma persists that ventricular myocytes are terminally differentiated cells and cardiac repair by myocyte regeneration is completely inhibited shortly after birth. On the basis that cardiac myocytes are unable to divide in the adult heart, myocyte growth under physiologic and patho...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1006/jmcc.2001.1506

    authors： Anversa P,Leri A,Kajstura J,Nadal-Ginard B

    更新日期：2002-02-01 00:00:00

  • Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres.

    abstract：:Ventricular trabeculae from adult and newborn ferret heart were chemically skinned by Triton X-100 which disrupts all cellular membranes. In newborn preparations, maximal Ca(2+)-activated tension was two times smaller than in adult fibres while Ca2+ sensitivity was higher. Caffeine (10 mM) and cyclopiazonic acid (100 ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0119

    authors： Bonnet V,Léoty C

    更新日期：1996-06-01 00:00:00

  • Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose.

    abstract：:Cell-based therapy after myocardial infarction (MI) is a promising therapeutic option but the relevant cell subsets and dosage requirements are poorly defined. We hypothesized that cell therapy for myocardial infarction is improved by ex vivo expansion and high-dose transplantation of defined hematopoietic progenitor ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2008.06.010

    authors： Templin C,Kotlarz D,Faulhaber J,Schnabel S,Grote K,Salguero G,Luchtefeld M,Hiller KH,Jakob P,Naim HY,Schieffer B,Hilfiker-Kleiner D,Landmesser U,Limbourg FP,Drexler H

    更新日期：2008-09-01 00:00:00

  • Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure.

    abstract：:The Gq-RhoA-Rho kinase pathway, activated by neurohormonal factors such as angiotensin II (Ang II), has been proposed to be one of the important signaling pathways involved in the progression of left ventricular (LV) hypertrophy to heart failure. We tested the hypothesis that chronic inhibition of Rho kinase prevents ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(02)00278-x

    authors： Satoh S,Ueda Y,Koyanagi M,Kadokami T,Sugano M,Yoshikawa Y,Makino N

    更新日期：2003-01-01 00:00:00

  • Protection against lipopolysaccharide-induced myocardial dysfunction in mice by cardiac-specific expression of soluble Fas.

    abstract：:The mechanisms responsible for myocardial dysfunction in the setting of sepsis remain undefined. Fas ligation with its cognate ligand (FasL) induces apoptosis and activates cellular inflammatory responses associated with tissue injury. We determined whether interruption of Fas/FasL interaction by cardiac-specific expr...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2007.09.016

    authors： Niu J,Azfer A,Kolattukudy PE

    更新日期：2008-01-01 00:00:00

  • Effect of ovariectomy and estrogen replacement on cardiovascular disease in heart failure-prone SHHF/Mcc- fa cp rats.

    abstract：:The importance of endogenous and exogenous estrogen levels to the development of cardiovascular disease in women in controversial. The purpose of our study was to examine the effect of estrogen on the development of hypertension, cardiac hypertrophy, ventricular function, and gene expression for atrial natriuretic pep...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.0985

    authors： Sharkey LC,Holycross BJ,Park S,Shiry LJ,Hoepf TM,McCune SA,Radin MJ

    更新日期：1999-08-01 00:00:00

  • Selective upregulation of cardiac brain natriuretic peptide at the transcriptional and translational levels by pro-inflammatory cytokines and by conditioned medium derived from mixed lymphocyte reactions via p38 MAP kinase.

    abstract：:An increase in circulating brain natriuretic peptide (BNP) but not atrial natriuretic factor (ANF) is observed coincident with cardiac allograft rejection that is reversed upon treatment with anti-lymphocyte therapy suggesting that pro-inflammatory cytokines may uniquely modulate BNP gene expression and secretion. Thi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2004.01.001

    authors： Ma KK,Ogawa T,de Bold AJ

    更新日期：2004-04-01 00:00:00

  • Ultrastructural localization of calcium in the myocardium of cardiomyopathic syrian hamsters.

    abstract：:Cardiomyopathy of the Syrian hamster is characterized by myocardial calcium overload and focal myocardial necrosis. The cause of the myocardial calcium overload is not yet fully understood. In this study, the ultrastructural localization of calcium was determined in normal hamster hearts and in non-necrotic and necrot...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(88)80019-1

    authors： Olbrich HG,Borgers M,Thoné F,Frotscher M,Mutschler E,Schneider M,Kober G,Kaltenbach M

    更新日期：1988-08-01 00:00:00

  • L-type calcium channel blockers and EGTA enhance superoxide production in cardiac fibroblasts.

    abstract：:Since the recognition of the importance of calcium ions to cardiac contractility, the effects of alterations in calcium homeostasis on cardiac myocyte function have attracted immense attention. However, the possibility that changes in extracellular calcium concentration or the administration of calcium channel blocker...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1309

    authors： Shivakumar K,Kumaran C

    更新日期：2001-02-01 00:00:00

  • Interaction of nitric oxide and endothelin-1 in ischemia/reperfusion injury of rat heart.

    abstract：:Although several studies have demonstrated that nitric oxide appears to be cardioprotective and endothelin-1 (ET-1) deleterious in myocardial ischemia/reperfusion injury, their interactions in the intact heart are unknown. Therefore, coronary effluent and interstitial fluid ("transudate") levels of ET-1 and cyclic GMP...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0470

    authors： Brunner F

    更新日期：1997-09-01 00:00:00

  • Ablation of biglycan attenuates cardiac hypertrophy and fibrosis after left ventricular pressure overload.

    abstract：AIMS:Biglycan, a small leucine-rich proteoglycan, has been shown to play an important role in stabilizing fibrotic scars after experimental myocardial infarction. However, the role of biglycan in the development and regression of cardiomyocyte hypertrophy and fibrosis during cardiac pressure overload and unloading rema...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2016.10.011

    authors： Beetz N,Rommel C,Schnick T,Neumann E,Lother A,Monroy-Ordonez EB,Zeeb M,Preissl S,Gilsbach R,Melchior-Becker A,Rylski B,Stoll M,Schaefer L,Beyersdorf F,Stiller B,Hein L

    更新日期：2016-12-01 00:00:00

  • Effects of neuropeptide Y on collateral development in a swine model of chronic myocardial ischemia.

    abstract：:We investigated the role of neuropeptide Y (NPY), abundant in the myocardial sympathetic nervous system and endothelial cells, in angiogenesis during chronic myocardial ischemia. Adult male Yorkshire swine underwent ameroid constrictor placement on the proximal left circumflex coronary artery. After 3 weeks, an osmoti...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2010.08.022

    authors： Robich MP,Matyal R,Chu LM,Feng J,Xu SH,Laham RJ,Hess PE,Bianchi C,Sellke FW

    更新日期：2010-12-01 00:00:00

  • Structure, regulation and function of avian glypican.

    abstract：:Glypicans are a group of membrane-bound heparan sulfate proteoglycans (HSPG) that are tissue specific and developmentally regulated. Transcripts for avian glypican are found in endocardial cushions, limb buds, somites and forebrain of early chick embryos. Since avian glypican is not well characterized, the cellular lo...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0618

    authors： Niu S,Bahl JJ,Adamson C,Morkin E

    更新日期：1998-03-01 00:00:00

  • Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2: additional amino acids generated by frameshift cause accelerated inactivation.

    abstract：OBJECTIVE:The function of the C-terminus region of the human ether-a-go-go related gene (HERG) has not been well characterized except for its involvement in trafficking. To understand further the role of C-terminus region, we performed a functional analysis of a novel frameshift mutation (1122fs/147) identified in a Ja...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2004.09.010

    authors： Sasano T,Ueda K,Orikabe M,Hirano Y,Kawano S,Yasunami M,Isobe M,Kimura A,Hiraoka M

    更新日期：2004-12-01 00:00:00

  • Cardiomegaly due to myocyte hyperplasia in perinatal rats exposed to 200 ppm carbon monoxide.

    abstract：:Exposure to carbon monoxide (CO) during the fetal and neonatal period was used to evaluate cardiac ventricular regional weight and myocyte growth response to an increased hemodynamic load. Date-mated Sprague-Dawley rats inhaled 200 ppm CO from day 7 of pregnancy until parturition; another group of pregnant rats inhale...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80913-0

    authors： Clubb FJ Jr,Penney DG,Baylerian MS,Bishop SP

    更新日期：1986-05-01 00:00:00

  • Alpha-adrenergic receptor agonists stimulate ribosome formation in hearts from enalapril-treated piglets.

    abstract：:Hearts from untreated or enalapril-treated piglets were used to measure rates of ribosome formation and total protein synthesis during perfusion as modified Langendorff preparations. Pretreatment of newborn piglets with enalapril maleate (5 mg, once daily for 3 days) resulted in a decreased rate of growth of the left ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1993.1046

    authors： Beinlich CJ,Baker KM,Morgan HE

    更新日期：1993-04-01 00:00:00

  • Cross-talk between cardiac kappa-opioid and beta-adrenergic receptors in developing hypertensive rats.

    abstract：:The kappa-opioid receptor exerts a negative modulatory action on the beta-adrenoceptor and the action is blunted in adult spontaneously hypertensive rats (SHR). In order to determine whether the blunted negative modulation of the beta-adrenoceptor by the kappa-opioid receptor contributes to the development of hyperten...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0896

    authors： Yu XC,Wang HX,Zhang WM,Wong TM

    更新日期：1999-03-01 00:00:00

  • Systemic hypertension induces disparate localized left ventricular action potential lengthening and altered sensitivity to verapamil in left ventricular myocardium.

    abstract：:Previously, we demonstrated that acute exposure to superfusate containing verapamil suppresses action potential plateau to a greater degree in cells at the tip of the anterior papillary muscle compared to those at its base in normal cat left ventricle (LV) studied in tissue bath. To determine the effects of chronic pr...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80469-2

    authors： Cameron JS,Miller LS,Kimura S,Kaiser CJ,Campbell DR,Kozlovskis PL,Gaide MS,Myerburg RJ,Bassett AL

    更新日期：1986-02-01 00:00:00

  • 7-Ketocholesterol predisposes human aorta smooth muscle cells to Fas-mediated death.

    abstract：:Human vascular smooth muscle cells (HVSMCs) are resistant to Fas-mediated death under normal physiological conditions. However, HVSMC death by activation of the receptor pathway was reported in the atherosclerotic lesions. In this study, we investigated whether 7-ketocholesterol, one of the major cholesterol oxides in...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.07.018

    authors： Rho MC,Kim YK,Chang JS,Lee HS,Baek JA,Chung MY,Lee HC,Lee HW,Rhim BY,Reidy MA,Kim K

    更新日期：2005-11-01 00:00:00

  • Fibronectin expression during physiological and pathological cardiac growth.

    abstract：:Fibronectin (FN) is a dimeric glycoprotein found in the extracellular matrix of most tissues that serves as a bridge between cells and the interstitial collagen meshwork and influences diverse processes including cell growth, adhesion, migration, and wound repair. Multiple FN forms arise by the alternative splicing of...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0022-2828(95)90067-5

    authors： Farhadian F,Contard F,Corbier A,Barrieux A,Rappaport L,Samuel JL

    更新日期：1995-04-01 00:00:00

  • Apoptosis repressor with caspase recruitment domain promotes cell proliferation and phenotypic modulation through 14-3-3ε/YAP signaling in vascular smooth muscle cells.

    abstract：AIMS:In response to vascular injury, vascular smooth muscle cells (VSMC) may change from a contractile phenotype to a proliferative phenotype and consequently become conducive to neointima formation. Apoptosis repressor with caspase recruitment domain (ARC) was initially discovered as an endogenous apoptosis inhibitor,...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.08.003

    authors： Liu M,Yu T,Li M,Fang X,Hou B,Liu G,Wang J

    更新日期：2020-10-01 00:00:00

  • Cardiac myosin isoforms exhibit differential rates of MgADP release and MgATP binding detected by myocardial viscoelasticity.

    abstract：:We measured myosin crossbridge detachment rate and the rates of MgADP release and MgATP binding in mouse and rat myocardial strips bearing one of the two cardiac myosin heavy chain (MyHC) isoforms. Mice and rats were fed an iodine-deficient, propylthiouracil diet resulting in ~100% expression of β-MyHC in the ventricl...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.10.010

    authors： Wang Y,Tanner BC,Lombardo AT,Tremble SM,Maughan DW,Vanburen P,Lewinter MM,Robbins J,Palmer BM

    更新日期：2013-01-01 00:00:00

  • Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.

    abstract：:There is increasing momentum toward the development of gene therapy for heart failure (HF) that is defined by impaired calcium (Ca2+) transport and reduced contractility. We have used FRET (fluorescence resonance energy transfer) between fluorescently-tagged SERCA2a (the cardiac Ca2+ pump) and PLB (phospholamban, vent...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.11.147

    authors： Stroik DR,Ceholski DK,Bidwell PA,Mleczko J,Thanel PF,Kamdar F,Autry JM,Cornea RL,Thomas DD

    更新日期：2020-01-01 00:00:00

  • Characterisation of murine cytomegalovirus myocarditis: cellular infiltration of the heart and virus persistence.

    abstract：:Myocarditis triggered by a viral infection has integral viral and immunological aspects associated with the pathogenesis of disease. The present study was performed to analyse the cellular inflammatory response in the heart and cytomegalovirus replication during the development of myocarditis in vivo. We examined muri...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2002.2003

    authors： Lenzo JC,Fairweather D,Cull V,Shellam GR,James Lawson CM

    更新日期：2002-06-01 00:00:00

  • Functional dissection of myosin binding protein C phosphorylation.

    abstract：:Cardiac myosin binding protein C (cMyBP-C) phosphorylation is differentially regulated in the normal heart and during disease development. Our objective was to examine in detail three phosphorylatable sites (Ser-273, Ser-282, and Ser-302) present in the protein's cardiac-specific sequences, as these residues are diffe...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2013.08.006

    authors： Gupta MK,Gulick J,James J,Osinska H,Lorenz JN,Robbins J

    更新日期：2013-11-01 00:00:00

  • Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium.

    abstract：:We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the per...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(88)80146-9

    authors： Seiden D,Navidad P,Weiss HR

    更新日期：1988-10-01 00:00:00

  • Hic-5 deficiency enhances mechanosensitive apoptosis and modulates vascular remodeling.

    abstract：:Forces associated with blood flow are crucial not only for blood vessel development but also for regulation of vascular pathology. Although there have been many studies characterizing the responses to mechanical stimuli, molecular mechanisms linking biological responses to mechanical forces remain unclear. Hic-5 (hydr...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2010.09.024

    authors： Kim-Kaneyama JR,Takeda N,Sasai A,Miyazaki A,Sata M,Hirabayashi T,Shibanuma M,Yamada G,Nose K

    更新日期：2011-01-01 00:00:00