当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Effect of ovariectomy and estrogen replacement on cardiovascular disease in heart failure-prone SHHF/Mcc- fa cp rats.

Effect of ovariectomy and estrogen replacement on cardiovascular disease in heart failure-prone SHHF/Mcc- fa cp rats.

Abstract：

:The importance of endogenous and exogenous estrogen levels to the development of cardiovascular disease in women in controversial. The purpose of our study was to examine the effect of estrogen on the development of hypertension, cardiac hypertrophy, ventricular function, and gene expression for atrial natriuretic peptide (ANP) and components of the renin angiotensin system in spontaneously hypertensive heart failure rats (SHHF/Mcc- facp). Development of hypertension was prevented in 3-month-old ovariectomized rats receiving subcutaneous 17 beta -estradiol implants (EST) compared to ovariectomized (OVX) and controls (CON). EST had the least left ventricular hypertrophy, CON were intermediate, and OVX had the most (P<0.05), correlating well with systolic blood pressure. OVX had significantly lower percentage V(1)myosin isoform compared to EST and CON, indicating reversion to a more immature phenotype associated with hypertrophy. Similarly, OVX had decreased percentage left ventricular shortening fraction by echocardiography compared to EST and CON. These changes were not accompanied by alterations in plasma ANP, or in expression of mRNA for left ventricular ANP, renal renin, or hepatic angiotensinogen. Serum angiotensin converting enzyme activity was lower in EST compared to CON or OVX. When 17 beta -estradiol was given to 17-month-old rats that had naturally ceased estrous cycling, there was no effect on hypertension, progression of cardiac functional decline, or survival. In conclusion, estradiol treatment given prior to the development of hypertension in SHHF prevented left ventricular hypertrophy and hypertension. Development of congestive heart failure was not delayed if 17 beta -estradiol was begun in the post-menopausal period. Effectiveness of estrogen therapy may depend on age or whether hypertension is already established at the time treatment is begun.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Sharkey LC,Holycross BJ,Park S,Shiry LJ,Hoepf TM,McCune SA,Radin MJ

doi

10.1006/jmcc.1999.0985

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

1527-37

issue

8

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(99)90985-9

journal_volume

31

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • Phenylephrine preconditioning involves modulation of cardiac sarcolemmal K(ATP) current by PKC delta, AMPK and p38 MAPK.

    abstract：:Preconditioning of hearts with the α(1)-adrenoceptor agonist phenylephrine decreases infarct size and increases the functional recovery of the heart following ischaemia-reperfusion. However, the cellular mechanisms responsible for this protection are not known. We investigated the role of protein kinase C ε and δ (PKC...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.06.015

    authors： Turrell HE,Rodrigo GC,Norman RI,Dickens M,Standen NB

    更新日期：2011-09-01 00:00:00

  • Deletion in the cardiac troponin I gene in a family from northern Sweden with hypertrophic cardiomyopathy.

    abstract：:The cardiac troponin I gene has been described to be associated with hypertrophic cardiomyopathy. Until now, mutations in this gene have been found only in the Japanese population. We now present the first non-Japanese family, from northern Sweden, with a mutation in the cardiac troponin I gene. Clinical diagnose was ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.1099

    authors： Mörner S,Richard P,Kazzam E,Hainque B,Schwartz K,Waldenström A

    更新日期：2000-03-01 00:00:00

  • Inhibition of angiotensin-converting enzyme increases the nitric oxide levels in canine ischemic myocardium.

    abstract：:Since angiotensin-converting enzyme (ACE) produces angiotensin II in the heart, ACE inhibitors may prevent coronary vasoconstriction and increase coronary blood flow. On the other hand, since ACE inhibitors also inhibit kininase II which results in reduced degradation of bradykinin, ACE inhibitors may increase cardiac...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0806

    authors： Kitakaze M,Node K,Minamino T,Asanuma H,Ueda Y,Kosaka H,Kuzuya T,Hori M

    更新日期：1998-11-01 00:00:00

  • Expression of aquaporin 1 in human cardiac and skeletal muscle.

    abstract：:Aquaporins (AQPs) are a family of water channel proteins that assist in maintenance of the cellular osmotic environment and whole body fluid balance. Specialized organ-specific AQPs are important in physiologic and pathologic processes but little is known about AQPs in the human heart. AQP1 has been identified in rode...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2004.01.009

    authors： Au CG,Cooper ST,Lo HP,Compton AG,Yang N,Wintour EM,North KN,Winlaw DS

    更新日期：2004-05-01 00:00:00

  • Alpha adrenergic receptor mechanism: biochemical events.

    abstract：:Immediate post-receptor events following alpha-adrenoceptor stimulation in cardiac ventricular muscle are still largely unknown. Since membrane redox systems appear to be present in cell plasma membranes and may be involved in trans-sarcolemma electron efflux, the possibility that Ca2+ inflow was controlled by electro...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80462-x

    authors： Clark MG,Rattigan S

    更新日期：1986-11-01 00:00:00

  • Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials.

    abstract：:Celecoxib is a COX-2 inhibitor that has been related to an increased cardiovascular risk and that exerts several actions on different targets. The aim of this study was to analyze the effects of this drug on human cardiac voltage-gated potassium channels (Kv) involved on cardiac repolarization Kv1.5 (I(Kur)), Kv4.3+KC...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2010.09.012

    authors： Macías A,Moreno C,Moral-Sanz J,Cogolludo A,David M,Alemanni M,Pérez-Vizcaíno F,Zaza A,Valenzuela C,González T

    更新日期：2010-12-01 00:00:00

  • Influence of noradrenaline and temperature on the isolated perfused rat heart.

    abstract：:Myocardial protection during open heart surgery is achieved by general cooling and cold cardioplegia. However sympathetic activation during the operation causes raised circulating catecholamine levels that might negatively influence the myocardial metabolism. Moreover, local liberation of catecholamines, in "poorly pe...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(83)90276-6

    authors： Berggren H,Ekroth R,Hjalmarson A,Holm S,William-Olsson G,Waldenström A

    更新日期：1983-04-01 00:00:00

  • Calcineurin B homologous protein 3 negatively regulates cardiomyocyte hypertrophy via inhibition of glycogen synthase kinase 3 phosphorylation.

    abstract：:Cardiac hypertrophy is a leading cause of serious heart diseases. Although many signaling molecules are involved in hypertrophy, the functions of some proteins in this process are still unknown. Calcineurin B homologous protein 3 (CHP3)/tescalcin is an EF-hand Ca(2+)-binding protein that is abundantly expressed in the...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2015.04.018

    authors： Kobayashi S,Nakamura TY,Wakabayashi S

    更新日期：2015-07-01 00:00:00

  • Fibronectin expression during physiological and pathological cardiac growth.

    abstract：:Fibronectin (FN) is a dimeric glycoprotein found in the extracellular matrix of most tissues that serves as a bridge between cells and the interstitial collagen meshwork and influences diverse processes including cell growth, adhesion, migration, and wound repair. Multiple FN forms arise by the alternative splicing of...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0022-2828(95)90067-5

    authors： Farhadian F,Contard F,Corbier A,Barrieux A,Rappaport L,Samuel JL

    更新日期：1995-04-01 00:00:00

  • Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells.

    abstract：BACKGROUND:Cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs) have great potential as a cell source for therapeutic applications such as regenerative medicine, disease modeling, drug screening, and toxicity testing. This potential is limited, however, by the immature state of the cardiomyocyte...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2014.04.005

    authors： Yang X,Rodriguez M,Pabon L,Fischer KA,Reinecke H,Regnier M,Sniadecki NJ,Ruohola-Baker H,Murry CE

    更新日期：2014-07-01 00:00:00

  • FGF-2-induced negative inotropism and cardioprotection are inhibited by chelerythrine: involvement of sarcolemmal calcium-independent protein kinase C.

    abstract：:Fibroblast growth factor-2 (FGF-2), administered to the isolated rat heart by perfusion and under constant pressure, is protective against ischemia-reperfusion (I-R). Here we have investigated whether FGF-2 cardioprotection: (a) is dependent on flow modulation; (b) is linked to effects on contractility; (c) is mediate...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1998.0832

    authors： Padua RR,Merle PL,Doble BW,Yu CH,Zahradka P,Pierce GN,Panagia V,Kardami E

    更新日期：1998-12-01 00:00:00

  • Identification of a high molecular weight alkaline protease in rat heart.

    abstract：:We have identified in soluble extracts of rat heart, a 500 000 dalton sulfhydryl-dependent protease which degrades globin and casein to acid-soluble peptides at an alkaline pH optimum. This enzyme was purified more than 1700-fold with respect to the postmicrosomal supernatant. On the basis of various catalytic and bio...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(83)90304-8

    authors： DeMartino GN

    更新日期：1983-01-01 00:00:00

  • Evolution of the surface of mouse myocardial cells during ontogenesis. II. Changes of fluorescent lectin-binding sites.

    abstract：:Fluorescein isothiocyanate-conjugated lectins (FTC-lectins) have been used to study the occurrence and the distribution of their receptors in the coating of mouse myocardial cells throughout their differentiation (from 10 days post-coitum to the adult stage). FTC-Con A, -WGA and -PNA specifically inhibited by alpha-ma...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(83)90285-7

    authors： Gros D,Bruce B,Kiéda C,Delmotte F,Monsigny M,Schrével J

    更新日期：1983-02-01 00:00:00

  • Different onset of nucleolar activation in endocardial endothelial cells and cardiomyocytes following pressure overload in rat heart.

    abstract：:We evaluated the time course of activation of endocardial endothelial cells and cardiomyocytes in adult rats with pressure overload induced by the abdominal aortic constriction. The silver staining technique for nucleolar organizer region was used to mark an increased transcriptional activity of the cells. An increase...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0484

    authors： Horký M,Horský P,Kolár F

    更新日期：1997-09-01 00:00:00

  • Syndecan-4 over-expression preserves cardiac function in a rat model of myocardial infarction.

    abstract：:Syndecan-4 (synd4) is a heparan sulfate proteoglycan, involved in repair following tissue damage, through modulating neovascularization and inflammation. In acute myocardial infarction its myocardial expression is up-regulated in a time-dependent manner, and in synd4-deficient mice severe cardiac dysfunction and abnor...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.04.014

    authors： Xie J,Wang J,Li R,Dai Q,Yong Y,Zong B,Xu Y,Li E,Ferro A,Xu B

    更新日期：2012-08-01 00:00:00

  • An analysis of lidocaine block of sodium current in isolated human atrial and ventricular myocytes.

    abstract：:Lidocaine is a Na+ channel blocker that is highly effective for the treatment of ventricular tachyarrhythmias, but is largely ineffective against atrial arrhythmias. If is not known if this differential efficacy is the result of differences in lidocaine inhibition of atrial v ventricular Na+ channels. The purpose of t...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(95)90090-x

    authors： Furukawa T,Koumi S,Sakakibara Y,Singer DH,Jia H,Arentzen CE,Backer CL,Wasserstrom JA

    更新日期：1995-02-01 00:00:00

  • Effects of endurance training on cholinergic and adrenergic receptors of rat heart.

    abstract：:To test the hypothesis that alterations in adrenergic or cholinergic receptors occur in response to physical training, and that changes in receptor properties could be mechanistically important in producting the altered cardiovascular physiology of the trained state, we studied the effects of endurance training by swi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(84)80611-2

    authors： Williams RS,Schaible TF,Bishop T,Morey M

    更新日期：1984-05-01 00:00:00

  • Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection.

    abstract：:Thoracic aortic aneurysm/dissection (TAAD) is characterized by excessive smooth muscle cell (SMC) loss, extracellular matrix (ECM) degradation and inflammation. However, the mechanism whereby signaling leads to SMC loss is unclear. We used senescence-associated (SA)-β-gal staining and analysis of expression of senesce...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2016.08.008

    authors： Zhang WM,Liu Y,Li TT,Piao CM,Liu O,Liu JL,Qi YF,Jia LX,Du J

    更新日期：2016-10-01 00:00:00

  • Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function.

    abstract：:Growing evidence suggests that the beta1-adrenoceptor-directed autoimmune mechanism may play an important role in the pathogenesis of idiopathic dilated cardiomyopathy. The aim of this study is to further study the effect of specific immunoabsorption of anti-beta1-adrenoceptor autoantibodies on cardiac structure and f...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.04.016

    authors： Matsui S,Larsson L,Hayase M,Katsuda S,Teraoka K,Kurihara T,Murano H,Nishikawa K,Fu M

    更新日期：2006-07-01 00:00:00

  • Cardioprotective and anti-oxidant effects of the terpenoid constituents of Ginkgo biloba extract (EGb 761).

    abstract：:Hemodynamic and electron spin resonance analyses were used to assess the in vivo and in vitro cardioprotective and antioxidant effects of therapeutically relevant doses of Ginkgo biloba extract (EGb 761) and its terpenoid constituents (ginkgolides A and B, bilobalide) in the rat. Significant anti-ischemic effects, ind...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0316

    authors： Pietri S,Maurelli E,Drieu K,Culcasi M

    更新日期：1997-02-01 00:00:00

  • Increased sympathoadrenomedullary activity and left ventricular hypertrophy in young patients with borderline hypertension.

    abstract：:Echocardiographic dimensions and endocrinological examination were performed in 71 young patients with borderline hypertension (BHT) and 31 age-matched normotensive subjects (NT). Patients with BHT had significantly higher relative wall thickness (RWT) and left ventricular mass index than NT, although all BHT patients...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(89)90769-4

    authors： Fujita T,Noda H,Ito Y,Isaka M,Sato Y,Ogata E

    更新日期：1989-12-01 00:00:00

  • Paracrine mechanisms of stem cell reparative and regenerative actions in the heart.

    abstract：:Stem cells play an important role in restoring cardiac function in the damaged heart. In order to mediate repair, stem cells need to replace injured tissue by differentiating into specialized cardiac cell lineages and/or manipulating the cell and molecular mechanisms governing repair. Despite early reports describing ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2010.08.005

    authors： Mirotsou M,Jayawardena TM,Schmeckpeper J,Gnecchi M,Dzau VJ

    更新日期：2011-02-01 00:00:00

  • Effect of ATP depletion on kinetics of Na/Ca exchange-mediated Ca influx in Na-loaded heart cells.

    abstract：:The kinetics of Ca influx by Na/Ca exchange into adult rat heart cells loaded with Na and depleted of ATP were investigated, to further elucidate how ATP regulates exchanger properties in the intact heart cell. We found an eight-fold reduction in Vmax for Ca uptake by ATP depletion, with no significant change in the K...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0294

    authors： Haworth RA,Biggs AV

    更新日期：1997-02-01 00:00:00

  • Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins.

    abstract：:Heterotrimeric G-proteins, composed of Galpha and Gbetagamma subunits, transmit numerous and diverse extracellular stimuli via a large family of heptahelical cell-surface receptors to various intracellular effector molecules. The Gbetagamma subunit plays a central role in G-protein signaling. The Gbeta subunit belongs...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2004.04.019

    authors： Chen S,Spiegelberg BD,Lin F,Dell EJ,Hamm HE

    更新日期：2004-08-01 00:00:00

  • Attenuation of myocardial ischaemic injury 24 h after diacylglycerol treatment in vivo.

    abstract：:Previous work suggests that delayed protection against infarction following ischaemic preconditioning of rabbit myocardium may involve the activation of protein kinase C (PKC). Preconditioning in the presence of chelerythrine, an inhibitor of PKC, abolished the late anti-infarct effect of preconditioning. In the studi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0436

    authors： Baxter GF,Mocanu MM,Yellon DM

    更新日期：1997-07-01 00:00:00

  • Altered cardiac mechanism and sarcoplasmic reticulum function in pressure overload-induced cardiac hypertrophy in rats.

    abstract：:Cardiac sarcoplasmic reticulum (SR) sequesters Ca2+ and plays a crucial role in the regulation of intracellular Ca2+. Its functional properties are central to the excitation-contraction (E-C) cycle of cardiac muscle. In this study, we examined the hypothesis that alterations in SR function occur during the development...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0250

    authors： Ohkusa T,Hisamatsu Y,Yano M,Kobayashi S,Tatsuno H,Saiki Y,Kohno M,Matsuzaki M

    更新日期：1997-01-01 00:00:00

  • A high-titer lentiviral production system mediates efficient transduction of differentiated cells including beating cardiac myocytes.

    abstract：:Human immunodeficiency virus (HIV, lentivirus) type-1 based vectors have a number of attractive features for gene therapy, including the ability to transduce non-dividing cells and long term transgene expression. We used a three-plasmid expression system to generate pseudotyped lentivirus-based vectors by transient tr...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.1035

    authors： Sakoda T,Kasahara N,Hamamori Y,Kedes L

    更新日期：1999-11-01 00:00:00

  • Electrophysiologic and extracellular ionic changes during acute ischemia in failing and normal rabbit myocardium.

    abstract：:The incidence of ventricular arrhythmias is higher in failing hearts than in control hearts, especially during acute ischemia. Electrophysiological and extracellular ionic changes during acute ischemia in normal and failing rabbit myocardium were assessed. Heart failure was induced in rabbits by combined volume and pr...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0012

    authors： Vermeulen JT,Tan HL,Rademaker H,Schumacher CA,Loh P,Opthof T,Coronel R,Janse MJ

    更新日期：1996-01-01 00:00:00

  • Quantifying antiarrhythmic drug blocking during action potentials in guinea-pig papillary muscle.

    abstract：:This report examines the blocking effects that several antiarrhythmic drugs have on rapid upstroke velocities of action potentials recorded from guinea-pig papillary muscle. A mathematical analysis is developed, that measures an effective "blocking rate' that acts during the action potential with the purpose being to ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(83)90334-6

    authors： Courtney KR

    更新日期：1983-11-01 00:00:00

  • Enhanced modification of cardiolipin during ischemia in the aged heart.

    abstract：:Aging enhances cardiac injury during ischemia and reperfusion compared to the adult heart, including in the Fischer 344 rat model of aging (F344). In interfibrillar cardiac mitochondria obtained from the elderly F344 rat, the rate of oxidative phosphorylation and the activity of electron transport complex III is decre...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2009.03.007

    authors： Lesnefsky EJ,Minkler P,Hoppel CL

    更新日期：2009-06-01 00:00:00