Fibronectin expression during physiological and pathological cardiac growth.

Abstract:

:Fibronectin (FN) is a dimeric glycoprotein found in the extracellular matrix of most tissues that serves as a bridge between cells and the interstitial collagen meshwork and influences diverse processes including cell growth, adhesion, migration, and wound repair. Multiple FN forms arise by the alternative splicing of a primary transcript originating from a single gene. The spatial and temporal alterations in FN expression in the myocardium has been studied in models of cardiac growth in vivo such as fetal development, and hypertrophy secondary to pressure overload. This review focuses on the differential expression of FN isoforms that are observed in different models of cardiac growth. Using a combination of qualitative and quantitative analyses it is shown that in the rat myocardium: (1) the FN phenotype is developmentally regulated, (2) the re-expression of the fetal FN isoforms is observed in different models of cardiac hypertrophy secondary to a sudden or progressive hypertension and (3) the changes in cardiac FN expression affect mostly the coronary artery smooth muscle cells.

journal_name

J Mol Cell Cardiol

authors

Farhadian F,Contard F,Corbier A,Barrieux A,Rappaport L,Samuel JL

doi

10.1016/0022-2828(95)90067-5

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

981-90

issue

4

eissn

0022-2828

issn

1095-8584

pii

0022-2828(95)90067-5

journal_volume

27

pub_type

杂志文章,评审
  • Influence of isoproterenol on contractile protein function, excitation-contraction coupling, and energy turnover of isolated nonfailing human myocardium.

    abstract::Previous animal experiments indicated that the effects of catecholamines on myocardial function and subcellular systems vary considerably depending on the species and type of myocardium investigated. In the present study, we used isometric force and heat measurements to investigate the influence of isoproterenol on en...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1994.1165

    authors: Hasenfuss G,Mulieri LA,Leavitt BJ,Alpert NR

    更新日期:1994-11-01 00:00:00

  • Mechanism of the positive inotropic effect of milrinone in cultured embryonic chick ventricular cells.

    abstract::Milrinone, a potent positive inotropic and vasodilating agent, has shown promise in the clinical treatment of congestive heart failure, but significant controversy about its mechanism of action exists. To approach these mechanistic problems in a non-innervated, non-diffusion-limited system, the effects of milrinone on...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(87)80548-5

    authors: Olson EM,Kim D,Smith TW,Marsh JD

    更新日期:1987-01-01 00:00:00

  • Arrested exocytosis of atrial secretory granules.

    abstract::Release of atrial natriuretic peptide (ANP) from atrial muscle cells is thought to occur by exocytosis of secretory granules, as in other secretory systems. However, in the atrial myocyte, exocytosis has previously proved difficult to detect ultrastructurally. In order to study the mechanism of ANP release and related...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/0022-2828(90)90089-k

    authors: Newman TM,Severs NJ

    更新日期:1990-07-01 00:00:00

  • Effect of high free fatty acids on the anti-contractile response of perivascular adipose tissue in rat aorta.

    abstract::To determine whether high free fatty acids (FFA) could affect the anti-contractile properties of perivascular adipose tissue (PVAT) in rat aortas. Wistar rats were divided into normal, obesity and fenofibrate groups and fed a normal, high-fat, and high-fat plus fenofibrate diet, respectively. Thoracic aortas with or w...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2013.07.018

    authors: Sun X,Hou N,Han F,Guo Y,Hui Z,Du G,Zhang Y

    更新日期:2013-10-01 00:00:00

  • Endogenous antioxidants in isolated hypertrophied cardiac myocytes and hypoxia-reoxygenation injury.

    abstract::Effects of hypoxia-reoxygenation (H-R) on myocytes isolated from 10 week hypertrophied and sham control rat hearts were studied. Myocyte hypertrophy was indicated by an increase in cell size. Superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) enzyme activities were significantly higher and lipid peroxidatio...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(08)80025-9

    authors: Kirshenbaum LA,Hill M,Singal PK

    更新日期:1995-01-01 00:00:00

  • Augmentation of arterial endothelial cell expression of the plasminogen activator inhibitor type-1 (PAI-1) gene by proinsulin and insulin in vivo.

    abstract::Diabetes mellitus is associated with an increased incidence and greater severity of primary atherosclerosis as well as restenosis after angioplasty for reasons not yet clear. We have shown previously that insulin and proinsulin-typically elevated in blood in patients with type II diabetes-increase plasma activity of p...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1998.0719

    authors: Nordt TK,Sawa H,Fujii S,Bode C,Sobel BE

    更新日期:1998-08-01 00:00:00

  • Isolation and characterization of beta 1-adrenergic receptors from adult, rat cardiac myocytes.

    abstract::The beta-receptors were isolated from rat cardiac myocytes and characterized. Isolated myocytes were prepared from adult rat hearts and characterized for viability. Membrane proteins were solubilized from myocytes with 1% Triton X-102. The solubilized membrane proteins were fractionated by DEAE-Sephacel ion exchange c...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(84)80023-1

    authors: Im JH,Puckett SW,Bowdon HR,Rogers WJ,Meezan E,Kim HD,Rackley CE

    更新日期:1984-10-01 00:00:00

  • Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy.

    abstract::Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K(+) channel ancillary subunit gene. New-onset postoperative AF (POAF) generally occurs 48-72 h after major surgery, particularly following procedures within t...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2012.05.010

    authors: Heerdt PM,Kant R,Hu Z,Kanda VA,Christini DJ,Malhotra JK,Abbott GW

    更新日期:2012-09-01 00:00:00

  • Functional abrogation of p53 is required for T-Ag induced proliferation in cardiomyocytes.

    abstract::Targeted expression of the SV40 large T-antigen oncoprotein (T-Ag) induces cardiomyocyte proliferation in the atria and ventricles of transgenic mice. Previous studies have identified the p53 tumor suppressor, p107 (a homologue of the retinoblastoma tumor suppressor), and p193 (a novel BH3 only proapoptosis protein) a...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.2001.1403

    authors: Huh NE,Pasumarthi KB,Soonpaa MH,Jing S,Patton B,Field LJ

    更新日期:2001-08-01 00:00:00

  • Intracellular angiotensin II fusion protein alters AT1 receptor fusion protein distribution and activates CREB.

    abstract::In recently published studies, we show that angiotensin II (AII) generated from an engineered rat angiotensinogen cDNA, and maintained intracellularly, is growth stimulatory for a rat hepatoma cell line. In the present study, we report that co-expression of AII fused to cyan fluorescent protein (ECFP/AII) and angioten...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2003.09.021

    authors: Cook JL,Re R,Alam J,Hart M,Zhang Z

    更新日期:2004-01-01 00:00:00

  • Celecoxib blocks cardiac Kv1.5, Kv4.3 and Kv7.1 (KCNQ1) channels: effects on cardiac action potentials.

    abstract::Celecoxib is a COX-2 inhibitor that has been related to an increased cardiovascular risk and that exerts several actions on different targets. The aim of this study was to analyze the effects of this drug on human cardiac voltage-gated potassium channels (Kv) involved on cardiac repolarization Kv1.5 (I(Kur)), Kv4.3+KC...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2010.09.012

    authors: Macías A,Moreno C,Moral-Sanz J,Cogolludo A,David M,Alemanni M,Pérez-Vizcaíno F,Zaza A,Valenzuela C,González T

    更新日期:2010-12-01 00:00:00

  • 31P-NMR analysis of congestive heart failure in the SHHF/Mcc-facp rat heart.

    abstract::31P-NMR was used to monitor myocardial bioenergetics in compensated and failing SHHF/MCC-fa(cp) (SHF) rat hearts. The SHHF/Mcc-fa(cp) (spontaneous hypertension and heart failure) rat is a relatively new genetic model in which all individuals spontaneously develop congestive heart failure, most during the second year o...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1997.0587

    authors: Michael O'Donnell J,Narayan P,Bailey MQ,Abduljalil AM,Altschuld RA,McCune SA,Robitaille PM

    更新日期:1998-02-01 00:00:00

  • Dok-5 is involved in cardiomyocyte differentiation through PKB/FOXO3a pathway.

    abstract::The insulin receptor substrate (IRS) family plays important roles in cellular growth, signaling, and survival in the brain. We identified IRS6/Dok-5, a member of the IRS family, also expressed in heart. Dok-5 expression level significantly increased during cardiomyocyte differentiation of P19CL6 cells. To understand t...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2009.09.015

    authors: Wen J,Xia Q,Wang C,Liu W,Chen Y,Gao J,Gong Y,Yin B,Ke Y,Qiang B,Yuan J,Peng X

    更新日期:2009-12-01 00:00:00

  • Stable high level expression of a transfected human HSP70 gene protects a heart-derived muscle cell line against thermal stress.

    abstract::Heat shock protein 70 (HSP70) has been shown to play a fundamental role in the induction of thermotolerance in many biological systems. Elevated synthesis of HSP70 in response to diverse stresses such as heat, anoxia, ischaemia, ethanol and heavy metals has been correlated with protection against subsequent more sever...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1994.1084

    authors: Heads RJ,Latchman DS,Yellon DM

    更新日期:1994-06-01 00:00:00

  • Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium.

    abstract::We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the per...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(88)80146-9

    authors: Seiden D,Navidad P,Weiss HR

    更新日期:1988-10-01 00:00:00

  • Localisation of cardiac GS alpha in transgenic mice overexpressing GS alpha.

    abstract::The biochemical and physiological effects of GS alpha activation are well known; however, little is known about the anatomical localisation of GS alpha in the myocardium. Knowledge of the localisation might yield insights into G protein function in heart. The utility of immunocytochemistry using immunofluorescent meth...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1997.0400

    authors: Muntz KH,Ishikawa Y,Wagner T,Homcy CJ,Vatner SF,Vatner DE

    更新日期:1997-06-01 00:00:00

  • Efficient transmural cardiac gene transfer by intrapericardial injection in neonatal mice.

    abstract::An efficient cardiac gene transfer technique in murine models would greatly facilitate the elucidation of the pathophysiology of cardiomyopathies and the development of genetic therapies. Direct myocardial injection or catheter-based intracoronary infusion is not easily achievable in mice and resultant transgene expre...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1998.0905

    authors: Zhang JC,Woo YJ,Chen JA,Swain JL,Sweeney HL

    更新日期:1999-04-01 00:00:00

  • Inhibition of myocardial reperfusion injury by ischemic postconditioning requires sirtuin 3-mediated deacetylation of cyclophilin D.

    abstract:RATIONALE:How ischemic postconditioning can inhibit opening of the mitochondrial permeability transition pore (PTP) and subsequent cardiac myocytes death at reperfusion remains unknown. Recent studies have suggested that de-acetylation of cyclophilin D (CyPD) by sirtuin 3 (SIRT3) can modulate its binding to the PTP. O...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2015.03.017

    authors: Bochaton T,Crola-Da-Silva C,Pillot B,Villedieu C,Ferreras L,Alam MR,Thibault H,Strina M,Gharib A,Ovize M,Baetz D

    更新日期:2015-07-01 00:00:00

  • Effects of caffeine and cyclopiazonic acid on contractile proteins of adult and newborn ferret cardiac fibres.

    abstract::Ventricular trabeculae from adult and newborn ferret heart were chemically skinned by Triton X-100 which disrupts all cellular membranes. In newborn preparations, maximal Ca(2+)-activated tension was two times smaller than in adult fibres while Ca2+ sensitivity was higher. Caffeine (10 mM) and cyclopiazonic acid (100 ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.1996.0119

    authors: Bonnet V,Léoty C

    更新日期:1996-06-01 00:00:00

  • Cytotoxic T lymphocytes are activated following myocardial infarction and can recognize and kill healthy myocytes in vitro.

    abstract::The damage of myocardial infarction (MI) is often progressive. A possible mechanism for subsequent myocardial damage and heart failure after MI is immune response against cardiac self-antigens. The purpose of our study was to test the hypothesis that cytotoxic T lymphocytes are activated following acute MI and may hav...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.2000.1261

    authors: Varda-Bloom N,Leor J,Ohad DG,Hasin Y,Amar M,Fixler R,Battler A,Eldar M,Hasin D

    更新日期:2000-12-01 00:00:00

  • Effects of hemodynamic variables on myocardial K+ balance during and after shortlasting ischemia.

    abstract::Ischemia-induced myocardial potassium loss and post-ischemic potassium reuptake was quantitated in 8 open chest pigs during control conditions and during hemodynamic alterations which have been shown to increase steady state sarcolemmal potassium fluxes. Myocardial K+ balance was continuously computed before, during a...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/0022-2828(89)90673-1

    authors: Aksnes G,Ellingsen O,Rutlen DL,Ilebekk A

    更新日期:1989-12-01 00:00:00

  • Differential reduction of HCN channel activity by various types of lipopolysaccharide.

    abstract::Recently it was shown that lipopolysaccharide (LPS) impairs the pacemaker current in human atrial myocytes. It was speculated that reduced heart rate variability (HRV), typical of patients with severe sepsis, may partially be explained by this impairment. We evaluated the effect of various types of LPS on the activity...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2011.05.004

    authors: Klöckner U,Rueckschloss U,Grossmann C,Ebelt H,Müller-Werdan U,Loppnow H,Werdan K,Gekle M

    更新日期:2011-08-01 00:00:00

  • Guanylate cyclase activation by organic nitrates is not mediated via nitrite.

    abstract::Nitrovasodilators relax vascular smooth muscle by stimulating guanylate cyclase. Ignarro et al. (1981) proposed a mechanistic scheme according to which organic nitrates release nitrite in the presence of thiols. The corresponding nitrous acid would decay leading to nitric oxide, which then would react with another thi...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(88)80130-5

    authors: Romanin C,Kukovetz WR

    更新日期:1988-05-01 00:00:00

  • Cardiomegaly due to myocyte hyperplasia in perinatal rats exposed to 200 ppm carbon monoxide.

    abstract::Exposure to carbon monoxide (CO) during the fetal and neonatal period was used to evaluate cardiac ventricular regional weight and myocyte growth response to an increased hemodynamic load. Date-mated Sprague-Dawley rats inhaled 200 ppm CO from day 7 of pregnancy until parturition; another group of pregnant rats inhale...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(86)80913-0

    authors: Clubb FJ Jr,Penney DG,Baylerian MS,Bishop SP

    更新日期:1986-05-01 00:00:00

  • Contractile performance of adult ventricular rat cardiomyocytes is not directly jeopardized by NO/cGMP-dependent induction of pro-apoptotic pathways.

    abstract::The activation of NO/cGMP pathways can induce pro-apoptotic pathways in cardiomyocytes although only a small number of cardiomyocytes fulfill the criteria of apoptosis. The same pathways reduce the contractile performance of cardiomyocytes. In the present study, we tested the hypothesis that exposure of cells to NO/cG...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2006.10.012

    authors: Tastan H,Abdallah Y,Euler G,Piper HM,Schlüter KD

    更新日期:2007-02-01 00:00:00

  • Mitochondrial complex II participates in normoxic and hypoxic regulation of α-keto acids in the murine heart.

    abstract::α-Keto acids (α-KAs) are not just metabolic intermediates but are also powerful modulators of different cellular pathways. Here, we tested the hypothesis that α-KA concentrations are regulated by complex II (succinate dehydrogenase=SDH), which represents an intersection between the mitochondrial respiratory chain for ...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2010.09.023

    authors: Mühling J,Tiefenbach M,López-Barneo J,Piruat JI,García-Flores P,Pfeil U,Gries B,Mühlfeld C,Weigand MA,Kummer W,Weissmann N,Paddenberg R

    更新日期:2010-12-01 00:00:00

  • Time course of the apoptotic cascade and effects of caspase inhibitors in adult rat ventricular cardiomyocytes.

    abstract::K. Suzuki, S. Kostin, V. Person, A. Elsässer and J. Schaper. Time Course of the Apoptotic Cascade and Effects of Caspase Inhibitors in Adult Rat Ventricular Cardiomyocytes. Journal of Molecular and Cellular Cardiology (2001) 33, 983-994. Interpretation of the rate of apoptosis in diseased hearts is hampered by the fac...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1006/jmcc.2001.1364

    authors: Suzuki K,Kostin S,Person V,Elsässer A,Schaper J

    更新日期:2001-05-01 00:00:00

  • Type 2 diabetes, mitochondrial biology and the heart.

    abstract::Diabetes is recognized as an independent risk factor for cardiovascular morbidity and mortality. This is due, in large part, to premature atherosclerosis, enhanced thrombogenicity and activation of systemic inflammatory programs with resultant vascular dysfunction. More enigmatic mechanisms underpinning diabetes-assoc...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章,评审

    doi:10.1016/j.yjmcc.2009.02.001

    authors: Sack MN

    更新日期:2009-06-01 00:00:00

  • Evidence for electrogenic Na+ pumping in human atrial myocardium.

    abstract::The resting potential of "sodium-loaded' cardiac cells can transiently hyperpolarize to levels negative to the steady state resting potential [3,5,6]. Hyperpolarization is associated with the coupled efflux of Na+ and influx of K+ driven by an active transport process and may result from an increased K+ equilibrium po...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/s0022-2828(84)80660-4

    authors: Rasmussen HH,TenEick RE,McCullough JR,Singer DH

    更新日期:1984-08-01 00:00:00

  • Stem cell therapy enhances electrical viability in myocardial infarction.

    abstract::Clinical studies suggest increased arrhythmia risk associated with cell therapy for myocardial infarction (MI); however, the underlying mechanisms are poorly understood. We hypothesize that the degree of electrical viability in the infarct and border zone associated with skeletal myoblast (SKMB) or mesenchymal stem ce...

    journal_title:Journal of molecular and cellular cardiology

    pub_type: 杂志文章

    doi:10.1016/j.yjmcc.2006.09.011

    authors: Mills WR,Mal N,Kiedrowski MJ,Unger R,Forudi F,Popovic ZB,Penn MS,Laurita KR

    更新日期:2007-02-01 00:00:00