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Influence of noradrenaline and temperature on the isolated perfused rat heart.

Abstract：

:Myocardial protection during open heart surgery is achieved by general cooling and cold cardioplegia. However sympathetic activation during the operation causes raised circulating catecholamine levels that might negatively influence the myocardial metabolism. Moreover, local liberation of catecholamines, in "poorly perfused' regions of the myocardium in patients with ischemic heart disease, might occur. In respect of these problems, we studied the influence of noradrenaline at different temperatures on the isolated perfused rat heart. The temperatures chosen were: 10, 20, 32, 37 and 39 degrees C. The results show clearcut adverse effect of noradrenaline at 32 degrees and higher, on metabolism and hemodynamic performance. At lower temperatures there still seem to be an adverse effect of noradrenaline although not statistically significant. The results of this study indicates the importance of presurgical myocardial protection especially of badly perfused myocardial areas. Such protection could be accomplished by beta-blockade and/or loading of the myocardium with glycogen by glucose-insulin-potassium infusion.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Berggren H,Ekroth R,Hjalmarson A,Holm S,William-Olsson G,Waldenström A

doi

10.1016/0022-2828(83)90276-6

subject

Has Abstract

pub_date

1983-04-01 00:00:00

pages

213-20

issue

4

eissn

0022-2828

issn

1095-8584

pii

0022-2828(83)90276-6

journal_volume

15

pub_type

杂志文章

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