当前位置： SCI文献检索 > JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY期刊下所有文献 > Effects of endurance training on cholinergic and adrenergic receptors of rat heart.

Effects of endurance training on cholinergic and adrenergic receptors of rat heart.

Abstract：

:To test the hypothesis that alterations in adrenergic or cholinergic receptors occur in response to physical training, and that changes in receptor properties could be mechanistically important in producting the altered cardiovascular physiology of the trained state, we studied the effects of endurance training by swimming upon beta adrenergic, alpha adrenergic, and muscarinic cholinergic receptors of rat heart. Because of previously reported sex-related differences in the cardiac adaptation to training, male and female rats were studied separately. Despite the occurrence of demonstrable training bradycardia in males, and of cardiac hypertrophy in females, there were no discernible effects of the training program upon the properties of cardiac beta adrenergic receptors. However, hearts from swimmers of both sexes demonstrated fewer numbers of muscarinic cholinergic and alpha adrenergic receptors than sedentary controls, without differences in the receptor affinities for antagonist or agonist compounds. These findings are inconsistent with the hypothesis that altered cardiac sensitivity to neurotransmitters contributes directly to training bradycardia.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Williams RS,Schaible TF,Bishop T,Morey M

doi

10.1016/s0022-2828(84)80611-2

subject

Has Abstract

pub_date

1984-05-01 00:00:00

pages

395-403

issue

5

eissn

0022-2828

issn

1095-8584

journal_volume

16

pub_type

杂志文章

相关文献

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY文献大全
  • Effects of hemodynamic variables on myocardial K+ balance during and after shortlasting ischemia.

    abstract：:Ischemia-induced myocardial potassium loss and post-ischemic potassium reuptake was quantitated in 8 open chest pigs during control conditions and during hemodynamic alterations which have been shown to increase steady state sarcolemmal potassium fluxes. Myocardial K+ balance was continuously computed before, during a...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(89)90673-1

    authors： Aksnes G,Ellingsen O,Rutlen DL,Ilebekk A

    更新日期：1989-12-01 00:00:00

  • Phenylephrine preconditioning involves modulation of cardiac sarcolemmal K(ATP) current by PKC delta, AMPK and p38 MAPK.

    abstract：:Preconditioning of hearts with the α(1)-adrenoceptor agonist phenylephrine decreases infarct size and increases the functional recovery of the heart following ischaemia-reperfusion. However, the cellular mechanisms responsible for this protection are not known. We investigated the role of protein kinase C ε and δ (PKC...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2011.06.015

    authors： Turrell HE,Rodrigo GC,Norman RI,Dickens M,Standen NB

    更新日期：2011-09-01 00:00:00

  • Alpha adrenergic receptor mechanism: biochemical events.

    abstract：:Immediate post-receptor events following alpha-adrenoceptor stimulation in cardiac ventricular muscle are still largely unknown. Since membrane redox systems appear to be present in cell plasma membranes and may be involved in trans-sarcolemma electron efflux, the possibility that Ca2+ inflow was controlled by electro...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80462-x

    authors： Clark MG,Rattigan S

    更新日期：1986-11-01 00:00:00

  • Atorvastatin-induced increase in progenitor cell levels is rather caused by enhanced receptor activator of NF-kappaB ligand (RANKL) cell proliferation than by bone marrow mobilization.

    abstract：BACKGROUND:Statins have been shown to increase the level of circulating progenitor cells in peripheral blood supposedly due to a mobilization of progenitor cells from the bone marrow niche. Osteoclast/osteoblast interaction has been associated with progenitor cell mobilization. Here, we investigated the role of statins...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2012.12.018

    authors： Steinmetz M,Pelster B,Lucanus E,Arnal JF,Nickenig G,Werner N

    更新日期：2013-04-01 00:00:00

  • Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection.

    abstract：:The mitochondrial permeability transition, an established mechanism for heart diseases, is a long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection. Several hypotheses about its molecular nature have been put forward over the years, and the prevailing view is that permeabilization ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.05.014

    authors： Carraro M,Carrer A,Urbani A,Bernardi P

    更新日期：2020-07-01 00:00:00

  • Interleukin-1α dependent survival of cardiac fibroblasts is associated with StAR/STARD1 expression and improved cardiac remodeling and function after myocardial infarction.

    abstract：AIMS:One unaddressed aspect of healing after myocardial infarction (MI) is how non-myocyte cells that survived the ischemic injury, keep withstanding additional cellular damage by stress forms typically arising during the post-infarction inflammation. Here we aimed to determine if cell survival is conferred by expressi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2020.10.013

    authors： Razin T,Melamed-Book N,Argaman J,Galin I,Lowy Y,Anuka E,Naftali-Shani N,Kandel-Kfir M,Garfinkel BP,Brielle S,Granot Z,Apte RN,Conway SJ,Molkentin JD,Kamari Y,Leor J,Orly J

    更新日期：2020-10-30 00:00:00

  • Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose.

    abstract：:Cell-based therapy after myocardial infarction (MI) is a promising therapeutic option but the relevant cell subsets and dosage requirements are poorly defined. We hypothesized that cell therapy for myocardial infarction is improved by ex vivo expansion and high-dose transplantation of defined hematopoietic progenitor ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2008.06.010

    authors： Templin C,Kotlarz D,Faulhaber J,Schnabel S,Grote K,Salguero G,Luchtefeld M,Hiller KH,Jakob P,Naim HY,Schieffer B,Hilfiker-Kleiner D,Landmesser U,Limbourg FP,Drexler H

    更新日期：2008-09-01 00:00:00

  • Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes.

    abstract：:During systole, Ca2+ is released from the sarcoplasmic reticulum (SR) through ryanodine receptors (RyRs) while, simultaneously, other ions (specifically K+, Mg2+, and Cl-) provide counter-ion flux. These ions move back into the SR during diastole through the SERCA pump and SR K+ and Cl- channels. In homeostasis, all i...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2016.10.018

    authors： Berti C,Zsolnay V,Shannon TR,Fill M,Gillespie D

    更新日期：2017-02-01 00:00:00

  • Myeloperoxidase upregulates endothelin receptor type B expression.

    abstract：:Neutrophil recruitment and activation are principal events in inflammation. Upon activation neutrophils release myeloperoxidase (MPO), a heme enzyme, which binds to and transcytoses endothelial cells. Whereas the significance of the subendothelial deposition of MPO has evolved as a critical prerequisite for the enzyme...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2013.12.007

    authors： Lau D,Szöcs K,Klinke A,Rudolph T,Rudolph V,Streichert T,Blankenberg S,Baldus S

    更新日期：2014-04-01 00:00:00

  • The interaction of phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine binding site.

    abstract：:The interaction of verapamil and other phenylalkylamine calcium channel blockers with the 1,4-dihydropyridine receptor was examined. Studies characterizing the interaction and relationship between calcium channel blocking potency and binding affinity were performed in rat myocardium. The 1,4-dihydropyridines, nifedipi...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80010-4

    authors： Zobrist RH,Giacomini KM,Nelson WL,Giacomini JC

    更新日期：1986-09-01 00:00:00

  • Appearance and regression of rat pouch tissue.

    abstract：:Fibrosis, a consequence of tissue repair, can become a final common pathway to organ failure, if progressive. Prevention and regression of organ fibrosis represent targets of considerable interest. The natural fate of fibrosis differs among various tissues being either persistent, progressive or regressive. Cellular a...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1999.0944

    authors： Zhang J,Sun Y,Zhang JQ,Ramires FJ,Weber KT

    更新日期：1999-05-01 00:00:00

  • Comparison between the effects of 2-3 butanedione monoxime (BDM) and calcium chloride on myocardial oxygen consumption.

    abstract：:The agent 2,3-butanedione monoxime (BDM) has been reported to reduce the sensitivity of myofilament force development to calcium ions, without affecting the calcium transient in myocardium. One would predict, therefore, that BDM should reduce the contractile state of the heart without reducing the amount of oxygen tha...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(92)91093-k

    authors： de Tombe PP,Burkhoff D,Hunter WC

    更新日期：1992-08-01 00:00:00

  • Depressed transient outward current density in ventricular myocytes from cardiomyopathic Syrian hamsters of different ages.

    abstract：:We determined whether the dilated cardiomyopathy which develops between 30 and 140 days of age in the Syrian hamster strain MS200, before the onset of cardiac hypertrophy and failure, is associated with alterations in both the action potential (AP) and the Ca(2+)-independent transient outward current, Ito1. AP was rec...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1996.0036

    authors： Thuringer D,Coulombe A,Deroubaix E,Coraboeuf E,Mercadier JJ

    更新日期：1996-02-01 00:00:00

  • Fatty acid regulation of glucose metabolism in the intact beating rat heart assessed by carbon-13 NMR spectroscopy: the critical role of pyruvate dehydrogenase.

    abstract：:Although the myocardium is capable of utilizing both glucose and fatty acid substrates, glucose metabolism is inhibited in the presence of fatty acid during normal perfusion conditions. Fatty acid regulation of glucose utilization in intact beating rat hearts was studied with 13C-enriched substrates and 13C and 31P NM...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/0022-2828(89)90787-6

    authors： Weiss RG,Chacko VP,Gerstenblith G

    更新日期：1989-05-01 00:00:00

  • Intracardiac administration of neutrophil protease cathepsin G activates noncanonical inflammasome pathway and promotes inflammation and pathological remodeling in non-injured heart.

    abstract：BACKGROUND:Inflammatory serine proteases (ISPs) play an important role in cardiac repair after injury through hydrolysis of dead cells and extracellular matrix (ECM) debris. Evidence also suggests an important role of ISPs in the coordination of the inflammatory response. However, the effect of ISPs on inflammation is ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.06.016

    authors： Miller SA,Kolpakov MA,Guo X,Du B,Nguyen Y,Wang T,Powel P,Dell'Italia LJ,Sabri A

    更新日期：2019-09-01 00:00:00

  • Protection by inhibition of poly (ADP-ribose) synthetase against oxidant injury in cardiac myoblasts In vitro.

    abstract：:Peroxynitrite and hydroxyl radical are reactive oxidants produced during myocardial reperfusion injury. In various cell types, including macrophages and smooth muscle cells, peroxynitrite and hydrogen peroxide cause DNA single strand breakage, which triggers the activation of the nuclear enzyme poly (ADP-ribose) synth...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0496

    authors： Gilad E,Zingarelli B,Salzman AL,Szabó C

    更新日期：1997-09-01 00:00:00

  • Proteotoxicity: an underappreciated pathology in cardiac disease.

    abstract：:In general, in most organ systems, intracellular protein homeostasis is the sum of many factors, including chromosomal state, protein synthesis, post-translational processing and transport, folding, assembly and disassembly into macromolecular complexes, protein stability and clearance. In the heart, there has been a ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2013.12.015

    authors： Sandri M,Robbins J

    更新日期：2014-06-01 00:00:00

  • Polyamines mediate coronary transcapillary macromolecular transport in the calcium paradox.

    abstract：:This study addresses the role of polyamines and their rate limiting enzyme, ornithine decarboxylase in regulation of macromolecular transport of two macromolecules, fluorescein and horseradish peroxidase, across coronary capillaries. Rat hearts were isolated and retrogradely perfused through the aorta (Langendorff met...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1994.1046

    authors： Trout JJ,Lu CY,Goldstone AD,Iqbal Z,Koenig H

    更新日期：1994-03-01 00:00:00

  • Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension.

    abstract：:Pyroptosis is a pro-inflammatory form of programmed cell death, whose genesis directly depended on caspase-1 activation. Pulmonary hypertension (PH) is a disease characterized, in part, by vascular fibrosis. Up to now, there is no report on the relationship between pyroptosis and vascular fibrosis in PH. Here, we conf...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.10.008

    authors： Zhang M,Xin W,Yu Y,Yang X,Ma C,Zhang H,Liu Y,Zhao X,Guan X,Wang X,Zhu D

    更新日期：2020-01-01 00:00:00

  • The axis of local cardiac endogenous Klotho-TGF-β1-Wnt signaling mediates cardiac fibrosis in human.

    abstract：BACKGROUND:Cardiovascular fibrosis is a major contributor to cardiovascular disease, the primary cause of death in patients with chronic kidney disease (CKD). We previously reported expression of endogenous Klotho in human arteries, and that CKD is a state of Klotho deficiency, resulting in vascular calcification, but ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2019.09.004

    authors： Liu Q,Zhu LJ,Waaga-Gasser AM,Ding Y,Cao M,Jadhav SJ,Kirollos S,Shekar PS,Padera RF,Chang YC,Xu X,Zeisberg EM,Charytan DM,Hsiao LL

    更新日期：2019-11-01 00:00:00

  • The effect of alterations to action potential duration on beta-adrenoceptor-mediated aftercontractions in human and guinea-pig ventricular myocytes.

    abstract：:Aftercontractions induced by beta-adrenoceptor stimulation in human and guinea-pig cardiomyocytes may be related to changes in action potential duration (APD). We investigated the effects of altering APD during the occurrence of isoproterenol-induced aftercontractions, using the KATP channel openers cromakalim and lem...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1997.0385

    authors： Tweedie D,O'Gara P,Harding SE,MacLeod KT

    更新日期：1997-05-01 00:00:00

  • Alterations in ventricular myocyte contraction caused by C-type natriuretic peptide and nitric oxide in eNOS-/- mice.

    abstract：:Lack of endothelial nitric oxide synthase (eNOS) may affect the sensitivity of cyclic GMP signaling through soluble guanylyl cyclase (sGC). We hypothesized that in eNOS knockout (eNOS-/-) mice, stimulation of guanylyl cyclase would have enhanced effects inhibiting cardiac contraction. We measured cell shortening and c...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2005.08.008

    authors： Su J,Tse J,Scholz PM,Weiss HR

    更新日期：2005-12-01 00:00:00

  • Pyruvate attenuation of hypoxia damage in isolated working guinea-pig heart.

    abstract：:Function and various parameters of myocardial substrate and energy metabolism were measured in preload-controlled isolated working guinea-pig hearts perfused with normoxic (95% O2) and hypoxic (30 to 45% O2) Krebs-Henseleit buffers ([Ca2+] = 1.25 mM). Energy-yielding substrates were glucose, pyruvate, lactate, and fat...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/s0022-2828(86)80905-1

    authors： Bünger R,Swindall B,Brodie D,Zdunek D,Stiegler H,Walter G

    更新日期：1986-04-01 00:00:00

  • Non-coding RNAs: Regulators of valvular calcification.

    abstract：:There is currently a growing global burden of valvular heart diseases due to aging populations and changing lifestyles. Valvular heart diseases mainly include the malfunctioning of aortic and mitral valves and are characterized by extensive tissue remodeling, which includes calcification, endothelial dysfunction, and ...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.yjmcc.2020.03.015

    authors： Gupta SK,Kumari S,Singh S,Barthwal MK,Singh SK,Thum T

    更新日期：2020-05-01 00:00:00

  • Bone marrow subpopulations contain distinct types of endothelial progenitor cells and angiogenic cytokine-producing cells.

    abstract：:Therapeutic angiogenesis can be induced by the implantation of bone marrow cells (BMCs). However, the mechanism of BMC-mediated neovascularization remains to be clarified. We investigated the differential activities of bone marrow subpopulations in angiogenesis and cytokine production. BMCs were separated into positiv...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2007.08.001

    authors： Miyamoto Y,Suyama T,Yashita T,Akimaru H,Kurata H

    更新日期：2007-11-01 00:00:00

  • Evidence that translocation of protein kinase C is a key event during ischemic preconditioning of rabbit myocardium.

    abstract：:We used three interventions to test critically the theory that ischemic preconditioning is the result of translocation of cytosolic protein kinase C (PKC) into the membranes where it can be activated. If that theory were true then kinase activity should not be necessary during the preconditioning ischemia and thus blo...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.1994.1078

    authors： Liu Y,Ytrehus K,Downey JM

    更新日期：1994-05-01 00:00:00

  • Temporal dissociation of frequency-dependent acceleration of relaxation and protein phosphorylation by CaMKII.

    abstract：:Frequency-dependent acceleration of relaxation (FDAR) is an important intrinsic mechanism that allows for diastolic filling of the ventricle at higher heart rates, yet its molecular mechanism is still not understood. Previous studies showed that FDAR is dependent on functional sarcoplasmic reticulum (SR) and can be ab...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.12.007

    authors： Huke S,Bers DM

    更新日期：2007-03-01 00:00:00

  • Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45.

    abstract：:Connexin40 (Cx40) and connexin45 (Cx45) are involved in both cardiac morphogenesis and propagation of electrical activity. We found that Cx40/Cx45 double deficiency (Cx40(-/-)/Cx45(+/-)) causes a variety of cardiac defects leading to high mortality during embryonic development and at birth. The majority of Cx40(-/-)/C...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1016/j.yjmcc.2006.07.005

    authors： Krüger O,Maxeiner S,Kim JS,van Rijen HV,de Bakker JM,Eckardt D,Tiemann K,Lewalter T,Ghanem A,Lüderitz B,Willecke K

    更新日期：2006-11-01 00:00:00

  • Magnesium-calcium exchange in cardiac troponin C bound to cardiac troponin I.

    abstract：:Understanding the process of Ca(2+)/Mg(2+)exchange during muscle excitation and relaxation is fundamental to elucidating the mechanism of Ca(2+)-regulated muscle contraction. During the resting phase, the C-domain of cardiac troponin C may be occupied by either Ca(2+)or Mg(2+). Here, complexes of recombinant cardiac t...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1174

    authors： Finley N,Dvoretsky A,Rosevear PR

    更新日期：2000-08-01 00:00:00

  • Differences in Ca(2+)-handling and sarcoplasmic reticulum Ca(2+)-content in isolated rat and rabbit myocardium.

    abstract：:We made novel measurements of the influence of rest intervals and stimulation frequency on twitch contractions and on sarcoplasmic reticulum (SR) Ca(2+)-content (using rapid cooling contractures, RCCs) in isolated ventricular muscle strips from rat and rabbit hearts at a physiological temperature of 37 degrees C. In a...

    journal_title：Journal of molecular and cellular cardiology

    pub_type： 杂志文章

    doi：10.1006/jmcc.2000.1252

    authors： Maier LS,Bers DM,Pieske B

    更新日期：2000-12-01 00:00:00