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Oxygen diffusion distance in thyroxine-induced hypertrophic rabbit myocardium.

Abstract：

:We studied the oxygen diffusion distance in the rabbit myocardium in untreated animals and in animals treated with thyroxine (T4) for 3 days and 16 days. The subepicardial and subendocardial regions were studied separately. Sixteen days of T4 treatment results in significant cardiac hypertrophy. After 16 days, the percentage of the myocardium occupied by myocytes decreases as the volume of extracellular matrix increases. After 3 days, the number of myocyte mitochondria per unit volume of myocardium increases without an increase in mitochondrial volume. After 16 days the volume density of the myocyte mitochondria increases. Oxygen diffusion distance was determined by measuring the distance between the myocardial capillaries and the cardiomyocyte mitochondria. The deposition of extracellular matrix results in an increase in the distance between the myocardial capillaries and the myocytes. The distribution of the mitochondria within the myocytes remains unchanged resulting in an increased distance between the capillaries and the mitochondria, hence, an increased oxygen diffusion distance. There is some evidence that the mitochondria most distant from the capillaries are the mitochondria in which division is most frequent with T4 stimulation. This may be related to the relative deprivation of oxygen of these mitochondria.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Seiden D,Navidad P,Weiss HR

doi

10.1016/s0022-2828(88)80146-9

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

917-30

issue

10

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(88)80146-9

journal_volume

20

pub_type

杂志文章

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