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Molecular architecture of the human specialised atrioventricular conduction axis.

Abstract：

:The atrioventricular conduction axis, located in the septal component of the atrioventricular junctions, is arguably the most complex structure in the heart. It fulfils a multitude of functions, including the introduction of a delay between atrial and ventricular systole and backup pacemaking. Like any other multifunctional tissue, complexity is a key feature of this specialised tissue in the heart, and this complexity is both anatomical and electrophysiological, with the two being inextricably linked. We used quantitative PCR, histology and immunohistochemistry to analyse the axis from six human subjects. mRNAs for ~50 ion and gap junction channels, Ca(2+)-handling proteins and markers were measured in the atrial muscle (AM), a transitional area (TA), inferior nodal extension (INE), compact node (CN), penetrating bundle (PB) and ventricular muscle (VM). When compared to the AM, we found a lower expression of Na(v)1.5, K(ir)2.1, Cx43 and ANP mRNAs in the CN for example, but a higher expression of HCN1, HCN4, Ca(v)1.3, Ca(v)3.1, K(ir)3.4, Cx40 and Tbx3 mRNAs. Expression of some related proteins was in agreement with the expression of the corresponding mRNAs. There is a complex and heterogeneous pattern of expression of ion and gap junction channels and Ca(2+)-handling proteins in the human atrioventricular conduction axis that explains the function of this crucial pathway.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Greener ID,Monfredi O,Inada S,Chandler NJ,Tellez JO,Atkinson A,Taube MA,Billeter R,Anderson RH,Efimov IR,Molenaar P,Sigg DC,Sharma V,Boyett MR,Dobrzynski H

doi

10.1016/j.yjmcc.2010.12.017

subject

Has Abstract

pub_date

2011-04-01 00:00:00

pages

642-51

issue

4

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(10)00490-6

journal_volume

50

pub_type

杂志文章

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