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Induced pluripotent stem cells as a new strategy for cardiac regeneration and disease modeling.

Abstract：

:The possibility to induce pluripotency in somatic cells or, even further, to induce cell transdifferentiation through the forced expression of reprogramming factors has offered new, attractive options for cardiovascular regenerative medicine. In fact, recent discoveries have demonstrated that induced pluripotent stem (iPS) cells can be differentiated into cardiomyocytes, suggesting that iPS cells have the potential to significantly advance future cardiac regenerative therapies. Herein, we provide an overview of the characteristics and differentiation potential associated with iPS cells. In addition, we discuss current methods for inducing their specification towards a cardiovascular phenotype as well as in vivo evidence supporting the therapeutic benefit of iPS-derived cardiac cells. Finally, we describe recent findings regarding the use of iPS-derived cells for modeling several genetic cardiac disorders, which have indicated that these pluripotent cells represent an ideal tool for drug testing and might contribute to the development of future personalized regenerative cell therapies.

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Iglesias-García O,Pelacho B,Prósper F

doi

10.1016/j.yjmcc.2013.04.022

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

43-50

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(13)00153-3

journal_volume

62

pub_type

杂志文章,评审

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