Beta-adrenergic receptor blockade modulates Bcl-X(S) expression and reduces apoptosis in failing myocardium.

abstract：:Disturbances of cellular calcium homeostasis due to oxidative stress are involved in reperfusion associated phenomena like myocardial stunning and reperfusion induced arrhythmias. This study investigates the effect of the major neutrophil-derived oxidant hypochlorous acid (HOCl) on the l-type calcium current (ICa,L) o...

journal_title：Journal of molecular and cellular cardiology

authors： Hammerschmidt S,Wahn H

更新日期：1998-09-01 00:00:00

abstract：:The effect of taurine on phenylephrine alpha-adrenergic action was studied in freshly-isolated guinea-pig ventricular myocytes. Intracellular calcium concentration was measured at nearly physiological extracellular CaCl2 in both cell suspension using quin-2 (mean intracellular calcium concentration 154.0 +/- 8.0 nM, n...

journal_title：Journal of molecular and cellular cardiology

authors： Failli P,Fazzini A,Franconi F,Stendardi I,Giotti A

更新日期：1992-11-01 00:00:00

abstract：:Little is known about the tissue-specific expression of contractile proteins during cardiogenesis in the mammalian heart. Since the myosin heavy chain (HC) isoform expressed in the adult correlates with myocardial functional capacity, we undertook an analysis of myosin HC expression in atrial and ventricular myocardia...

journal_title：Journal of molecular and cellular cardiology

authors： Sweeney LJ,Kelley SW

更新日期：1990-03-01 00:00:00

abstract：:The biochemical and physiological effects of GS alpha activation are well known; however, little is known about the anatomical localisation of GS alpha in the myocardium. Knowledge of the localisation might yield insights into G protein function in heart. The utility of immunocytochemistry using immunofluorescent meth...

journal_title：Journal of molecular and cellular cardiology

authors： Muntz KH,Ishikawa Y,Wagner T,Homcy CJ,Vatner SF,Vatner DE

更新日期：1997-06-01 00:00:00

abstract：:Heart and skeletal muscle cells rapidly lose potassium ions after withdrawal of oxygen. In myocardial ischemia, cellular release of potassium and interruption of extracellular washout produce a rapid and marked increase of extracellular K+ concentration. Harris et al. were the first to observe the coincidence of the K...

journal_title：Journal of molecular and cellular cardiology

authors： Kléber AG,Riegger CB,Janse MJ

更新日期：1987-10-01 00:00:00

abstract：:Monoclonal and polyclonal antibodies to the major sarcoplasmic reticulum proteins of rabbit skeletal and canine cardiac muscle have been used to identify and characterize the corresponding components of human cardiac sarcoplasmic reticulum. The Ca2(+)-transporting ATPase of human cardiac sarcoplasmic reticulum was ide...

journal_title：Journal of molecular and cellular cardiology

authors： Movsesian MA,Leveille C,Krall J,Colyer J,Wang JH,Campbell KP

更新日期：1990-12-01 00:00:00

abstract：:Transgenic mice with cardiac-specific overexpression of G alpha q exhibit a biochemical and physiological phenotype of load-independent cardiac hypertrophy with contractile dysfunction. To elucidate the cellular basis for altered contractility, we measured cellular contraction, Ca(2+)transients, and l -type Ca(2+)chan...

journal_title：Journal of molecular and cellular cardiology

authors： Yatani A,Frank K,Sako H,Kranias EG,Dorn GW 2nd

更新日期：1999-07-01 00:00:00

abstract：:Vascular tone is regulated by a variety of neurotransmitters, vasoactive hormones and autacoids, and vasoactive drugs. These actions are mediated, at least in part, by actions on the membrane ion channels, exerted either directly or indirectly. In this article, we described evidence that four different protein kinase ...

journal_title：Journal of molecular and cellular cardiology

authors： Xiong Z,Sperelakis N

更新日期：1995-01-01 00:00:00

abstract：:Hypertrophic cardiomyopathy occurs in two variants, either as an autosomal dominant familial disorder or as a sporadic disease without familial involvement. Different genes coding sarcomeric proteins of the heart have been identified as causing hypertrophic cardiomyopathy. Missense mutations in the cardiac beta-myosin...

journal_title：Journal of molecular and cellular cardiology

authors： Greber-Platzer S,Marx M,Fleischmann C,Suppan C,Dobner M,Wimmer M

更新日期：2001-01-01 00:00:00

abstract：:Identification of proteins that interact with Cx43 has been instrumental in the understanding of gap junction (GJ) regulation. An in vitro phosphorylation screen identified that Protein tyrosine kinase 2 beta (Pyk2) phosphorylated purified Cx43CT and this led us to characterize the impact of this phosphorylation on Cx...

journal_title：Journal of molecular and cellular cardiology

authors： Zheng L,Trease AJ,Katsurada K,Spagnol G,Li H,Shi W,Duan B,Patel KP,Sorgen PL

更新日期：2020-12-01 00:00:00

abstract：:Echocardiographic dimensions and endocrinological examination were performed in 71 young patients with borderline hypertension (BHT) and 31 age-matched normotensive subjects (NT). Patients with BHT had significantly higher relative wall thickness (RWT) and left ventricular mass index than NT, although all BHT patients...

journal_title：Journal of molecular and cellular cardiology

authors： Fujita T,Noda H,Ito Y,Isaka M,Sato Y,Ogata E

更新日期：1989-12-01 00:00:00

abstract：:The two-pore domain potassium (K(+)) channel TWIK-1 (or K2P1.1) contributes to background K(+) conductance in diverse cell types. TWIK-1, encoded by the KCNK1 gene, is present in the human heart with robust expression in the atria, however its physiological significance is unknown. To evaluate the cardiac effects of T...

journal_title：Journal of molecular and cellular cardiology

authors： Christensen AH,Chatelain FC,Huttner IG,Olesen MS,Soka M,Feliciangeli S,Horvat C,Santiago CF,Vandenberg JI,Schmitt N,Olesen SP,Lesage F,Fatkin D

更新日期：2016-08-01 00:00:00

abstract：:(±)-Sodium5-bromo-2-(α-hydroxypentyl) benzoate (brand name: brozopine, BZP, 1a), derived from L-3-n-butylphthalide (L-NBP), has been reported to protect the brain from stoke and has been approved by CFDA in Phase I-II clinical trials. However, it remains to be investigated whether 1a may exhibit any cardioprotective e...

journal_title：Journal of molecular and cellular cardiology

authors： Xiao Y,Song C,Lin Q,Shi X,Yu W,Huang X,Wang H,Chen Y,Wang R,Geng X,Qin M,Hu K,Fan Y,Qiao Y,Gao E,Zhao W,Chang J

更新日期：2019-10-01 00:00:00

abstract：:Since angiotensin-converting enzyme (ACE) produces angiotensin II in the heart, ACE inhibitors may prevent coronary vasoconstriction and increase coronary blood flow. On the other hand, since ACE inhibitors also inhibit kininase II which results in reduced degradation of bradykinin, ACE inhibitors may increase cardiac...

journal_title：Journal of molecular and cellular cardiology

authors： Kitakaze M,Node K,Minamino T,Asanuma H,Ueda Y,Kosaka H,Kuzuya T,Hori M

更新日期：1998-11-01 00:00:00

abstract：:This study sought to evaluate the use of tetrazolium salt XTT reduction as an indicator of valvular viability in a cryoprocessed porcine cardiac homograft model. The XTT tetrazolium assays was based on the metabolic reduction of Sodium 3'-[1-(phenylamino-carbonyl)-3,4-Tetrazolium]-bis(4-methoxy-6-nitro) benzene sulfon...

journal_title：Journal of molecular and cellular cardiology

authors： Lu JH,Chiu YT,Sung HW,Hwang B,Chong CK,Chen SP,Mao SJ,Yang PZ,Chang Y

更新日期：1997-04-01 00:00:00

abstract：:The regulation of the resting intracellular ionized calcium concentration [( Ca2+]i) has been studied in ferret papillary muscle using the photoprotein aequorin to measure [Ca2+]i. Elevating [Ca2+]o produced an initial rapid increase of [Ca2+]i and tension which then decayed to a steady level. This secondary fall of [...

journal_title：Journal of molecular and cellular cardiology

authors： Eisner DA,Orchard CH,Allen DG

更新日期：1984-02-01 00:00:00

abstract：:Cardiomyocyte progenitor cells (CMPCs) can be isolated from the human heart and differentiated into cardiomyocytes in vitro. A comprehensive assessment of their electrical phenotype upon differentiation is essential to predict potential future applications of this cell source. CMPCs isolated from human fetal heart wer...

journal_title：Journal of molecular and cellular cardiology

authors： de Boer TP,van Veen TA,Jonsson MK,Kok BG,Metz CH,Sluijter JP,Doevendans PA,de Bakker JM,Goumans MJ,van der Heyden MA

更新日期：2010-01-01 00:00:00

abstract：:Oxygen deprivation for prolonged periods leads to cardiac cell death and ventricular dysfunction. The ability to prevent myocardial cell death would be of significant therapeutic value in maintaining cardiac function after injury. While caspases have been suggested to play a critical role in apoptosis, their involveme...

journal_title：Journal of molecular and cellular cardiology

authors： de Moissac D,Gurevich RM,Zheng H,Singal PK,Kirshenbaum LA

更新日期：2000-01-01 00:00:00

abstract：:The role of protein kinase C (PKC) in the protection of ischemic preconditioning (PC) is still controversial, partly because of the multiple isozymes of PKC and the inability to directly measure PKC activity in vivo. In this study we have used novel peptide inhibitors which correspond to part of the amino acid sequenc...

journal_title：Journal of molecular and cellular cardiology

authors： Liu GS,Cohen MV,Mochly-Rosen D,Downey JM

更新日期：1999-10-01 00:00:00

abstract：:Isolated and perfused rat hearts were examined by 2-dimensional gel electrophoresis and liquid scintillation counting to determine the effect of ischemia or perfusion temperature on protein synthesis. Isolated hearts were subjected to ischemia at either 4 degrees, 20 degrees, or 30 degrees C and then perfused at 37 de...

journal_title：Journal of molecular and cellular cardiology

authors： Currie RW

更新日期：1987-08-01 00:00:00

abstract：:Lone atrial fibrillation (AF) is associated with various ion channel gene sequence variants, notably the common S38G loss-of-function polymorphism in the KCNE1 K(+) channel ancillary subunit gene. New-onset postoperative AF (POAF) generally occurs 48-72 h after major surgery, particularly following procedures within t...

journal_title：Journal of molecular and cellular cardiology

authors： Heerdt PM,Kant R,Hu Z,Kanda VA,Christini DJ,Malhotra JK,Abbott GW

更新日期：2012-09-01 00:00:00

abstract：:Autophagy is a process that removes damaged proteins and organelles and is of particular importance in terminally differentiated cells such as cardiomyocytes, where it has primarily a protective role. We investigated the involvement of inositol(1,4,5)trisphosphate (Ins(1,4,5)P(3)) and its receptors in autophagic respo...

journal_title：Journal of molecular and cellular cardiology

authors： Wong A,Grubb DR,Cooley N,Luo J,Woodcock EA

更新日期：2013-01-01 00:00:00

abstract：:Interactions between platelets with injured vascular endothelium contribute to thrombotic occlusion. A murine monoclonal antibody [7E3 F(ab')2] to the platelet GPIIb/IIIa receptor complex was used to inhibit platelet aggregation in an experimental model of coronary artery thrombosis. Prevention of thrombotic occlusion...

journal_title：Journal of molecular and cellular cardiology

authors： Mickelson JK,Simpson PJ,Lucchesi BR

更新日期：1989-04-01 00:00:00

abstract：:To determine whether catecholamines produce alterations in myocardial myosin-actin cycling kinetics, we investigated the effects of isoproterenol upon mechanical characteristics of constantly activated heart muscle thought to reflect crossbridge behavior. In isolated rabbit right ventricular papillary muscles in bariu...

journal_title：Journal of molecular and cellular cardiology

authors： Berman MR,Peterson JN,Yue DT,Hunter WC

更新日期：1988-05-01 00:00:00

abstract：:Recent evidence has shown that the cardioprotection afforded by the late phase of ischemic preconditioning (PC) is mediated by upregulation of inducible nitric oxide synthase (iNOS). However, the specific cardiac cell type(s) that express(es) iNOS in response to ischemic PC remains unknown. Thus, mice underwent a sequ...

journal_title：Journal of molecular and cellular cardiology

authors： Wang Y,Guo Y,Zhang SX,Wu WJ,Wang J,Bao W,Bolli R

更新日期：2002-01-01 00:00:00

abstract：:Fibroblast growth factor receptor (FGFR) is expressed in a variety of cells and is involved in their proliferation/migration/survival. To elucidate FGFR-mediated specific action of vascular endothelial cells (ECs) on myocardial ischemia, we generated endothelium-targeted transgenic mice overexpressing constitutively a...

journal_title：Journal of molecular and cellular cardiology

authors： Matsunaga S,Okigaki M,Takeda M,Matsui A,Honsho S,Katsume A,Kishita E,Che J,Kurihara T,Adachi Y,Mansukhani A,Kobara M,Matoba S,Tatsumi T,Matsubara H

更新日期：2009-05-01 00:00:00

abstract：:Systemic deletion of the gene encoding for adipose triglyceride lipase (ATGL) in mice leads to severe cardiac dysfunction due to massive accumulation of neutral lipids in cardiomyocytes. Recently, impaired peroxisome proliferator-activated receptor α (PPARα) signaling has been described to substantially contribute to ...

journal_title：Journal of molecular and cellular cardiology

authors： Mussbacher M,Stessel H,Wölkart G,Haemmerle G,Zechner R,Mayer B,Schrammel A

更新日期：2014-12-01 00:00:00

abstract：:Heat shock protein 27 (Hsp27) and alpha B-crystallin (alphaBC) are small heat shock proteins that stabilize the myofilament during stress. We utilized two-dimensional gel electrophoresis (2-DE), phospho-fluorescence staining, titanium dioxide (TiO(2)) phosphopeptide purification and mass spectrometry (MS) to fully cha...

journal_title：Journal of molecular and cellular cardiology

authors： White MY,Hambly BD,Jeremy RW,Cordwell SJ

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:Activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) is established as a central intracellular trigger for various cardiac pathologies such as hypertrophy, heart failure or arrhythmias in animals and humans suggesting CaMKII as a promising target protein for future medical treatments. However, ...

journal_title：Journal of molecular and cellular cardiology

authors： Baier MJ,Klatt S,Hammer KP,Maier LS,Rokita AG

更新日期：2020-01-01 00:00:00

abstract：:The histologic examination and planimetric evaluation of tissue slices has been so far the only available technique for studying the extent of experimental myocardial infarcts in long-term studies; however, this approach is rather time-consuming when the sample size is large. This study describes a new biochemical met...

journal_title：Journal of molecular and cellular cardiology

authors： Chiariello M,Ambrosio G,Cappelli-Bigazzi M,Perrone-Filardi P,Brigante F,Sifola C

更新日期：1986-03-01 00:00:00