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Gene therapy strategies for cardiac electrical dysfunction.

Abstract：

:Cardiac disease is frequently associated with abnormalities in electrical function that can severely impair cardiac performance with potentially fatal consequences. The available therapeutic options have some efficacy but are far from perfect. The curative potential of gene therapy makes it an attractive approach for the treatment of cardiac arrhythmias. To date, gene therapy research strategies have targeted three major classes of cardiac arrhythmias: (1) ventricular arrhythmias, (2) atrial fibrillation, and (3) bradyarrhythmias. Various vehicles for gene transfer have been employed with adeno-associated viral gene delivery being the preferred choice for long-term gene expression and adenoviral gene delivery for short-term proof-of-concept work. In combination with the development of novel delivery methods, gene therapy may prove to be an effective strategy to eliminate the most debilitating of arrhythmias. This article is part of a Special Section entitled "Special Section: Cardiovascular Gene Therapy".

journal_name

J Mol Cell Cardiol

journal_title

Journal of molecular and cellular cardiology

authors

Greener I,Donahue JK

doi

10.1016/j.yjmcc.2010.07.022

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

759-65

issue

5

eissn

0022-2828

issn

1095-8584

pii

S0022-2828(10)00289-0

journal_volume

50

pub_type

杂志文章,评审

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