abstract：:The hypothalamic tuberoinfundibular dopaminergic (TIDA) neurones are critical with respect to regulating prolactin secretion from the anterior pituitary. Under most physiological conditions, they are stimulated by prolactin to release dopamine into the median eminence which subsequently suppresses further prolactin se...

journal_title：Journal of neuroendocrinology

authors： Yip SH,Araujo-Lopes R,Szawka RE,York J,Hyland B,Grattan DR,Bunn SJ

更新日期：2020-11-01 00:00:00

abstract：:Feeding is a complex behaviour entailing elaborate interactions between forebrain, hypothalamic and brainstem neuronal circuits via multiple orexigenic and anorexigenic neuropeptides. Nucleobindin-2 (NUCB2)/nesfatin-1 is a negative regulator of food intake and body weight with a widespread distribution in rodent brain...

journal_title：Journal of neuroendocrinology

authors： Psilopanagioti A,Makrygianni M,Nikou S,Logotheti S,Papadaki H

更新日期：2020-09-01 00:00:00

abstract：:Depolarisation-secretion coupling is assumed to be dependent only on extracellular calcium ([Ca2+ ]o ). Ryanodine receptor (RyR)-sensitive stores in hypothalamic neurohypophysial system (HNS) terminals produce sparks of intracellular calcium ([Ca2+ ]i ) that are voltage-dependent. We hypothesised that voltage-elicited...

journal_title：Journal of neuroendocrinology

authors： Velázquez-Marrero C,Custer EE,Marrero H,Ortiz-Miranda S,Lemos JR

更新日期：2020-04-01 00:00:00

abstract：:It has been well established, particularly in animal models, that oestrogens exert neuroprotective effects in brain areas linked to cognitive processes. A key protective role could reside in the capacity of oestrogen to modulate the inflammatory response. However, the direct neuroprotective actions of oestrogens on ne...

journal_title：Journal of neuroendocrinology

authors： Sarchielli E,Guarnieri G,Idrizaj E,Squecco R,Mello T,Comeglio P,Gallina P,Maggi M,Vannelli GB,Morelli A

更新日期：2020-03-01 00:00:00

abstract：:Kisspeptin within the arcuate nucleus of the hypothalamus is a critical neuropeptide in the regulation of reproduction. Together with neurokinin B and dynorphin A, arcuate kisspeptin provides the oscillatory activity that drives the pulsatile secretion of gonadotrophin-releasing hormone (GnRH), and therefore luteinisi...

journal_title：Journal of neuroendocrinology

authors： Lass G,Li XF,de Burgh RA,He W,Kang Y,Hwa-Yeo S,Sinnett-Smith LC,Manchishi SM,Colledge WH,Lightman SL,O'Byrne KT

更新日期：2020-02-01 00:00:00

abstract：:Rapid nonclassical effects of 17β-oestradiol (E2 ) on intracellular signalling have been identified in the basal forebrain, although the extent to which these actions may be different in males and females is unknown. Previous work has shown that E2 rapidly phosphorylates cAMP responsive element binding protein (CREB) ...

journal_title：Journal of neuroendocrinology

authors： Kim S,Barad Z,Cheong RY,Ábrahám IM

更新日期：2020-01-01 00:00:00

abstract：:The central nervous system regulates fertility via the release of gonadotrophin-releasing hormone (GnRH). This control revolves around the hypothalamic-pituitary-gonadal axis, which operates under traditional homeostatic feedback by sex steroids from the gonads in males and most of the time in females. An exception is...

journal_title：Journal of neuroendocrinology

authors： Moenter SM,Silveira MA,Wang L,Adams C

更新日期：2020-01-01 00:00:00

abstract：:Glucocorticoid hormones are particularly potent with respect to enhancing memory formation. Notably, this occurs in close synergy with arousal (i.e., when norepinephrine levels are enhanced). In the present study, we examined whether glucocorticoid and norepinephrine hormones regulate the number of spines in hippocamp...

journal_title：Journal of neuroendocrinology

authors： Lesuis SL,Timmermans W,Lucassen PJ,Hoogenraad CC,Krugers HJ

更新日期：2020-01-01 00:00:00

abstract：:The interaction of animals with conspecifics, termed social behaviour, has a major impact on the survival of many vertebrate species. Neuropeptide hormones modulate the underlying physiology that governs social interactions, and many findings concerning the neuroendocrine mechanisms of social behaviours have been extr...

journal_title：Journal of neuroendocrinology

authors： Robinson KJ,Bosch OJ,Levkowitz G,Busch KE,Jarman AP,Ludwig M

更新日期：2019-12-01 00:00:00

abstract：:Folate is an important regulator of hippocampal neurogenesis, and folic acid is needed prenatally to reduce the risk of neural tube defects. Both high levels of folic acid and low levels of folate can be harmful to health because low levels of folate have been linked to several diseases while high folic acid supplemen...

journal_title：Journal of neuroendocrinology

authors： Qiu W,Gobinath AR,Wen Y,Austin J,Galea LAM

更新日期：2019-10-01 00:00:00

abstract：:Norepinephrine (NE) activates adrenergic receptors (ARs) in the hypothalamic paraventricular nucleus (PVN) to increase excitatory currents, depolarise neurones and, ultimately, augment neuro-sympathetic and endocrine output. Such cellular events are known to potentiate intracellular calcium ([Ca2+ ]i ); however, the r...

journal_title：Journal of neuroendocrinology

authors： Milanick WJ,Polo-Parada L,Dantzler HA,Kline DD

更新日期：2019-10-01 00:00:00

abstract：:Doe rabbits nurse once/day for approximately 3 minutes, with circadian periodicity, inside the nest box. The amount of suckling received at each bout regulates this behaviour because reducing the litter size to four kits or less disrupts nursing circadian periodicity and increases suckling bout duration. Additionally,...

journal_title：Journal of neuroendocrinology

authors： Jiménez A,González-Mariscal G

更新日期：2019-09-01 00:00:00

abstract：:Parents lay the foundation for their children's socio-emotional experiences by sensitively responding to their needs. The hormonal and neurobiological changes that occur during the transition to parenthood importantly contribute to the parents' caregiving behaviour toward their children. Much research has emphasised t...

journal_title：Journal of neuroendocrinology

authors： Rajhans P,Goin-Kochel RP,Strathearn L,Kim S

更新日期：2019-09-01 00:00:00

abstract：:Postpartum depression (PPD) is a common but complex condition that is poorly understood and multifactorial in aetiology. It is a condition that can compromise the mother's care for her infant, which may pose challenges to the formation of the mother-infant bond and the infant's overall development. Past research has l...

journal_title：Journal of neuroendocrinology

authors： Nguyen AJ,Hoyer E,Rajhans P,Strathearn L,Kim S

更新日期：2019-09-01 00:00:00

abstract：:The roles of epidermal growth factor (EGF) in the regulation of prolactin (PRL) gene expression in the normal pituitary gland remain poorly understood. In the present study, the effects of EGF and an inhibitor of the EGF receptor, erlotinib, on PRL gene expression were examined both in the pituitary tumour cell line G...

journal_title：Journal of neuroendocrinology

authors： Nogami H,Koshida R,Omori H,Shibata M,Harigaya T,Takei Y

更新日期：2019-08-01 00:00:00

abstract：:Brain mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) respond to the same glucocorticoid hormones but can have differential effects on cellular function. Several lines of evidence suggest that MR-specific target genes must exist and might underlie the distinct effects of the receptors. The present...

journal_title：Journal of neuroendocrinology

authors： van Weert LTCM,Buurstede JC,Sips HCM,Vettorazzi S,Mol IM,Hartmann J,Prekovic S,Zwart W,Schmidt MV,Roozendaal B,Tuckermann JP,Sarabdjitsingh RA,Meijer OC

更新日期：2019-08-01 00:00:00

abstract：:Ghrelin is a gut hormone that signals to the hypothalamus to stimulate growth hormone release, increase food intake and promote fat deposition. The ghrelin receptor, also known as growth hormone secretagogue receptor (GHS-R), is highly expressed in the brain, with the highest expression in agouti-related peptide (AgRP...

journal_title：Journal of neuroendocrinology

authors： Wu CS,Bongmba OYN,Lee JH,Tuchaai E,Zhou Y,Li DP,Xue B,Chen Z,Sun Y

更新日期：2019-07-01 00:00:00

abstract：:Subsequent to the discovery of ghrelin as the endogenous ligand of growth hormone secretagogue receptor 1a, this unique gut peptide has been found to exert numerous physiological effects, such as appetite stimulation and lipid accumulation via the central regulating mechanisms in the hypothalamus, stimulation of gastr...

journal_title：Journal of neuroendocrinology

authors： Tauber M,Coupaye M,Diene G,Molinas C,Valette M,Beauloye V

更新日期：2019-07-01 00:00:00

abstract：:In addition to its established lactational roles, prolactin acts on multiple target tissues and its circulating levels are responsive to a range of physiological stimuli. The present study used immunohistochemistry to demonstrate that systemic administration of prolactin activates target cells in the arcuate nucleus a...

journal_title：Journal of neuroendocrinology

authors： Kirk SE,Grattan DR,Bunn SJ

更新日期：2019-06-01 00:00:00

abstract：:Humans have engineered a dietary environment that has driven the global prevalence of obesity and several other chronic metabolic diseases to pandemic levels. To prevent or treat obesity and associated comorbidities, it is crucial that we understand how our dietary environment, especially in combination with a sedenta...

journal_title：Journal of neuroendocrinology

authors： Slomp M,Belegri E,Blancas-Velazquez AS,Diepenbroek C,Eggels L,Gumbs MCR,Joshi A,Koekkoek LL,Lamuadni K,Ugur M,Unmehopa UA,la Fleur SE,Mul JD

更新日期：2019-05-01 00:00:00

abstract：:Metabolic health founds on a homeostatic balance that has to integrate the daily changes of rest/activity and feeding/fasting cycles. A network of endogenous 24-hour circadian clocks helps to anticipate daily recurring events and adjust physiology and behavioural functions accordingly. Circadian clocks are self-sustai...

journal_title：Journal of neuroendocrinology

authors： Kolbe I,Brehm N,Oster H

更新日期：2019-05-01 00:00:00

abstract：:Tanycytes are located at the base of the brain and retain characteristics from their developmental origins, such as radial glial cells, throughout their life span. With transport mechanisms and modulation of tight junction proteins, tanycytes form a bridge connecting the cerebrospinal fluid with the external limiting ...

journal_title：Journal of neuroendocrinology

authors： Rodríguez E,Guerra M,Peruzzo B,Blázquez JL

更新日期：2019-03-01 00:00:00

abstract：:Much progress has been made during the past 30 years with respect to elucidating the neural and endocrine pathways by which bodily needs for water and energy are brought to conscious awareness through the generation of thirst and hunger. One way that circulating hormones influence thirst and hunger is by acting on neu...

journal_title：Journal of neuroendocrinology

authors： McKinley MJ,Denton DA,Ryan PJ,Yao ST,Stefanidis A,Oldfield BJ

更新日期：2019-03-01 00:00:00

abstract：:Recent findings relate obesity to inflammation in key hypothalamic areas for body weight control. Hypothalamic inflammation has also been related to oxidative stress. Palmitic acid (PA) is the most abundant free fatty acid found in food, and in vitro studies indicate that it triggers a pro-inflammatory response in the...

journal_title：Journal of neuroendocrinology

authors： Ramírez D,Saba J,Turati J,Carniglia L,Imsen M,Mohn C,Scimonelli T,Durand D,Caruso C,Lasaga M

更新日期：2019-02-01 00:00:00

abstract：:Although the RFamide-related peptide (RFRP) preproprotein sequence is known in mice, until now, the molecular structure of the mature, functional peptides processed from the target precursor molecule has not been determined. In the present study, we purified endogenous RFRP1 and RFRP3 peptides from mouse hypothalamic ...

journal_title：Journal of neuroendocrinology

authors： Gospodarska E,Kozak LP,Jaroslawska J

更新日期：2019-01-01 00:00:00

abstract：:Seasonal rhythms in physiology are widespread among mammals living in temperate zones. These rhythms rely on the external photoperiodic signal being entrained to the seasons, although they persist under constant conditions, revealing their endogenous origin. Internal long-term timing (circannual cycles) can be reveale...

journal_title：Journal of neuroendocrinology

authors： Sáenz de Miera C

更新日期：2019-01-01 00:00:00

abstract：:The pars tuberalis (PT) of the pituitary is central to the control of seasonal breeding. In mammals, the PT translates the photoperiodic message carried by melatonin into an endocrine thyroid-stimulating hormone output, which controls local thyroid hormone (TH) signalling in tanycytes of the neighbouring hypothalamus....

journal_title：Journal of neuroendocrinology

authors： Dardente H,Lomet D

更新日期：2018-09-01 00:00:00

abstract：:Both animal and human studies have provided conclusive evidence that oxytocin (OXT) acts in the brain (eg, medial preoptic area, ventral tegmental area, nucleus accumbens) to promote parental behaviour under different reproductive and physiological conditions. OXT appears to accelerate and strengthen the neural proces...

journal_title：Journal of neuroendocrinology

authors： Olazábal DE

更新日期：2018-07-01 00:00:00

abstract：:The impairment in arginine vasopressin (AVP) secretion during sepsis is described in clinical and experimental studies and has been associated with oxidative stress, apoptosis, and diminished activation of hypothalamic neurons. Few studies have, however, assessed these abnormalities in sepsis survivors. Here we perfor...

journal_title：Journal of neuroendocrinology

authors： Santos-Junior NN,Catalão CH,Costa LH,Rossignoli BB,Dos-Santos RC,Malvar D,Mecawi AS,Rocha MJ

更新日期：2018-05-01 00:00:00

abstract：:The spatial and temporal expression of steroidogenic genes in zebrafish has not been fully characterised. Because zebrafish are increasingly employed in endocrine and stress research, a better characterisation of steroidogenic pathways is required to target specific steps in the biosynthetic pathways. In the present s...

journal_title：Journal of neuroendocrinology

authors： Weger M,Diotel N,Weger BD,Beil T,Zaucker A,Eachus HL,Oakes JA,do Rego JL,Storbeck KH,Gut P,Strähle U,Rastegar S,Müller F,Krone N

更新日期：2018-04-01 00:00:00

abstract：:Subclinical hypothyroidism (SCH) is characterized by mild elevation of thyroid stimulating hormone (TSH) (range 5-10 μIU/ml) and normal free triiodothyronine (FT3) and free thyroxine (FT4). The cognitive function impairment is well known in thyroid disorders such as hypothyroidism and hyperthyroidism, but little is kn...

journal_title：Journal of neuroendocrinology

authors： Kumar M,Modi S,Rana P,Kumar P,Kanwar R,Sekhri T,D'souza M,Khushu S

更新日期：2018-03-05 00:00:00

abstract：:Damaraland mole rats (Fukomys damarensis) are cooperatively breeding, subterranean mammals that exhibit a high reproductive skew. Reproduction is monopolised by the dominant female of the group, whereas subordinates are physiologically suppressed to the extent that they are anovulatory. In these latter animals, it is ...

journal_title：Journal of neuroendocrinology

authors： Voigt C,Bennett NC

更新日期：2018-03-01 00:00:00

abstract：:Metabotropic glutamate receptor subtype 7 (mGluR7) is one of the group III mGluRs, which are negatively coupled to adenylate cyclase via Gi/Go proteins and localised to presynaptic active zones of the mammalian central nervous system. We previously reported that mGluR7 is essential for intermale aggression and amygdal...

journal_title：Journal of neuroendocrinology

authors： Masugi-Tokita M,Yoshida T,Kageyama S,Kawata M,Kawauchi A

更新日期：2018-03-01 00:00:00

abstract：:Social play is a highly rewarding and motivated behavior predominately displayed by juveniles and expressed by nearly all mammalian species. Prior work suggested that the vasopressin (AVP) and oxytocin (OT) systems can regulate the expression of social play in sex-specific ways. Here we investigated whether there are ...

journal_title：Journal of neuroendocrinology

authors： Reppucci CJ,Gergely CK,Veenema AH

更新日期：2018-02-09 00:00:00

abstract：:It is becoming well established that the gut microbiome has a profound impact on human health and disease. In this review, we explore how steroids can influence the gut microbiota and, in turn, how the gut microbiota can influence hormone levels. Within the context of the gut microbiome-brain axis, we discuss how pert...

journal_title：Journal of neuroendocrinology

authors： Tetel MJ,de Vries GJ,Melcangi RC,Panzica G,O'Mahony SM

更新日期：2018-02-01 00:00:00

abstract：:Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) is an oestrogen receptor (ER) coregulator protein identified by our collaborative group. Work from our laboratory and others has shown that PELP1 is a scaffold protein that interacts with ERs and kinase signalling factors, as well as proteins involved in chro...

journal_title：Journal of neuroendocrinology

authors： Thakkar R,Sareddy GR,Zhang Q,Wang R,Vadlamudi RK,Brann D

更新日期：2018-02-01 00:00:00

abstract：:When individuals undergo gestation in an obese dam, they are at increased risk for impairments in the ability of the brain to regulate body weight. In rodents, gestation in an obese dam leads to a number of changes to the development of the hypothalamic neurones that regulate body weight, including reduced neuronal co...

journal_title：Journal of neuroendocrinology

authors： Sanders TR,Glendining KA,Jasoni CL

更新日期：2017-12-01 00:00:00

abstract：:Patients suffering anorexia nervosa (AN) become anhedonic, unable or unwilling to derive normal pleasures and tend to avoid rewarding outcomes, most profoundly in food intake. The activity-based anorexia model recapitulates many of the pathophysiological and behavioural hallmarks of the human condition, including a re...

journal_title：Journal of neuroendocrinology

authors： Foldi CJ,Milton LK,Oldfield BJ

更新日期：2017-10-01 00:00:00

abstract：:Peptide YY 3-36 (PYY3-36) is known as a critical satiety factor that reduces food intake both in rodents and humans. Although the anorexic effect of PYY3-36 is assumed to be mediated mainly by the Y2 receptor, the involvement of other Y-receptors in this process has never been conclusively resolved. Amongst them, the ...

journal_title：Journal of neuroendocrinology

authors： Shi YC,Ip CK,Reed F,Sarruf DA,Wulff BS,Herzog H

更新日期：2017-10-01 00:00:00

abstract：:Diet-induced obesity is associated with hypothalamic inflammation and this phenomenon has been proposed to explain leptin resistance. In the present study, we used a short-term high-fat diet (HFD) paradigm for 10 days and analysed the cellular and physiological responses to leptin administration in C57BL6 mice. In par...

journal_title：Journal of neuroendocrinology

authors： Balland E,Cowley MA

更新日期：2017-10-01 00:00:00