A tumultuous transition to motherhood: Altered brain and hormonal responses in mothers with postpartum depression.


:Postpartum depression (PPD) is a common but complex condition that is poorly understood and multifactorial in aetiology. It is a condition that can compromise the mother's care for her infant, which may pose challenges to the formation of the mother-infant bond and the infant's overall development. Past research has looked at abnormalities in the brain circuitry and hormonal profiles of mothers with PPD compared to non-depressed mothers. However, abnormalities in PPD that may specifically affect the mother's care of her infant have not been clearly assessed. Thus, the present review aims to synthesise studies of altered brain and hormonal responses in mothers with PPD in relation to their care of their infant. First, we review maternal brain responses and their relation to PPD symptomatology, focusing on the salience/fear network, reward/attachment network and default mode network. Next, we discuss oxytocin and hypothalamic-pituitary-adrenal axis hormones in the context of maternal behaviour and PPD. Finally, we synthesise these findings and propose how future studies may benefit from the combined study of both neural and hormonal activity to better understand the underlying neurobiology of maternal care in PPD.


J Neuroendocrinol


Nguyen AJ,Hoyer E,Rajhans P,Strathearn L,Kim S




Has Abstract


2019-09-01 00:00:00












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    abstract::To study whether central systems that are implicated in functions associated with reproduction show different changes in males and females that become parental, the central vasopressin (AVP) innervation was compared in two species of voles: prairie voles, in which males and females provide parental care, and meadow vo...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Bamshad M,Novak MA,De Vries GJ

    更新日期:1993-06-01 00:00:00

  • Expression of neurotensin and its receptors in pituitary adenomas.

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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Giorgi RR,Chile T,Bello AR,Reyes R,Fortes MA,Machado MC,Cescato VA,Musolino NR,Bronstein MD,Giannella-Neto D,Corrêa-Giannella ML

    更新日期:2008-09-01 00:00:00

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    abstract::The supraoptic (SON) and paraventricular nuclei (PVN) of the human hypothalamus are production sites of vasopressin (AVP) and oxytocin (OXT). Although the hypothalamus is affected in Alzheimer's disease (AD), previous work has not only shown that in these two nuclei no neurons are lost, neither during aging nor in AD,...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    journal_title:Journal of neuroendocrinology

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    journal_title:Journal of neuroendocrinology

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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    更新日期:2017-08-01 00:00:00

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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    更新日期:2000-06-01 00:00:00

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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


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    更新日期:2007-06-01 00:00:00

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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Melamed P,Savulescu D,Lim S,Wijeweera A,Luo Z,Luo M,Pnueli L

    更新日期:2012-12-01 00:00:00

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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


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    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


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    更新日期:1992-08-01 00:00:00