Inhibition of epidermal growth factor receptor stimulates prolactin expression in primary culture of the mouse pituitary gland.


:The roles of epidermal growth factor (EGF) in the regulation of prolactin (PRL) gene expression in the normal pituitary gland remain poorly understood. In the present study, the effects of EGF and an inhibitor of the EGF receptor, erlotinib, on PRL gene expression were examined both in the pituitary tumour cell line GH3 and in a primary culture of the mouse pituitary gland under similar experimental conditions. The results showed that EGF stimulated PRL expression in GH3 cells, but not in normal cells. Erlotinib was found to counteract EGF in GH3 cells inhibiting the PRL expression enhanced by EGF. By contrast, erlotinib induced an elevation in the PRL mRNA levels in the primary culture of the adult pituitary gland and the initiation of PRL production in the culture of the foetal pituitary gland in which PRL production had not yet occurred. Western blot analyses showed that EGF induced and erlotinib inhibited the activation of extracellular regulated protein kinase equally in GH3 and normal cells. These results suggest that the consequences of EGF receptor activation in normal PRL cells contradict those in adenomatous PRL cells.


J Neuroendocrinol


Nogami H,Koshida R,Omori H,Shibata M,Harigaya T,Takei Y




Has Abstract


2019-08-01 00:00:00












  • Reproductively-relevant stimuli induce Fos-immunoreactivity within progestin receptor-containing neurons in localized regions of female rat forebrain.

    abstract::An experiment was conducted to determine if neurons that respond to stimuli associated with mating in female brain also contain progestin receptors. We found that a portion of the neurons that respond to stimuli associated with mating also contains progestin receptors. While the appropriate hormonal conditions are imp...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Auger AP,Moffatt CA,Blaustein JD

    更新日期:1996-11-01 00:00:00

  • Alteration in intrinsic and extrinsic functional connectivity of resting state networks associated with subclinical hypothyroid.

    abstract::Subclinical hypothyroidism (SCH) is characterized by mild elevation of thyroid stimulating hormone (TSH) (range 5-10 μIU/ml) and normal free triiodothyronine (FT3) and free thyroxine (FT4). The cognitive function impairment is well known in thyroid disorders such as hypothyroidism and hyperthyroidism, but little is kn...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Kumar M,Modi S,Rana P,Kumar P,Kanwar R,Sekhri T,D'souza M,Khushu S

    更新日期:2018-03-05 00:00:00

  • Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function.

    abstract::Impaired cognitive function and enhanced activity of the hypothalamic-pituitary-adrenocortical system are among the cardinal symptoms of major depression in humans that resolve after successful antidepressant treatment. We used a transgenic mouse model expressing antisense RNA complementary to that of glucocorticoid r...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Montkowski A,Barden N,Wotjak C,Stec I,Ganster J,Meaney M,Engelmann M,Reul JM,Landgraf R,Holsboer F

    更新日期:1995-11-01 00:00:00

  • Isolation and identification of endogenous RFamide-related peptides 1 and 3 in the mouse hypothalamus.

    abstract::Although the RFamide-related peptide (RFRP) preproprotein sequence is known in mice, until now, the molecular structure of the mature, functional peptides processed from the target precursor molecule has not been determined. In the present study, we purified endogenous RFRP1 and RFRP3 peptides from mouse hypothalamic ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Gospodarska E,Kozak LP,Jaroslawska J

    更新日期:2019-01-01 00:00:00

  • Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade.

    abstract::Following the cloning of the melanocortin receptor and agouti protein genes, a model was developed for the central melanocortin system with respect to the regulation of energy and glucose homeostasis. This model comprised leptin regulation of melanocortin peptides and agouti-related peptide (AgRP) produced from centra...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Mountjoy KG

    更新日期:2015-06-01 00:00:00

  • Sympathoadrenal system differentially affects photoperiodic changes in humoral immunity of Siberian hamsters (Phodopus sungorus).

    abstract::Siberian hamsters (Phodopus sungorus) rely on photoperiod as a primary cue to coordinate seasonally appropriate changes in physiology and behaviour. Among these seasonal changes is reduced immune function in short 'winter-like' days, compared to long 'summer-like' days. Previous evidence suggests that immune function ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Demas GE,Drazen DL,Jasnow AM,Bartness TJ,Nelson RJ

    更新日期:2002-01-01 00:00:00

  • Emotion and mood adaptations in the peripartum female:complementary contributions of GABA and oxytocin.

    abstract::Peripartum hormones and sensory cues from young modify the maternal brain in ways that can render females either at risk for, or resilient to, elevated anxiety and depression. The neurochemical systems underlying these aspects of maternal emotional and mood states include the inhibitory neurotransmitter GABA and the n...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Lonstein JS,Maguire J,Meinlschmidt G,Neumann ID

    更新日期:2014-10-01 00:00:00

  • Chronic glucocorticoid deficiency-induced abnormal aggression, autonomic hypoarousal, and social deficit in rats.

    abstract::Certain aggression-related psychopathologies are associated with decreased glucocorticoid production and autonomic functions in humans. We have previously shown that experimentally-induced chronic glucocorticoid deficiency leads to abnormal forms of attack in rats. Here, we compared the effects of acute and chronic gl...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Haller J,Halász J,Mikics E,Kruk MR

    更新日期:2004-06-01 00:00:00

  • Noradrenergic modulation of gonadotrophin-inhibitory hormone gene expression in the brain of Japanese quail.

    abstract::Gonadotrophin-inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotrophin synthesis and release in birds and mammals. In Japanese quail, GnIH neurones express the noradrenergic receptor and receive noradrenergic innervation. Treatment with noradrenaline (NA) stimulates GnIH release from dience...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Tobari Y,Kansaku N,Tsutsui K

    更新日期:2017-08-01 00:00:00

  • Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks.

    abstract::The melanocortin system together with other appetite-related systems plays a significant role in appetite regulation. The appetite-related effects of one such melanocortin, beta-melanocyte-stimulating hormone (MSH), are well documented in rodents; however, its effects in the avian class are not thoroughly understood. ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Smith ML,Prall B,Nandar W,Cline MA

    更新日期:2008-02-01 00:00:00

  • Circannual variation in thyroid hormone deiodinases in a short-day breeder.

    abstract::At temperate latitudes, many mammals and birds show internally timed, long-term changes in seasonal physiology, synchronised to the seasons by changing day length (photoperiod). Photoperiodic control of thyroid hormone levels in the hypothalamus dictates the timing. This is effected through reciprocal regulation of th...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Sáenz de Miera C,Hanon EA,Dardente H,Birnie M,Simonneaux V,Lincoln GA,Hazlerigg DG

    更新日期:2013-04-01 00:00:00

  • Development of gonadotrophs and thyrotrophs in the female foetal sheep pituitary: immunocytochemical localization studies.

    abstract::In order to investigate the ontogenesis of cell types in the pituitary gland, anterior pituitaries were collected from female foetal sheep at days 70, 100 and 130 of gestation (term = 145 days). Cells containing the common alpha-subunit and the specific beta-subunits of luteinizing hormone (LH), follicle-stimulating h...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Thomas GB,McNeilly AS,Brooks AN

    更新日期:1993-04-01 00:00:00

  • The hypothalamic-neurohypophyseal system: from genome to physiology.

    abstract::The elucidation of the genomes of a large number of mammalian species has produced a huge amount of data on which to base physiological studies. These endeavours have also produced surprises, not least of which has been the revelation that the number of protein coding genes needed to make a mammal is only 22 333 (give...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Murphy D,Konopacka A,Hindmarch C,Paton JF,Sweedler JV,Gillette MU,Ueta Y,Grinevich V,Lozic M,Japundzic-Zigon N

    更新日期:2012-04-01 00:00:00

  • The role of the endocannabinoid system in atherosclerosis.

    abstract::Our current understanding of the pathophysiology of atherosclerosis suggests a prominent role for immune responses from its initiation through its complications. Given the increasing prevalence of cardiovascular risk factors worldwide, there is an urgent need to better understand the underlying mechanisms to improve c...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Mach F,Steffens S

    更新日期:2008-05-01 00:00:00

  • Ontogeny of aromatase and tyrosine hydroxylase activity and of aromatase-immunoreactive cells in the preoptic area of male and female Japanese quail.

    abstract::The aromatization of testosterone into oestrogens plays a key role in the control of many behavioural and physiological aspects of reproduction. In the quail preoptic area (POA), aromatase activity and the number of aromatase-immunoreactive (ARO-ir) cells are sexually differentiated (males > females). This sex differe...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Balthazart J,Tlemçani O,Harada N,Baillien M

    更新日期:2000-09-01 00:00:00

  • Molecular identification of two types of interleukin-1 receptors in the murine pituitary gland.

    abstract::The present study was carried out to characterize interleukin-1 (IL-1) receptors on murine pituitary cells. Receptor autoradiography confirmed the existence of binding sites for IL-1 alpha in the murine adenohypophysis, but not in the neural or intermediate lobes. Specific binding of IL-1 to isolated pituitary membran...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Parnet P,Brunke DL,Goujon E,Mainard JD,Biragyn A,Arkins S,Dantzer R,Kelley KW

    更新日期:1993-04-01 00:00:00

  • Changes in the expression of corticotrophin-releasing hormone, mineralocorticoid receptor and glucocorticoid receptor mRNAs in the hypothalamic paraventricular nucleus induced by fornix transection and adrenalectomy.

    abstract::The paraventricular nucleus (PVN) in the hypothalamus receives inputs from the hippocampus The present study explored the influence of the hippocampus on genes mediating glucocorticoid feedback in the PVN. Accordingly, the expression of mRNAs for corticotrophin-releasing hormone (CRH), the mineralocorticoid receptor (...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Han F,Ozawa H,Matsuda KI,Lu H,De Kloet ER,Kawata M

    更新日期:2007-04-01 00:00:00

  • Preterm labour: tsunami waves?

    abstract::Preterm labour and birth can be delayed but are generally unstoppable, threatening the health of the mother-baby duo. This may be a result of peripheral signals prematurely recruiting the oxytocin neurones that co-ordinate the timing of birth and, via specialised activity and secretion patterns, drive uterine contract...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Douglas AJ

    更新日期:2010-09-01 00:00:00

  • Nucleobindin 2/nesfatin-1 expression and colocalisation with neuropeptide Y and cocaine- and amphetamine-regulated transcript in the human brainstem.

    abstract::Feeding is a complex behaviour entailing elaborate interactions between forebrain, hypothalamic and brainstem neuronal circuits via multiple orexigenic and anorexigenic neuropeptides. Nucleobindin-2 (NUCB2)/nesfatin-1 is a negative regulator of food intake and body weight with a widespread distribution in rodent brain...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Psilopanagioti A,Makrygianni M,Nikou S,Logotheti S,Papadaki H

    更新日期:2020-09-01 00:00:00

  • Sex differences and the roles of sex steroids in apoptosis of sexually dimorphic nuclei of the preoptic area in postnatal rats.

    abstract::The brain contains several sexually dimorphic nuclei that exhibit sex differences with respect to cell number. It is likely that the control of cell number by apoptotic cell death in the developing brain contributes to creating sex differences in cell number in sexually dimorphic nuclei, although the mechanisms respon...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Tsukahara S

    更新日期:2009-03-01 00:00:00

  • Vasopressin Expression in Cultured Neurons is Stimulated by Cyclic AMP.

    abstract::Abstract Vasopressin and oxytocin genes are expressed in mutually exclusive sets of magnocellular neurons in the hypothalamus. Cell specificity and regulation are probably controlled by extra- and intracellular signals acting on one or the other gene. In order to identify factors that regulate peptide expression, we h...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Ceding P,Schilling K,Schmale H

    更新日期:1990-12-01 00:00:00

  • Mechanisms mediating oestradiol modulation of the developing brain.

    abstract::The brain has been known to be a sensitive target organ for the permanent organisational effects of gonadal steroids for close to 50 years. Recent advances have revealed a variety of unexpected cellular mechanisms by which steroids impact on the synaptic profile of hypothalamic nuclei critical to the control of reprod...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: McCarthy MM,Schwarz JM,Wright CL,Dean SL

    更新日期:2008-06-01 00:00:00

  • Neuromedin U in the paraventricular and arcuate hypothalamic nuclei increases non-exercise activity thermogenesis.

    abstract::Brain neuromedin U (NMU) has been associated with the regulation of both energy intake and expenditure. We hypothesized that NMU induces changes in spontaneous physical activity and nonexercise activity thermogenesis (NEAT) through its actions on hypothalamic nuclei. We applied increasing doses of NMU directly to the ...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Novak CM,Zhang M,Levine JA

    更新日期:2006-08-01 00:00:00

  • Seasonal regulation of membrane and intracellular corticosteroid receptors in the house sparrow brain.

    abstract::A number of studies have demonstrated seasonal regulation of the adrenocortical response to stress, or of corticosteroid binding globulins, but very few studies have examined seasonal regulation of corticosteroid receptor levels. As a result, there have been few attempts to produce an integrated picture of seasonal pl...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Breuner CW,Orchinik M

    更新日期:2001-05-01 00:00:00

  • The paraventricular nucleus modulates thyroidal motilin release and rat gastric motility.

    abstract::Motilin, an important endocrine regulator of gastrointestinal motility, was once considered to be produced in the gastrointestinal tract and brain. In recent years, however, motilin has been found in the human thyroid, as well as in that of the guinea pig. The physiological function and central modulation of thyroidal...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Guo F,Xu L,Sun X,Gao S,Zhu H

    更新日期:2011-09-01 00:00:00

  • Vasopressin anti-idiotypic antibody staining in the rat brain: colocalization with [35S] [pGlu4, Cyt6]AVP(4-9) binding sites.

    abstract::Vasopressin and its fragment peptides such as [pGlu4, Cyt6]AVP(4-9) (AVP(4-9) represent putative neuromodulators within central nervous homeostatic, memory and behavioural circuits. To localize their central receptor systems, the previously characterized monoclonal anti-idiotypic antibody mAb 237 was employed in immun...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Jurzak M,Fahrenholz F,Gerstberger R

    更新日期:1993-10-01 00:00:00

  • The G protein-coupled oestrogen receptor, GPER1, mediates direct anti-inflammatory effects of oestrogens in human cholinergic neurones from the nucleus basalis of Meynert.

    abstract::It has been well established, particularly in animal models, that oestrogens exert neuroprotective effects in brain areas linked to cognitive processes. A key protective role could reside in the capacity of oestrogen to modulate the inflammatory response. However, the direct neuroprotective actions of oestrogens on ne...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Sarchielli E,Guarnieri G,Idrizaj E,Squecco R,Mello T,Comeglio P,Gallina P,Maggi M,Vannelli GB,Morelli A

    更新日期:2020-03-01 00:00:00

  • APJ receptor mRNA expression in the rat hypothalamic paraventricular nucleus: regulation by stress and glucocorticoids.

    abstract::The apelin receptor (APJ receptor, APJR) has recently come to prominence following the isolation and identification of its endogenous ligand, apelin, from bovine stomach tissue extracts. Investigation of APJR mRNA expression has revealed a hypothalamic distribution similar to that of vasopressin suggesting that the ap...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: O'Carroll AM,Don AL,Lolait SJ

    更新日期:2003-11-01 00:00:00

  • Cannabinoids modulate synaptic activity in the rat supraoptic nucleus.

    abstract::In the present study, we investigated the effects of the cannabinoid receptor agonist CP55,940 on excitatory and inhibitory synaptic transmission in the rat supraoptic nucleus. Whole-cell patch clamp recordings were performed on supraoptic neurones in in vitro brain slice preparations. CP55,940 significantly reduced t...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章


    authors: Soya A,Serino R,Fujihara H,Onaka T,Ozaki Y,Saito T,Nakamura J,Ueta Y

    更新日期:2005-09-01 00:00:00

  • Interplay of central and peripheral circadian clocks in energy metabolism regulation.

    abstract::Metabolic health founds on a homeostatic balance that has to integrate the daily changes of rest/activity and feeding/fasting cycles. A network of endogenous 24-hour circadian clocks helps to anticipate daily recurring events and adjust physiology and behavioural functions accordingly. Circadian clocks are self-sustai...

    journal_title:Journal of neuroendocrinology

    pub_type: 杂志文章,评审


    authors: Kolbe I,Brehm N,Oster H

    更新日期:2019-05-01 00:00:00