abstract：:Many interventions have been investigated for the treatment of nonalcoholic steatohepatitis (NASH). This study aims to summarize all investigated options to date and review the use of specific endpoints at different stages of ongoing trials of noncirrhotic NASH treatments. Using a horizon scanning approach, evidence w...

journal_title：Annals of hepatology

authors： Patikorn C,Veettil SK,Phisalprapa P,Pham T,Kowdley KV,Chaiyakunapruk N

更新日期：2021-01-27 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Little is known about the etiology of acute liver failure (ALF) in Latin America. The objective of this paper is to investigate the main etiologies of ALF in Brazil, including Drug Induced Liver Injury (DILI) using stringent causality criteria. PATIENTS OR MATERIAL AND METHODS:All the cases...

journal_title：Annals of hepatology

authors： Junior GOS,Figueira ERR,D'Albuquerque LAC,Lisboa PB,de Almeida MD,Filgueira NA,de Fátima Santana Ferreira Boin I,Porta G,da Silva RCMA,Viana CFG,Faria LC,Alvares-da-Silva MR,de Moraes ACP,Morsoletto DBG,Codes L,Filho RPF

更新日期：2021-01-25 00:00:00

abstract：INTRODUCTION:Nonalcoholic fatty liver disease (NAFLD) patients can progress to cirrhosis. In these, there is a compensated stage in which esophageal varices can exist. However, no more than 20% of these patients have varices needing treatment (VNT). OBJECTIVE:Evaluate the accuracy of non-invasive models to predict eso...

journal_title：Annals of hepatology

authors： Galizzi HO,Couto CA,Taranto DOL,Araújo SIO,Vilela EG

更新日期：2021-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Differentiating biliary atresia from other causes of neonatal cholestasis is challenging, particularly when cytomegalovirus (CMV) and biliary atresia occur simultaneously. We aimed to elucidate whether CMV infection would affect the differential diagnosis of biliary atresia and intrahepatic ...

journal_title：Annals of hepatology

authors： Zhao D,Gong X,Li Y,Sun X,Chen Y,Deng Z,Zhang Y

更新日期：2020-11-12 00:00:00

abstract：:The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker which has been investigated as a prognostic indicator in post-therapeutic recurrence and survival of patients with HCC. Our aim was to review all studies that assessed the prognostic value of pre-treatment NLR in predicting patient survival, cancer rec...

journal_title：Annals of hepatology

authors： Mouchli M,Reddy S,Gerrard M,Boardman L,Rubio M

更新日期：2020-09-05 00:00:00

abstract：INTRODUCTION AND AIM:Occult hepatitis B virus infection (OBI) is characterized by the presence of replication-competent hepatitis B virus (HBV) DNA in the liver and/or serum of patients with undetectable levels of the HBV surface antigen (HBsAg). Due to the shared infection routes HIV positive patients are at higher ri...

journal_title：Annals of hepatology

authors： Enriquez-Navarro K,Maldonado-Rodriguez A,Rojas-Montes O,Torres-Ibarra R,Bucio-Ortiz L,De la Cruz MA,Torres-Flores J,Xoconostle-Cazares B,Lira R

更新日期：2020-01-01 00:00:00

abstract：:In 2016 WHO member states endorsed the 69th World Health Assembly's Global Health Sector Strategies (GHSS) towards eliminating Hepatitis B (HBV) infections by 2030. Substantial progress has been made in Mexico regarding HBV vaccination, blood safety and health-care setting injection safety but minor progress has been ...

journal_title：Annals of hepatology

authors： García-Sepúlveda CA,Laguna-Meraz S,Panduro A

更新日期：2020-01-01 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) currently represents an epidemic worldwide. NAFLD is the most frequently diagnosed chronic liver disease, affecting 20-30% of the general population. Furthermore, its prevalence is predicted to increase exponentially in the next decades, concomitantly with the global epidemic ...

journal_title：Annals of hepatology

authors： Arab JP,Dirchwolf M,Álvares-da-Silva MR,Barrera F,Benítez C,Castellanos-Fernandez M,Castro-Narro G,Chavez-Tapia N,Chiodi D,Cotrim H,Cusi K,de Oliveira CPMS,Díaz J,Fassio E,Gerona S,Girala M,Hernandez N,Marciano S,Mass

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Infantile hepatic hemangioendothelioma (IHHE) is a benign liver tumor, associated with hypothyroidism and vascular malformations along the skin, brain, digestive tract and other organs. Here, we determined a single-center patient cohort by evaluating the effectiveness and safety of propranol...

journal_title：Annals of hepatology

authors： Tian R,Liang Y,Wang J,Shan Y,Gao H,Zhang L,Xie C,Li J,Xu M,Gu S

更新日期：2020-01-01 00:00:00

abstract：:CD98 is a multifunctional glycoprotein that is involved in various biological processes such as amino acid transport, cell adhesion, diffusion, adhesion, and proliferation. The role of CD98 in liver disease has not thoroughly been examined and is limited reports in the literature. Among these reports, direct associati...

journal_title：Annals of hepatology

authors： Canup BSB,Song H,Laroui H

更新日期：2020-01-01 00:00:00

abstract：:Primary biliary cholangitis and primary sclerosing cholangitis are rare diseases affecting the bile ducts and the liver. The limited knowledge of their pathogenesis leads to limited therapeutic options. Nevertheless, the landscape of novel therapies for these cholangiopathies is now rapidly changing, providing new tre...

journal_title：Annals of hepatology

authors： Gerussi A,D'Amato D,Cristoferi L,O'Donnell SE,Carbone M,Invernizzi P

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Hepatocellular liver injury is characterized by elevations in serum alanine (ALT) and aspartate (AST) aminotransferases while cholestasis is associated with elevated serum alkaline phosphatase (ALP) levels. When both sets of enzymes are elevated, distinguishing between the two patterns of li...

journal_title：Annals of hepatology

authors： Iluz-Freundlich D,Zhang M,Uhanova J,Minuk GY

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Liver transplantation candidates are among the most comorbid patients awaiting lifesaving intervention. Health related quality of life (HRQOL) measured by instruments that incorporate dynamic computerized adaptive testing, could improve their assessment. We aimed to determine the feasibility...

journal_title：Annals of hepatology

authors： Stine JG,Stukenborg GJ,Wang J,Adkins A,Niccum B,Zimmet A,Argo CK

更新日期：2020-01-01 00:00:00

abstract：:Studies have suggested that the presence of sarcopenia in patients with cirrhosis could be a predisposing risk factor for hepatic encephalopathy. This systematic review and meta-analysis were conducted to summarize all available evidence on this relationship. A systematic review was carried out in Medline and EMBASE d...

journal_title：Annals of hepatology

authors： Wijarnpreecha K,Werlang M,Panjawatanan P,Kroner PT,Cheungpasitporn W,Lukens FJ,Pungpapong S,Ungprasert P

更新日期：2020-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Chronic liver inflammation may lead to hepatic cirrhosis, limiting its regenerative capacity. The clinical standard of care is transplantation, although stem cell therapy may be an alternative option. The study aim was to induce endogenous hematopoietic stem cells (HSCs) with granulocyte col...

journal_title：Annals of hepatology

authors： De Luna-Saldivar MM,Marino-Martinez IA,Franco-Molina MA,Rivera-Morales LG,Alarcón-Galván G,Cordero-Pérez P,Rojas-Martínez A,Rodríguez-Padilla C,Muñoz-Espinosa LE

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Serum glypican-3 (GPC3) has been explored as a non-invasive biomarker of hepatocellular carcinoma (HCC). However, controversy remains on its diagnostic accuracy. Therefore, we aimed to conduct a systematic review and metaanalysis to evaluate the differential diagnostic accuracy of serum GPC3 betwee...

journal_title：Annals of hepatology

authors： Xu D,Su C,Sun L,Gao Y,Li Y

更新日期：2019-01-01 00:00:00

abstract：:Budd-Chiari syndrome (BCS) is a heterogeneous group of disorders characterized by hepatic venous outflow obstruction. Abernethy malformation is a congenital vascular malformation defined by diversion of portal blood away from the liver. Both conditions are rare vascular diseases. We report here the first case of a pat...

journal_title：Annals of hepatology

authors： Ding PX,Han XW,Liu C

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Data on the efficacy and tolerance of interferon-free treatment in chronic hepatitis C (CHC) in elderly patients are limited in phase II-III trials. MATERIAL AND METHODS:A prospective cohort of adult patients with CHC treated in French general hospitals. RESULTS:Data from 1,123 patients, distribu...

journal_title：Annals of hepatology

authors： Pariente A,Arpurt JP,Remy AJ,Rosa-Hezode I,Causse X,Heluwaert F,Macaigne G,Henrion J,Renou C,Schnee M,Salloum H,Hommel S,Pilette C,Arotcarena R,Barjonet G,Lison H,Bourhis F,Jouannaud V,Pauwels A,Le-Bricquir Y,Geag

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Patients with NASH have increased risk for sepsis or cardiovascular disease after Liver transplantation. An important role of Toll-like receptor (TLR) 4 in the pathogenesis of nonalcoholic steatohepatitis (NASH) was demonstrated. Here, we study the role of miR-182-5p in TLR4 expression and high-fat...

journal_title：Annals of hepatology

authors： Liang Q,Chen H,Xu X,Jiang W

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Four regimens are recommended for treating hepatitis C (HCV) genotype 1 infection. Study aims were to (1) compare frequencies of contraindicated drug interactions (XDDIs) when each HCV regimen is added to medication profiles of HCV-monoinfected patients, (2) quantify the proportion of patien...

journal_title：Annals of hepatology

authors： Ahmed A,Schriever C,Britt N,Yager J,Amin R,McGuey L,Patel N

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:AKI is known to be associated with increased risk of mortality, however limited information is available on how AKI impacts healthcare costs and resource utilization in hospitalized patients with cirrhosis. Previous studies have had variable definitions of AKI, resulting in inconsistent repo...

journal_title：Annals of hepatology

authors： Karagozian R,Bhardwaj G,Wakefield DB,Verna EC

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Although hepatotoxicity accounts for 10% of adverse drug reactions, it remains poorly understood and underreported. This study aimed to summarize case reports of herb- and drug-induced liver injury in Brazil. METHODOLOGY:Systematic review in the following databases: PubMed, SciELO, Science ...

journal_title：Annals of hepatology

authors： Becker MW,Lunardelli MJM,Tovo CV,Blatt CR

更新日期：2019-01-01 00:00:00

abstract：:Acute liver failure (ALF) is a severe condition secondary to a myriad of causes associated with poor outcomes. The prompt diagnosis and identification of the aetiology allow the administration of specific treatments plus supportive strategies and to define the overall prognosis, the probability of developing complicat...

journal_title：Annals of hepatology

authors： Rovegno M,Vera M,Ruiz A,Benítez C

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Studies have shown that two polymorphisms were associated with steatosis and progression of non-alcoholic fatty liver disease (NAFLD) in different populations: the Patatin-like Phospholipase Domain Containing 3 (PNPLA3) and Transmembrane 6 Superfamily Member 2 (TM6SF2). However, the frequency and s...

journal_title：Annals of hepatology

authors： Mazo DF,Malta FM,Stefano JT,Salles APM,Gomes-Gouvea MS,Nastri ACS,Almeida JR,Pinho JRR,Carrilho FJ,Oliveira CP

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Viral hepatitis is an endemic and epidemic disease of relevance in public health. This study estimated the frequency of viral hepatitis by occupational and non-occupational infections and analyzed the factors associated with case notifications in Brazil from 2007 to 2014. MATERIAL AND METHO...

journal_title：Annals of hepatology

authors： Cordeiro TMSC,Ferreira Filho RP,D'Oliveira Júnior A

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVES:Niemann-Pick disease type A (NPD-A) and B (NPD-B) are lysosomal storage diseases with a birth prevalence of 0.4-0.6/100,000. They are caused by a deficiency in acid sphingomyelinase, an enzyme encoded by SMPD1. We analyzed the phenotype and genotype of four unrelated Mexican patients, one wi...

journal_title：Annals of hepatology

authors： Cerón-Rodríguez M,Vázquez-Martínez ER,García-Delgado C,Ortega-Vázquez A,Valencia-Mayoral P,Ramírez-Devars L,Arias-Villegas C,Monroy-Muñoz IE,López M,Cervantes A,Cerbón M,Morán-Barroso VF

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:The interleukin-33/interleukin-13 pathway is involved in the immunopathology of liver fibrosis and recently characterized group 2 innate lymphoid cells (ILC2) were identified as profibrotic immune cells in the liver of mouse models. Our aim was to elucidate whether ILC2 might be present in human liver tiss...

journal_title：Annals of hepatology

authors： Gonzalez-Polo V,Pucci-Molineris M,Cervera V,Gambaro S,Yantorno SE,Descalzi V,Tiribelli C,Gondolesi GE,Meier D

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Hepatitis B virus (HBV) infection remains a public health problem worldwide. In addition, HBV infection results are influenced by various virological, immunological, and genetic factors. Inducible T-cell costimulator (ICOS) polymorphisms involving chronic HBV infection have been confirmed in previo...

journal_title：Annals of hepatology

authors： Song XM,Li QL,Guo F,Peng H,Guo JJ

更新日期：2018-10-16 00:00:00

abstract：INTRODUCTION AND AIM:Hepatocellular carcinoma (HCC) is a lethal malignancy, but the molecular mechanisms of hepatocarcinogenesis remain undefined. The present study aims to investigate the relationship between polymorphisms of the hepatic lipase (HL) gene promoters and risk of HCC. MATERIAL AND METHODS:Totally, 279 HC...

journal_title：Annals of hepatology

authors： Niu CZ,Zhang FH,Li Y,Liu JJ,Bao CX

更新日期：2018-10-16 00:00:00

abstract：INTRODUCTION AND AIMS:Serum electrolyte derangements are common in patients with decompensated cirrhosis hospitalized for hepatic encephalopathy. There are limited data describing the association between electrolyte levels and outcomes in hepatic encephalopathy. We assessed the association between initial serum electro...

journal_title：Annals of hepatology

authors： Alsaad AA,Stancampiano FF,Palmer WC,Henry AM,Jackson JK,Heckman MG,Diehl NN,Keaveny AP

更新日期：2018-08-24 00:00:00

abstract：INTRODUCTION AND AIM:Olfactory functions are altered to a variable degree by chronic liver disease. Few studies including only small populations of patients emphasized the possibility of hepatic encephalopathy (HE) influencing olfactory nervous tasks. So far, no study has explicitly focused on olfactory function depend...

journal_title：Annals of hepatology

authors： Heiser C,Haller B,Sohn M,Hofauer B,Knopf A,Mühling T,Freiherr J,Bender M,Tiller M,Schmidt A,Schepp W,Gundling F

更新日期：2018-08-24 00:00:00

abstract：:Hepatocellular carcinoma (HCC) represents 90% of liver tumors. Statins, may reduce the incidence of various tumors, including HCC. Antitumoral activities may be mediated by changes in transforming growth factor-beta (TGF-β1) and thyroid hormones (TH) regulation. INTRODUCTION AND AIM:Hepatocellular carcinoma (HCC) rep...

journal_title：Annals of hepatology

authors： Ridruejo E,Romero-Caími G,Obregón MJ,Kleiman de Pisarev D,Alvarez L

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION AND AIM:Multiple prognostic scores are available for acute liver failure (ALF). Our objective was to compare the dynamicity of model for end stage liver disease (MELD), MELD-sodium, acute liver failure early dynamic model (ALFED), chronic liver failure (CLIF)-consortium ACLF score and King's College Hospit...

journal_title：Annals of hepatology

authors： Shalimar,Sonika U,Kedia S,Mahapatra SJ,Nayak B,Yadav DP,Gunjan D,Thakur B,Kaur H,Acharya SK

更新日期：2018-05-01 00:00:00

abstract：INTRODUCTION:Hepatitis B virus (HBV) infection leads to a chronic liver disease that is distributed worldwide. The characterization of HBV into genotypes/subgenotypes is not only a mere procedure for distinguishing different HBV strains around the world because determining their geographic distribution is crucial to un...

journal_title：Annals of hepatology

authors： Cruz-Santos MD,Gomes-Gouvêa MS,Costa-Nunes JD,Malta-Romano C,Teles-Sousa M,Fonseca-Barros LM,Carrilho FJ,Paiva-Ferreira AS,Rebello-Pinho JR

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION:Effective prevention strategies require specific actions during the different phases of ischemia-reperfusion (I-R) injury. The objective of our study is to evaluate the effect of aqueous extract of Hypericum humifusum leaves (HHL) on liver I-R model in Rat. MATERIAL AND METHODS:Animals were subjected to 9...

journal_title：Annals of hepatology

authors： Ferchichi H,Salouage I,Bacha S,Kourda N,Jebabli N,Gaies E,Klouz A,Trabelsi S

更新日期：2018-01-01 00:00:00

abstract：INTRODUCTION AND AIM:Neonatal cholestasis constitutes for 19 to 33% of all chronic liver disease in India. Cholestasis leads to fibrosis of liver and ultimately cirrhosis. There are various methods of diagnosis of fibrosis of liver like fibroscan, APRI index, FIB-4, fibro index, forns index, heap score, magnetic elasto...

journal_title：Annals of hepatology

authors： Shah I,Madgum N

更新日期：2018-01-01 00:00:00

abstract：:Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as signaling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic m...

journal_title：Annals of hepatology

authors： Di Ciaula A,Wang DQ,Molina-Molina E,Lunardi Baccetto R,Calamita G,Palmieri VO,Portincasa P

更新日期：2017-11-01 00:00:00

abstract：:Bile acids (BAs), the end products of cholesterol catabolism, are essential for the absorption of lipids and fat-soluble vitamins; but they have also emerged as novel signaling molecules that act as metabolic regulators. It has been well described that the enterohe-patic circulation, a nuclear (FXR) and a cytoplasmic ...

journal_title：Annals of hepatology

authors： Alberto González-Regueiro J,Moreno-Castañeda L,Uribe M,Carlos Chávez-Tapia N

更新日期：2017-11-01 00:00:00

abstract：:Bile acids (BA) are key molecules in generating bile flow, which is an essential function of the liver. In the last decades there have been great advances in the understanding of the role of a number of specific transport proteins present at the sinusoidal and canalicular membrane domains of hepatocytes and cholangioc...

journal_title：Annals of hepatology

authors： Arab JP,Cabrera D,Arrese M

更新日期：2017-11-01 00:00:00

abstract：INTRODUCTION:Endovascular therapy represents a less invasive alternative to open surgery for reconstruction of the portal vein (PV) and the spleno-mesenteric venous confluence to treat Portal hypertension. The objective of this study is to determine if the Model for End-Stage Liver Disease (MELD) score is a useful meth...

journal_title：Annals of hepatology

authors： Torres-Machorro A,Guerrero-Hernandez M,Anaya-Ayala JE,Torre A,Laparra-Escareno H,Cuen-Ojeda C,Garcia-Alva R,Hinojosa CA

更新日期：2017-11-01 00:00:00