abstract：:The telencephalon of adult mammals shows constitutive neurogenesis, and disease or traumatic injuries alter the rate of neurogenesis in the adult brain. Understanding the molecular signals that control adult brain neurogenesis is of crucial importance for the development of therapies to promote regeneration in the inj...

journal_title：Prostaglandins & other lipid mediators

authors： Barreiro-Iglesias A

更新日期：2021-02-01 00:00:00

abstract：:Biologically active glutathione (GSH) conjugates of oxygenated fatty acids comprise a group of pro- and anti-inflammatory lipid mediators. While arachidonic acid (AA)-derived conjugates, as the cysteinyl leukotrienes (cys-LTs) and eoxins (EXs) have pro-inflammatory properties, conjugates in tissue regeneration (CTRs) ...

journal_title：Prostaglandins & other lipid mediators

authors： Liening S,Fischer J,Jagusch H,Pohnert G,Höcker O,Neusüß C,Werz O,Scriba GKE,Garscha U

更新日期：2021-02-01 00:00:00

abstract：:The purpose of this study was to clarify whether human amniotic fluid (AF) contains a significant level of bioactive lysophosphatidic acid (LPA) and, whether autotaxin (ATX) is involved in the production of LPA, if present. Using LC-MS/MS, we found a higher ratio of levels of LPA and its precursor lysophosphatidylchol...

journal_title：Prostaglandins & other lipid mediators

authors： Fukui M,Tsutsumi T,Yamamoto-Mikami A,Morito K,NaokoTakahashi,Tanaka T,Iwasa T,Kuwahara A,Irahara M,Tokumura A

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Dexamethasone is commonly given as an antiemetic during surgical procedures. It has immunosuppressive effects and can affect key enzymes involved in the synthesis of specialised lipid mediators of inflammation resolution (SPM) that direct inflammation resolution and have anti-nociceptive actions. This study ...

journal_title：Prostaglandins & other lipid mediators

authors： Barden A,Phillips M,Mas E,Hill LM,Mowat I,Loh PS,Corcoran T,Mori TA

更新日期：2020-08-01 00:00:00

abstract：:Androgen deprivation induces vascular dysfunction in which altered release and action of prostanoids has been extensively studied. On the other hand, the vascular organ-culture system has been reported as a valid model for phenotypic changes that occur in several cardiovascular pathologies. Since there are no studies ...

journal_title：Prostaglandins & other lipid mediators

authors： Villalpando DM,Gómez Rivas J,Flynn D,R de Bethencourt F,Ferrer M

更新日期：2020-06-01 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) converts several FFA epoxides to corresponding diols. As many as 15 FFA epoxide-diol ratios are measured to infer sEH activity from their ratios. Using previous data, we assessed if individual epoxide-diol ratios all behave similarly to reflect changes in sEH activity, and whether analy...

journal_title：Prostaglandins & other lipid mediators

authors： Stefanovski D,Shih PB,Hammock BD,Watanabe RM,Youn JH

更新日期：2020-06-01 00:00:00

abstract：:Infection with L. donovani affects mainly visceral organs. Importantly, the parasitic load differs in different visceral organs; therefore there is a need to understand the organ specific immune regulation, particularly in the spleen and liver. Comparative studies between these organs in Leishmania infected hamster (M...

journal_title：Prostaglandins & other lipid mediators

authors： Saini S,Singh B,Prakash S,Kumari S,Kureel AK,Dube A,Sahasrabuddhe AA,Rai AK

更新日期：2020-04-01 00:00:00

abstract：:Pulmonary hypertension (PH) is characterized by an elevation of mean pulmonary artery pressure and it is classified into five groups. Among these groups, PH Group-III is defined as PH due to lung disease or hypoxia. Prostacyclin (PGI2) analogues (iloprost, treprostinil) and endothelin-1 (ET-1) receptor antagonists (ER...

journal_title：Prostaglandins & other lipid mediators

authors： Ozen G,Benyahia C,Amgoud Y,Patel J,Abdelazeem H,Bouhadoun A,Yung S,Li F,Mahieddine Y,Silverstein AM,Castier Y,Cazes A,Longrois D,Clapp LH,Norel X

更新日期：2020-02-01 00:00:00

abstract：:A major part of oxygenated metabolites of polyunsaturated fatty acids - i.e. eicosanoids and other oxylipins - in biological samples is found in the esterified form. Yet, their biological role is only poorly understood. For quantification of esterified oxylipins in biological samples current protocols mostly apply alk...

journal_title：Prostaglandins & other lipid mediators

authors： Ostermann AI,Koch E,Rund KM,Kutzner L,Mainka M,Schebb NH

更新日期：2020-02-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a lysophospholipid mediator, promoting angiogenesis and inflammation via interactions with its receptors (S1P1-5), but the receptors and signaling pathways responsible for the progression of choroidal neovascularization (CNV) remain unknown. We investigated the roles of S1P/S1P recepto...

journal_title：Prostaglandins & other lipid mediators

authors： Terao R,Honjo M,Totsuka K,Miwa Y,Kurihara T,Aihara M

更新日期：2019-12-01 00:00:00

abstract：:Platelet activation plays an important role in acute and chronic cardiovascular disease states. Multiple pathways contribute to platelet activation including those dependent upon arachidonic acid. Arachidonic acid is released from the platelet membrane by phospholipase A2 action and is then metabolized in the cytosol ...

journal_title：Prostaglandins & other lipid mediators

authors： Trostchansky A,Moore-Carrasco R,Fuentes E

更新日期：2019-12-01 00:00:00

abstract：:Notwithstanding the ongoing debate on their full potential in health and disease, there is general consensus that n-3 PUFAs play important physiological roles. Increasing dietary n-3 PUFA intake results in increased DHA and EPA content in cell membranes as well as an increase in n-3 derived oxylipin and -endocannabino...

journal_title：Prostaglandins & other lipid mediators

authors： de Bus I,Witkamp R,Zuilhof H,Albada B,Balvers M

更新日期：2019-10-01 00:00:00

abstract：:Cannabinoid receptor activation is involved in homeostatic regulation of the body. These receptors are activated by cannabinoids, that include the active constituents of Cannabis sativa, as well as endocannabinoids (eCBs). The eCBs are endogenously synthesized from the omega-6 and omega-3 polyunsaturated fatty acids (...

journal_title：Prostaglandins & other lipid mediators

authors： Watson JE,Kim JS,Das A

更新日期：2019-08-01 00:00:00

abstract：:Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) as gefitinib are standard treatment of non-small cell lung cancer (NSCLC), but resistance often occurs. This study demonstrates that NSCLC cells resistant to gefitinib (GR cells) displayed a significantly higher microsomal prostaglandin E synthase...

journal_title：Prostaglandins & other lipid mediators

authors： Terzuoli E,Costanza F,Ciccone V,Ziche M,Morbidelli L,Donnini S

更新日期：2019-08-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) is a simple phospholipid that exerts pleiotropic effects on numerous cell types by activating its family of cognate G protein-coupled receptors (GPCRs) and participates in many biological processes, including organismal development, wound healing, and carcinogenesis. Bone cells, such as bon...

journal_title：Prostaglandins & other lipid mediators

authors： Wu X,Ma Y,Su N,Shen J,Zhang H,Wang H

更新日期：2019-08-01 00:00:00

abstract：:5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the innate immune system. 5-LO can shuttle between the cytosol and the nucleus. Upon cell activation the protein translocates from soluble ...

journal_title：Prostaglandins & other lipid mediators

authors： Häfner AK,Kahnt AS,Steinhilber D

更新日期：2019-06-01 00:00:00

abstract：:Prostaglandin (PG)E2 seems to promote tumor proliferation by regulating cell growth, inhibiting apoptosis, promoting angiogenesis, and suppressing host immune surveillance of cancer cells. The suppression of prostaglandins biosynthesis is thought to be the main molecular mechanism for non-steroidal anti-inflammatory d...

journal_title：Prostaglandins & other lipid mediators

authors： Verratti V,Brunetti L,Ferrante C,Orlando G,Recinella L,Chiavaroli A,Leone S,Wang R,Berardinelli F

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:The renin angiotensin-aldosterone system (RAAS) and lipoxins (LXs) have similar roles in many processes. We previously reported that BML-111, a Lipoxin receptor agonist, inhibited chronic injury hepatic fibrosis by regulating RAAS, but whether LXs are involved in BML-111-mediated protection from acute injury...

journal_title：Prostaglandins & other lipid mediators

authors： Chen QF,Hao H,Kuang XD,Hu QD,Huang YH,Zhou XY

更新日期：2019-02-01 00:00:00

abstract：:Metabolites of arachidonic acid via CYP450 such as epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), have vasoactive and natriuretic properties and have been implicated in BP homeostasis and the incidence of cardio- and cerebrovascular diseases in animal studies. In humans, genetic studie...

journal_title：Prostaglandins & other lipid mediators

authors： Fava C,Bonafini S

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Cysteinyl leukotrienes (CysLTs), the potent lipid inflammatory mediators, are elevated in many pathological conditions and implicated in various inflammatory diseases including asthma, however their role in airway epithelial cells modulation is not clearly understood. We have investigated the effects of a Cy...

journal_title：Prostaglandins & other lipid mediators

authors： Dholia N,Yadav UCS

更新日期：2018-05-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) supplementation has demonstrated beneficial effects in a number of inflammatory diseases. Increasingly, important contributions to its favorable effects are attributed downstream metabolites called docosanoids. Herein, we investigated the role of DHA-derived oxidized lipid metabolites on inf...

journal_title：Prostaglandins & other lipid mediators

authors： Caron JP,Gandy JC,Brown JL,Sordillo LM

更新日期：2018-05-01 00:00:00

abstract：:We previously reported that female spontaneously hypertensive rats (SHR) have greater cyclooxygenase-2 (COX-2) expression in the renal medulla and enhanced urinary excretion of prostaglandin (PG) E2 (PGE2) metabolites compared to male SHR. Based on the role of COX-2-derived prostanoids in the regulation of cardiovascu...

journal_title：Prostaglandins & other lipid mediators

authors： Elmarakby AA,Katary M,Pollock JS,Sullivan JC

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:The current study investigated for the first time the possible beneficial effect of zileuton, a selective 5-lipoxygenase inhibitor (5-LOX), against cisplatin-induced acute renal failure. METHODOLOGY:Male Sprague-Dawley rats (180-200 g) were administered cisplatin once (5 mg/kg, i.p.) alone or combined with o...

journal_title：Prostaglandins & other lipid mediators

authors： Helmy MM,Hashim AA,Mouneir SM

更新日期：2018-03-01 00:00:00

abstract：:Little is currently known of the role(s) of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE) in hypertensive pregnancies. We hypothesized that specific inhibition of 20-HETE would attenuate increases in blood pressure in the reduced uterine perfusion pressure (RUPP) rat model of preeclampsia. Specific 20-...

journal_title：Prostaglandins & other lipid mediators

authors： Faulkner JL,Plenty NL,Wallace K,Amaral LM,Cunningham MW,Murphy S,LaMarca B

更新日期：2018-01-01 00:00:00

abstract：:Docosahexaenoic acid (DHA) is an n-3 long chain polyunsaturated fatty acid (PUFA) that is involved in a wide range of cellular processes in human cells. Brain lipid binding protein (BLBP) exhibits a high affinity for n-3 PUFAs, especially DHA, but the precise functional contributions of DHA and BLBP in astrocytes are ...

journal_title：Prostaglandins & other lipid mediators

authors： Li H,Yang Q,Han X,Tan X,Qin J,Jin G

更新日期：2018-01-01 00:00:00

abstract：:Coronary artery disease is one of the leading causes of death in wordwide. There is growing evidence that prostanoids are involved in the physiology and pathophysiology of the human coronary artery by controlling vascular tone, remodelling of the vascular wall or angiogenesis. In this review, the production of prostan...

journal_title：Prostaglandins & other lipid mediators

authors： Ozen G,Norel X

更新日期：2017-11-01 00:00:00

abstract：:Anorexia nervosa (AN) is a complex psychiatric disorder with high morbidity and mortality rates. While many individuals make full recoveries, up to a third of patients develop a chronic, treatment-resistant form of the illness that leads to a premature death in 15-20% of those affected. There have been few advances in...

journal_title：Prostaglandins & other lipid mediators

authors： Shih PB,Morisseau C,Le T,Woodside B,German JB

更新日期：2017-11-01 00:00:00

abstract：:The CD200/CD200R signalling pathway downregulates the synthesis of proinflammatory mediators and induces the synthesis of antiinflammatory mediators in macrophages and microglia. However, very little is known about the effect of this immunosuppressive pathway on the synthesis of lipid mediators. Therefore, we determin...

journal_title：Prostaglandins & other lipid mediators

authors： Kern K,Pierre S,Schreiber Y,Angioni C,Thomas D,Ferreirós N,Geisslinger G,Scholich K

更新日期：2017-11-01 00:00:00

abstract：:Studies over the last couple of decades suggest that failed resolution of a chronic inflammatory response is an important driving force in the progression of atherosclerosis. Resolution of inflammation is mediated in part by lipid-derived specialized pro-resolving mediators (SPMs) such as lipoxins, resolvins, protecti...

journal_title：Prostaglandins & other lipid mediators

authors： Heinz J,Marinello M,Fredman G

更新日期：2017-09-01 00:00:00

abstract：:The production of prostaglandin E2 (PGE2) seems to play an important role in the ovulation process. PGE2 was found to induce cumulus expansion and meiosis resumption in mice, but little is known about its role in pigs. The goals of this study were (a) to assess the effect of PGE2 on the expression levels of cumulus ex...

journal_title：Prostaglandins & other lipid mediators

authors： Blaha M,Prochazka R,Adamkova K,Nevoral J,Nemcova L

更新日期：2017-05-01 00:00:00

abstract：:Increasing interest is focused on omega-3 fatty acids (FA) because of their potential beneficial effects, particularly in cardiovascular disease prevention. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two major omega-3 FA, are mainly consumed through diet, particularly from fish and seafood intake, whe...

journal_title：Prostaglandins & other lipid mediators

authors： Bonafini S,Fava C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes. We aim to investigate the efficacy of Prostaglandin E1 (PGE1) treatment in addition to intensive insulin therapy on DPN in patients with type 2 diabetes. METHODS:Seventy-seven patients with DPN received daily intraveno...

journal_title：Prostaglandins & other lipid mediators

authors： Wu JD,Tao S,Jin X,Jiang LL,Shen Y,Luo Y,Zhang P,Lee KO,Ye L,Ma JH

更新日期：2016-11-01 00:00:00

abstract：:Arachidonic acid (AA) is metabolized in mammals by enzymes of the CYP4A and 4F families to 20-hydroxyeicosatetraeonic acid (20-HETE) which plays an important role in the regulation of renal function, vascular tone and arterial pressure. In the vasculature, 20-HETE is a potent vasoconstrictor, the up-regulation of whic...

journal_title：Prostaglandins & other lipid mediators

authors： Waldman M,Peterson SJ,Arad M,Hochhauser E

更新日期：2016-09-01 00:00:00

abstract：:Hypovolaemia can be associated with substantial morbidity, particularly when it occurs in the setting of trauma and in patients with comorbid diseases. Hypovolaemia and inflammation such as occur in the setting of trauma and surgery, are associated with systemic oxidative stress and free-radical injury. Free-radical i...

journal_title：Prostaglandins & other lipid mediators

authors： Corcoran TB,Mas E,Barden AE,Roberts LJ 2nd,Mori TA,O'Loughlin E

更新日期：2016-07-01 00:00:00

abstract：:Marfan syndrome (MFS) is associated with progressive aortic dilatation and endothelial dysfunction that lead to early acute dissection and rupture of the aorta and sudden death. Alteration in fatty acid (FA) metabolism can stimulate nitric oxide (NO) overproduction which increases the activity of the inducible form of...

journal_title：Prostaglandins & other lipid mediators

authors： Soto ME,Iturriaga Hernández AV,Guarner Lans V,Zuñiga-Muñoz A,Aranda Fraustro A,Velázquez Espejel R,Pérez-Torres I

更新日期：2016-03-01 00:00:00

abstract：:Microsomal prostaglandin E synthase-1 (mPGES-1) is primarily expressed in granulosa cells (GCs) in the preovulatory follicle. Both prostaglandin E2 (PGE2) and progesterone (P4) are implicated in various reproductive functions. Here, we demonstrate that mPges-1 may be a direct downstream target gene of the P4 receptor ...

journal_title：Prostaglandins & other lipid mediators

authors： Tamura K,Naraba H,Hara T,Nakamura K,Yoshie M,Kogo H,Tachikawa E

更新日期：2016-03-01 00:00:00

abstract：:Inflammation is an important part of the innate immune response and is involved in the healing of many disease processes; however, chronic inflammation is a harmful component of many diseases. The regulatory mechanisms of inflammation are incompletely understood. One possible regulatory mechanism is the endocannabinoi...

journal_title：Prostaglandins & other lipid mediators

authors： Szafran B,Borazjani A,Lee JH,Ross MK,Kaplan BL

更新日期：2015-09-01 00:00:00

abstract：:The cholinergic anti-inflammatory pathway controls innate immune responses and inflammation. The prostaglandin (PG) system is involved in several neuro-processes and associated with inflammatory activation of cells in vagal nuclei. Here we aimed to investigate the potential role of PG in cholinergic neuro-regulation. ...

journal_title：Prostaglandins & other lipid mediators

authors： Le Maître E,Revathikumar P,Idborg H,Raouf J,Korotkova M,Jakobsson PJ,Lampa J

更新日期：2015-09-01 00:00:00

abstract：:Streptococcus uberis mastitis results in severe mammary tissue damage in dairy cows due to uncontrolled inflammation. Oxylipids are potent lipid mediators that orchestrate pathogen-induced inflammatory responses, however, changes in oxylipid biosynthesis during S. uberis mastitis are unknown. Thus, the current objecti...

journal_title：Prostaglandins & other lipid mediators

authors： Ryman VE,Pighetti GM,Lippolis JD,Gandy JC,Applegate CM,Sordillo LM

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:A high intake of omega-3 polyunsaturated fatty acids (ω-3 PUFAs), has been associated with reduced levels of blood pressure (BP). Their antihypertensive action may be due to the reduction of the ω-6/ω-3 ratio and the resulting competitive effect of ω-3 as compared to arachidonic acid (an ω-6 PUFA) as a subst...

journal_title：Prostaglandins & other lipid mediators

authors： Tagetti A,Ericson U,Montagnana M,Danese E,Almgren P,Nilsson P,Engström G,Hedblad B,Minuz P,Orho-Melander M,Fava C,Melander O

更新日期：2015-07-01 00:00:00