abstract：:Caffeic acid and its derivatives because of its biological activities, including antioxidants, antithrombosis, antihypertensive, antifibrosis, antiviral, and anti-tumor properties are good candidates as adjuvants in anticancer therapy. The aim of this study was the examination of cyto- and genotoxic effect of caffeic ...

journal_title：Acta poloniae pharmaceutica

authors： Matejczyk M,Swislocka R,Kalinowska M,Swidersk G,Lewandowsk W,Jablonska-Trypuo A

更新日期：2017-05-01 00:00:00

abstract：:Hepatic diseases are becoming common day by day and pose serious health threats to the life of humans. In order to treat these diseases, the attention of man is diverting towards herbal drugs, which are much safer and cost effective than synthetic drugs. The aim of present study was to investigate hepatoprotective act...

journal_title：Acta poloniae pharmaceutica

authors： Alamgeer,Nasir Z,Qaisar MN,Uttra AM,Ahsan H,Khan KU,Khan IU,Saleem M,Khadijai,Asif H,Sharif A,Younis W,Naz H

更新日期：2017-05-01 00:00:00

abstract：:Tuberculosis (TB) is an infectious disease that is communicable from one person to another. Pakistan stands forefront among few unfortunate countries that still have heavy burden of TB infection. Being a developing country, TB patients in Pakistan have to face different socio-economic constraints that upset life of th...

journal_title：Acta poloniae pharmaceutica

authors： Khan AA,Akhtar N,Madni A,Tahir N,Rehman M,Raza A,Qadir A

更新日期：2017-05-01 00:00:00

abstract：:New analytical methods have been developed and validated on high performance liquid chromatography (HPLC) to assess the assay, content uniformity and dissolution of immediate release candesartan cilexetil 32 mg tablets. Method development studies were performed on cyano column. Mobile phase of assay and content unifor...

journal_title：Acta poloniae pharmaceutica

authors： Yuce M,Capan Y

更新日期：2017-03-01 00:00:00

abstract：:This article describes the synthesis of new bioactive quinoxalines as potential anticancer and antimicrobial agents; 2,3-dichloroquinoxaline was used as the key molecule for the preparation of various mono or disubstituted quinoxalines 2-7, pyridoimidazoquinoxaline derivative 8, thiazolo[4,5-b]quinoxaline derivatives ...

journal_title：Acta poloniae pharmaceutica

authors： Abbas HS,Al-Marhabi ARM,Ammar YA

更新日期：2017-03-01 00:00:00

abstract：:High shear wet granulation is a significant component procedure in the pharmaceutical industry. The objective of the study was to investigate the influence of two independent formulation variables; polyvinypyrrolidone (PVP) as a binder (X,) and croscarmellose sodium (CCS) as a disintegrant (X2) on the crit- ical quali...

journal_title：Acta poloniae pharmaceutica

authors： Fayed MH,Abdel-Rahman SI,Alanazi FK,Ahmed MO,Tawfeek HM,Ali BE

更新日期：2017-03-01 00:00:00

abstract：:Previously it was documented that transgenic flax plants, which contained an increased level of polyphenolic compounds, significantly improved healing of skin wounds lesions. In order to recognize mechanisms of beneficial action of transgenic flax fabrics on wound healing, in the present study the impact of flax fabri...

journal_title：Acta poloniae pharmaceutica

authors： Gebarowski T,Moreira H,Szyjka A,Wiatrak B,Wojtasik W,Kulma A,Szopa J,Gasiorowski K

更新日期：2017-03-01 00:00:00

abstract：:The aim of this study was, at first, to examine the influence of metal ions on digestion process of hyaluronic acid by hyaluronidase (HAse) using high performance capillary electrophoresis (HPCE) method. The influence of copper(H), zinc(Il), manganese(II) ions on enzymatic degradation of HA by hyaluronidase enzyme (HA...

journal_title：Acta poloniae pharmaceutica

authors： Urbaniak B,Plewa S,Kokot ZJ

更新日期：2017-01-01 00:00:00

abstract：:A series of 2-oxindole derivatives were synthesized and evaluated for cytotoxic activity against different human and murine cancer cell lines and cancer chemopreventive activity. Among the tested compounds VS-06, 08, 12 and 17 displayed cytotoxic activity in the range of 5.0 to 8.5 pM against human T-lymphocyte cells ...

journal_title：Acta poloniae pharmaceutica

authors： Bhadauria VS,Sravanthi V,Kumar S,DAS D,DE Clercq E,Schols D,Tokuda H,Karki SS

更新日期：2017-01-01 00:00:00

abstract：:Microemulsion was prepared using several concentrations of selected oil (pine oil), surfactant (cre- mophor RH40), co-surfactant (isopropanol) and water to improve bioavailability by increasing solubility and permeability of lomoxicam, which was then incorporated to carbomer 940 gel base to fabricate microemulsion bas...

journal_title：Acta poloniae pharmaceutica

authors： Naeem M,Pervaiz F,Nawaz Z,Yousup M,Ali A,Khalid N,Khan JA

更新日期：2017-01-01 00:00:00

abstract：:Simple, precise and accurate densitometric methods were developed for the determination of two antihistamine drugs. rupatadine and fexofenadine. Silica gel 60 F₂₅₄ HPTLC plates were used as stationary phase, while mixtures of acetonitrile - water - 25% ammonia (90 : 10 : 1, v/v/v) and acetonitrile - methanol -acetate ...

journal_title：Acta poloniae pharmaceutica

authors： Czerwinska K,Wyszomirska E,Kublin E,Malanowic E,Mazurek AP

更新日期：2016-11-01 00:00:00

abstract：:An endophytic fungus NFWI, possessing antimicrobial activity against bacterial and fungal pathogens, was isolated from indigenous Taxus fauna. Phylogenetic analysis coupled with cultural and morphological characteristics revealed that endophyte NFWI closely resembles Epicoccum sp. It showed optimum growth and antimicr...

journal_title：Acta poloniae pharmaceutica

authors： Jadoon M,Fatima N,Murtaza S,Chang LC,Ali N,Ahmed S

更新日期：2016-11-01 00:00:00

abstract：:Aim of present study was to develop metoprolol matrix patches using different enhancers. Combination of two hydrophobic polymers, ethyl cellulose and eudragit RL 100 (8 : 2) were used for preparation of unilaminated matrix patch. 10% w/w of isopropyl myristate (IPM), dimethyl sulfoxide (DMSO), span (20 (S20), Tween 20...

journal_title：Acta poloniae pharmaceutica

authors： Yaqoob A,Ahmad M,Mahmood A,Sarfraz RM

更新日期：2016-11-01 00:00:00

abstract：:Worldwide, pharmaceutical care has been recognized as the primary mission of pharmacy. According to the philosophy of pharmaceutical care, pharmacist is not only responsible to dispense the medicines but also responsible to improve the patient's quality of life. Pharmaceutical care practice is required to be introduce...

journal_title：Acta poloniae pharmaceutica

authors： Azhir S,Kousar R,Khan SA,Murtaza G

更新日期：2016-09-01 00:00:00

abstract：:The aim of the study was to characterize a series of isoxazole derivatives in several immunological tests in vitro and in vivo, in mouse and human models. The human model included measurement of: viability of peripheral blood mononuclear cells (PBMC), phytohemagglutinin A (PHA)-induced proliferation of PBMC, productio...

journal_title：Acta poloniae pharmaceutica

authors： Maczynski M,Artym J,Kocieba M,Sockacka-Cwikla A,Drozd-Szczygiel E,Ryng S,Zimecki M

更新日期：2016-09-01 00:00:00

abstract：:Amorphous and crystalline forms of cefuroxime axetil were identified and characterized using DSC, XRPD, SEM, FT-IR and Raman spectroscopy. Based on the results of chromatographic studies, changes in the kinetic mechanism and rate of degradation of the crystalline form of cefuroxime axetil in binary systems with excipi...

journal_title：Acta poloniae pharmaceutica

authors： Talaczynska A,Mizera M,Szybowicz M,Nowicka AB,Garbacki P,Paczkowska M,Zalewski P,Kozak M,Oszczapowicz I,Jelinska A,Cielecka-Piontek J

更新日期：2016-09-01 00:00:00

abstract：:The changing role of the modern pharmacies involves reporting adverse drug reactions (ADR's). The aim of the study is to investigate the knowledge of community pharmacy professional staff (PS) about the new pharmacovigilance (PG) legislation and to analyze patients' attitudes towards the community pharmacy role in PG ...

journal_title：Acta poloniae pharmaceutica

authors： Zimmermann A,Gaworska-Krzeminska A,Flis A

更新日期：2016-09-01 00:00:00

abstract：:Chlorogenic acid (CGA; (IS,3R,4R.5R)-3-{[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid) is a naturally occurring polyphenol mostly present in vegetables and fruits. CGA is a prominent component of Traditional Chinese Medicines and is known for various pharmacological activiti...

journal_title：Acta poloniae pharmaceutica

authors： Maalik A,Bukhari SM,Zaidi A,Shah KH,Khan FA

更新日期：2016-07-01 00:00:00

abstract：:Ranunculus muricatus Linn. (RML) have been traditionally used for the treatment of various cardiovascular disorders. The aim of present study was to evaluate their cardiovascular effects in isolated perfused rabbit heart. The methanolic extract of RML was prepared by cold maceration process. The methanolic extract of ...

journal_title：Acta poloniae pharmaceutica

authors： Alamgeer,Khan AQ,Ahmad T,Mushtaq MN,Malik MNH,Naz H,Ahsan H,Asif H,Noor N,Rahman MSU,Dar U,Rashid M

更新日期：2016-07-01 00:00:00

abstract：:The present study aimed at developing the sustained release matrix tablets of enalapril maleate and evaluating the effect of polymer concentration and viscosity grade on drug release. The sustained release enalapril maleate tablets were successfully formulated by direct compression method using nonionic cellulose ethe...

journal_title：Acta poloniae pharmaceutica

authors： Shah A,Khan GM,Ullah H,Khan KA,Ullah K,Khan SA

更新日期：2016-07-01 00:00:00

abstract：:Two simple and selective spectrophotometric methods are described for the determination of trifluoperazine dihydrochloride (TFH) as base form (TFP) in bulk drug, and in tablets. The methods are based on the molecular charge-transfer complexation of trifluoperazine base (TFP) with either 2,4,6-trinitrophenol (picric ac...

journal_title：Acta poloniae pharmaceutica

authors： Prashanth KN,Swamy N,Basavaiah K

更新日期：2016-05-01 00:00:00

abstract：:Atorvastatin reduces morbidity and mortality due to cardiovascular events. This study was conducted to assess the prices and pharmaceutical quality of innovator atorvastatin 20 mg with its locally available generics in Palestine and to assess the suitability of their interchangeability. The prices of innovator and gen...

journal_title：Acta poloniae pharmaceutica

authors： Shawahna R,Hroub AK,Abed E,Jibali S,Al-Saghir R,Zaid AN

更新日期：2016-05-01 00:00:00

abstract：:The main objective of this study was to assess the practice at retail pharmacies in Pakistan and to compare the same in rural and urban areas. The maintenance of pharmacy and drug inspectors' visit was also assessed. This cross sectional study was conducted in Abbottabad, Pakistan during October-November, 2012. A samp...

journal_title：Acta poloniae pharmaceutica

authors： Ullah H,Zada W,Khan MS,Iqbal M,Chohan O,Raza N,Khawaja NR,Abid SM,Murtazai G

更新日期：2016-05-01 00:00:00

abstract：:A new antidepressant, levomilnacipran, is the levorotatory enantiomer of milnacipran. The drug belongs to selective serotonin-norepinephrine reuptake inhibitors (SNRI) and has the highest noradrenergic selectivity of all members of this group of antidepressants. Clinical trials have confirmed the effectiveness of levo...

journal_title：Acta poloniae pharmaceutica

authors： Zadka Ł,Dziwota E,Olajossy M

更新日期：2016-03-01 00:00:00

abstract：:Honey is a natural product consisting of multiple components which determine its dietary and medicinal properties. In this work there were studied methanol fractions obtained from seven honeys from Lower Silesia (Poland) collected in different seasons of three successive years. Melissopalynologic studies revealed that...

journal_title：Acta poloniae pharmaceutica

authors： Mazol I,Sroka Z,Sowa A,Ostrowska A,Dryś A,Gamian A

更新日期：2016-03-01 00:00:00

abstract：:In the past few years, there are number of researchers carrying out their research on the excipients derived from polysaccharides and some of these researches show that natural excipients are comparable and can serve as an alternative to the synthetic excipients. Hence, the objectives of this research are to character...

journal_title：Acta poloniae pharmaceutica

authors： Meka VS,Yee P,Sheshala R

更新日期：2016-03-01 00:00:00

abstract：:The evaluation of a new group of distamycin analogues 1-6 as potential minor groove binders for the treatment of cancer were investigated. The activity of the new compounds against several restriction enzymes was examined. The studied compounds did not block GC-rich sequences regions of DNA but inhibited catalytic act...

journal_title：Acta poloniae pharmaceutica

authors： Drozdowska D,Rusak M,Miltyk W,Markowska A,Samczuki P

更新日期：2016-01-01 00:00:00

abstract：:Scientific literature provides a great deal of studies supporting antioxidant effects of rosemary, protecting the body's cells against reactive oxygen species and their negative impact. Ethanol rosemary extracts were produced by maceration method. To assess biological activity of rosemary extracts, antioxidant and ant...

journal_title：Acta poloniae pharmaceutica

authors： Ramanauskiene K,Zilius M,Kancauskas M,Juskaite V,Cizinauskas V,Inkeniene A,Petrikaite V,Rimdeika R,Briedis V

更新日期：2016-01-01 00:00:00

abstract：:Modern society expects pharmacists to be more involved in monitoring and supervising pharmacotherapy. International documents clearly define pharmacists as guardians of the safety and effectiveness of pharmacotherapy, not coincidentally putting safety matters first. With regard to this issue, the National Section of P...

journal_title：Acta poloniae pharmaceutica

authors： Skowron A,Bułaś L,Drozd M,Karolewicz B,Machalska J

更新日期：2016-01-01 00:00:00

abstract：:Physical, chemical and microbiological stability of total parenteral nutrient (TPN) admixtures was studied as a function of storage time and temperature. Particle size analysis and zeta potential measurements were carried out to evaluate the possible changes in the kinetic stability of the emulsions as a function of s...

journal_title：Acta poloniae pharmaceutica

authors： Turmezei J,Jávorszky E,Szabó E,Dredán J,Kállai-Szabó B,Zelkó R

更新日期：2015-09-01 00:00:00

abstract：:A number of imidazo[2,1-b][1,3,4]thiadiazole derivatives having alkyl and aryl moieties attached to positions 2 and 6 of imidazo[2,1-b][1,3,4]thiadiazole nucleus, respectively, were prepared and characterized by IR, NMR and mass spectroscopy. Antiinflammatory activity was evaluated by carrageenan-induced rat paw edema...

journal_title：Acta poloniae pharmaceutica

authors： Karki SS,Rana V,Sivan RU,Kumar S,Renuka V,Ramareddy SA,Subbarao PG,Si SC

更新日期：2015-09-01 00:00:00

abstract：:The social sciences within health care and pharmacy provide various points of view on issues often managed by professionals both inside and outside of the health care system. This multidisciplinary perspective often leads to divergent views and sometimes seemingly contradictory viewpoints and solutions. This paper is ...

journal_title：Acta poloniae pharmaceutica

authors： Kostriba J,Kotlarova J,Vlcek J

更新日期：2015-09-01 00:00:00

abstract：:The kidneys are important organs which have many functions in the body, including the production of hormones, absorbtion of minerals and the filtration of blood, producing urine. Their failure can be fatal, therefore, to focus the study of such herbs which may be useful in treating renal disease is the need of hour. I...

journal_title：Acta poloniae pharmaceutica

authors： Ullah N,Khan S,Khan A,Ahmad W,Shah Y,Ahmad L,Ullah I

更新日期：2015-07-01 00:00:00

abstract：:A series of novel sulfonamide isoxazolo[5,4-b]pyridines were synthesized. The substrates for their synthesis were 3-aminoisoxazolo[5,4-b]pyridine and selected aryl sulfonic chlorides, chlorosulfonic acid and selected amines. Reactions were carried out using the classical and microwave methods. Selected compounds were ...

journal_title：Acta poloniae pharmaceutica

authors： Poręba K,Pawlik K,Rembacz KP,Kurowska E,Matuszyk J,Długosz A

更新日期：2015-07-01 00:00:00

abstract：:The stability-indicating LC assay method was developed and validated for quantitative determination of cefozopran hydrochloride (CZH) in the presence of degradation products formed during the forced degradation studies. An isocratic, RP-HPLC method was developed with C-18 (250 mm x 4.6 mm, 5 µm) column and 12 mM ammon...

journal_title：Acta poloniae pharmaceutica

authors： Zalewski P,Garbacki P,Cielecka-Piontek J,Bednarek-Rajewska K,Krause A

更新日期：2015-05-01 00:00:00

abstract：:Drug market changes dynamically causing many analytical challenges for police experts. Among illicit substances there are synthetic designer products but also herbal material. Plant material is usually in fine-cut or powdered form, thus difficult to identify. For such fragmented material classic taxonomical identifica...

journal_title：Acta poloniae pharmaceutica

authors： Kowalczuk AP,Łozak A,Kiljan M,Mętrak K,Zjawiony JK

更新日期：2015-05-01 00:00:00

abstract：:There is a growing awareness amongst Muslims to avoid all items containing non-Halal ingredients. This sentiment has now progressed into the field of various medications. It therefore, required a study to assess the knowledge, attitude and perception (KAP) relating to pharmaceuticals containing non-Halal ingredients a...

journal_title：Acta poloniae pharmaceutica

authors： Sadeeqa S,Sarriff A,Masood I,Atif M,Farooqui M

更新日期：2015-05-01 00:00:00

abstract：:The new pyrrolo[3,4-c]pyridines and 2,7-naphthyridine derivatives have been synthesized. 4-Hydroxy-8-methyl-l-oxo-6-phenyl-1,2-dihydro-2,7-naphthyridine-3-carboxylic acid hydrazide (4) was the key intermediate for the synthesis of the novel derivatives of various chemical structures: Schiff bases, 1,3,4-oxadiazoles, p...

journal_title：Acta poloniae pharmaceutica

authors： Wójcicka A,Becan L

更新日期：2015-03-01 00:00:00

abstract：:Many specialists note that the food offered today - as a result of very complex technological processing - is devoid of many components that are important for the organism and the shortages have to be supplemented. The simplest for it is to consume diet supplements that provide the missing element in a concentrated fo...

journal_title：Acta poloniae pharmaceutica

authors： Ratajczak M,Kubicka MM,Kamińska D,Długaszewska J

更新日期：2015-03-01 00:00:00

abstract：:The oxidation of cyanide (CN-) to a much less toxic thiocyanate (SCN-) is the main in vivo biochemical pathway for CN- detoxification. SCN- is excreted mainly in urine. This study was performed to investigate the effect of lipoic acid (LA) on the urinary excretion of thiocyanate (SCN-; rhodanate) in rats. Groups of th...

journal_title：Acta poloniae pharmaceutica

authors： Bilska-Wilkosz A,Dudek M,Knutelska J,Włodek L

更新日期：2015-01-01 00:00:00