abstract：PURPOSE:The initiation of enzyme-replacement therapy prior to the occurrence of substantial and irreversible organ damage in patients with Fabry disease is of critical importance. The Fabry Outcome Survey is an international disease registry of patients with a confirmed diagnosis of Fabry disease. In this study, data f...

journal_title：Clinical therapeutics

authors： Feriozzi S,Linhart A,Ramaswami U,Kalampoki V,Gurevich A,Hughes D,Fabry Outcome Survey Study Group.

更新日期：2020-12-01 00:00:00

abstract：:The placenta is vital to the health and development of the fetus, serving to deliver oxygen and nutrients, facilitate the removal of waste products, and provide a barrier to pathogens and other harmful substances present in the maternal circulation. When these processes fail to operate normally, they can lead to compl...

journal_title：Clinical therapeutics

authors： Weinberg DH

更新日期：2020-11-24 00:00:00

abstract：PURPOSE:Stroke is the second leading cause of death and the third leading cause of disability worldwide. Diabetes mellitus and the associated hyperglycemia are important risk factors for acute ischemic stroke and are associated with poor prognosis. Neurovascular protection is an important therapeutic target to achieve ...

journal_title：Clinical therapeutics

authors： Al Hamed FA,Elewa H

更新日期：2020-11-01 00:00:00

abstract：PURPOSE:It is unclear whether vitamin D provides any benefit against the pro-inflammatory effects of homocysteine in elderly patients with type 2 diabetes mellitus (T2DM). METHODS:We compared lymphocyte counts for CD3, CD19, CD4, and CD8 subsets between elderly (age ≥65 years) T2DM patients (n = 5098) and nondiabetes ...

journal_title：Clinical therapeutics

authors： Ma C,Zhao Y,Liu Z

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Phenylephrine is a commonly used vasopressor for the treatment of spinal-induced hypotension in obstetric patients, but it is associated with reflex bradycardia and a corresponding decrease in cardiac output. This study aims to assess the effectiveness of continuous epinephrine versus phenylephrine infusion in ...

journal_title：Clinical therapeutics

authors： Wang YB,Yang ZY,Zhang WP

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Despite modern reperfusion and pharmacologic therapies, myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide. Therefore, the development of further therapeutics affecting post-MI recovery poses significant benefits. This review focuses on the post-MI immune response and immuno...

journal_title：Clinical therapeutics

authors： Hume RD,Chong JJH

更新日期：2020-10-01 00:00:00

abstract：:Against the backdrop of the COVID pandemic, the scientific and medical communities are working with all deliberate speed with state-of-the-art technologies to develop diagnostic and therapeutic products that can identify, treat, and prevent infection with SARS-CoV-2. These activities may only be legally conducted with...

journal_title：Clinical therapeutics

authors： Beninger P

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Glucosamine is widely used by patients with osteoarthritis (OA) to provide symptomatic relief and to delay disease progression. However, clinical studies have reported inconsistent clinical outcomes. The current study hypothesized that the reported inconsistent clinical results could be, in part, due to variabl...

journal_title：Clinical therapeutics

authors： Asthana C,Peterson GM,Shastri MD,Jones G,Patel RP

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:The limitations of current US Food and Drug Administration (FDA)-approved medications for the treatment of attention-deficit/hyperactivity disorder (ADHD) set the need for the development of novel, effective, and tolerable medications to treat this disorder. The purpose of this study was to evaluate whether tre...

journal_title：Clinical therapeutics

authors： Nasser A,Liranso T,Adewole T,Fry N,Hull JT,Chowdhry F,Busse GD,Cutler AJ,Jones NJ,Findling RL,Schwabe S

更新日期：2020-08-01 00:00:00

abstract：PURPOSE:Chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C) are common functional gastrointestinal disorders. The prevalence of constipation-related issues tends to increase with age. This analysis pooled data from Phase III trials in CIC and IBS-C to assess the safety and effic...

journal_title：Clinical therapeutics

authors： Menees SB,Franklin H,Chey WD

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Despite the availability of numerous pharmacologic and nonpharmacologic antiseizure therapies, a fraction of patients with epilepsy remain refractory to current treatment options, underscoring the need for novel drugs and neuromodulatory therapies. Transcranial magnetic stimulation (TMS), coupled with either el...

journal_title：Clinical therapeutics

authors： Tsuboyama M,Kaye HL,Rotenberg A

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The goal of this study was to review recent clinical studies of azilsartan medoxomil (AZL-M) and chlorthalidone (CLD), a combined angiotensin receptor blocker and thiazide-like diuretic, and its role in recently published guidelines. This review explores the role of AZL-M/CLD in treating patients with hypertens...

journal_title：Clinical therapeutics

authors： Kwon A,Kim GH

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Neuromodulation holds great promise for the treatment of drug-resistant epilepsy. This article reviews the most common types of neuromodulation as well as potential future applications of preclinical techniques such as optogenetics. This review serves as a reference for treating neurologists on the latest scien...

journal_title：Clinical therapeutics

authors： Davis P,Gaitanis J

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Efavirenz exhibits high interindividual variability in plasma concentrations, leading to unpredictable efficacy and toxicity. Polymorphism of CYP2B6 516G > T has been found to predominantly contribute to efavirenz variability. However, dosage recommendations incorporating CYP2B6 516G > T polymorphism have not b...

journal_title：Clinical therapeutics

authors： Chaivichacharn P,Avihingsanon A,Manosuthi W,Ubolyam S,Tongkobpetch S,Shotelersuk V,Punyawudho B

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:Levodopa (LD) is the most effective oral pharmacotherapy for the management of motor symptoms in Parkinson's disease. However, LD use is complicated by a progressive shortening of the duration of efficacy of a dose, resulting in episodes of inadequate responsiveness, or OFF periods. OFF periods may also occur u...

journal_title：Clinical therapeutics

authors： Safirstein BE,Ellenbogen A,Zhao P,Henney HR 3rd,Kegler-Ebo DM,Oh C

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Vitamin D supplementation has been suggested to increase testosterone levels. The primary purpose of this literature review was to critically assess the physiologic effects of vitamin D supplementation on serum testosterone concentrations in men and the secondary purpose was to evaluate the feasibility of vitam...

journal_title：Clinical therapeutics

authors： Santos HO,Howell S,Nichols K,Teixeira FJ

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:To evaluate the safety and efficacy of glycoprotein IIb/IIIa inhibitors (GPIs) in patients with acute myocardial infarction (AMI) in the presence of intracoronary thrombus undergoing percutaneous coronary interventions. METHODS:This study, performed from January 1, 2004, to November 31, 2014, at 55 centers in ...

journal_title：Clinical therapeutics

authors： Zheng C,Kang J,Yang HM,Han JK,Park KW,Kang HJ,Koo BK,Kim HS

更新日期：2020-05-01 00:00:00

abstract：PURPOSE:Hypertension occurs in >50% of US nursing home (NH) residents, but it is unclear which antihypertensive classes offer the best balance of benefits and risks in this population. The objectives of this study were to describe the patterns of antihypertensive medication treatment in this population, focusing on thi...

journal_title：Clinical therapeutics

authors： Boockvar KS,Song W,Lee S,Intrator O

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:The Enhancing Quality of Prescribing Practices for Older Veterans Discharged From the Emergency Department (EQUIPPED) program is a quality improvement initiative that combines education, clinical decision support (ie, geriatric pharmacy order sets), and in-person academic detailing coupled with audit and feedba...

journal_title：Clinical therapeutics

authors： Burningham Z,Jackson GL,Kelleher J,Stevens M,Morris I,Cohen J,Maloney G,Vaughan CP

更新日期：2020-04-01 00:00:00

abstract：PURPOSE:We performed an emergency department (ED)-based substance use screening, motivational interview-based intervention, and treatment referral program with the goal of determining sex-specific outcomes. Specifically, in this quality improvement project, we aimed to determine whether there was a difference among sex...

journal_title：Clinical therapeutics

authors： Amaducci AM,Greenberg MR,Sheen AW,Warren HR,Parikh PM,Roth P,Weaver KR,Richardson DM,Burmeister DB,Stephens JL,Cannon RD

更新日期：2020-03-01 00:00:00

abstract：:The United States maternal mortality rate has been rising for many years putting the US out of step with peer countries. There are many complex reasons for the rise in maternal deaths and recent data has demonstrated that there is a disproportionate risk for women of color. This article provides an overview of current...

journal_title：Clinical therapeutics

authors： Villavicencio JC,McHugh KW,Edmonds BT

更新日期：2020-03-01 00:00:00

abstract：PURPOSE:In China, dabigatran and rivaroxaban are the only approved non-vitamin K antagonist oral anticoagulants for the treatment of atrial fibrillation (AF). The goal of this article was to assess the cost-effectiveness of dabigatran versus rivaroxaban for the prevention of stroke and systemic embolism in Chinese pati...

journal_title：Clinical therapeutics

authors： Dong SJ,Wu B,Zhai SD,Zhang YJ,Chu YB,Gupta P,Li YH

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:During amyotrophic lateral sclerosis progression, up to 85% of patients develop dysphagia. Riluzole oral suspension 50 mg/10 mL is bioequivalent to riluzole 50-mg film-coated tablets administered orally under fasting conditions. Here, we compare the bioavailability of a single 50-mg dose of riluzole oral suspen...

journal_title：Clinical therapeutics

authors： Brooks BR,Bettica P,Cazzaniga S

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Current data suggest potential benefits with β-lactam plus macrolide combination therapy for empiric treatment of intensive care unit (ICU) patients with severe community-acquired pneumonia (CAP). However, it is unclear whether deescalation to β-lactam monotherapy in the absence of positive results on diagnosti...

journal_title：Clinical therapeutics

authors： Hopkins TM,Juang P,Weaver K,Kollef MH,Betthauser KD

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:This study examined the utility of therapeutic drug monitoring (TDM) of imatinib, nilotinib, and dasatinib in adult patients with chronic-phase chronic myeloid leukemia (CML). TDM in CML entails the measurement of plasma tyrosine kinase inhibitor (TKI) concentration to predict efficacy and tolerability outcomes...

journal_title：Clinical therapeutics

authors： García-Ferrer M,Wojnicz A,Mejía G,Koller D,Zubiaur P,Abad-Santos F

更新日期：2019-12-01 00:00:00

abstract：PURPOSE:Our purpose was to determine satisfaction and confidence of the Ixcellence Network training program on health care practitioners using botulinum toxin A (BoNT-A) for neurologic disorders, including spastic paresis and cervical dystonia. METHODS:The Ixcellence Network training program was designed by a scientif...

journal_title：Clinical therapeutics

authors： Colosimo C,Bhidayasiri R,Fheodoroff K,Bhatia K,Chung TM,Landreau T,Jacinto LJ

更新日期：2019-11-01 00:00:00

abstract：PURPOSE:The goal of this study was to assess the long-term safety and efficacy of mepolizumab in patients with the most severe eosinophilic asthma. METHODS:This multicenter, open-label, long-term, Phase IIIb study (COSMEX [COSMOS Extension]; 201312/NCT02135692) enrolled patients from the 52-week, open-label extension ...

journal_title：Clinical therapeutics

authors： Khurana S,Brusselle GG,Bel EH,FitzGerald JM,Masoli M,Korn S,Kato M,Albers FC,Bradford ES,Gilson MJ,Price RG,Humbert M

更新日期：2019-10-01 00:00:00

abstract：PURPOSE:Pain in the neonate is often challenging to assess but important to control. Physicians often must balance the need for optimal pain control with the need to minimize oversedation and prolonged opioid use. Both inadequate pain control and overuse of opioids can have long-term consequences, including poor develo...

journal_title：Clinical therapeutics

authors： Squillaro A,Mahdi EM,Tran N,Lakshmanan A,Kim E,Kelley-Quon LI

更新日期：2019-09-01 00:00:00

abstract：PURPOSE:Allergic rhinitis (AR) is a highly prevalent disease, affecting the quality of life of millions of Americans. Intranasal corticosteroids (INCs) are widely recommended as first-line therapy for moderate to severe AR. Although these drugs exhibit similar safety and efficacy, a potentially differentiating factor w...

journal_title：Clinical therapeutics

authors： May JR,Dolen WK

更新日期：2019-08-01 00:00:00

abstract：:This study categorizes the types of inappropriate intravenous prescriptions in hospitalized patients in China. Prescription data from 2016 were retrospectively analyzed based on predefined categories of inappropriateness. Of the 123,521 patients included, 89.2% received intravenous medications, contributing to 80% of ...

journal_title：Clinical therapeutics

authors： Zeng S,Wang D,Yan Y,Zhu M,Liu W,Gong Z,Wang L,Sun S

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the effects of a dietary supplement containing primarily an extract of salmon's milt (semen) on symptoms and blood levels of proinflammatory molecules in patients with fibromyalgia syndrome (FMS), a chronic, painful musculoskeletal disease without a distinct pathogenesis or...

journal_title：Clinical therapeutics

authors： Tsilioni I,Pipis H,Freitag MSC,Izquierdo MDC,Freitag K,Theoharides TC

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:The Tufts Center for the Study of Drug Development (CSDD) and the Drug Information Association (DIA) in collaboration with 8 pharmaceutical and biotechnology companies conducted a study examining the adoption and effect of artificial intelligence (AI), such as machine learning, on drug development. The study wa...

journal_title：Clinical therapeutics

authors： Lamberti MJ,Wilkinson M,Donzanti BA,Wohlhieter GE,Parikh S,Wilkins RG,Getz K

更新日期：2019-08-01 00:00:00

abstract：:The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and with the development of therapies for the treatment of an impressive range of immune-mediated rheumatic diseases. In recent years new milestones have been achieved. These include the reco...

journal_title：Clinical therapeutics

authors： Cope AP

更新日期：2019-07-01 00:00:00

abstract：PURPOSE:The objective of this study was to characterize the population pharmacokinetics of voriconazole and to identify factors that significantly affect pharmacokinetic parameters and to further investigate optimal dosage regimens in Chinese adult patients with hematologic malignancies. METHODS:A prospective populati...

journal_title：Clinical therapeutics

authors： Liu Y,Qiu T,Liu Y,Wang J,Hu K,Bao F,Zhang C

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Pulmonary arterial hypertension (PAH) is a life-threatening disease that typically causes shortness of breath and exercise intolerance. Combination therapy with ambrisentan and tadalafil has proven to be more effective at preventing clinical failure events in patients with PAH than either drug alone. The aim of...

journal_title：Clinical therapeutics

authors： Okour M,Puri A,Chen G,Port K,Berni A,Khindri S,Schneider I,Tenero D

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:Clopidogrel is a thienopyridine prodrug that inhibits platelet aggregation. It is prescribed to prevent atherothrombotic and thromboembolic events in patients receiving a stent implant in carotid, vertebral, or cranial arteries. The influence of cytochrome P-450 (CYP) 2C19 on the response to clopidogrel has bee...

journal_title：Clinical therapeutics

authors： Saiz-Rodríguez M,Belmonte C,Caniego JL,Koller D,Zubiaur P,Bárcena E,Romero-Palacián D,Eugene AR,Ochoa D,Abad-Santos F

更新日期：2019-06-01 00:00:00

abstract：PURPOSE:The benefits and disadvantages of cervical extraction during hysterectomy are unclear in the literature. We intended to compare total (TH) with subtotal or supracervical (SH) hysterectomy regarding intraoperative and postoperative outcomes (quality of life, sexual function, pain and cyclical bleeding). METHODS...

journal_title：Clinical therapeutics

authors： Aleixo GF,Fonseca MCM,Bortolini MAT,Brito LGO,Castro RA

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:The complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine and immune regulation, including the hypothalamic-pituitary-adrenal axis, the hypothal...

journal_title：Clinical therapeutics

authors： Morris MC,Cooney KE,Sedghamiz H,Abreu M,Collado F,Balbin EG,Craddock TJA,Klimas NG,Broderick G,Fletcher MA

更新日期：2019-04-01 00:00:00

abstract：PURPOSE:Nemonoxacin is a novel C-8-methoxy nonfluorinated quinolone that has been approved for the treatment of community-acquired pneumonia (CAP) in adults. The goals of this study were to evaluate the pharmacokinetic (PK) and population PK parameters of nemonoxacin and to provide the appropriate dose adjustment recom...

journal_title：Clinical therapeutics

authors： Kang Y,Li Y,Xu F,Zhang J,Wang K,Chen Y,Wu J,Guo B,Yu J,Zhang Y

更新日期：2019-03-01 00:00:00

abstract：PURPOSE:Frailty is a syndrome of vulnerability and physical decline with aging that increases risk for disability, hospitalizations, and death. To date, interventions for frailty have primarily focused on exercise and/or nutritional interventions, many of which show improvement in frailty-related characteristics, such ...

journal_title：Clinical therapeutics

authors： Espinoza SE,Jiwani R,Wang J,Wang CP

更新日期：2019-03-01 00:00:00