Human endogenous retrovirus IDDMK(1,2)22 and mouse mammary tumor virus superantigens differ in their ability to stimulate murine T cell hybridomas.

abstract：:Modulation of the IgE response by PHA treatment in relation to animal sex was analysed. Male and female RF mice were immunized with ovalbumin in aluminum hydroxide gel and PHA was injected 1 or 2 days before immunization. Castrated mice were also immunized and received PHA on day -2. The results show that the IgE resp...

journal_title：Immunology letters

authors： Astorquiza MI,Cisternas C,Leal X

更新日期：1987-10-01 00:00:00

abstract：:For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...

journal_title：Immunology letters

authors： Thomé R,Lopes SC,Costa FT,Verinaud L

更新日期：2013-06-01 00:00:00

abstract：:In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...

journal_title：Immunology letters

authors： Caprara GV,Nisini R,Castellani V,Vittorio P,Alessandri G,Vincenzo Z,Claudia F,Valentina G,Andrea PD,Biondo MI,Milanetti F,Salerno G,Vincenzo V,Mario P,Aniballi E,Simonetta S,Angela S,D'Amelio R

更新日期：2017-08-01 00:00:00

abstract：:Members of the transforming growth factor beta (TGF-beta) superfamily are soluble factors that regulate a variety of functional responses including proliferation, differentiation, apoptosis and cell cycle, among others, depending not only on the cell type and its differentiation state, but also on the milieu of cytoki...

journal_title：Immunology letters

authors： Licona-Limón P,Soldevila G

更新日期：2007-03-15 00:00:00

abstract：:Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...

journal_title：Immunology letters

authors： Cerny O,Holden DW

更新日期：2019-11-01 00:00:00

abstract：:Protective immunity against Salmonella infection is known to require CD4 Th1 cells and B cells, but the role of MHC class-I-restricted CD8 T cells is less clear. Previous studies have suggested that CD8 T cells participate in secondary, but not primary, bacterial clearance. However, these studies have used experimenta...

journal_title：Immunology letters

authors： Lee SJ,Dunmire S,McSorley SJ

更新日期：2012-12-17 00:00:00

abstract：:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

journal_title：Immunology letters

authors： Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

更新日期：2003-01-02 00:00:00

abstract：:Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis)...

journal_title：Immunology letters

authors： Yamada K,Senju S,Shinohara T,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

更新日期：2001-10-01 00:00:00

abstract：:The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has al...

journal_title：Immunology letters

authors： Li Y,Liu J,Gao L,Liu Y,Meng F,Li X,Qin FX

更新日期：2020-04-01 00:00:00

abstract：:The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related ...

journal_title：Immunology letters

authors： Denesyuk AI,Lundell J,Zav'yalov V,Korpela T

更新日期：1994-07-01 00:00:00

abstract：:Treatment of purified human C5 with hydrogen peroxide leads to a reduction of functional activity in the classical immune haemolysis assay. The effect of H2O2 is enhanced by traces of iron-EDTA, and becomes even stronger when ascorbic acid is present in addition. The enhancement by iron and protective effects of vario...

journal_title：Immunology letters

authors： von Zabern WV,Hesse D,Nolte R,Haller Y

更新日期：1987-02-01 00:00:00

abstract：:Clinical immunology is in the Netherlands a separate clinical specialty within internal medicine and pediatrics. Clinical immunologists work closely together with nephrologists, rheumatologists and many other medical specialists. Apart from research and teaching, clinical immunologists are taking care of patients with...

journal_title：Immunology letters

authors： Tervaert JW,Kallenberg CG

更新日期：2014-12-01 00:00:00

abstract：:T-cell immunoglobulin mucin-1 (TIM-1) is associated with the regulation of T helper type 2 (Th2) immune responses and has been associated with asthma susceptibility. Previous studies have shown that administration of TIM-1 results in T cell hyperproliferation and increased Th2 cytokine secretion. TIM-1 has also been s...

journal_title：Immunology letters

authors： Hein RM,Woods ML

更新日期：2007-01-15 00:00:00

abstract：:The immunological phenotyping of peripheral blood mononuclear cells (PBMC) was assayed in a series of 22 patients suffering from severe cancer-associated malnutrition. A marked decrease of the T-lymphocyte subsets (CD3+, CD4+, CD8+) and of the CD20+ B lymphocytes occurred; there was however an increased percentage of ...

journal_title：Immunology letters

authors： Garraud O,Daculsi R,Merlio JP,Lobera A,Legrand E

更新日期：1987-05-01 00:00:00

abstract：:Antigen receptor (AgR) crosslinking by antigens or AgR-specific antibodies induces a cascade of enzymatic events in lymphocytes which involves activation of several non-receptor tyrosine- and serine/threonine kinases, phosphatases, phospholipases, etc. Here we show data demonstrating that a thiol group-reactive protei...

journal_title：Immunology letters

authors： Rozsnyay Z,Sarmay G,Gergely J

更新日期：1993-08-01 00:00:00

abstract：:This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...

journal_title：Immunology letters

authors： Blackwell JM,Roach TI,Atkinson SE,Ajioka JW,Barton CH,Shaw MA

更新日期：1991-10-01 00:00:00

abstract：:Mimotopes derived from peptide phage display libraries may reproduce basic functions of epitopes including their antigenicity. In case of toxins, this property makes phage displayed mimotopes highly specific vaccine components free of the toxicity. To explore the potential of mimotopes for vaccine development, their a...

journal_title：Immunology letters

authors： Hernández R,Gazarian TG,Hérion PS,Gazarian KG

更新日期：2002-02-01 00:00:00

abstract：:Cells engulf particles larger than 0.5 μm in diameter by phagocytosis, which is driven by cytoskeletal rearrangements. Phagocytosis by alveolar epithelial cells (AECs) helps to maintain the alveolar homeostasis. Yes-associated protein (YAP), a transcriptional coactivator of the Hippo pathway, affects proliferation, di...

journal_title：Immunology letters

authors： Gao P,Mu M,Chen Y,He J,Tao X,Song C

更新日期：2020-09-01 00:00:00

abstract：:While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...

journal_title：Immunology letters

authors： Wu P,Hyodoh F,Hatayama T,Sakaguchi H,Hatada S,Miura Y,Takata-Tomokuni A,Katsuyama H,Otsuki T

更新日期：2005-04-15 00:00:00

abstract：:While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...

journal_title：Immunology letters

authors： Choudhry MA,Plackett TP,Schilling EM,Faunce DE,Gamelli RL,Kovacs EJ

更新日期：2003-04-03 00:00:00

abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...

journal_title：Immunology letters

authors： van Bohemen CG,Langenberg ML,Rauws EA,Oudbier J,Weterings E,Zanen HC

更新日期：1989-01-15 00:00:00

abstract：:Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...

journal_title：Immunology letters

authors： Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin G

更新日期：1990-08-01 00:00:00

abstract：:Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...

journal_title：Immunology letters

authors： Roth-Walter F,Bohle B,Schöll I,Untersmayr E,Scheiner O,Boltz-Nitulescu G,Gabor F,Brayden DJ,Jensen-Jarolim E

更新日期：2005-09-15 00:00:00

abstract：:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

journal_title：Immunology letters

authors： Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

更新日期：1987-04-01 00:00:00

abstract：:The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...

journal_title：Immunology letters

authors： Gern L,Rais O,Capiau C,Hauser P,Lobet Y,Simoen E,Voet P,Pêtre J

更新日期：1994-03-01 00:00:00

abstract：:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...

journal_title：Immunology letters

authors： Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis A

更新日期：1997-07-01 00:00:00

abstract：:Antibodies reactive with native double stranded DNA are characteristic of the chronic inflammatory disease systemic lupus erythematosus. Native DNA is however, a poor immunogen and the mechanism of anti-DNA antibody production is incompletely understood. Modification of DNA can increase its immunogenicity and in infla...

journal_title：Immunology letters

authors： Blount S,Griffiths HR,Staines NA,Lunec J

更新日期：1992-10-01 00:00:00

abstract：:Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages. In this report we have examined the effect of the in vivo administration of adrenaline on TNF serum levels induced by LPS. In agre...

journal_title：Immunology letters

authors： Monastra G,Secchi EF

更新日期：1993-10-01 00:00:00

abstract：:Experimental systemic lupus erythematosus (SLE), similar to that observed after immunization with the human anti-DNA mAb 16/6 Id+, could be induced in mice by injection of 16/6 Id specific T-cell lines. The above T-cell lines were exclusively CD4+ CD8- and the majority of cells expressed the Vbeta8 T-cell receptor (TC...

journal_title：Immunology letters

authors： Ruiz PJ,Waisman A,Mozes E

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVES:Cytokine production from activated T cells play a pathogenetic role in mucosal lesions of coeliac disease (CD). Active interleukin (IL)-18 is expressed in the small intestinal mucosa in CD but not in healthy controls. IL-18 enhances intercellular adhesion molecule-1 (ICAM-1) expression. We analyzed IL-18 ser...

journal_title：Immunology letters

authors： Merendino RA,Di Pasquale G,Sturniolo GC,Ruello A,Albanese V,Minciullo PL,Di Mauro S,Gangemi S

更新日期：2003-02-03 00:00:00