Abstract：
:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneously with house dust mite antigen three times with 7 days interval after skin barrier disruption. A remarkable infiltration of polymorphonuclear granulocytes and monocytes in the cutis was observed in mice treated with this antigen, high serum IgE levels and IL-4 mRNA expression in local lymph node cells was also observed. CD19(+) B cell numbers overturned to CD4(+) helper T cells. In these mice, there was significant increase of B7.2 (CD86) expression on CD19(+) B cells. These results indicate that house dust mite antigen sensitizes BALB/c mice and skews their Th1/Th2 balance toward Th2.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota Sdoi
10.1016/s0165-2478(02)00196-7subject
Has Abstractpub_date
2003-01-02 00:00:00pages
5-12issue
1eissn
0165-2478issn
1879-0542pii
S0165247802001967journal_volume
85pub_type
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