The quantitative characteristics of efficiency of ballistic transfection of chimeric antibody genes.

abstract：:After exposure to a concanavalin A (Con A)-unreactive variant of alpha 1-acid glycoprotein (AGP), macrophages released an inhibitor of interleukin-1 (IL-1) proliferative activity in the thymocyte comitogenic assay. This effect was observed with AGP concentrations above 100 micrograms/ml in the macrophage supernatant a...

journal_title：Immunology letters

authors： Bories PN,Kodari E,Feger J,Rouzeau JD,Agneray J,Durand G

更新日期：1990-10-01 00:00:00

abstract：:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...

journal_title：Immunology letters

authors： Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis A

更新日期：1997-07-01 00:00:00

abstract：:Previously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or af...

journal_title：Immunology letters

authors： Noh K,Lim H,Moon SK,Kang JS,Lee WJ,Lee D,Hwang YI

更新日期：2005-04-15 00:00:00

abstract：:Dendritic cells (DCs) from cancer patients, as well as tumor-infiltrating DCs, are reported to have suppressed immunostimulatory capacity. One of the major problems in the clinical use of DCs for treating tumors is that the DCs must be autologous ones obtained from patients. Compared with normal DCs (nDCs), flow-cytom...

journal_title：Immunology letters

authors： Furumoto K,Mori A,Yamasaki S,Inoue N,Yang W,Nakau M,Yasuda S,Arii S,Imamura M

更新日期：2002-08-01 00:00:00

abstract：:In transgenic mice over-expressing CD200 (CD200(tg)) graft survival is associated with increased intra-graft expression of mRNAs for genes associated with altered T cell subset differentiation (Foxp3; TGFβ; IL-10). Grafts are rejected in recipients lacking the inhibitory receptor for CD200, CD200R1. We compared grafts...

journal_title：Immunology letters

authors： Yu K,Chen Z,Gorczynski R

更新日期：2013-01-01 00:00:00

abstract：:Indoleamine 2,3-dioxygenase (IDO) is an enzyme with an immunosuppressive effect whose function is diverted by tumor cells to counteract immune cell functions, inducing immune escape of tumor cells. The aim of this study was to investigate the clinical significance of IDO in nasopharyngeal carcinoma (NPC). Compared to ...

journal_title：Immunology letters

authors： Ben-Haj-Ayed A,Moussa A,Ghedira R,Gabbouj S,Miled S,Bouzid N,Tebra-Mrad S,Bouaouina N,Chouchane L,Zakhama A,Hassen E

更新日期：2016-01-01 00:00:00

abstract：:Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk factor for child type 1 diabetes mellitus development. To test the role of IL-18 gene polymorphism in predisposition to adult type 1 diabetes (T1DM) and latent autoimmune diabetes in adults (LADA), we analysed SNPs at position -607 (C/A) and ...

journal_title：Immunology letters

authors： Novota P,Kolostova K,Pinterova D,Novak J,Treslova L,Andel M,Cerna M

更新日期：2005-01-31 00:00:00

abstract：:We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...

journal_title：Immunology letters

authors： Sunnemark D,Andersson R,Harris RA,Jeddi-Tehrani M,Orn A

更新日期：1998-02-01 00:00:00

abstract：:Much evidence indicates that atherosclerotic lesions are largely of an inflammatory nature. Activated macrophages and macrophage-derived foam cells laden with cholesterol esters are a major constituent of these lesions and can influence lesion formation via several potential mechanisms. One such mechanism is Fcgamma r...

journal_title：Immunology letters

authors： Ratcliffe NR,Kennedy SM,Morganelli PM

更新日期：2001-07-02 00:00:00

abstract：:The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...

journal_title：Immunology letters

authors： Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui K

更新日期：2015-03-01 00:00:00

abstract：:An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...

journal_title：Immunology letters

authors： Naiki M,Imai Y,Kamita Y,Osawa T

更新日期：1988-08-01 00:00:00

abstract：:The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...

journal_title：Immunology letters

authors： Arena A,Gugliandolo C,Stassi G,Pavone B,Iannello D,Bisignano G,Maugeri TL

更新日期：2009-04-27 00:00:00

abstract：:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

journal_title：Immunology letters

authors： Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

更新日期：2003-01-02 00:00:00

abstract：:To study the mechanism(s) responsible for the appearance of Epstein-Barr virus (EBV)-induced anti-histone autoantibodies, peripheral blood B lymphocytes from healthy donors were infected with EBV and the resulting lymphoblastoid cell lines were tested for secretion of antibodies reacting with histones. It was found th...

journal_title：Immunology letters

authors： Garzelli C,Incaprera M,Bazzichi A,Manunta M,Rognini F,Falcone G

更新日期：1994-03-01 00:00:00

abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...

journal_title：Immunology letters

authors： Martínez-Pomares L,Gordon S

更新日期：1999-01-01 00:00:00

abstract：:Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors. Co-aggregation of receptors is essential because BCR activated kinases must phosphorylate FcgammaRIIB to recruit SHIP and mediate inhibitory signals. Pre-B cells als...

journal_title：Immunology letters

authors： Brauweiler AM,Cambier JC

更新日期：2004-03-29 00:00:00

abstract：BACKGROUND:Takayasu's arteritis (TA) is a chronic inflammation that affects the large vessels; however, its etiology is still unknown. Human serum paraoxonase hydrolyzes oxidized lipids into low-density lipoproteins and could therefore be associated with the prevalence of inflammation processes. Therefore, the purpose ...

journal_title：Immunology letters

authors： Huesca-Gómez C,Soto ME,Castrejón-Téllez V,Pérez-Méndez O,Gamboa R

更新日期：2013-04-01 00:00:00

abstract：:T cell specific, B cell specific and Ia specific polyclonal antisera, as well as monoclonal antibodies, were employed to characterize cells involved in regulation of T cells, proliferating upon stimulation with concanavalin A or phytohaemagglutinin. Evidence for Ia+ accessory cells was obtained and the constellation o...

journal_title：Immunology letters

authors： Ponsard DC,Chou CT,Cinader B,Dubiski S

更新日期：1986-08-01 00:00:00

abstract：:Two of the better characterized antimicrobial mechanisms displayed by human neutrophils are the reactive oxygen species (ROS) production and the induction of apoptosis. Their importance in mycobacterial infections is, however, controversial and we aimed to analyze them simultaneously in neutrophils infected with eithe...

journal_title：Immunology letters

authors： González-Cortés C,Reyes-Ruvalcaba D,Diez-Tascón C,Rivero-Lezcano OM

更新日期：2009-09-22 00:00:00

abstract：:Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory...

journal_title：Immunology letters

authors： Shao W,Chen J,Dai H,Peng Y,Wang F,Xia J,Thorlacius H,Zhu Q,Qi Z

更新日期：2011-08-30 00:00:00

abstract：:Cell-surface 5'-nucleotidase was assayed by incubating intact cells with 5' [3H]AMP in iso-osmotic buffer and measuring [3H]adenosine production. The activity of cell surface 5'-nucleotidase in small resting lymphocytes and in cells of the B cell line BCL1 was 5.7 and 1.1 nmol/min/mg protein respectively at 37 degrees...

journal_title：Immunology letters

authors： Hauschildt S,Bessler WG

更新日期：1988-09-01 00:00:00

abstract：:The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...

journal_title：Immunology letters

authors： Winstead CJ

更新日期：2014-12-01 00:00:00

abstract：:Sera from 2 subacute sclerosing panencephalitis (SSPE) patients were absorbed with a concentrated preparation of measles virus. Measles-specific IgG was eluted from the precipitates containing measles antigen-antibody complex. These IgGs, when subjected to immunofixation after isoelectric focusing showed a number of o...

journal_title：Immunology letters

authors： Mehta PD,Thormar H

更新日期：1982-02-01 00:00:00

abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...

journal_title：Immunology letters

authors： Otsuki T,Sakaguchi H,Tomokuni A,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Kawakami Y,Kusaka M,Kita S,Ueki A

更新日期：2000-05-01 00:00:00

abstract：:We have mapped a T cell epitope in the circumsporozoite (CS) protein of the murine malaria parasite, Plasmodium yoelii. A 21-mer synthetic peptide corresponding to the amino acid positions 59-79 (referred to as Py1), induced specific proliferation in BALB/c and C57BL/6 mice, and provided help for the production of ant...

journal_title：Immunology letters

authors： Del Giudice G,Grillot D,Rénia L,Müller I,Corradin G,Louis JA,Mazier D,Lambert PH

更新日期：1990-08-01 00:00:00

abstract：:The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed ...

journal_title：Immunology letters

authors： Mohammed Ali HH,Drela N

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...

journal_title：Immunology letters

authors： Truxova I,Pokorna K,Kloudova K,Partlova S,Spisek R,Fucikova J

更新日期：2014-07-01 00:00:00

abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

journal_title：Immunology letters

authors： Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

更新日期：2009-01-29 00:00:00

abstract：:The photobleaching energy transfer (pbFRET) technique is a fluorescence method to measure proximity relationships between molecules, especially cell surface proteins, labeled with fluorophore-conjugated monoclonal antibodies, on a pixel-by-pixel base using digital imaging microscopy. This technique enables analysis of...

journal_title：Immunology letters

authors： Bacsó Z,Bene L,Bodnár A,Matkó J,Damjanovich S

更新日期：1996-12-01 00:00:00

abstract：:Secondary lymphoid organs (SLO) are crucial structures for immune-surveillance and rapid immune responses allowing resident lymphocytes to encounter antigen-presenting cells that carry antigens from peripheral tissues. These structures develop during embryonic life through a tightly regulated process that involves int...

journal_title：Immunology letters

authors： Coles M,Veiga-Fernandes H

更新日期：2013-11-01 00:00:00