Abstract：
:We have mapped a T cell epitope in the circumsporozoite (CS) protein of the murine malaria parasite, Plasmodium yoelii. A 21-mer synthetic peptide corresponding to the amino acid positions 59-79 (referred to as Py1), induced specific proliferation in BALB/c and C57BL/6 mice, and provided help for the production of antibodies to peptides from the repetitive region, (QGPGAP)n, of the same CS protein, when mice were immunized with the Py1 peptide conjugated to the repetitive peptide. Long-term CD3+CD4+CD8-TCR alpha beta+ T cell lines and clones were derived from both strains of mice. These lines and clones, that proliferated in an MHC-restricted fashion, did not recognize peptides from the homologous region of another murine malaria parasite, P. berghei. About 50% of these clones produced detectable amounts of IFN-gamma and IL-2, whereas the remaining produced IL-4, IL-5, and IL-6. In preliminary experiments, some of these clones specifically inhibited P. yoelii sporozoite development in vitro and conferred protection in vivo in passive transfer experiments. These findings show that heterogenous T cell populations are activated in mice upon immunization with a short peptide from the P. yoelii CS protein and that some of these cells could be active in the effector arm of the immune response against malaria sporozoites.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Del Giudice G,Grillot D,Rénia L,Müller I,Corradin G,Louis JA,Mazier D,Lambert PHdoi
10.1016/0165-2478(90)90092-5subject
Has Abstractpub_date
1990-08-01 00:00:00pages
59-63issue
1-3eissn
0165-2478issn
1879-0542pii
0165-2478(90)90092-5journal_volume
25pub_type
杂志文章abstract：:When dimerized by Stem Cell Factor (SCF), the Receptor Tyrosine Kinase Kit triggers the proliferation of hematopoietic progenitors, including pro-B cells, and of some differentiated cells, including mast cells. We found previously that anti-Kit antibodies can mimic SCF and that anti-Kit-induced mast cell proliferation...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.02.007
更新日期：2012-03-30 00:00:00
abstract：:Oral vaccine responsiveness is often lower in children from less developed countries. Childhood malnutrition may be associated with poor immune response to oral vaccines. The present study was designed to investigate whether protein energy malnutrition (PEM) impairs B cell immunity and ultimately reduces oral vaccine ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.08.025
更新日期：2017-10-01 00:00:00
abstract：:Pulmonary intraparenchymal leukocytes were purified from normal mice. By flow cytometry, 20-30% of the lymphocytes were positive for the expression of Mac1, a cell-surface antigen largely restricted to macrophages, neutrophils and natural killer (NK) cells. Sorted Mac1+ lung lymphocytes were large and had abundant cyt...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00034-3
更新日期：1995-05-01 00:00:00
abstract：:Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(96)02602-8
更新日期：1996-09-01 00:00:00
abstract：:Immunoglobulin species, recombined from Fab and Fc fragments with anti-red cell specificity were used as cytophilic antibodies in studies of triggering the effector activity of immunoglobulins. Recombinant immunoglobulins containing a single Fab' appeared inactive in binding to cell receptors and triggering antibody d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90046-4
更新日期：1984-01-01 00:00:00
abstract：:The cellular source of murine LAIF detected by an indirect leukocyte adherence inhibition (LAI) assay using capillary tubes was investigated using non-inducing peritoneal cells (PC) from normal and spindle-cell sarcoma-bearing A/J mice. Cell populations containing greater than 95% T-cells, B-cells or macrophages were ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(81)90005-5
更新日期：1981-11-01 00:00:00
abstract：:Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line. In Jurkat lymphoma cells, AFP decreases the synthesis of prostaglandins and increases the release of arachidonic acid and leukotrienes. The...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90092-7
更新日期：1987-01-01 00:00:00
abstract：:Autoimmune hepatitis (AIH) is a chronic liver disease mediated by immunity, and could lead to liver fibrosis and hepatocellular carcinoma. However, the mechanisms for breaking hepatic tolerance and driving AIH still remain elusive. We herein reported that the non-specific liver inflammation triggered by carbon tetrach...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2019.11.010
更新日期：2020-02-01 00:00:00
abstract：:There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2017.11.014
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Diabetic neuropathy (DN) is one of the microvascular complications of diabetes that leads to peripheral sensorimotor and autonomic nervous system damages. In this study, we first examined the expression of lncRNA NEAT-1 and its downstream microRNAs, miR-183-5p, miR-433-3p, and then examined mRNA expression o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2021.01.007
更新日期：2021-01-25 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00156-9
更新日期：1998-05-01 00:00:00
abstract：:A broad array of biological responses including cell polarization, movement, immune and inflammatory responses, as well as prevention of HIV-1 infection, are triggered by the chemokines, a family of secreted and structurally related chemoattractant proteins that bind to class A-specific seven-transmembrane receptors l...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2012.04.012
更新日期：2012-07-30 00:00:00
abstract：:SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90102-1
更新日期：1986-03-01 00:00:00
abstract：:Donor-specific blood transfusion (DST) improves allograft survival, although the exact mechanism(s) is not completely understood. The purpose of this study was to determine the role of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in DST-protective effects, using a rat cardiac transplantation model. Lewis rats (RT...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00086-x
更新日期：2002-09-02 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.10.012
更新日期：2005-04-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90084-n
更新日期：1991-09-01 00:00:00
abstract：:Silicosis is clinically characterized not only by respiratory disorders but by immunological abnormalities such as the appearance of autoantibodies and complications of autoimmune diseases. Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, has been considered to play a role in the pathogen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00177-2
更新日期：2000-05-01 00:00:00
abstract：:Antigen receptor (AgR) crosslinking by antigens or AgR-specific antibodies induces a cascade of enzymatic events in lymphocytes which involves activation of several non-receptor tyrosine- and serine/threonine kinases, phosphatases, phospholipases, etc. Here we show data demonstrating that a thiol group-reactive protei...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90031-v
更新日期：1993-08-01 00:00:00
abstract：:Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.018
更新日期：2006-02-28 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90086-7
更新日期：1988-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.12.001
更新日期：2015-03-01 00:00:00
abstract：:The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90004-5
更新日期：1985-01-01 00:00:00
abstract：:Applying 2 M KBr, membranes of Ehu were solubilized. By C3-affinity chromatography an activity could be isolated that inhibited the immune adherence reaction and C3b-dependent rosette formation. Since this material did not agglutinate EAC14oxy23b we termed it monovalent C3b receptor (mC3bR). PAGE and SDS-PAGE and stai...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90069-4
更新日期：1982-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.05.012
更新日期：2017-08-01 00:00:00
abstract：BACKGROUND:The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs) can down-regulate autoimmunity, but also promote tumor growth. The objective of this study was to examine the levels of AIRE, AchR, and Foxp3 ex...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.04.008
更新日期：2014-09-01 00:00:00
abstract：:Recombinant gp120 of the HIV-1(IIIB) isolate (BH10 clone) has been mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted. A variety of studies have shown that the CD4 binding domain (CD4bd) is very well exposed in PR12 in contrast to rgp120(LAI). Us...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00289-9
更新日期：2001-12-03 00:00:00
abstract：:The diminished expression of HLA-DR on monocytes has been proposed as a reliable marker of immunosuppression occuring during septic shock. The objective of the present observational study was to establish the time-dependent relation between plasma cytokines interleukin (IL)-10, transforming growth factor (TGF)-beta1, ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.07.009
更新日期：2004-09-01 00:00:00
abstract：:Humanized mouse models present an important tool for preclinical evaluation of new vaccines and therapeutics. Here we show the human variable repertoire of antibody sequences cloned from a previously described human immune system (HIS) mouse model that possesses functional human CD4+ T cells and B cells, namely HIS-CD...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.06.001
更新日期：2017-08-01 00:00:00
abstract：:A variety of cell types may be involved in the regulation of IgA secretion at the intestinal mucosa. Intestinal epithelial cells (IEC) are known to have the capacity to secrete several cytokines which may exert an important regulatory effect on local immunoglobulin secretion by mucosal B cells. In this study, we have ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00112-6
更新日期：1999-03-15 00:00:00
abstract：:The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90069-2
更新日期：1989-01-15 00:00:00
