Abstract:
:SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. Diet fats have a differential effect on age-dependent changes in suppressor activity; a low P/S diet prevents or delays loss of suppressor activity for antibody formation and a high P/S diet prevents or delays the development of suppressor activity in CPS reactions.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Cinader B,Clandinin MT,Koh SW,Brown WR,Ramsay CAdoi
10.1016/0165-2478(86)90102-1subject
Has Abstractpub_date
1986-03-01 00:00:00pages
175-9issue
2-3eissn
0165-2478issn
1879-0542pii
0165-2478(86)90102-1journal_volume
12pub_type
杂志文章abstract::Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00060-1
更新日期:1998-10-01 00:00:00
abstract::Alpha-fetoprotein (AFP), an onco-fetal protein which binds specifically polyunsaturated fatty acids, has been shown to modulate arachidonic acid metabolism in a human T-cell line. In Jurkat lymphoma cells, AFP decreases the synthesis of prostaglandins and increases the release of arachidonic acid and leukotrienes. The...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90092-7
更新日期:1987-01-01 00:00:00
abstract::The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02570-9
更新日期:1996-07-01 00:00:00
abstract::Maturation of dendritic cells is a key step during induction of adaptive immune responses. Multiple pathways and factors are involved in the regulation of dendritic cell maturation. Alternative splicing of pre-mRNA, which is regulated by splicing factors, plays an important role in many biological processes, including...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.06.004
更新日期:2013-06-01 00:00:00
abstract::The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90166-x
更新日期:1994-03-01 00:00:00
abstract::Phosphatidylinositol 3-kinase (PI3K) is critical player in cell proliferation and survival. The effects of LY294002 and wortmannin, inhibitors of PI3K, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in lipoploysaccharide (LPS)-induced Raw 264.7 cells were investigated. Significan...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.12.007
更新日期:2005-06-15 00:00:00
abstract::In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.08.005
更新日期:2013-07-01 00:00:00
abstract::Microparticles are recently recognized players of intercellular communication. They are involved in signal transduction, cell activation and apoptosis. Their importance is also suggested in autoimmune diseases such as rheumatoid arthritis and systemic sclerosis. We investigated the role of microparticles in polymyosit...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.12.018
更新日期:2010-02-16 00:00:00
abstract::In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90213-t
更新日期:1991-07-01 00:00:00
abstract::Even though IgA is considered to play an important role in immunity, surprisingly little is known about the presence of IgA Fc receptor (Fc alpha R)-expressing effector cells in tissues. Difficulties in obtaining human tissue macrophages, led us to study peritoneal macrophages in a human Fc alpha RI transgenic (Tg) mo...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00034-6
更新日期:1999-05-03 00:00:00
abstract::The immunosuppressant rapamycin is known to be a potent inhibitor of cytokine driven proliferation of T-lymphocytes and other cell types. Here we have examined the effect of rapamycin on the myeloblastic cell line M1 which responds to interleukin-6 (IL-6) with growth arrest and monocytoid differentiation. Single-agent...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00110-7
更新日期:1997-11-01 00:00:00
abstract::Two chicken monoclonal antibodies (MAbs), HU/Ch2-7 and HU/Ch6-1, against heterophil Hanganutziu-Deicher (HD) antigens with N-glycolylneuraminic acid (NeuGc) at a terminal carbohydrate were established by cell fusions using chicken B cell lines lacking thymidine kinase and spleen cells from chickens immunized with II3N...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90205-3
更新日期:1992-03-01 00:00:00
abstract::Pathogens in general and pathogenic viruses in particular have evolved a myriad of mechanisms to escape the immune response of mammalian species. Viruses that cause acute disease tend to bear characteristics that make them very contagious, as survival does not derive from chronicity of infection, but spread of disease...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2013.05.007
更新日期:2013-05-01 00:00:00
abstract::An essential key to pathogenicity in Yersinia is the presence of a 70 kb plasmid (pYV) which encodes a type-III secretion system and several virulence outer proteins whose main function is to enable the bacteria to survive in the host. Thus, a specific immune response is needed in which cytokines are engaged. The aim ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.04.007
更新日期:2004-06-15 00:00:00
abstract::We studied CD10 Ag of neutral endopeptidase (NEP) and CD13 Ag of aminopeptidase N (APN) expression on peripheral blood mononuclear cells (PBMC) as cells activation markers and for their transendothelial migration properties in three groups of MS patients (total 58); with acute exacerbation of MS (n = 18), primary prog...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00176-5
更新日期:2000-02-01 00:00:00
abstract::The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradati...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90145-7
更新日期:1994-07-01 00:00:00
abstract::While cases of silicosis are often complicated by various autoimmune disorders, patients with asbestosis develop malignant tumors such as lung cancer and malignant mesothelioma. These differences may derive from different biological effects, particularly on immunological cells, of silica and asbestos. To find differen...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.11.005
更新日期:2005-04-15 00:00:00
abstract::Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(00)00285-6
更新日期:2000-12-01 00:00:00
abstract:PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.005
更新日期:2013-05-01 00:00:00
abstract::CD27, which belongs to the TNF receptor family, is a costimulatory molecule that participates in T-cell activation. Unlike costimulatory molecules such as OX40 and 4-1BB, little is known about the role CD27 plays a role in the development of experimental diseases. We asked whether CD27 and its ligand CD70 participate ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2008.05.004
更新日期:2008-08-15 00:00:00
abstract::It has been previously shown that normal human peripheral blood mononuclear cells produce a soluble factor(s) that causes selective inhibition of collagen production by cultured human diploid fibroblasts, and that stimulation of the mononuclear cells by appropriate mitogens greatly enhances its production. Because of ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90145-2
更新日期:1985-01-01 00:00:00
abstract::The 19S proteasome regulatory particle plays a critical role in cellular proteolysis. However, emerging evidence suggests roles for 19S proteasome subunits in regulating yeast and mammalian transcription. It has been previously shown that Sug1 is important for the transcription of MHC II molecules. We report here that...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.06.005
更新日期:2012-09-01 00:00:00
abstract::Linoleic and arachidonic acid concentrations in neutrophils from rats maintained on a diet with only 0.3% of the energy content as essential fatty acid (EFA, EFAD group) were reduced by 70 +/- 2.2% and 34.8 +/- 5.2%, respectively, compared with controls fed a diet with a normal 3% EFA content. Neutrophil chemiluminesc...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90053-2
更新日期:1986-10-01 00:00:00
abstract::The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2009.12.009
更新日期:2010-05-04 00:00:00
abstract::Genetic or DNA-based immunization, including genomic immunization, has shown to be a viable alternative approach to induce protective immunity against a number of pathogens in several disease models. Here we describe a new method, cDNA expression library immunization (cDELI), based on the use of a large number of cDNA...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00039-x
更新日期:1998-07-01 00:00:00
abstract::To explore the genetic association of single nucleotide polymorphisms (SNPs) in the coding region of the NOTCH4, exon 3 C+1297T and exon 5 A+3063G, in a case-control analysis of 58 rheumatoid arthritis (RA) and 98 alopecia areata (AA) and 100 ethnically matched healthy subjects. NOTCH4 polymorphisms were genotyped by ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.01.002
更新日期:2013-02-01 00:00:00
abstract::A CD8+ cytotoxic T-cell clone that recognized HIV p24gag was isolated from an infected individual. The minimal epitope was localized to amino acids 308-316 (QASQEVKNW). Using allogeneic target cells, we found that lysis was restricted by the HLA-Cw0401 molecule. We observed that C1R cells, that express the HLA-Cw0401 ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)02696-5
更新日期:1997-03-01 00:00:00
abstract::Incorporation of [3h]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentag...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90057-8
更新日期:1982-06-01 00:00:00
abstract:BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.03.010
更新日期:2014-07-01 00:00:00
abstract::This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title:Immunology letters
pub_type: 撤回出版物
doi:10.1016/j.imlet.2017.08.015
更新日期:2017-08-26 00:00:00