Abstract：
:In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination and type of graft, as well as the nature, dose and timing of transfusion. Although the effect is donor-specific, partial sharing of MHC and/or minor antigens between the blood and organ donor may be sufficient to prolong graft survival. The mechanisms underlying the enhancing effect of blood transfusion and other protocols which lead to specific unresponsiveness in the adult animal are undoubtedly complex and still poorly understood. In contrast to neonatal tolerance, where there is complete clonal deletion or anergy, lymphocytes from enhanced animals often show normal alloreactivity in vitro. Blood transfusion provokes an accelerated immune response to an allograft with rapid leukocyte infiltration of the graft and associated induction of class I and class II MHC target antigens. Moreover, graft infiltrating cells obtained from non-rejecting grafts in transfused recipients show levels of in vitro specific cytotoxicity equivalent to or in excess of those found in rejecting grafts. Despite the heightened cellular response provoked by blood transfusion, host regulatory mechanisms override the rejection response and there is substantial evidence for the existence in transfused animals of T cells with antigen specific suppressor activity. However, the site in the rejection process at which suppression is mediated is unknown.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bradley JAdoi
10.1016/0165-2478(91)90213-tsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
127-32issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(91)90213-Tjournal_volume
29pub_type
杂志文章,评审abstract：:For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.07.004
更新日期：2013-06-01 00:00:00
abstract：:The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradati...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90145-7
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.03.010
更新日期：2014-07-01 00:00:00
abstract：:Donor-reactive memory T cells mediated accelerated rejection is known as a barrier to the survival of transplanted organs. We investigated the combination of different monoclonal antibodies (mAbs) and donor-specific transfusion (DST) in memory T cells-based adoptive mice model. In the presence of donor-reactive memory...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.03.009
更新日期：2011-08-30 00:00:00
abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.06.011
更新日期：2020-10-01 00:00:00
abstract：BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...
journal_title：Immunology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.imlet.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.12.014
更新日期：2014-05-01 00:00:00
abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2013.12.009
更新日期：2014-10-01 00:00:00
abstract：:Wnt5a is a secreted pleiotropic glycoprotein produced in an inflammatory state by a wide spectrum of ubiquitous cell populations. Recently, we demonstrated that Wnt5a skews the differentiation of human monocyte derived dendritic cells (moDCs) to a tolerogenic functional state. In this study we focus our interest on th...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.08.015
更新日期：2014-11-01 00:00:00
abstract：:E1, E3-deleted, replication-deficient recombinant adenoviruses are widely studied as vectors for their capacity to transfer therapeutic genes in vivo. They can infect a wide variety of dividing and quiescent cells from different organs and possess a large packaging capacity. One of the major limitations in the use of ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00049-7
更新日期：1997-06-01 00:00:00
abstract：:Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropher...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.04.011
更新日期：2016-06-01 00:00:00
abstract：:Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00043-5
更新日期：1995-05-01 00:00:00
abstract：:Umbilical cord blood transplants are associated with a lower incidence of graft-versus-host disease (GVHD) than adult marrow or peripheral blood stem cell transplants, and this could be related to a difference in cytokine production between fetal and adult mononuclear cells after allogeneic stimulation. Mixed lymphocy...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.10.004
更新日期：2004-01-30 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) is critical player in cell proliferation and survival. The effects of LY294002 and wortmannin, inhibitors of PI3K, on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in lipoploysaccharide (LPS)-induced Raw 264.7 cells were investigated. Significan...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.12.007
更新日期：2005-06-15 00:00:00
abstract：:The inflammatory response plays an important role during the induction of several neonatal diseases. Previous studies have shown that during newborn infections, the natural imbalance between pro- and anti-inflammatory responses shifts toward the production of pro-inflammatory cytokines. In this study, we employed an a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.12.004
更新日期：2016-02-01 00:00:00
abstract：:It has been considered before that human naive and memory/effector CD4+ T-cells cannot be subdivided solely according to the differential expression of CD45 isoforms. By the lack of expression of CD31 we have identified a subset of CD4+ CD45RA+ CD31- cells which show distinct features of antigen-experienced Th1 cells....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00056-4
更新日期：1997-06-01 00:00:00
abstract：:The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/s0165-2478(98)00153-9
更新日期：1999-03-01 00:00:00
abstract：:Oral vaccine responsiveness is often lower in children from less developed countries. Childhood malnutrition may be associated with poor immune response to oral vaccines. The present study was designed to investigate whether protein energy malnutrition (PEM) impairs B cell immunity and ultimately reduces oral vaccine ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.08.025
更新日期：2017-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.09.010
更新日期：2018-11-01 00:00:00
abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90194-f
更新日期：1991-07-01 00:00:00
abstract：:Previously we reported that a mega-dose of Vitamin C enhanced the initial stage of delayed-type hypersensitivity reaction in Balb/c mice. In this study its effects were further evaluated as follows. Mice were administered Vitamin C intraperitoneally at 0.625 mg/day or at 5mg/day for variable days before, during, or af...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.10.012
更新日期：2005-04-15 00:00:00
abstract：:Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00184-x
更新日期：2000-06-01 00:00:00
abstract：:The human homologue of 4-1BB (H4-1BB) cDNA was isolated from PMA plus ionomycin-treated human peripheral T-cell cDNA libraries. The amino acid sequence deduced from the nucleotide sequence showed that the protein is composed of 255 amino acids with 2 potential N-linked glycosylation sites. The molecular weight of its ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00227-i
更新日期：1995-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00320-0
更新日期：2002-02-01 00:00:00
abstract：:CD8+CD28- regulatory T cells (Tregs) play important roles in chronic viral infections. Programmed death 1 (PD-1) is highly expressed on hepatitis C virus (HCV)-specific CTLs. However, little is known regarding the role of CD8+CD28-PD1+ T cells in hepatitis C. Herein, we found that the frequency of CD8+CD28-PD1+, but n...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.07.008
更新日期：2018-10-01 00:00:00
abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.10.008
更新日期：2012-01-30 00:00:00
abstract：:BAFF deficiency in mice impairs B cell development beyond the transitional stage 1 in the spleen and thus severely reduces the size of follicular and marginal zone B cell compartments. Moreover, humoral immune responses in these mice are dramatically impaired. We now addressed the question whether the decrease in matu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.03.007
更新日期：2010-06-15 00:00:00
abstract：:Monoclonal antibodies of the Orthoclone series were used to identify total T lymphocytes (OKT3) and their helper-inducer (OKT4) and cytotoxic-suppressor (OKT8) subsets in 25 patients with chronic Chagas' disease and 25 healthy controls. No significant difference in the number of total T cells (OKT3+) circulating in th...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90011-7
更新日期：1984-01-01 00:00:00
abstract：:A TNF-like factor was purified from lipopolysaccharide (LPS) induced New Zealand white rabbit serum. The TNF-like factor was purified by DEAE-Sephacel, Sephacryl S-200, Mono-Q, CM-affi gel Blue, Superose 12 H/R preparative columns to the specific activity of 4 x 10(6) U/mg protein. The purified protein was 45 kDa in i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00134-x
更新日期：1998-02-01 00:00:00
abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(96)02655-7
更新日期：1996-12-01 00:00:00
