Live attenuated SIV--a model of a vaccine for AIDS.

abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...

journal_title：Immunology letters

authors： Sármay G,Koncz G,Gergely J

更新日期：1996-12-01 00:00:00

abstract：:The expression of antigen presenting MHC class I molecules can be enhanced through cytokines, e.g. upon infection with bacteria or viruses, either directly by enhancing class I gene transcription or by increasing the amounts of accessory proteins of the loading complex. Tapasin plays a significant role in the peptide ...

journal_title：Immunology letters

authors： Abarca-Heidemann K,Friederichs S,Klamp T,Boehm U,Guethlein LA,Ortmann B

更新日期：2002-10-01 00:00:00

abstract：:Graft failure (GF) following bone marrow transplantation (BMT) in man is usually attributed to allograft rejection; however, other mechanisms of GF exist. Exposure of the developing allograft to viruses, myelotoxic drugs, and damage to the host-derived marrow stroma during graft-versus-host disease (GVHD) may all caus...

journal_title：Immunology letters

authors： Hows JM

更新日期：1991-07-01 00:00:00

abstract：:Age-related changes of different individuals multicentric and polymorphic. We have approached this problem of age-related changes by examining (1) membrane densities of receptors of various ligands in different organs, and (2) changes in different classes of T cells and of antibody response. Three strategies have been...

journal_title：Immunology letters

authors： Cinader B

更新日期：1987-12-01 00:00:00

abstract：:Cloned human T-cell lines were produced by limiting dilution of lymphocytes alloactivated in mixed leukocyte cultures, followed by expansion of clonal progeny with interleukin 2. Selected clones were analyzed for cell-mediated cytotoxicity (CTX) against a variety of targets susceptible or resistant to lytic attack by ...

journal_title：Immunology letters

authors： Pawelec G,Hadam M,Müller C,Wernet P

更新日期：1982-05-01 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC) is a well-known medication, primarily used as a mucolytic agent in pulmonary disease. Recently, we have found that NAC possesses antipyretic properties. The aim of the present study was to investigate the mechanism by which NAC attenuates fever. The concentration of interleukin (IL)-10 and pr...

journal_title：Immunology letters

authors： Wrotek S,Jędrzejewski T,Piotrowski J,Kozak W

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor ne...

journal_title：Immunology letters

authors： Singh S,Verma SK,Kumar S,Ahmad MK,Nischal A,Singh SK,Dixit RK

更新日期：2018-04-01 00:00:00

abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

journal_title：Immunology letters

authors： Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

更新日期：2009-01-29 00:00:00

abstract：:The cell-surface glycoproteins encoded by the major histocompatibility complex (MHC) bind to processed foreign antigens and present them to T lymphocytes. Two classes of MHC molecules and their corresponding gene sequences have been extensively studied in eutherian mammals and birds, but data on the marsupial MHC are ...

journal_title：Immunology letters

authors： Lam MK,Belov K,Harrison GA,Cooper DW

更新日期：2001-02-01 00:00:00

abstract：:The HIV-1 envelope protein contains several regions with amino acid homology to HLA class I and class II molecules. We evaluated possible changes in antibody responses to those regions during vaccination with rgp 160 produced in a baculovirus system. Forty asymptomatic HIV-infected patients with CD4 cell counts above ...

journal_title：Immunology letters

authors： Lundholm P,Wahren M,Sandström E,Volvovitz F,Wahren B

更新日期：1994-07-01 00:00:00

abstract：:We aimed to investigate if angiopoietin-2 (Ang-2) participates in the septic process and what may be the role of monocytes as a site of release of Ang-2 in sepsis. Concentrations of Ang-2 were estimated in sera and in supernatants of monocytes derived form one already described cohort of 90 patients with septic syndro...

journal_title：Immunology letters

authors： Kranidioti H,Orfanos SE,Vaki I,Kotanidou A,Raftogiannis M,Dimopoulou I,Kotsaki A,Savva A,Papapetropoulos A,Armaganidis A,Giamarellos-Bourboulis EJ

更新日期：2009-06-30 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

journal_title：Immunology letters

authors： Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

更新日期：2005-11-15 00:00:00

abstract：:The regulatory effect of Z-100 on the balance of Th1/Th2 cell responses in BALB/c mice bearing Meth-A fibrosarcoma was investigated. In tumor bearing mice, Th1 cytokine production (IL-2, IFN-gamma) are suppressed and Th2 cytokine production (IL-4, IL-10) are increased, as compared with those of normal mice. The admini...

journal_title：Immunology letters

authors： Oka H,Emori Y,Ohya O,Kobayashi N,Sasaki H,Tanaka Y,Hayashi Y,Nomoto K

更新日期：1999-11-01 00:00:00

abstract：:Liposome-encapsulated conalbumin (L(conalbumin)) is an antigen that is efficiently phagocytosed by bone marrow-derived macrophages and presented to effector cells as part of the major histocompatibility complex (MHC) class I complex. In this report, we show that the conalbumin component of L(conalbumin) is degraded to...

journal_title：Immunology letters

authors： Rothwell SW,Wassef NM,Alving CR,Rao M

更新日期：2000-10-03 00:00:00

abstract：:It has been shown that engraftment of human peripheral blood lymphocytes (PBL) from Epstein-Barr virus (EBV) seropositive donors in C.B-17/SCID mice is associated with a high incidence of human B cell tumors. More recently, we described a new approach enabling engraftment of human PBL in normal strains of mice or rats...

journal_title：Immunology letters

authors： Marcus H,Burakova T,Shezen E,David M,Canaan A,Lubin I,Reisner Y

更新日期：1996-03-01 00:00:00

abstract：:We have investigated the cellular responses of guinea-pig macrophages to human C4a. C4a induced a biphasic Ca2+ mobilization; a rapid temporary Ca2+ mobilization from intracellular Ca2+ pool followed by a weak Ca2+ influx of extracellular Ca2+. Although the C4a-treated macrophages did not respond again to C4a, that is...

journal_title：Immunology letters

authors： Murakami Y,Yamamoto T,Imamichi T,Nagasawa S

更新日期：1993-06-01 00:00:00

abstract：:DC are unique antigen presenting cells, and their ability to induce proliferation of T cells in a mixed leukocyte reaction (MLR) assay is commonly used for the evaluation of their function. To determine the mechanisms involved in DC-induced T cell activation in a primary MLR assay, a variety of different agents were e...

journal_title：Immunology letters

authors： Tourkova IL,Yurkovetsky ZR,Shurin MR,Shurin GV

更新日期：2001-09-03 00:00:00

abstract：:Thymocyte conditioned medium (TCM) was prepared using 2 lots of fetal calf, and 1 lot each of horse and rabbit sera. The 4 TCM and the respective sera alone were compared in their ability to support primary in vitro sensitization to sheep red blood cells (SRBC) as assayed by direct plaque formation. As would be expect...

journal_title：Immunology letters

authors： White LL,Smith RA

更新日期：1987-01-01 00:00:00

abstract：:Although there is growing evidence that NKT cells play an important role in various immune responses through the invariant T cell receptor, other cell surface molecules responsible for their function are not fully understood. Here we study the role of ICOS, the third member of the CD28 family of costimulatory receptor...

journal_title：Immunology letters

authors： Watanabe S,Ohnuki K,Hara Y,Ishida Y,Ikarashi Y,Ogawa S,Kishimoto H,Tanabe K,Abe R

更新日期：2010-01-18 00:00:00

abstract：:Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2...

journal_title：Immunology letters

authors： Nguyen TG

更新日期：2018-11-01 00:00:00

abstract：:The binding of anti-IgM IgG to human monoclonal IgM has been studied calorimetrically and results have been compared with parallel turbidity measurements of the same reaction. In the first series of experiments using the flow calorimeter equipped with a mixing cell, varied flow rates gave identical values for the ther...

journal_title：Immunology letters

authors： Rialdi G,Raffanti S

更新日期：1984-01-01 00:00:00

abstract：:Direct interaction between Fusobacterium nucleatum and human neutrophils resulted in the secretion of a neutrophil self-regulatory factor(s). The secretion of this factor was bacteria specific, and depended on the integrity of the bacteria cell surface. Factor secretion occurred within 15 min of bacteria--neutrophil i...

journal_title：Immunology letters

authors： Seow WK,Thong YH

更新日期：1987-01-01 00:00:00

abstract：:Melanoma is a prototype of immunogenic tumor to which various types of immunotherapy have been applied extensively over the past decades. Melanoma vaccines are designed for the purpose of immune modulation and subsequent anti-tumor effects in the process of an active specific immunotherapy. Previous attempts of these ...

journal_title：Immunology letters

authors： Schadendorf D,Paschen A,Sun Y

更新日期：2000-09-15 00:00:00

abstract：:Interleukin 1 beta (IL1 beta) is an inducible polypeptide with many roles in host defence and homoeostasis. It has also been implicated as a mediator of infectious, inflammatory and autoimmune diseases, and the kinetics of its production are relevant to an understanding of the pathogenesis of these conditions. We repo...

journal_title：Immunology letters

authors： di Giovine FS,Symons JA,Duff GW

更新日期：1991-08-01 00:00:00

abstract：:In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey...

journal_title：Immunology letters

authors： Yoshida T,Suzuki S,Iwasaki Y,Kaneko A,Saito A,Enomoto Y,Higashino A,Watanabe A,Suzuki J,Inoue K,Kuroda T,Takada M,Ito R,Ito M,Akari H

更新日期：2013-07-01 00:00:00

abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

journal_title：Immunology letters

authors： Kowalczyk D,Pryjma J,Zembala M

更新日期：1986-08-01 00:00:00

abstract：:We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...

journal_title：Immunology letters

authors： Sunnemark D,Andersson R,Harris RA,Jeddi-Tehrani M,Orn A

更新日期：1998-02-01 00:00:00

abstract：:Culture of high density resting murine B cells with recombinant IL-4 caused changes in the patterns of phosphoproteins associated with the plasma membranes isolated from such cells. The principal difference was the appearance of an alkali-resistant phosphoprotein of Mr = 75,000-80,000. Culture with LPS also gave rise ...

journal_title：Immunology letters

authors： McGarvie GM,Cushley W

更新日期：1989-09-01 00:00:00

abstract：:Multiple antigen peptides (MAP), consisting of a number of peptide copies synthesized on a branching lysyl core, offer a novel approach for rendering small peptides immunoreactive in solid-phase immunoassays. An octameric MAP, carrying 6 repeats of the sequence -N-A-A-G-, tandem repeated in the immunodominant region o...

journal_title：Immunology letters

authors： Habluetzel A,Pessi A,Bianchi E,Rotigliano G,Esposito F

更新日期：1991-09-01 00:00:00

abstract：:In this study, we tried to establish a relationship between the immunopotentiating effects and the antioxidant activity of the immunostimulating compound, diethyldithiocarbamate (DDC). We studied the effects of DDC treatment on enriched T and B murine spleen lymphocytes in an in vivo-ex vivo model of O2-induced immune...

journal_title：Immunology letters

authors： Lacombe P,Carre I,Fay M,Pocidalo JJ

更新日期：1988-06-01 00:00:00