Immune-modulation via IgD B-cell receptor suppresses allergic skin inflammation in experimental contact hypersensitivity models despite of a Th2-favoured humoral response.

abstract：:The presence of specific glutamate receptors on T lymphocytes separated from normal human blood was investigated. Upon study of T lymphocytes interaction with [3H]glutamate the last one was found to bind specifically to these cells, Kd = 2.36 x 10(-7) M. Thirteen unlabelled compounds were tested as potential glutamate...

journal_title：Immunology letters

authors： Kostanyan IA,Merkulova MI,Navolotskaya EV,Nurieva RI

更新日期：1997-08-01 00:00:00

abstract：:In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of the...

journal_title：Immunology letters

authors： Bellora F,Castriconi R,Dondero A,Carrega P,Mantovani A,Ferlazzo G,Moretta A,Bottino C

更新日期：2014-10-01 00:00:00

abstract：:In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is as...

journal_title：Immunology letters

authors： Mendlovic S,Mozes E,Eilat E,Doron A,Lereya J,Zakuth V,Spirer Z

更新日期：1999-04-01 00:00:00

abstract：:Based on the fact that monoclonal antibody (mAb) 2F5 recognizing ELDKWA-epitope on HIV-1 gp41 separately or in combination with other mAbs showed potent neutralizing activity to a wide range of primary HIV-1 isolates in vivo and in vitro, but this epitope undergoes restricted mutation. ELNKWA is a neutralizing-resista...

journal_title：Immunology letters

authors： Dong XN,Xiao Y,Chen YH

更新日期：2001-01-01 00:00:00

abstract：:Many alterations of innate and adaptive immunity are common in the aging population, which reflect a deterioration of the immune system, and have lead to the terms "immune aging" or "immunosenescence". Systems Biology aims to the comprehensive knowledge of the structure, dynamics, control and design that define a give...

journal_title：Immunology letters

authors： O'Connor JE,Herrera G,Martínez-Romero A,de Oyanguren FS,Díaz L,Gomes A,Balaguer S,Callaghan RC

更新日期：2014-11-01 00:00:00

abstract：:Retroplacental blood lymphocytes (RPL) obtained from women without complications at the term delivery were studied for proliferative response to mitogens and surface phenotype and were compared with autologous peripheral blood lymphocytes (PBL). Proliferation of RPL induced by phytohemagglutinin (PHA) was significantl...

journal_title：Immunology letters

authors： Yoshida M,Kanzaki H,Tokushige M,Sato S,Wang HS,Uchida A,Kasakura S,Mori T

更新日期：1988-03-01 00:00:00

abstract：:In transgenic mice over-expressing CD200 (CD200(tg)) graft survival is associated with increased intra-graft expression of mRNAs for genes associated with altered T cell subset differentiation (Foxp3; TGFβ; IL-10). Grafts are rejected in recipients lacking the inhibitory receptor for CD200, CD200R1. We compared grafts...

journal_title：Immunology letters

authors： Yu K,Chen Z,Gorczynski R

更新日期：2013-01-01 00:00:00

abstract：:The three-dimensional structures of cyclosporin A complexed with cyclophilin A or Fab fragment of a monoclonal antibody were compared. In these two complexes conformations of the fragment D-alanine8-N-methylvaline11 in cyclosporin A were in a good agreement. In addition, cyclophilin A and the Fab fragment had related ...

journal_title：Immunology letters

authors： Denesyuk AI,Lundell J,Zav'yalov V,Korpela T

更新日期：1994-07-01 00:00:00

abstract：:Oral vaccine responsiveness is often lower in children from less developed countries. Childhood malnutrition may be associated with poor immune response to oral vaccines. The present study was designed to investigate whether protein energy malnutrition (PEM) impairs B cell immunity and ultimately reduces oral vaccine ...

journal_title：Immunology letters

authors： Rho S,Kim H,Shim SH,Lee SY,Kim MJ,Yang BG,Jang MH,Han BW,Song MK,Czerkinsky C,Kim JO

更新日期：2017-10-01 00:00:00

abstract：:It has been considered before that human naive and memory/effector CD4+ T-cells cannot be subdivided solely according to the differential expression of CD45 isoforms. By the lack of expression of CD31 we have identified a subset of CD4+ CD45RA+ CD31- cells which show distinct features of antigen-experienced Th1 cells....

journal_title：Immunology letters

authors： Thiel A,Schmitz J,Miltenyi S,Radbruch A

更新日期：1997-06-01 00:00:00

abstract：:Pretreatment of murine bone marrow-derived macrophages with wheat germ agglutinin (WGA) and concanavalin A (Con A) markedly enhanced the uptake of Staphylococcus aureus H and Escherichia coli 08, respectively. Pretreatment of the respective bacteria with these lectins also greatly increased their uptake by the macroph...

journal_title：Immunology letters

authors： Gallily R,Stain I,Zaady O

更新日期：1986-09-01 00:00:00

abstract：:We have studied the mechanisms involved in the activation or suppression of the immune response by the tumor cells, which is also dependent on the site of tumor transplantation. AK-5 tumor cells when transplanted s.c. activated peritoneal macrophages through the induction of different cytokines, whereas tumor cells wh...

journal_title：Immunology letters

authors： Mitra R,Bhaumik S,Khar A

更新日期：2002-07-03 00:00:00

abstract：:Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a mu...

journal_title：Immunology letters

authors： Yoshie O,Wada J,Ishida N

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. orientale, respectively)...

journal_title：Immunology letters

authors： Gou KJ,Zeng R,Ren XD,Dou QL,Yang QB,Dong Y,Qu Y

更新日期：2018-09-01 00:00:00

abstract：:Galectin-1 (Gal-1) has been implicated in tumor progression partly via the induction of T-cell apoptosis. However the mechanism of Gal-1 induced T-cell death was mostly studied using recombinant, soluble Gal-1 producing controversial results. To explore the true mechanism of Gal-1 and hence tumor cell-induced T-cell d...

journal_title：Immunology letters

authors： Kovács-Sólyom F,Blaskó A,Fajka-Boja R,Katona RL,Végh L,Novák J,Szebeni GJ,Krenács L,Uher F,Tubak V,Kiss R,Monostori E

更新日期：2010-01-04 00:00:00

abstract：:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...

journal_title：Immunology letters

authors： Hartung HP,Toyka KV

更新日期：1983-01-01 00:00:00

abstract：:Although several components of the microbial wall of gram-positive bacteria and fungi possess immunostimulatory properties, their pathogenetic role remains incompletely evaluated. The purpose of this study was to assess the basic immune status of patients susceptible to infections and their capability for cytokine pro...

journal_title：Immunology letters

authors： Tsigou E,Aloizos S,Myrianthefs P,Gourgiotis S,Tsakris A,Baltopoulos G

更新日期：2014-05-01 00:00:00

abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

journal_title：Immunology letters

authors： Kaslow DC,Kumar S

更新日期：1996-07-01 00:00:00

abstract：:It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...

journal_title：Immunology letters

authors： Comerford I,Nibbs RJ

更新日期：2005-01-31 00:00:00

abstract：:The influence of pretreatment with interferon (IFN) on subsequent IFN synthesis was investigated in macrophage cultures of DBA/2 and C57BL/6 mice. The doses of IFN alpha/beta for pretreatment ranged from 10,000 U/ml to 100 U/ml and the incubation time was between 18 and 2 h. No blocking effect was observed for chemica...

journal_title：Immunology letters

authors： Giese M,Kirchner H

更新日期：1988-06-01 00:00:00

abstract：:Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the presen...

journal_title：Immunology letters

authors： Shi W,Kou Y,Jiang H,Gao F,Kong W,Su W,Xu F,Jiang C

更新日期：2018-06-01 00:00:00

abstract：:Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...

journal_title：Immunology letters

authors： Van Houdt K,Nicasi I,Van Mechelen E,Veulemans B,De Ley M

更新日期：1992-03-01 00:00:00

abstract：:The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...

journal_title：Immunology letters

authors： Naouali A,Kaabachi W,Tizaoui K,Amor AB,Hamzaoui A,Hamzaoui K

更新日期：2015-03-01 00:00:00

abstract：:Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from co...

journal_title：Immunology letters

authors： Bánki Z,Stoiber H,Dierich MP

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is a non-specific inflammation, which involves the airways, lung parenchyma and pulmonary vessels. The inflammation causes the activation of inflammatory cells and the release of various inflammatory mediators such as interleukin-1 beta, interleukin-6 and tumor ne...

journal_title：Immunology letters

authors： Singh S,Verma SK,Kumar S,Ahmad MK,Nischal A,Singh SK,Dixit RK

更新日期：2018-04-01 00:00:00

abstract：:The immunological phenotyping of peripheral blood mononuclear cells (PBMC) was assayed in a series of 22 patients suffering from severe cancer-associated malnutrition. A marked decrease of the T-lymphocyte subsets (CD3+, CD4+, CD8+) and of the CD20+ B lymphocytes occurred; there was however an increased percentage of ...

journal_title：Immunology letters

authors： Garraud O,Daculsi R,Merlio JP,Lobera A,Legrand E

更新日期：1987-05-01 00:00:00

abstract：:Interleukin 1 beta (IL1 beta) is an inducible polypeptide with many roles in host defence and homoeostasis. It has also been implicated as a mediator of infectious, inflammatory and autoimmune diseases, and the kinetics of its production are relevant to an understanding of the pathogenesis of these conditions. We repo...

journal_title：Immunology letters

authors： di Giovine FS,Symons JA,Duff GW

更新日期：1991-08-01 00:00:00

abstract：:We have mapped a T cell epitope in the circumsporozoite (CS) protein of the murine malaria parasite, Plasmodium yoelii. A 21-mer synthetic peptide corresponding to the amino acid positions 59-79 (referred to as Py1), induced specific proliferation in BALB/c and C57BL/6 mice, and provided help for the production of ant...

journal_title：Immunology letters

authors： Del Giudice G,Grillot D,Rénia L,Müller I,Corradin G,Louis JA,Mazier D,Lambert PH

更新日期：1990-08-01 00:00:00

abstract：:The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...

journal_title：Immunology letters

authors： Hoffman SL,Weiss W,Mellouk S,Sedegah M

更新日期：1990-08-01 00:00:00

abstract：:Dendritic cells (DCs) are very important for the generation of long lasting immune responses against pathogens or the induction of anti-tumor responses. Targeting antigen to dendritic cells via monoclonal antibodies specific for DC cell surface receptors such as DEC205 was shown to elicit potent cellular and humoral i...

journal_title：Immunology letters

authors： Heidkamp GF,Neubert K,Haertel E,Nimmerjahn F,Nussenzweig MC,Dudziak D

更新日期：2010-08-16 00:00:00