Abstract：
:Graft failure (GF) following bone marrow transplantation (BMT) in man is usually attributed to allograft rejection; however, other mechanisms of GF exist. Exposure of the developing allograft to viruses, myelotoxic drugs, and damage to the host-derived marrow stroma during graft-versus-host disease (GVHD) may all cause GF. Later, in the posttransplant course, recurrence of the original disease may ultimately destroy or replace the graft. Overall allogeneic rejection remains the most important cause of GF and most in vivo and in vitro evidence points to a T cell mechanism. The incidence of rejection after clinical BMT is very variable and highly dependent on HLA and non HLA histocompatibility differences between donor and recipient, the level of recipient sensitisation pre-BMT and the immunosuppressive protocols used pre-transplant and for the prevention of GVHD.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hows JMdoi
10.1016/0165-2478(91)90204-nsubject
Has Abstractpub_date
1991-07-01 00:00:00pages
77-80issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(91)90204-Njournal_volume
29pub_type
杂志文章,评审abstract：:Receptor-binding by the B-subunit of Escherichia coli heat-labile enterotoxin (EtxB) induces apoptosis of peripheral CD8(+), but not CD4(+) T-cells. Given that peripheral CD8(+) and CD4(+) T cells arise from a common developmental pathway in the thymus, we investigated the effects of EtxB on different thymocyte popula...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(03)00049-x
更新日期：2003-07-03 00:00:00
abstract：:We have recently generated CD4 clones from BALB/c mice immunized with a plasmid DNA containing the gene encoding for the catalytic domain of trans-sialidase, an important enzyme expressed on the surface of Trypanosoma cruzi trypomastigotes. These clones allowed us to study in vitro the interaction between T cells and ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00205-4
更新日期：2000-07-03 00:00:00
abstract：:Multiple activation signals (including antigen, co-stimulation, and cytokines) during T-cell priming affect the subsequent generation of memory T cells, whose survival is maintained by IL-7 and IL-15. Since the IL-7 receptor is highly expressed not only on the surface of memory T cells but also on naïve T cells, we pr...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.12.019
更新日期：2010-02-16 00:00:00
abstract：:Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90018-6
更新日期：1991-10-01 00:00:00
abstract：BACKGROUND:Diabetic neuropathy (DN) is one of the microvascular complications of diabetes that leads to peripheral sensorimotor and autonomic nervous system damages. In this study, we first examined the expression of lncRNA NEAT-1 and its downstream microRNAs, miR-183-5p, miR-433-3p, and then examined mRNA expression o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2021.01.007
更新日期：2021-01-25 00:00:00
abstract：:The aim of the present work was to develop an in vitro model of eosinophil cytotoxicity which mimics numerous in vivo situations characterized by complement activation through the alternative pathway. Our results demonstrate that eosinophilic granulocytes from patients with parasitic diseases and blood eosinophilia we...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90078-7
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:Vitamin D (vitD) is involved in important regulatory functions of the innate and adaptive immune system. So, it has been hypothesized that vitD might influence the course of atopic dermatitis (AD). Also obesity may have impact on immune system. The aim of our study was to investigate vitamin D status and bod...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.11.004
更新日期：2017-01-01 00:00:00
abstract：:The effects of cilostazol on stimulating heme oxygenase (HO)-1 expression including signal pathways and suppression of inflammatory cytokines and molecules were studied. Cilostazol stimulation time (1-8 h)- and concentration (1-30 μM)-dependently increased the HO-1 mRNA and protein expression associated with increased...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.01.003
更新日期：2011-05-01 00:00:00
abstract：:Cysticercosis caused by Taenia solium is a very common disease in developing countries that seriously affects human health. Diagnosis can only be confirmed with the aid of computerized tomography or nuclear magnetic resonance (NMR) creating obvious difficulties for epidemiological studies. Reliable immunoassays employ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00166-2
更新日期：2000-01-10 00:00:00
abstract：:We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90035-o
更新日期：1990-03-01 00:00:00
abstract：:The monocytic cell line I937 was derived from U937 by sorting for cells with high expression of MHC class II molecules. Further analysis of these class II molecules revealed the presence of the HLA-DR3 subtype suggesting that the cell line was a potential candidate for testing antigen presentation to T cells restricte...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02478-6
更新日期：1996-01-01 00:00:00
abstract：:Retroplacental blood lymphocytes (RPL) obtained from women without complications at the term delivery were studied for proliferative response to mitogens and surface phenotype and were compared with autologous peripheral blood lymphocytes (PBL). Proliferation of RPL induced by phytohemagglutinin (PHA) was significantl...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90042-9
更新日期：1988-03-01 00:00:00
abstract：:Isolated inherited deficiency states of almost every complement protein have been recognized. Almost all are autosomal recessive traits. Deficiency of the early-acting components C1, C4 and C2 is associated with increased risk of immune complex disease, particularly systemic lupus erythematosus. Patients with deficien...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90098-8
更新日期：1987-02-01 00:00:00
abstract：:A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90021-0
更新日期：1986-11-17 00:00:00
abstract：:Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.12.002
更新日期：2006-05-15 00:00:00
abstract：BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...
journal_title：Immunology letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.imlet.2017.12.008
更新日期：2018-02-01 00:00:00
abstract：:It is well known that most physiological functions change with aging, including the immune response. Data concerning the aging of lymphocyte subpopulations are conflicting. The antigen density of peripheral blood lymphocytes has been determined by fluorescently tagged OKT-3, OKT-4, OKT-8, OKT-11 and OKM1 monoclonal an...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90072-x
更新日期：1990-02-01 00:00:00
abstract：:We have investigated the cellular responses of guinea-pig macrophages to human C4a. C4a induced a biphasic Ca2+ mobilization; a rapid temporary Ca2+ mobilization from intracellular Ca2+ pool followed by a weak Ca2+ influx of extracellular Ca2+. Although the C4a-treated macrophages did not respond again to C4a, that is...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90104-a
更新日期：1993-06-01 00:00:00
abstract：:Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.02.008
更新日期：2017-04-01 00:00:00
abstract：:Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)00043-5
更新日期：1995-05-01 00:00:00
abstract：:CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a 'primary' cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-92...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90127-4
更新日期：1982-01-01 00:00:00
abstract：:Circulating lymphocytes were enumerated in 25 patients with coeliac disease and in 24 healthy donors by immunofluorescent staining using monoclonal antibodies for T cell surface phenotypic markers T11 (mature), T4 (helper) and T8 (suppressor) or polyvalent antisera for surface immunoglobulins (B cells). Proportions of...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90119-7
更新日期：1986-08-01 00:00:00
abstract：:Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a mu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90115-4
更新日期：1985-01-01 00:00:00
abstract：:Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors. Co-aggregation of receptors is essential because BCR activated kinases must phosphorylate FcgammaRIIB to recruit SHIP and mediate inhibitory signals. Pre-B cells als...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2003.11.028
更新日期：2004-03-29 00:00:00
abstract：:It is well-established that chemokines play a critical role in the orchestration of inflammation and immunity. Interactions between chemokines and their receptors are essential for the homing of specific subsets of leukocytes to their functional microenvironments. They also influence other diverse biological processes...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.08.018
更新日期：2005-01-31 00:00:00
abstract：BACKGROUND AND PURPOSE:Polygonum orientale L. (family: Polygonaceae), named Hongcao in China, has effects of dispelling wind and dampness, promoting blood circulation, and relieving pain. Our group has already studied and confirmed that POEa and POEe (ethyl acetate and ethyl ether extract of P. orientale, respectively)...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.11.009
更新日期：2018-09-01 00:00:00
abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90194-f
更新日期：1991-07-01 00:00:00
abstract：:The induction of antigen (Ag)-specific tolerance is critical for the prevention of autoimmunity and maintenance of immune homeostasis. Recently, attention has been focused on induction of active suppression by regulatory T cells (Treg cells). Also, a role for dendritic cells (DCs) in the promotion of peripheral tolera...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2004.04.015
更新日期：2004-06-15 00:00:00
abstract：:Disease-modifying osteoarthritis (OA) therapy is not yet available. Several adjuvant therapies have demonstrated promising results in the treatment of OA. The present study aimed to investigate the therapeutic effects and underlying mechanisms of a combination of Lactobacillus acidophilus, vitamin B, and curcumin in t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.10.008
更新日期：2020-12-01 00:00:00
abstract：:The human immune system is a complex machinery involving numerous proteins. Proteins located at the cell surface of immune cells are of particular relevance due not only to their participation in the network of interactions that regulate the immune response but also to their potential as excellent targets for diagnost...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.09.016
更新日期：2011-01-30 00:00:00
