Selective induction of CD8+CD4- thymocyte apoptosis mediated by the B-subunit of Escherichia coli heat-labile enterotoxin.

abstract：:The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhib...

journal_title：Immunology letters

authors： Fábry Z,Erdei A,Gergely J

更新日期：1983-06-01 00:00:00

abstract：:Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...

journal_title：Immunology letters

authors： Tonevitsky AG,Rakhmanova VA,Agapov II,Shamshiev AT,Usacheva EA,Prokoph'ev SA,Denisenko ON,Alekseev YuO,Pfueller U

更新日期：1995-01-01 00:00:00

abstract：:Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in cancers, identification and synthesis of autoantibodies against specif...

journal_title：Immunology letters

authors： Iizuka A,Komiyama M,Oshita C,Kume A,Ashizawa T,Mitsuya K,Hayashi N,Nakasu Y,Yamaguchi K,Akiyama Y

更新日期：2014-05-01 00:00:00

abstract：:Adult T-cell leukemia-derived factor (ADF)/human thioredoxin (TRX) has thiol-dependent reducing activities and is known to have regulatory roles on the DNA-protein interaction and cell activation. Inducive effect of ultraviolet (UV) has been indicated because of the enhanced expression of ADF/TRX in epidermal cells of...

journal_title：Immunology letters

authors： Sachi Y,Hirota K,Masutani H,Toda K,Okamoto T,Takigawa M,Yodoi J

更新日期：1995-01-01 00:00:00

abstract：:Humans frequently produce serum IgM autoantibodies reactive with T-cell receptor beta chains at a determinant defined by peptides corresponding to the first complementarity determining region. It is likely that this determinant serves as a public idiotype involved in immunoregulation. Following screening of culture su...

journal_title：Immunology letters

authors： Dedeoglu F,Kaymaz H,Klein G,Marchalonis JJ

更新日期：1993-11-01 00:00:00

abstract：:A survey of the appearance of natural antibodies in C57BL/6 mice, measured by a complement-dependent cytotoxicity test against syngeneic radiation leukemia virus-induced lymphoma, was performed. Activity could be detected in sera from 5- to 14-month-old animals. This activity could be attributed mainly to IgM antibodi...

journal_title：Immunology letters

authors： Rubio N

更新日期：1981-10-01 00:00:00

abstract：:We have previously reported that the capacity of highly malignant B16BL6 murine melanoma cells to induce cell death in naive syngeneic lymphocytes stems from the absence of major histocompatibility complex (MHC) class I glycoproteins in these melanoma cells. Our present study provides evidence that the above-mentioned...

journal_title：Immunology letters

authors： Kellman-Pressman S,Fishman D,Tsory S,Segal S

更新日期：2005-09-15 00:00:00

abstract：:Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...

journal_title：Immunology letters

authors： Roitt IM,Cooke A

更新日期：1987-12-01 00:00:00

abstract：:The Nramp1 gene was originally described as Ity/Lsh/Bcg, a single gene controlling resistance and susceptibility of inbred mice to a range of intramacrophage pathogens. Functional studies demonstrated that Ity/Lsh/Bcg had multiple pleiotropic effects on macrophage activation pathways, broadening interest in the gene t...

journal_title：Immunology letters

authors： Blackwell JM,Searle S

更新日期：1999-01-01 00:00:00

abstract：:Adult B-acute lymphoblastic leukemia (B-ALL) does not share the favorable prognosis seen in pediatric patients with the same disease. Less than 50% of patients experience long-term survival and for those adults over age 60, long-term survival is only 10%. At time of relapse, 5-year prognosis is a dismal 7%. Novel and ...

journal_title：Immunology letters

authors： Sikaria S,Aldoss I,Akhtari M

更新日期：2016-04-01 00:00:00

abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...

journal_title：Immunology letters

authors： Santoni A,Arcuri E

更新日期：2020-10-01 00:00:00

abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...

journal_title：Immunology letters

authors： Fallah-Mehrjardi K,Mirzaei HR,Masoumi E,Jafarzadeh L,Rostamian H,Khakpoor-Koosheh M,Alishah K,Noorbakhsh F,Hadjati J

更新日期：2020-07-01 00:00:00

abstract：:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...

journal_title：Immunology letters

authors： Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis A

更新日期：1997-07-01 00:00:00

abstract：:The possibility of inducing immune responses to murine interleukin-4 (IL-4) and IL-13 and generating anti-cytokine monoclonal antibodies (mAbs) was studied in IL-4- and IL-13-knockout mice. The minimal doses of IL-4 or IL-13 that could induce significant anti-cytokine responses with titers of 5000-10,000 were 20 micro...

journal_title：Immunology letters

authors： Shichkin VP,Spivak NY

更新日期：2006-02-15 00:00:00

abstract：:The effect of oligosaccharides and C-terminal lysine residues on the thermal stability of a recombinant IgG(1) monoclonal antibody was investigated using differential scanning calorimetry (DSC). The C-terminal lysine did not appear to affect the thermal stability of this IgG(1) molecule. However, oligosaccharides, whi...

journal_title：Immunology letters

authors： Liu H,Bulseco GG,Sun J

更新日期：2006-08-15 00:00:00

abstract：:Accumulating evidence has demonstrated the importance of cytotoxic T lymphocytes (CTLs) and helper T lymphocytes in controlling HIV-1 replication. We have elicited immune responses in rhesus monkeys utilizing DNA vaccines augmented by the administration of IL-2/Ig, a fusion protein consisting of interleukin-2 and the ...

journal_title：Immunology letters

authors： Barouch DH,Fu TM,Montefiori DC,Lewis MG,Shiver JW,Letvin NL

更新日期：2001-11-01 00:00:00

abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...

journal_title：Immunology letters

authors： Lang K,Drell TL,Niggemann B,Zänker KS,Entschladen F

更新日期：2003-12-15 00:00:00

abstract：UNLABELLED:To study the pathogenic importance of the rheumatoid factor (RF) in rheumatoid arthritis (RA) and to identify genes differentially expressed in patients and healthy individuals, total RNA was isolated from peripheral blood mononuclear cells (PBMC) from eight RF-positive and six RF-negative RA patients, and s...

journal_title：Immunology letters

authors： Bovin LF,Rieneck K,Workman C,Nielsen H,Sørensen SF,Skjødt H,Florescu A,Brunak S,Bendtzen K

更新日期：2004-05-15 00:00:00

abstract：:The first step in the clearance of apoptotic cells is chemotactic migration of macrophages towards the apoptotic cells guided by find-me signals provided by the dying cells. Upon sensing the chemotactic signals, macrophages release ATP. ATP is then degraded to ADP, AMP and adenosine to trigger purinergic receptors con...

journal_title：Immunology letters

authors： Joós G,Jákim J,Kiss B,Szamosi R,Papp T,Felszeghy S,Sághy T,Nagy G,Szondy Z

更新日期：2017-03-01 00:00:00

abstract：:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces ...

journal_title：Immunology letters

authors： Kaslow DC,Kumar S

更新日期：1996-07-01 00:00:00

abstract：:Many details in the expression pattern of Epstein-Barr virus (EBV)-encoded proteins, their role in blast and growth transformation in infected B lymphocytes are known, but 'black holes' still exist. The two main types of virus-B lymphocyte interactions are denoted as Type I and Type III. These are characterized by the...

journal_title：Immunology letters

authors： Klein E,Teramoto N,Gogolák P,Nagy N,Björkholm M

更新日期：1999-05-03 00:00:00

abstract：:In addition to expressing inhibitory cytokines and suppressive molecules, Treg cells could downplay inflammation by releasing cytotoxic molecules and eliminating proinflammatory immune cells. Colorectal cancer (CRC) is a common malignancy that has led to many cancer-related deaths. In this study, we investigated the c...

journal_title：Immunology letters

authors： Sun B,Liu M,Cui M,Li T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to...

journal_title：Immunology letters

authors： Liu Y,Ye S,Guo X,Li W,Xia Y,Wen X,Yu J,Jia Y,Liu X,Guo Y,Zhao Y

更新日期：2020-04-01 00:00:00

abstract：:While the cytoskeletal protein talin binds to the β-chain of LFA-1, the immune cell adaptor SKAP1 (SKAP-55) binds to the α-chain of the same integrin via RapL. Whereas calpain protease cleavage of talin is important for LFA-1 activation, it has been unclear whether SKAP1 can alter the function of talin or its associat...

journal_title：Immunology letters

authors： Lim D,Lu Y,Rudd CE

更新日期：2016-04-01 00:00:00

abstract：:The thymus contains a low frequency of B cells, about 0.1-0.5% of total population of thymocytes that were shown to contribute in thymic negative selection. The fact that B cells in the periphery have been contributed in the generation of the T regulatory cell compartment emerged the idea that this process may indeed ...

journal_title：Immunology letters

authors： Mohammed Ali HH,Drela N

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...

journal_title：Immunology letters

authors： Yen JH,Tsai WC,Chen CJ,Lin CH,Ou TT,Hu CJ,Liu HW

更新日期：2003-08-05 00:00:00

abstract：:A375 human melanoma cell cultures grown in the presence of TGF beta contained greatly reduced cell numbers and exhibited drastic alterations in cell morphology compared to the control cultures. Preincubation of the cells with the cytokine for only 18 h was sufficient to induce these changes irreversibly. Examination o...

journal_title：Immunology letters

authors： Larisch-Bloch S,Yarom R,Sulitzeanu D

更新日期：1992-07-01 00:00:00

abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...

journal_title：Immunology letters

authors： Lanchbury JS

更新日期：1991-07-01 00:00:00

abstract：:Liposome-encapsulated conalbumin (L(conalbumin)) is an antigen that is efficiently phagocytosed by bone marrow-derived macrophages and presented to effector cells as part of the major histocompatibility complex (MHC) class I complex. In this report, we show that the conalbumin component of L(conalbumin) is degraded to...

journal_title：Immunology letters

authors： Rothwell SW,Wassef NM,Alving CR,Rao M

更新日期：2000-10-03 00:00:00

abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...

journal_title：Immunology letters

authors： Thomson AW,Brown PA,Simpson JG,Whiting PH,Davidson RJ

更新日期：1985-01-01 00:00:00