Abstract:
:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces cerevisiae the 19-kDa a carboxy-terminus of Pv200 as a His6-tagged, secreted polypeptide. Five of seven H-2 congenic mouse strains elicited antibodies that recognized yeast produced PV200(19) by ELISA. The vaccine appears to be immunogenic and widely recognized, and to contain one or more helper T cell epitopes that may allow boosting with subsequent natural infections.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Kaslow DC,Kumar Sdoi
10.1016/0165-2478(96)02570-9subject
Has Abstractpub_date
1996-07-01 00:00:00pages
187-9issue
3eissn
0165-2478issn
1879-0542pii
0165247896025709journal_volume
51pub_type
杂志文章abstract::A docile substrain of lymphocytic choriomeningitis virus (LCMV) causes a persistent infection in adult C3HeB mice and induces a severe autoimmune hemolytic anemia (AIHA) which is maximal around three weeks post infection (PI). Evaluations of serum immunoglobulin levels of these mice demonstrated grossly elevated IgG2a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90126-9
更新日期:1992-02-15 00:00:00
abstract::In the current study, the possible association of positivity (POS), recently defined as general disposition to view life under positive outlook, with immune markers and post-stress modifications, was analyzed. Circulating lymphocyte subsets and serum cytokine levels were evaluated before and after a standard mild acut...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.05.012
更新日期:2017-08-01 00:00:00
abstract::The expression level of complement regulators in ovarian and corpus uteri tumors was not fully established so far. In current manuscript we performed gene expression analysis by the real-time PCR approach to investigate both membrane bound - CD55 and CD59 and fluid phase - factor H and factor H-like 1 complement regul...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.06.017
更新日期:2015-10-01 00:00:00
abstract::Classical swine fever (CSF) and pseudorabies (PR) are both major infectious diseases of pigs, causing enormous economic losses to the swine industry in many countries. A marker vaccine that enables differentiation of infected from vaccinated animals (DIVA) is highly desirable for control and eradication of these two d...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.04.014
更新日期:2016-06-01 00:00:00
abstract::In this study the effect of PHA activation on the phosphatase activity of CD45 has been investigated in human leukemic T-cell lines. It has been found that in vivo activation of the cells with PHA resulted in 2-4-fold increase in enzyme activity. Addition of PHA to the postnuclear supernatant of cell lysates also resu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90086-8
更新日期:1994-10-01 00:00:00
abstract::SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90102-1
更新日期:1986-03-01 00:00:00
abstract::Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00034-5
更新日期:1997-07-01 00:00:00
abstract::This article has been withdrawn at the request of the authors and Guest Editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.09.015
更新日期:2009-10-04 00:00:00
abstract::Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00010-x
更新日期:2002-05-01 00:00:00
abstract::Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90037-3
更新日期:1984-01-01 00:00:00
abstract::The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2009.12.009
更新日期:2010-05-04 00:00:00
abstract::Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.10.011
更新日期:2016-12-01 00:00:00
abstract::The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90085-3
更新日期:1984-01-01 00:00:00
abstract::Six hybridomas secreting monoclonal antibodies directed against human fetal liver metallothioneins (MTs) have been generated and characterized. One antibody, K5A6, was specific for MT-1, the others recognized all isoMTs present in the human fetal liver. Each of these antibodies showed a unique cross-reactivity pattern...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90193-r
更新日期:1992-03-01 00:00:00
abstract::Mimotopes derived from peptide phage display libraries may reproduce basic functions of epitopes including their antigenicity. In case of toxins, this property makes phage displayed mimotopes highly specific vaccine components free of the toxicity. To explore the potential of mimotopes for vaccine development, their a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00320-0
更新日期:2002-02-01 00:00:00
abstract::Two crucial mediators of monocyte activation by lipopolysaccharide (LPS) are the acute phase plasma factor, lipopolysaccharide binding protein (LBP) and cell-surface-expressed CD14. Whether macrophage (M phi) recognized and respond to LPS in a similar manner is unknown. Here we show that human monocyte-derived M phi r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02645-4
更新日期:1996-12-01 00:00:00
abstract::Maturation of dendritic cells is a key step during induction of adaptive immune responses. Multiple pathways and factors are involved in the regulation of dendritic cell maturation. Alternative splicing of pre-mRNA, which is regulated by splicing factors, plays an important role in many biological processes, including...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.06.004
更新日期:2013-06-01 00:00:00
abstract::Within the 3' end of nucleotide sequence of human adult T-cell leukaemia virus (ATLV) four small open frames in various phases were found previously. The frames code for 10,000-, 11,000-, 12,000- and 27,000-dalton polypeptides, one of which can be responsible for virus transforming activity. By means of methods of pre...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90093-9
更新日期:1987-01-01 00:00:00
abstract::Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.014
更新日期:2014-12-01 00:00:00
abstract::Linoleic and arachidonic acid concentrations in neutrophils from rats maintained on a diet with only 0.3% of the energy content as essential fatty acid (EFA, EFAD group) were reduced by 70 +/- 2.2% and 34.8 +/- 5.2%, respectively, compared with controls fed a diet with a normal 3% EFA content. Neutrophil chemiluminesc...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90053-2
更新日期:1986-10-01 00:00:00
abstract::Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors. Co-aggregation of receptors is essential because BCR activated kinases must phosphorylate FcgammaRIIB to recruit SHIP and mediate inhibitory signals. Pre-B cells als...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.11.028
更新日期:2004-03-29 00:00:00
abstract::When human peripheral blood lymphocytes (PBL) are cultured with either concanavalin A (Con A)-treated or control autologous T lymphocytes, the mitogenic responses of the PBL co-cultured with Con A-treated cells are much lower. We have investigated the cell surface receptor changes during culture of T cells with and wi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90031-2
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Integrin αvβ6 can convert the transforming growth factor (TGF)-β precursor to the mature form. Resiquimod (R848) can generate TGF-β-producing regulatory T cells (Treg). Thus, to concurrent administration of specific antigen and R848 may generate antigen-specific Tregs, that is expected to restore immune tole...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.12.011
更新日期:2021-02-01 00:00:00
abstract::The effect of ageing on thymocyte progenitors in the bone marrow was studied in an in vitro experimental model that permits T lymphocyte development. The model is based on co-culture of BM cells from young and old mice with lymphoid depleted fetal thymus explants. We applied different strategies of thymic colonization...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)00059-x
更新日期:1994-06-01 00:00:00
abstract::Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...
journal_title:Immunology letters
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract::Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.06.015
更新日期:2014-11-01 00:00:00
abstract::Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages. In this report we have examined the effect of the in vivo administration of adrenaline on TNF serum levels induced by LPS. In agre...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90177-4
更新日期:1993-10-01 00:00:00
abstract::Rabbit anti-ovalbumin antibodies were found to bind to Swiss NIH 3T3 fibroblasts by indirect immunofluorescence, and to induce DNA synthesis when these cells were arrested in G0 phase of their replicating cycle (G0-S activity). The proof that these effects were related to the ovalbumin paratopes is based on the follow...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90069-1
更新日期:1987-05-01 00:00:00
abstract::In the present investigations we aimed to study the effect of Shigella sonnei lipopolysaccharide (LPS) on delayed type hypersensitivity (DTH) to non-bacterial antigen in CBA mice. These experiments showed that intraperitoneal injection of phenol-water extracted LPS and avirulent S. sonnei did not affect the level of D...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00298-x
更新日期:2002-01-01 00:00:00
abstract::Two of the better characterized antimicrobial mechanisms displayed by human neutrophils are the reactive oxygen species (ROS) production and the induction of apoptosis. Their importance in mycobacterial infections is, however, controversial and we aimed to analyze them simultaneously in neutrophils infected with eithe...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.07.006
更新日期:2009-09-22 00:00:00