Expression and immunogenicity of the C-terminus of a major blood-stage surface protein of Plasmodium vivax, Pv200(19), secreted from Saccharomyces cerevisiae.

Abstract:

:The carboxy-terminus of the major merozoite surface protein of Plasmodium has been shown to be the target of protective immunity in a number of non-vivax malaria parasite species. In an effort to develop a protective vaccine for Plasmodium vivax, the most prevalent form of human malaria, we expressed in Saccharomyces cerevisiae the 19-kDa a carboxy-terminus of Pv200 as a His6-tagged, secreted polypeptide. Five of seven H-2 congenic mouse strains elicited antibodies that recognized yeast produced PV200(19) by ELISA. The vaccine appears to be immunogenic and widely recognized, and to contain one or more helper T cell epitopes that may allow boosting with subsequent natural infections.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Kaslow DC,Kumar S

doi

10.1016/0165-2478(96)02570-9

subject

Has Abstract

pub_date

1996-07-01 00:00:00

pages

187-9

issue

3

eissn

0165-2478

issn

1879-0542

pii

0165247896025709

journal_volume

51

pub_type

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