Abstract：
:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters, including NK cell cytotoxicity, and the migration of NK cells and CTL within a three-dimensional collagen lattice. Using peripheral blood CTL and NK cells, we show that the neurotransmitters endorphin, histamine and substance P increase NK cell cytotoxicity, while norepinephrine inhibits cytotoxicity. Moreover, substance P reduces migratory activity, while norepinephrine increases NK cell and CTL migration. Furthermore, all three steroid hormones which were investigated, namely cortisone, testosterone, and estradiol, had regulatory influence on both cytotoxicity and migration of NK cells. These results further specify the functional basis of the complex interconnection between the immune and neuro-endocrine systems.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Lang K,Drell TL,Niggemann B,Zänker KS,Entschladen Fdoi
10.1016/j.imlet.2003.09.004subject
Has Abstractpub_date
2003-12-15 00:00:00pages
165-72issue
2-3eissn
0165-2478issn
1879-0542pii
S0165247803002190journal_volume
90pub_type
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journal_title：Immunology letters
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2009-04-27 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.09.007
更新日期：2015-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(93)90028-z
更新日期：1993-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.03.012
更新日期：2017-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)02712-0
更新日期：1997-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90048-9
更新日期：1986-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90128-w
更新日期：1991-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00243-2
更新日期：2003-02-03 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(97)00153-3
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journal_title：Immunology letters
pub_type： 杂志文章
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1994-07-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.02.011
更新日期：2005-07-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90004-8
更新日期：1992-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.08.028
更新日期：2017-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2009.12.009
更新日期：2010-05-04 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90048-3
更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.07.017
更新日期：2014-12-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.10.008
更新日期：2012-01-30 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.11.018
更新日期：2006-04-15 00:00:00
abstract：BACKGROUND:Dendritic cells (DCs) are professional antigen-presenting cells that are capable of inducing immune responses. DC-based vaccines are normally generated using a standard 5- to 7-day protocol. To shorten the DC-based vaccine production for use in cancer immunotherapy, we have developed a fast DC protocol by co...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.03.010
更新日期：2014-07-01 00:00:00
