Abstract:
:Regulated upon activation normal T expressed and secreted (RANTES) is a new inducible protein member of the human C-C branch of chemokines. RANTES is a potent monocyte and lymphocyte chemoattractant and is a mediator of inflammatory responses. In these studies we found that RANTES 10 ng/50 microl chemoattracts basophilic cells in a dose-dependent manner 4 h after an intradermal injection in rat skin sites, as revealed by optic microscopy. Moreover, in biopsy specimens from rat skin injection sites histamine release was significantly higher (P < 0.05) than in controls (PBS 50 microl) after 4 h from RANTES treatment. The presence of basophilic cells in rat skin injection sites after RANTES-treatment was also confirmed by electron microscopy studies. In addition, histidine decarboxylase (HDC) mRNA was increased in rat skin sites injected with RANTES compared to sites injected with PBS (controls). Our report describes additional biological activities for RANTES, suggesting that this human chemoattractant protein may play a fundamental role in histamine and HDC generation, along with basophilic cell recruitment.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Conti P,Reale M,Barbacane RC,Frydas S,Felaco M,Grilli A,Placido FC,Cataldo I,Feliciani C,Di Gioacchino M,Anogianakis G,Dimitriadou D,Vacalis D,Trakatellis Adoi
10.1016/s0165-2478(97)00034-5subject
Has Abstractpub_date
1997-07-01 00:00:00pages
101-6issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(97)00034-5journal_volume
58pub_type
杂志文章abstract::Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90008-c
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02655-7
更新日期:1996-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90198-8
更新日期:1994-04-01 00:00:00
abstract::The production of neutralizing antibodies against the central portion of HIV-1 gp120 requires cooperation between T cell and B cell epitopes of this region. We found a motif common to the carboxyterminus of the second conserved region of HIV-1 gp120 and sequences of some human proteins, most of which participate in im...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90145-g
更新日期:1990-11-01 00:00:00
abstract::The basic functions of the immune system are protection from pathogens and maintenance of tolerance to self. The maintenance of commensal microbiota at mucosal surfaces adds a layer of complexity to these basic functions. Recent reports suggest follicular helper T cells (Tfh), a CD4(+) T cell subset specialized to pro...
journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
abstract::Retroplacental blood lymphocytes (RPL) obtained from women without complications at the term delivery were studied for proliferative response to mitogens and surface phenotype and were compared with autologous peripheral blood lymphocytes (PBL). Proliferation of RPL induced by phytohemagglutinin (PHA) was significantl...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90042-9
更新日期:1988-03-01 00:00:00
abstract::The regulatory effect of Z-100 on the balance of Th1/Th2 cell responses in BALB/c mice bearing Meth-A fibrosarcoma was investigated. In tumor bearing mice, Th1 cytokine production (IL-2, IFN-gamma) are suppressed and Th2 cytokine production (IL-4, IL-10) are increased, as compared with those of normal mice. The admini...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00130-3
更新日期:1999-11-01 00:00:00
abstract::Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.12.002
更新日期:2006-05-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2003-01-02 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1986-11-17 00:00:00
abstract::The experimental infection of macaques with simian immunodeficiency virus (SIV) has provided strong evidence that it may be possible to develop a vaccine against AIDS. Live attenuated SIV vaccines have been found to confer the most potent protection against challenge with a variety of pathogenic viruses. This article ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(98)00153-9
更新日期:1999-03-01 00:00:00
abstract:BACKGROUND:Omalizumab therapy was found to be safe and effective as an add-on therapy for patients with poorly controlled severe asthma. Although several studies over the last decade have demonstrated its efficacy in other Immunoglobulin E related diseases, its use in such conditions is off-label. OBJECTIVE:This study...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.08.002
更新日期:2020-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.imlet.2012.12.001
更新日期:2013-01-01 00:00:00
abstract::Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.05.002
更新日期:2013-05-01 00:00:00
abstract::In order to directly demonstrate the roles of CD8(+) T lymphocytes in non-human primates, in vivo depletion of the CD8(+) T cells by administration of a CD8-specific monoclonal antibody (mAb) is one of the crucial techniques. Recently, the common marmoset (Callithrix jacchus), which is classified as a New World monkey...
journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2013-07-01 00:00:00
abstract::Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.05.001
更新日期:2014-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.05.013
更新日期:2005-11-15 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2001-09-03 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:2003-01-02 00:00:00
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pub_type: 杂志文章
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journal_title:Immunology letters
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更新日期:2015-08-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:2020-06-01 00:00:00
abstract::Differentiation between a non-infective and an infective Leishmania promastigote population was demonstrated. Promastigotes in the stationary phase (day 5) were found to be highly infective in vitro to BALB/c mouse peritoneal macrophages, compared with those of the logarithmic phase (day 3). The infective promastigote...
journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1997-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90074-2
更新日期:1981-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90040-8
更新日期:1983-01-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90086-7
更新日期:1988-02-01 00:00:00
abstract::We studied CD10 Ag of neutral endopeptidase (NEP) and CD13 Ag of aminopeptidase N (APN) expression on peripheral blood mononuclear cells (PBMC) as cells activation markers and for their transendothelial migration properties in three groups of MS patients (total 58); with acute exacerbation of MS (n = 18), primary prog...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00176-5
更新日期:2000-02-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.12.014
更新日期:2014-05-01 00:00:00