Abstract：
:Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, anti-FMD virus antibody was measured at 14 and 28 days post-vaccination. Although IL-1 could enhance the response against the virus antigen, in particular when administered 24 h before the vaccine, this was not as strong as that obtained when MDP was adjuvant. In contrast, IL-2 was at least as efficient as MDP when applied concomitantly with the antigen. If the IL-2 treatment preceded the vaccination by 24 h, a diminution in the magnitude of the response was seen; however, this was countered by the fact that 10 times less IL-2 was required, compared with concomitant cytokine/vaccine administration, in order to have the maximum effect. When both IL-1 and IL-2 were used together, an even greater enhancement of the immune response against FMD virus antigen was observed, but only when given concomitantly with the antigen. These results demonstrate the relevance of T lymphocyte growth factors to the immune response against FMD virus, and how current immunological and biotechnological knowledge could be applied to the improvement of adjuvant systems in a chemically and biologically defined manner.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
McCullough KC,Pullen L,Parkinson Ddoi
10.1016/0165-2478(92)90008-csubject
Has Abstractpub_date
1992-01-01 00:00:00pages
41-6issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(92)90008-Cjournal_volume
31pub_type
杂志文章abstract：:The monoclonal antibody (mAb) AHT-107 recognized a determinant distal to the interleukin 2 (IL-2) binding site on the p55 subunit of the IL-2 receptor (IL-2R) (the Tac antigen, CD25) of human T lymphoblasts, while the mAb AHT-54 recognized a determinant close to the IL-2 binding site as did the anti-Tac. The AHT-107 i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(89)90081-3
更新日期：1989-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90158-7
更新日期：1991-03-01 00:00:00
abstract：:Serum obtained from mice infected with Trypanosoma cruzi have antibodies able to induce immune lysis in presence of complement. Gel filtration in Sephadex G-200 and affinity chromatography with rabbit anti-mouse IgG and protein A-Sepharose showed that the antibodies responsible for the immune serum lytic activity are ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90040-8
更新日期：1983-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90002-5
更新日期：1982-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
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更新日期：1985-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
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更新日期：2005-03-15 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90056-3
更新日期：1987-10-01 00:00:00
abstract：:Recent data have shown that piperlongumine (PL), an important component of Piper longum fruits, is known to possess anti-inflammatory and vascular-protective activities. This study aimed to examine the therapeutic effects and underlying mechanisms of PL on lupus-prone MRL-Fas(lpr) mice. Female MRL-Fas(lpr) mice were i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2014.05.001
更新日期：2014-09-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(94)00202-3
更新日期：1995-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00123-6
更新日期：1999-10-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.12.014
更新日期：2014-05-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2015.12.004
更新日期：2016-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(95)02440-9
更新日期：1995-11-01 00:00:00
abstract：:During their differentiation, thymocytes are subjected to two rounds of selection. First, CD4-8- double-negative (DN) thymocytes with a functional TCR-beta chain express a alpha-beta+ CD3 complex on their surface and, as a consequence, are selected to mature to the CD4+8+ double-positive (DP) stage. This round ends af...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)00197-y
更新日期：1995-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.05.011
更新日期：2006-08-15 00:00:00
abstract：:As the most common non-traumatic disabling disease among adolescents, multiple sclerosis (MS) is a devastating neurological inflammatory disease of the central nervous system. Research has not yet fully elucidated its pathogenesis, but it has shown MS to be a complex, multifactorial disease with many interplaying fact...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.02.012
更新日期：2020-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00235-8
更新日期：2001-09-03 00:00:00
abstract：:This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
journal_title：Immunology letters
pub_type： 撤回出版物
doi：10.1016/j.imlet.2017.08.015
更新日期：2017-08-26 00:00:00
abstract：:Mechanistic target for rapamycin (mTOR) is a serine/threonine protein kinase that forms two distinct complexes mTORC1 and mTORC2, integrating mitogen and nutrient signals to regulate cell survival and proliferation; processes which are commonly deregulated in human cancers. mTORC1 and mTORC2 have divergent molecular a...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2018.01.015
更新日期：2018-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90049-1
更新日期：1988-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00340-6
更新日期：2002-04-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.12.011
更新日期：2021-02-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(83)90063-9
更新日期：1983-01-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.04.009
更新日期：2010-08-16 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90102-1
更新日期：1986-03-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2012.01.001
更新日期：2012-02-29 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90035-0
更新日期：1986-06-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90127-6
更新日期：1986-08-01 00:00:00
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journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2019.06.001
更新日期：2019-08-01 00:00:00
abstract：:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constit...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2016.07.004
更新日期：2016-11-01 00:00:00
