HIV and human complement: inefficient virolysis and effective adherence.

Abstract:

:Both, HIV envelope proteins gp120 and gp41 can directly activate complement system, even in the absence of HIV-specific antibodies. During the budding process HIV acquires host membrane-associated molecules among these complement regulatory proteins (CRPs). The presence of CRPs on the viral surface rescues HIV from complement-mediated virolysis. The inefficient virolysis results in the deposition of complement-fragments on the viral surface allowing interactions of HIV with complement receptor expressing cells. In this review, the interaction of HIV with the complement system and the consequences of complement opsonisation on virus infection will be discussed.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Bánki Z,Stoiber H,Dierich MP

doi

10.1016/j.imlet.2004.11.007

subject

Has Abstract

pub_date

2005-03-15 00:00:00

pages

209-14

issue

2

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(04)00312-8

journal_volume

97

pub_type

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