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Innate lymphoid cells, precursors and plasticity.

Abstract：

:Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world. It is currently hypothesized that ILCs constitute an evolutionary older version of the lymphoid immune system. They are found at all primary entry points for pathogens such as mucosal surfaces of the lung and gastrointestinal system, the skin and the liver, which is the central contact point for pathogens that breach the intestinal barrier and enter the circulation. There, ILC contribute to the first line defense as well as to organ homeostasis. However, ILC are not only involved in classical defense tasks, but also contribute to the organogenesis of lymphoid organs as well as tissue remodeling and even stem cell regeneration. ILC may, therefore, implement different functions according to their emergence in ontogeny, their development and their final tissue location. We will review here their early development from precursors of the fetal liver and the adult bone marrow as well as their late plasticity in adaptation to their environment.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Gronke K,Kofoed-Nielsen M,Diefenbach A

doi

10.1016/j.imlet.2016.07.004

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

9-18

eissn

0165-2478

issn

1879-0542

pii

S0165-2478(16)30113-4

journal_volume

179

pub_type

杂志文章,评审

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