The effect of T cell independent and cross-reactive antigen on the immune response to pneumococcal conjugate vaccination.

abstract：:Sequence-comparison indicates existing sequence-similarity between receptor-binding regions of human type 1 IFNs (IFN-alpha, -beta and -omega) and HIV-1 gp41. Previous findings had suggested that the increased levels of antibodies against human IFN-alpha and -beta in HIV-1-infected individuals are associated with a co...

journal_title：Immunology letters

authors： Chen YH,Wu W,Yang J,Sui SF,Sun J,Dierich MP

更新日期：1999-08-03 00:00:00

abstract：:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...

journal_title：Immunology letters

authors： Harfst E,Andersson J,Grawunder U,Ceredig R,Rolink AG

更新日期：2005-11-15 00:00:00

abstract：:This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in pa...

journal_title：Immunology letters

authors： Petrasca A,Melo AM,Breen EP,Doherty DG

更新日期：2018-04-01 00:00:00

abstract：:Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three...

journal_title：Immunology letters

authors： Herrera-Maya G,Vargas-Alarcon G,Ramirez-Bello J,Perez-Mendez O,Posadas-Sanchez R,Lopez-Marure R,Granados J,Nieto-Lima B,Fragoso JM

更新日期：2020-12-01 00:00:00

abstract：:Parenteral administration of antigen induces in the earthworms Lumbricus terrestris and Eisenia foetida the formation of antigen-binding protein. Labelled antigen was efficiently digested in the coelomic fluids of both species since the total amount of radioactivity in the coelomic fluids decreased. Antigen internaliz...

journal_title：Immunology letters

authors： Rejnek J,Tucková L,Síma P,Bilej M

更新日期：1993-05-01 00:00:00

abstract：:The human homologue of 4-1BB (H4-1BB) cDNA was isolated from PMA plus ionomycin-treated human peripheral T-cell cDNA libraries. The amino acid sequence deduced from the nucleotide sequence showed that the protein is composed of 255 amino acids with 2 potential N-linked glycosylation sites. The molecular weight of its ...

journal_title：Immunology letters

authors： Zhou Z,Kim S,Hurtado J,Lee ZH,Kim KK,Pollok KE,Kwon BS

更新日期：1995-02-01 00:00:00

abstract：:Based on the cerebral malaria coma scale, 39 falciparum malaria autopsy cases from the Hospital for Tropical Diseases, Mahidol University, Bangkok, Thailand were divided into two groups of patients that had either cerebral malaria or non-cerebral malaria. We then studied significant pathological differences, such as p...

journal_title：Immunology letters

authors： Riganti M,Pongponratn E,Tegoshi T,Looareesuwan S,Punpoowong B,Aikawa M

更新日期：1990-08-01 00:00:00

abstract：:Tumor cells express a range of antigens including self-antigens (those whose expression is shared by normal host tissue) and non-self antigens (such as those that arise as a result of mutations in normal cellular genes or in the case of some tumors, viral antigens). Immune responses to both types of antigen have been ...

journal_title：Immunology letters

authors： Jones E,Dahm-Vicker M,Golgher D,Gallimore A

更新日期：2003-01-22 00:00:00

abstract：:After exposure to a concanavalin A (Con A)-unreactive variant of alpha 1-acid glycoprotein (AGP), macrophages released an inhibitor of interleukin-1 (IL-1) proliferative activity in the thymocyte comitogenic assay. This effect was observed with AGP concentrations above 100 micrograms/ml in the macrophage supernatant a...

journal_title：Immunology letters

authors： Bories PN,Kodari E,Feger J,Rouzeau JD,Agneray J,Durand G

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether the concentrations of serum tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, increased in type 2 diabetes mellitus (T2DM) and type 2 diabetic nephropathy (T2DN) patients. METHODS:The four databases (PubMed, CNKI, WanFang and Chinese-Cqvip) were s...

journal_title：Immunology letters

authors： Chen YL,Qiao YC,Xu Y,Ling W,Pan YH,Huang YC,Geng LJ,Zhao HL,Zhang XX

更新日期：2017-06-01 00:00:00

abstract：:Crosslinking of the B-cell receptor (BCR) for antigen to low-affinity receptors for IgG (Fc gamma RII) inhibits B-cell activation induced by BCR aggregation. The cell-triggering properties of the BCR depend on tyrosine-containing activation motifs (TAM), in the intracytoplasmic domain of its Ig alpha and Ig beta subun...

journal_title：Immunology letters

authors： Daëron M,Malbec O,Latour S,Espinosa E,Pina P,Fridman WH

更新日期：1995-01-01 00:00:00

abstract：:Tumor cells have been used as the tumor antigen sources for developing cancer vaccines. Due to their low immunogenicity, tumor antigens are combined with various adjuvants to enhance immunogenicity of cancer vaccines. Among them, a natural killer T cell (NKT)-ligand, α-galactosylceramide (αGC) has been reported as a p...

journal_title：Immunology letters

authors： Hong S,Lee H,Jung K,Lee SM,Lee SJ,Jun HJ,Kim Y,Song H,Bogen B,Choi I

更新日期：2013-11-01 00:00:00

abstract：:Linoleic and arachidonic acid concentrations in neutrophils from rats maintained on a diet with only 0.3% of the energy content as essential fatty acid (EFA, EFAD group) were reduced by 70 +/- 2.2% and 34.8 +/- 5.2%, respectively, compared with controls fed a diet with a normal 3% EFA content. Neutrophil chemiluminesc...

journal_title：Immunology letters

authors： Gyllenhammar H,Ringertz B,Becker W,Svensson J,Palmblad J

更新日期：1986-10-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...

journal_title：Immunology letters

authors： Schiött A,Sjögren HO,Lindvall M

更新日期：2000-06-01 00:00:00

abstract：:Dendritic cell (DC)-based tumor vaccine is a promising therapy for malignancies. Recent studies showed greater potency with DC/tumor fusion vaccines against acute myeloid leukemia and melanoma compared with lysate-pulsed DC vaccines. We compared these two vaccine strategies against murine colon cancer and investigated...

journal_title：Immunology letters

authors： Kao JY,Zhang M,Chen CM,Chen JJ

更新日期：2005-11-15 00:00:00

abstract：:Granulomatous inflammation around parasite eggs is the prominent lesion in human schistosomiasis. Studies have suggested the involvement of a series of suppressive mechanisms in the control of this reaction, such as macrophages, cytokines, idiotypic interactions and immune complexes (IC). The studies examine the role ...

journal_title：Immunology letters

authors： Rezende SA,Gollob KJ,Correa-Oliveira R,Goes AM

更新日期：1998-06-01 00:00:00

abstract：:The question is still unresolved whether in insulin-dependent (type I) diabetes T-lymphocytes mediate an autoimmune response towards pancreatic islets. We now present direct evidence in an animal model for autoimmune T-lymphocytes with specificity for islet antigens. Mice of strain C57BL/6 were immunized repeatedly wi...

journal_title：Immunology letters

authors： Kolb H,Ben-Nun A,Cohen IR,Barberena I,Kiesel U

更新日期：1985-01-01 00:00:00

abstract：:Wistar rats submitted to 3 intravenous (i.v.) or intraperitoneal (i.p.) immunizations with saline extract of rat male accessory glands (RAG) associated to liposomes developed a delayed type hypersensitivity (DTH) response to RAG after the first immunization, a remission state after the second immunization and a specif...

journal_title：Immunology letters

authors： Correa SG,Riera CM

更新日期：1991-04-01 00:00:00

abstract：:Abnormal activation of the transcriptional factor STAT3 (signal transducer and activator of transcription 3) was recently associated with Alzheimer Disease (AD). STAT3 phosphorylation is critical for cytokine secretion linked to neuroinflammation. Moreover, STAT3 may act as a transcriptional regulator of BACE1 (β-APP ...

journal_title：Immunology letters

authors： Millot P,San C,Bennana E,Porte B,Vignal N,Hugon J,Paquet C,Hosten B,Mouton-Liger F

更新日期：2020-12-01 00:00:00

abstract：:Screening of expression cDNA libraries derived from human neoplasms with autologous sera (SEREX) is an established method for defining antigens immunogenic in individual cancer patients. Although the majority of SEREX-derived cDNA clones encode autoantigens, some of them represent shared cancer antigens with cancer-re...

journal_title：Immunology letters

authors： Lagarkova MA,Koroleva EP,Kuprash DV,Boitchenko VE,Kashkarova UA,Nedospasov SA,Shebzukhov YV

更新日期：2003-01-02 00:00:00

abstract：:In the following study we have analyzed cytokine secretion of T-cells of suicidal and non-suicidal depressed patients and healthy controls. It was found that T-cells of suicidal depressed patients have Th1 characteristics, while T-cells of non-suicidal depressed patients have Th2 characteristics. Th1 environment is as...

journal_title：Immunology letters

authors： Mendlovic S,Mozes E,Eilat E,Doron A,Lereya J,Zakuth V,Spirer Z

更新日期：1999-04-01 00:00:00

abstract：:The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradati...

journal_title：Immunology letters

authors： Tucková L,Bilej M

更新日期：1994-07-01 00:00:00

abstract：:Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a mu...

journal_title：Immunology letters

authors： Yoshie O,Wada J,Ishida N

更新日期：1985-01-01 00:00:00

abstract：:The spontaneous migration in vitro, production of T cell migration inhibitory factor (TIF) and the response to TIF of OKT4+ and OKT8+ human T cell subsets were studied. The OKT4+ lymphocytes migrated far better than the OKT8+ cells although the movement of both subsets was comparably inhibited by TIF. The OKT8+ subset...

journal_title：Immunology letters

authors： Kowalczyk D,Pryjma J,Zembala M

更新日期：1986-08-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) is an attractive target for the treatment of epithelial cancers. However, EGFR antagonists have low clinical response rates and frequently induce resistance mainly caused by the hypermutation of the extracellular and intracellular domains and the heterodimerization of EGFR. Dime...

journal_title：Immunology letters

authors： Guo T,Zhao L,Zhang Y,Liu G,Yao Y,Li H

更新日期：2016-12-01 00:00:00

abstract：:Four murine monoclonal antibodies (mAbs) showing similar reactivity with a cell-wall extract and mannan preparation obtained from Candida albicans were examined for epitope specificity. An enzyme-linked immunosorbent assay (ELISA) was used to determine total mAb binding to extracted cell-wall antigen when each mAb was...

journal_title：Immunology letters

authors： Chaffin WL,Morrow KJ Jr

更新日期：1989-07-01 00:00:00

abstract：:Multiple activation signals (including antigen, co-stimulation, and cytokines) during T-cell priming affect the subsequent generation of memory T cells, whose survival is maintained by IL-7 and IL-15. Since the IL-7 receptor is highly expressed not only on the surface of memory T cells but also on naïve T cells, we pr...

journal_title：Immunology letters

authors： Guo Z,Wang G,Miyahara Y,Khattar M,Linkes SP,Wang C,Xia J,Pan Y,Chen W,He X,Stepkowski SM

更新日期：2010-02-16 00:00:00

abstract：:B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...

journal_title：Immunology letters

authors： Matesanz-Isabel J,Sintes J,Llinàs L,de Salort J,Lázaro A,Engel P

更新日期：2011-01-30 00:00:00

abstract：:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

journal_title：Immunology letters

authors： Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

更新日期：2003-01-02 00:00:00

abstract：:A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...

journal_title：Immunology letters

authors： Fernan A,Burrows SR,Moss DJ,Saul A,Suhrbier A

更新日期：1991-11-01 00:00:00