Abstract：
:Tumor cells have been used as the tumor antigen sources for developing cancer vaccines. Due to their low immunogenicity, tumor antigens are combined with various adjuvants to enhance immunogenicity of cancer vaccines. Among them, a natural killer T cell (NKT)-ligand, α-galactosylceramide (αGC) has been reported as a powerful adjuvant showing therapeutic effects in solid tumors as well as hematological malignancies including lymphoma. In this study, we applied αGC-based tumor cell vaccine in mouse multiple myeloma model. The αGC-loaded MOPC315BM myeloma cell vaccine efficiently retarded tumor growth, induced regression of established tumors, and protected surviving mice from tumor rechallenge. Therapeutic responses were associated with induction of strong humoral immune responses, including myeloma-specific antibodies, and cellular immune responses, including myeloma-specific CD8(+) cytotoxic T lymphocytes and memory T cells. In addition, regulatory T cells were significantly decreased in mice that received the αGC-loaded myeloma cell vaccine. Thus, our results demonstrated that αGC-loaded myeloma vaccine efficiently promoted NKT-dependent anti-tumor immunity in a mouse model. These findings are informative for improving the efficacy of tumor-cell-based immunotherapy for patients with MM and other CD1d-expressing tumors.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hong S,Lee H,Jung K,Lee SM,Lee SJ,Jun HJ,Kim Y,Song H,Bogen B,Choi Idoi
10.1016/j.imlet.2013.10.002subject
Has Abstractpub_date
2013-11-01 00:00:00pages
132-9issue
1-2eissn
0165-2478issn
1879-0542pii
S0165-2478(13)00161-2journal_volume
156pub_type
杂志文章abstract：:Estimation of a content of secondary structures from amino acid composition of IL-2 (TCGF), PDGF and transforming protein p28sis of simian sarcoma virus by means of the previously suggested nomograms (V.P. Zav'yalov and A.I. Denesyuk (1982) Immunol. Lett. 4, 7-14) allowed us to conclude that a dominant secondary struc...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90178-6
更新日期：1985-01-01 00:00:00
abstract：:After exposure to a concanavalin A (Con A)-unreactive variant of alpha 1-acid glycoprotein (AGP), macrophages released an inhibitor of interleukin-1 (IL-1) proliferative activity in the thymocyte comitogenic assay. This effect was observed with AGP concentrations above 100 micrograms/ml in the macrophage supernatant a...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90184-r
更新日期：1990-10-01 00:00:00
abstract：:Pretreatment of murine bone marrow-derived macrophages with wheat germ agglutinin (WGA) and concanavalin A (Con A) markedly enhanced the uptake of Staphylococcus aureus H and Escherichia coli 08, respectively. Pretreatment of the respective bacteria with these lectins also greatly increased their uptake by the macroph...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90048-9
更新日期：1986-09-01 00:00:00
abstract：:In several diseases where the immune system plays an important role there has been a tremendous progress in treatment efficacy during the last decades. Based on necessary basic science these improvements are results of rapid, numerous and open-minded clinical trials where pieces of positive results step by step have b...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2014.02.006
更新日期：2014-05-01 00:00:00
abstract：:Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2019.01.006
更新日期：2019-11-01 00:00:00
abstract：:In the H-2-incompatible donor-recipient combination (BALB/c----CBA/H) local administration of cyclosporin allows a 4-fold reduction in a single dose prolonging survival of heart tissue allografts. These results suggest that local administration of cyclosporin may be useful for certain grafts. ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90067-z
更新日期：1990-02-01 00:00:00
abstract：:Thymocyte development requires an integration of extracellular cues to enforce lineage commitment at multiple defined checkpoints in a stage-specific manner. Critical signals from the pre-TCR, Notch, and the receptor for interleukin-7 (IL-7) dictate cellular differentiation from the CD4(-)CD8(-) (double negative) stag...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2007.12.008
更新日期：2008-03-15 00:00:00
abstract：:To explore the genetic association of single nucleotide polymorphisms (SNPs) in the coding region of the NOTCH4, exon 3 C+1297T and exon 5 A+3063G, in a case-control analysis of 58 rheumatoid arthritis (RA) and 98 alopecia areata (AA) and 100 ethnically matched healthy subjects. NOTCH4 polymorphisms were genotyped by ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2013.01.002
更新日期：2013-02-01 00:00:00
abstract：:The surface phenotypes of lymphoid cells in the developing embryonic thymus were characterized by using monoclonal antibodies. FT-2 antigen thus defined was predominantly expressed on thymocytes in the earlier embryonic stages in all the inbred mouse strains tested. The immunofluorescence and immunoperoxidase tests in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90004-5
更新日期：1985-01-01 00:00:00
abstract：:Interleukin-37 (IL-37) has been identified as a novel anti-inflammatory cytokine. The present study aimed to evaluate the expression of IL-37 in serum and in peritoneal fluid to determine its clinical significance in endometriosis. Enzyme-linked immunosorbent assay (ELISA) was performed to examine serum IL-37 levels i...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.03.012
更新日期：2017-05-01 00:00:00
abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(94)90051-5
更新日期：1994-06-01 00:00:00
abstract：:Lymphoid cell infiltration of periodontal tissues undergoing pathological destruction suggests a functional interdependence between connective tissue proteins such as collagen, fibronectin and elastin and mononuclear cells, mainly T lymphocytes. The aim of the study was to assess T lymphocyte proliferation after stimu...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00060-1
更新日期：1998-10-01 00:00:00
abstract：:Several immunodominant B-cell epitopes of the P. falciparum antigen blood stage Pf155/RESA, a major vaccine candidate antigen, are located in the molecular regions containing amino acid repeats. We started to map Pf155/RESA for T cell reactive epitopes. For this purpose, short synthetic peptides corresponding to the 3...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90147-2
更新日期：1988-11-01 00:00:00
abstract：:In recent years, several investigators have shown that transfer of dendritic cells (DC) prevents diabetes development in non-obese diabetic (NOD) mice. Accumulating evidences showing that DC cultured in medium containing fetal calf serum (FCS) can induce a dominant unspecific immune response in tumor models after i.v....
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.11.007
更新日期：2007-02-15 00:00:00
abstract：:Isolated inherited deficiency states of almost every complement protein have been recognized. Almost all are autosomal recessive traits. Deficiency of the early-acting components C1, C4 and C2 is associated with increased risk of immune complex disease, particularly systemic lupus erythematosus. Patients with deficien...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(87)90098-8
更新日期：1987-02-01 00:00:00
abstract：:Several studies have implicated a role for the cell surface glycoprotein CD44 in lymphocyte differentiation, adhesion to the matrix, homing, activation and apoptosis. However, the requirement of CD44 in B cell maturation remains elusive. To address this point, we analyzed the generation and activation of B lymphocytes...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.06.004
更新日期：2004-08-15 00:00:00
abstract：:Common γ chain (γC) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2015.11.007
更新日期：2016-01-01 00:00:00
abstract：:It is well known that most physiological functions change with aging, including the immune response. Data concerning the aging of lymphocyte subpopulations are conflicting. The antigen density of peripheral blood lymphocytes has been determined by fluorescently tagged OKT-3, OKT-4, OKT-8, OKT-11 and OKM1 monoclonal an...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90072-x
更新日期：1990-02-01 00:00:00
abstract：:Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 micrograms/ml and between 3 micrograms and 1 mg/ml for immunoglobulins. The s...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90080-4
更新日期：1984-01-01 00:00:00
abstract：:In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90213-t
更新日期：1991-07-01 00:00:00
abstract：BACKGROUND:Hereditary angioedema with C1-inhibitor deficiency (C1-INH-HAE) is a rare, autosomal dominant disorder. The characteristic episodes of subcutaneous/submucosal edema formation may be preceded by erythema marginatum (EM) - the occurrence of a 'map-like' pattern on the skin. EM can occur as an isolated finding ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.05.015
更新日期：2017-09-01 00:00:00
abstract：:Thirteen synthetic peptides corresponding to different regions of the SV40 large T antigen were used as immunogens after coupling to a carrier protein. All peptide conjugates elicited sera that recognized the inducing peptide. In 10 cases the corresponding sites in the native large T antigen also were recognized, as d...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(86)90006-4
更新日期：1986-04-01 00:00:00
abstract：:Murine peritoneal macrophages were isolated by adherence and their listericidal activity assessed in the presence or absence of selected cytokines. Untreated macrophages were not highly listericidal, showing moderate killing in the first 2 h after infection, and allowed progressive microbial growth thereafter (up to 9...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90158-7
更新日期：1991-03-01 00:00:00
abstract：:Cell-surface 5'-nucleotidase was assayed by incubating intact cells with 5' [3H]AMP in iso-osmotic buffer and measuring [3H]adenosine production. The activity of cell surface 5'-nucleotidase in small resting lymphocytes and in cells of the B cell line BCL1 was 5.7 and 1.1 nmol/min/mg protein respectively at 37 degrees...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(88)90122-8
更新日期：1988-09-01 00:00:00
abstract：:A variety of straightforward biochemical techniques have been applied to the analysis of HLA molecules. These techniques centre largely on two components: monoclonal antibodies (mAbs) and gel analysis systems. Although only the basic applications are discussed here, the techniques have broad applications. Monoclonal-g...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(91)90194-f
更新日期：1991-07-01 00:00:00
abstract：:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90197-x
更新日期：1990-01-01 00:00:00
abstract：:Interleukin-18 (IL-18) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). Vascular endothelial growth factor (VEGF) plays an important role in angiogenesis in rheumatoid synoviocytes. In present study, we examined the effect of IL-18 on VEGF productio...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.10.020
更新日期：2006-03-15 00:00:00
abstract：:Recent studies indicate that the pulmonary immune response in humans and experimental animals is different in newborn, adult and elderly age groups. The aim of this study was to investigate the influence of age on the leukocyte composition in different lung compartments and peripheral blood of weaned and adult rats. A...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2006.12.008
更新日期：2007-02-15 00:00:00
abstract：:The phenomenon of virus neutralization is a function of three variables: the antibody (Ab), the virus and the target cell. Variation in any one of these parameters may drastically affect the results of assays for neutralization. In focusing on the virus as a variable in assays for the neutralization of HIV-1, it has b...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/0165-2478(96)02560-6
更新日期：1996-06-01 00:00:00
abstract：:It remains unclear whether lipopolysaccharide (LPS) pre-treatment, which prevents Th2-type responses via Toll-like receptor 4 (TLR4), inhibits anaphylaxis. To determine the dose-dependent effects of LPS pre-treatment on anaphylactic decreases in rectal temperature caused by ovalbumin (OVA) re-exposure in immunized mic...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.001
更新日期：2008-06-15 00:00:00
