Abstract：
:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 cells. The fact that Th0 cells could be identified in cell populations obtained from unimmunized mice suggested a possible role for Th0 in the differentiation pathways of Th1 and Th2. Antigen-specific Th0 clones were thus established and observed to convert to a Th2 phenotype after prolonged culture. The relevance of these findings is discussed in the context of current models of CD4+ T cell subsets.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Torbett BE,Laxer JA,Glasebrook ALdoi
10.1016/0165-2478(90)90197-xsubject
Has Abstractpub_date
1990-01-01 00:00:00pages
227-33issue
3eissn
0165-2478issn
1879-0542pii
0165-2478(90)90197-Xjournal_volume
23pub_type
杂志文章abstract：BACKGROUND:Previous studies have reported an association between polymorphisms in Il17A and IL17F genes and the prevalence of rheumatoid arthritis (RA) in Caucasian populations. The aim of the current study was to investigate that polymorphisms in both genes may affect RA susceptibility in the Tunisian population and t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.01.013
更新日期：2017-03-01 00:00:00
abstract：:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly r...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2005.05.013
更新日期：2005-11-15 00:00:00
abstract：:Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2017.02.008
更新日期：2017-04-01 00:00:00
abstract：:Both CD8 and CD2 are T cell surface receptors involved in physical cell interaction and in transmembrane signalling. The present paper addresses their role in the induction of two different functions of the cloned murine cytotoxic T cell C196: target cell lysis and IFN-gamma production. These functions were induced in...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(91)90018-6
更新日期：1991-10-01 00:00:00
abstract：:Studies on natural cytotoxicity of peripheral blood monocytes were conducted in patients with acute viral hepatitis B, patients with chronic aggressive hepatitis etiopathogenically linked to viral hepatitis B, and in asymptomatic carriers of HBs antigen. In the majority of cases of viral hepatitis in the acute stage o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90016-1
更新日期：1985-01-01 00:00:00
abstract：:Opioid receptors are expressed not only on neuroendocrine cells but also on immunocompetent cells such as lymphocytes, monocytes and macrophages. micro-Opioid receptor agonists were found to exert immunosuppressive effects, whereas delta-opioid receptor agonists have been shown to act as immunostimulants. delta-Opioid...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.03.006
更新日期：2008-06-15 00:00:00
abstract：:Cell surface molecules are present on several lymphocyte subsets and are differentially expressed during lymphocyte development and activation. Human Leukocyte Differentiation Antigen (HLDA) Workshops have played an essential role in the identification and characterization of the molecules found in the membrane of hem...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.10.009
更新日期：2011-01-30 00:00:00
abstract：:Myelin basic protein (MBP), is a major component of the central nervous system (CNS) myelin. MBP can stimulate T cells that migrate into the CNS, initiating a cascade of events that result in perivascular infiltration and demyelination. EAE is an inflammatory and demyelinating autoimmune disease of the CNS that serves...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(99)00089-9
更新日期：1999-06-01 00:00:00
abstract：:Incorporation of [3h]thymidine ([3H]TdR) into concanavalin A (Con A)-stimulated murine splenocytes was found to be enhanced by addition of certain concentrations of ethanol, 2-propanol and acetone. The alcohol/acetone-induced enhancement of the Con A response was found to be accompanied by an increase of the percentag...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(82)90057-8
更新日期：1982-06-01 00:00:00
abstract：:We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2009.11.007
更新日期：2010-01-18 00:00:00
abstract：:Acute coronary syndrome (ACS) is a multi-factorial condition with a strong inflammatory component, which is immune-mediated by chemokines. The CCL5 is a chemokine that has been suggested to be an important participant in the development of the atherosclerotic plaque. Therefore, in this work, we evaluated whether three...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.10.006
更新日期：2020-12-01 00:00:00
abstract：:Human natural killer (NK) cell activity was not significantly affected by leukotriene (LT) B4 over a wide concentration range (10(-6)-10(-14) M), whether added directly to the NK cell assay or after preincubation of effector cells for 2 h with the drug before addition of Cr labelled K562 target cells. In addition, LTB...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(85)90003-3
更新日期：1985-01-01 00:00:00
abstract：:We infected umbilical cord blood lymphocytes (CBL) with EBV in vitro. Analysis of the cell population in 3- and 6-day-old cultures showed a relative increase of B cells and outgrowth of B cells after prolonged culture period. The immunomodulator PSK was added to parallel cultures. In these cultures, B cell growth was ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00330-3
更新日期：2002-03-01 00:00:00
abstract：:In spite of impressive results in the treatment of acute lymphoblastic B cell leukemia (B-ALL) with chimeric antigen receptor (CAR) T cells, the clinical outcome of some hematological cancers like follicular lymphoma (FL) and chronic lymphocytic leukemia (CLL) has not been very promising likely due to immunosuppressiv...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2020.04.005
更新日期：2020-07-01 00:00:00
abstract：:Soluble C3d applied to human blood-derived B lymphocytes inhibited anti-mu, T cell-produced growth factor, and EBV-induced DNA synthesis in serum-free culture. C3d added to the B cell cultures 1 and 2 days after the stimulus, still exerted inhibition, though with gradually diminishing efficiency. C3d, fixed on zymosan...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(90)90175-p
更新日期：1990-10-01 00:00:00
abstract：:Antibodies reactive with native double stranded DNA are characteristic of the chronic inflammatory disease systemic lupus erythematosus. Native DNA is however, a poor immunogen and the mechanism of anti-DNA antibody production is incompletely understood. Modification of DNA can increase its immunogenicity and in infla...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90237-i
更新日期：1992-10-01 00:00:00
abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective way to cure hematological malignancies. However, graft-versus-host disease (GVHD) following transplantation limits the clinical application to some extent. The donor T lymphocytes play a central role in the occurrence and development of GVH...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2011.01.010
更新日期：2011-05-01 00:00:00
abstract：:Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(92)90092-3
更新日期：1992-06-01 00:00:00
abstract：:Seroma is a frequent complication of breast cancer surgery, the etiology of which remains indefinite. It represents a subcutaneous accumulation of fluid frequently reported after surgical procedures such as axillary lymph node dissection. Despite previous studies have associated seroma fluid to an inflammatory exudate...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2010.03.002
更新日期：2010-06-15 00:00:00
abstract：:Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only di...
journal_title：Immunology letters
pub_type： 杂志文章,评审
doi：10.1016/j.imlet.2020.06.011
更新日期：2020-10-01 00:00:00
abstract：:Pertussis, or whooping cough, has recently reemerged as a major public health threat despite high levels of vaccination. The development of a novel pertussis vaccine, especially an intranasal (i.n.) vaccine is undoubtedly necessary, and mucosal adjuvants have been explored to enhance the immune response. In the presen...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2018.03.012
更新日期：2018-06-01 00:00:00
abstract：:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/0165-2478(84)90056-7
更新日期：1984-01-01 00:00:00
abstract：:In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to ...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(98)00181-3
更新日期：1999-03-01 00:00:00
abstract：:CD103(+)CD11b(+) dendritic cells (DC) are the major migratory DC subset in the small intestine lamina propria (siLP) and their survival is dependent on the transcription factor interferon regulatory factor 4 (IRF4). Mice with a DC-specific deletion of irf4 (CD11c-cre.Irf4 mice) have reduced mucosal CD103(+)CD11b(+) DC...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2016.05.012
更新日期：2016-08-01 00:00:00
abstract：:B cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important survival factor for B cells, and is able to regulate T cell activation. Recently, we have demonstrated that human soluble BAFF (hsBAFF) potently elevates NK cell activity of murine splenic cells in vi...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2008.07.005
更新日期：2008-10-30 00:00:00
abstract：:The prevalence of asthma and allergic disease has increased in many countries and there has been speculation that immunization promotes allergic sensitization. Bordetella pertussis infection exacerbates allergic asthmatic responses. We investigated whether whole-cell pertussis vaccine (Pw) enhanced or prevented B. per...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/j.imlet.2004.10.011
更新日期：2005-02-15 00:00:00
abstract：:Type I Diabetes mellitus (DM1) is the effect of T cell dependent autoimmune destruction of insulin producing beta cells in the pancreas islet. T cells are activated in response to islet dominant autoantigens, the result being the development of DM1. Insulin is one of the islet autoantigens responsible for activation o...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(00)00309-6
更新日期：2001-01-15 00:00:00
abstract：:At least three B cell subsets, B-1a (Ly-1B), B-1b and B-2, are present in the mouse periphery. B-1a and B1-b cells represent a small population in the adult spleen and are abundant in the peritonial and pleural cavities. It has been demonstrated in our laboratory that B-1b cells spontaneously proliferated in stationar...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(02)00266-3
更新日期：2003-03-03 00:00:00
abstract：:Recombinant gp120 of the HIV-1(IIIB) isolate (BH10 clone) has been mutated to form the PR12 protein with the first 74 C-terminal amino acids and the V1, V2 and V3 hypervariable loops deleted. A variety of studies have shown that the CD4 binding domain (CD4bd) is very well exposed in PR12 in contrast to rgp120(LAI). Us...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(01)00289-9
更新日期：2001-12-03 00:00:00
abstract：:The attenuated androgen Danazol can partially reverse the biochemical defect and prevent angioedema in patients with inherited C1-inhibitor (C1-INH) deficiency (hereditary angioedema, HAE). Though its clinical effectiveness is independent from significant increase of C1-INH plasma levels, its mechanism of action remai...
journal_title：Immunology letters
pub_type： 杂志文章
doi：10.1016/s0165-2478(03)00029-4
更新日期：2003-05-01 00:00:00
