Abstract:
:Peripheral blood from 11 newly diagnosed patients with insulin-dependent diabetes mellitus (IDDM) was studied for the proportion of monoclonal antibody (HNK 1, Leu 7) defined natural killer (NK) cells using a fluorescence-activated cell sorter analyzer. The proportion of Leu 7+ cells in patients with IDDM (7.0 +/- 4.0) was significantly (P less than 0.001) lower than in simultaneously studied healthy controls (16.8 +/- 7.0). A 2-yr-old boy with recent onset IDDM had a deficiency of Leu 7+ NK cells (6.1%), while his healthy identical twin had normal proportions of Leu 7+ cells (22.2%), when compared to a simultaneously studied healthy control. Two patients reexamined in remission and one other studied in remission alone, showed deficiency of Leu 7+ NK cells. This study demonstrates a quantitative deficiency of monoclonal antibody (Leu 7+) defined NK cells in newly diagnosed patients with IDDM that persists during remission of the disease and therefore appears to be independent of metabolic abnormality. The deficiency of NK cells may predispose genetically susceptible individuals to viral-induced islet cell injury, contributing to the pathogenesis of IDDM.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Chandy KG,Charles MA,Buckingham B,Waldeck N,Kershnar A,Gupta Sdoi
10.1016/0165-2478(84)90056-7subject
Has Abstractpub_date
1984-01-01 00:00:00pages
89-91issue
2eissn
0165-2478issn
1879-0542pii
0165-2478(84)90056-7journal_volume
8pub_type
杂志文章abstract::The production of interleukin 1 (IL-1) by lipopolysaccharide (LPS)-stimulated myelomonocytic cell lines ML-1, THP-1 and PL-21 was significantly enhanced by the addition of insulin, insulin-like growth factor (IGF)-I or IGF-II into the cell cultures. The IL-1 activity in the supernatants from cell cultures stimulated w...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90220-i
更新日期:1992-12-01 00:00:00
abstract::It has been previously shown that normal human peripheral blood mononuclear cells produce a soluble factor(s) that causes selective inhibition of collagen production by cultured human diploid fibroblasts, and that stimulation of the mononuclear cells by appropriate mitogens greatly enhances its production. Because of ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90145-2
更新日期:1985-01-01 00:00:00
abstract::Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90008-c
更新日期:1992-01-01 00:00:00
abstract::Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine and has been shown to play an important role in maintaining immune homeostasis. However, the effect of IL-35 on human asthma remains unclear. The present study is to investigate the expression and significance of IL-35 in childhood asthma. Forty-one asthmati...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.06.002
更新日期:2014-11-01 00:00:00
abstract::HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...
journal_title:Immunology letters
pub_type: 信件
doi:10.1016/j.imlet.2009.08.005
更新日期:2009-09-22 00:00:00
abstract::Interleukin 18 (IL-18) gene polymorphisms have been reported to be associated with the outcomes of hepatitis C virus (HCV) infection in Americans, Indians and Europeans. We aimed to investigate whether the association can be replicated in Chinese Han population. Three IL-18 variants, -656G>T, -137G>C and +105A>C, were...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.08.007
更新日期:2013-07-01 00:00:00
abstract::Heat-sensitive serum masking cofactor(s) of antiphospholipid antibody (aPL) in normal human sera (NHS) are specifically inactivated at 56 degrees C. The degree of binding in ELISA by unmasked aPL in NHS was equivalent to that in non-heated, aPL-reactive autoimmune SLE sera. Previously "negative" SLE sera also reacted ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90189-w
更新日期:1990-01-01 00:00:00
abstract::It is well known that most physiological functions change with aging, including the immune response. Data concerning the aging of lymphocyte subpopulations are conflicting. The antigen density of peripheral blood lymphocytes has been determined by fluorescently tagged OKT-3, OKT-4, OKT-8, OKT-11 and OKM1 monoclonal an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90072-x
更新日期:1990-02-01 00:00:00
abstract::Interleukin-18 (IL-18) plays a central role in the immune response by acting on Th1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-18 in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, colonic cancer and C...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(00)00285-6
更新日期:2000-12-01 00:00:00
abstract:AIM:To develop new approach for tumor immunotherapy with VEGFR2-based DNA vaccine. METHODS:VEGFR2 derived from different species were prepared by RT-PCR and subjected to recombinant constructs. The chimeric gene of VEGFR2 was prepared by integrating different epitopes in different species. By transfecting into cells, ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.07.013
更新日期:2009-09-22 00:00:00
abstract::In addition to its hematopoietic activities, interleukin-3 (IL-3) can modulate macrophage functions. We have studied the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the presence or absence of IL-3. Int...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90109-n
更新日期:1991-05-01 00:00:00
abstract::Chagas' disease is accompanied by severe anemia and oxidative stress, which may contribute to mortality. In this study, we investigated the role of 5-lipoxygenase (5-LO) in the control of parasitism and anemia associated with oxidative damage of erythrocytes in experimental Trypanosoma cruzi infection. Wild-type C57BL...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.02.002
更新日期:2009-03-24 00:00:00
abstract::Development of novel bi-functional or even tri-functional Fab-effector fusion proteins would have a great potential in the biomedical sciences. However, the expression of Fab-effector fusion proteins in Escherichia coli is problematic especially when a eukaryotic effector moiety is genetically linked to a Fab due to t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.02.008
更新日期:2017-04-01 00:00:00
abstract::Mechanistic target for rapamycin (mTOR) is a serine/threonine protein kinase that forms two distinct complexes mTORC1 and mTORC2, integrating mitogen and nutrient signals to regulate cell survival and proliferation; processes which are commonly deregulated in human cancers. mTORC1 and mTORC2 have divergent molecular a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::Lethally irradiated (1000 rad) CBA/J mice were transplanted with anti-Thy 1 treated BALB/c bone marrow. Under these conditions, we uniformly observed the development of pathology suggestive of acute graft-vs.-host disease (GVHD), i.e. weight loss, diarrhoea, hypogammaglobulinemia and thymic hypoplasia. If, 2 wk before...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90109-9
更新日期:1985-01-01 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) is usually known as an immunosuppressive cytokine, but we and others have shown stimulatory effects of TGF-beta on activation of Th2 T-lymphocytes. In the present investigation we have studied the effect of TGF-beta1 on phosphorylation of ERK, a MAP-kinase downstream of the R...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00184-x
更新日期:2000-06-01 00:00:00
abstract::Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are thought to play key roles in viral control and liver damage. We have used HLA-A*02 tetramer complex to human HBV core 18-27 (Tc 18-27), envelope 183-191 (Te 183-191), envelope 335-343 (Te 335-343), and polymerase 575-583 (Tp 575-583) epitopes to chara...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2004.01.002
更新日期:2004-04-15 00:00:00
abstract::The presence of dendritic cells (DCs) in mycobacterium-containing granulomas, as well as in other granuloma-inducing diseases, is beginning to be appreciated. This review will summarize what is known about DCs with regards to the granuloma and discuss the potential roles DCs may be playing during mycobacterial infecti...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2009.12.009
更新日期:2010-05-04 00:00:00
abstract::The immunomodulatory and antiviral effects of an extracellular polysaccharide (EPS-2), produced by a strain of Geobacillus thermodenitrificans isolated from a shallow marine vent of Vulcano Island (Italy), were evaluated. In the present study, we show for the first time that EPS-2 treatment hinder HSV-2 replication in...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.03.001
更新日期:2009-04-27 00:00:00
abstract::While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00022-1
更新日期:2003-04-03 00:00:00
abstract::SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90102-1
更新日期:1986-03-01 00:00:00
abstract::We have analysed the relative T cell receptor (TCR) BV gene usage in T cells from hearts and spleens of CBA/HJ mice chronically infected with the Tulahuén strain of Trypanosoma cruzi. During chronic infection, CBA/HJ mice recruit T cells at the major site of inflammation (i.e. the heart), with over-representation of c...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00153-3
更新日期:1998-02-01 00:00:00
abstract::Apoptosis markers and the rate of lymphocyte apoptosis were followed in the peripheral blood of HIV infected persons at various stages of disease. Our study suggests that the early increase in memory cells following therapy may also be due to a significant decrease in apoptosis in this subset. The intrinsic resistance...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00167-9
更新日期:1999-03-01 00:00:00
abstract::To test whether apoptotic thymocytes can be identified by altered packing of lipids in their plasma membranes, thymocytes were isolated from mice injected with hydrocortisone and stained with merocyanine 540 (MC540), a fluorescent probe sensitive to lipid packing. At 9-10 h after injection, a subpopulation of H2-Klo c...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90101-7
更新日期:1993-06-01 00:00:00
abstract::Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2006.12.009
更新日期:2007-03-15 00:00:00
abstract::Cell-surface 5'-nucleotidase was assayed by incubating intact cells with 5' [3H]AMP in iso-osmotic buffer and measuring [3H]adenosine production. The activity of cell surface 5'-nucleotidase in small resting lymphocytes and in cells of the B cell line BCL1 was 5.7 and 1.1 nmol/min/mg protein respectively at 37 degrees...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90122-8
更新日期:1988-09-01 00:00:00
abstract::The immunological alterations observed in chronic alcoholic patients may be due to alterations of signal transduction across the lymphocyte membrane. Upon binding of mitogens or antigens to specific plasma membrane receptors, the activation of phospholipase C leads to the hydrolysis of inositol phospholipids, producin...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00019-2
更新日期:1995-05-01 00:00:00
abstract::The influence of pretreatment with interferon (IFN) on subsequent IFN synthesis was investigated in macrophage cultures of DBA/2 and C57BL/6 mice. The doses of IFN alpha/beta for pretreatment ranged from 10,000 U/ml to 100 U/ml and the incubation time was between 18 and 2 h. No blocking effect was observed for chemica...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90049-1
更新日期:1988-06-01 00:00:00
abstract::While the spleen is an active site for myelopoiesis during the late embryonal and perinatal stages, the activity is gradually lost later. However, myelopoiesis in the adult spleen can be reactivated by irradiation or various stimulants. In this study we investigated factors which determine the myelopoiesis-supporting ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90091-f
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:Diabetic neuropathy (DN) is one of the microvascular complications of diabetes that leads to peripheral sensorimotor and autonomic nervous system damages. In this study, we first examined the expression of lncRNA NEAT-1 and its downstream microRNAs, miR-183-5p, miR-433-3p, and then examined mRNA expression o...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2021.01.007
更新日期:2021-01-25 00:00:00