Abstract：
:The peripheral B-cell pool is in dynamic equilibrium and is controlled by a variety of factors. The rate of generation of B cells can influence both the composition and size of the peripheral B-cell compartment. Mice deficient for lambda5 gene expression have a block in early B-cell development leading to a markedly reduced number of peripheral B cells. To address the question of how this early developmental block influences the composition of the B-cell pool, we have analyzed mature B-cell subpopulations in lambda5-deficient mice. In analogy with other situations of B lymphopenia, the proportion was increased but not the absolute number of marginal-zone B cells, whereas those of follicular B cells were decreased. Immunohistology revealed that B-cell follicles were smaller in overall size and contained a prominent B-cell replete marginal zone. BrdU labelling kinetics showed slower turnover of follicular as well as of marginal-zone B cells. Functionally, lambda5(-/-) mice were able to mount not only primary but also secondary thymus-dependent as well as thymus-independent responses, albeit mostly at reduced levels.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Harfst E,Andersson J,Grawunder U,Ceredig R,Rolink AGdoi
10.1016/j.imlet.2005.05.013subject
Has Abstractpub_date
2005-11-15 00:00:00pages
173-84issue
2eissn
0165-2478issn
1879-0542pii
S0165-2478(05)00134-3journal_volume
101pub_type
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