Expression of CD44 splice variants in metastatic and non-metastatic mouse tumour cell lines.

abstract：:Antisera were raised in rabbits against a monoclonal antibody (McAb 103) of C3H.SW origin which is specific to the synthetic polypeptide (T,G)-A-L and was shown to express the major idiotypic determinants of conventional anti-(T,G)-A-L antibodies. Antibodies were purified and were shown in a binding assay to recognize...

journal_title：Immunology letters

authors： Axelrod O,Stanislawski M,Mozes E

更新日期：1985-01-01 00:00:00

abstract：:N-Chlorotaurine (NCT) plays an important role in the human defense system as a main component of long-lived oxidants, and shows bactericidal, fungicidal, and virucidal activity. Besides this role, NCT seems to act regulatory on immunocompetent cells by altering cytokine production. NCT inhibited nitric oxide, TNF-alph...

journal_title：Immunology letters

authors： Wirleitner B,Neurauter G,Nagl M,Fuchs D

更新日期：2004-05-15 00:00:00

abstract：:Others have reported that a monoclonal anti-human IL-2 receptor antibody (anti-CD25) specifically binds a membrane receptor on Xenopus laevis PHA-induced and paraformaldehyde-fixed splenic blasts. In this paper, we present evidence suggesting that this binding is an artifact of membrane damage. Specifically, significa...

journal_title：Immunology letters

authors： Haynes L,Moynihan JA,Cohen N

更新日期：1990-12-01 00:00:00

abstract：:Interleukin-37 (IL-37) has been identified as a novel anti-inflammatory cytokine. The present study aimed to evaluate the expression of IL-37 in serum and in peritoneal fluid to determine its clinical significance in endometriosis. Enzyme-linked immunosorbent assay (ELISA) was performed to examine serum IL-37 levels i...

journal_title：Immunology letters

authors： Kaabachi W,Kacem O,Belhaj R,Hamzaoui A,Hamzaoui K

更新日期：2017-05-01 00:00:00

abstract：:Cross-linking of BCR rapidly induces protection of B cells from Fas-mediated apoptosis, which has been assumed one of the important survival mechanisms of B cells during antigen stimulation. In the mouse B cell line A20, which is sensitive to Fas-mediated apoptosis, stimulation of BCR inhibited apoptosis induced via F...

journal_title：Immunology letters

authors： Moriyama H,Yonehara S

更新日期：2007-03-15 00:00:00

abstract：:In transgenic mice over-expressing CD200 (CD200(tg)) graft survival is associated with increased intra-graft expression of mRNAs for genes associated with altered T cell subset differentiation (Foxp3; TGFβ; IL-10). Grafts are rejected in recipients lacking the inhibitory receptor for CD200, CD200R1. We compared grafts...

journal_title：Immunology letters

authors： Yu K,Chen Z,Gorczynski R

更新日期：2013-01-01 00:00:00

abstract：:Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...

journal_title：Immunology letters

authors： Janelidze S,Enell K,Visse E,Darabi A,Salford LG,Siesjö P

更新日期：2005-11-15 00:00:00

abstract：:The immunological alterations observed in chronic alcoholic patients may be due to alterations of signal transduction across the lymphocyte membrane. Upon binding of mitogens or antigens to specific plasma membrane receptors, the activation of phospholipase C leads to the hydrolysis of inositol phospholipids, producin...

journal_title：Immunology letters

authors： Hrelia S,Celadon M,Bordoni A,Castelli E,Foschi FG,Stefanini GF,Rossi CA,Biagi PL

更新日期：1995-05-01 00:00:00

abstract：:This study tested the hypothesis that the Vδ3 subset of human γδ T cells, like their Vδ2 counterparts, can influence differentiation, antibody secretion and cytokine production by B cells. Vδ3 T cells constitute a minor subset of peripheral blood lymphocytes but are enriched in the liver and gut and are expanded in pa...

journal_title：Immunology letters

authors： Petrasca A,Melo AM,Breen EP,Doherty DG

更新日期：2018-04-01 00:00:00

abstract：:The production of neutralizing antibodies against the central portion of HIV-1 gp120 requires cooperation between T cell and B cell epitopes of this region. We found a motif common to the carboxyterminus of the second conserved region of HIV-1 gp120 and sequences of some human proteins, most of which participate in im...

journal_title：Immunology letters

authors： Veljković V,Metlas R

更新日期：1990-11-01 00:00:00

abstract：:Using micro-electrode technique we studied the effects of interleukin-2 (50 ng/ml) on bio-electric activity of rat atrial myocardium under normal conditions and after gradual stretching of the tissue. It was shown that interleukin-2 caused increasing in the duration of action potential at the levels of 25, 50, and 90%...

journal_title：Immunology letters

authors： Aksyonov A,Mitrokhin VM,Mladenov MI

更新日期：2015-09-01 00:00:00

abstract：:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...

journal_title：Immunology letters

authors： Hartung HP,Toyka KV

更新日期：1983-01-01 00:00:00

abstract：:Immunoglobulin species, recombined from Fab and Fc fragments with anti-red cell specificity were used as cytophilic antibodies in studies of triggering the effector activity of immunoglobulins. Recombinant immunoglobulins containing a single Fab' appeared inactive in binding to cell receptors and triggering antibody d...

journal_title：Immunology letters

authors： Uracz W,Bobrzecka K,Konieczny L,Rybarska J,Zembala M

更新日期：1984-01-01 00:00:00

abstract：:This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...

journal_title：Immunology letters

authors： Zhang J,Xu M,Zheng Q,Zhang Y,Ma W,Zhang Z

更新日期：2014-11-01 00:00:00

abstract：:The cellular source of murine LAIF detected by an indirect leukocyte adherence inhibition (LAI) assay using capillary tubes was investigated using non-inducing peritoneal cells (PC) from normal and spindle-cell sarcoma-bearing A/J mice. Cell populations containing greater than 95% T-cells, B-cells or macrophages were ...

journal_title：Immunology letters

authors： Myers WL,O'Keefe ML,Gregory S

更新日期：1981-11-01 00:00:00

abstract：:The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...

journal_title：Immunology letters

authors： Bharti AC,Singh SM

更新日期：2000-04-03 00:00:00

abstract：:Hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTLs) are thought to play key roles in viral control and liver damage. We have used HLA-A*02 tetramer complex to human HBV core 18-27 (Tc 18-27), envelope 183-191 (Te 183-191), envelope 335-343 (Te 335-343), and polymerase 575-583 (Tp 575-583) epitopes to chara...

journal_title：Immunology letters

authors： Wu Y,Zhang J,Chen S,Chen A,Wang L,Li J,Zhao T,Zou L,Tang Y,Tingrong L,Wang F

更新日期：2004-04-15 00:00:00

abstract：:Antibody direct cloning from single B cells is simple and efficient and has been successful in antibody identification of infectious diseases. However, although a recent whole-exome sequencing revealed abundant heterogeneic mutation accumulation in cancers, identification and synthesis of autoantibodies against specif...

journal_title：Immunology letters

authors： Iizuka A,Komiyama M,Oshita C,Kume A,Ashizawa T,Mitsuya K,Hayashi N,Nakasu Y,Yamaguchi K,Akiyama Y

更新日期：2014-05-01 00:00:00

abstract：:We have utilized a limiting dilution assay, involving a minimum of in vitro culture, to determine the frequencies of CD4+ T cells which have the capacity to secrete IL-2 (Th1), IL-4 (Th2) or IL-2 and IL-4 (Th0). CD4+ lymph node cells obtained from unimmunized mice were found to contain 40% Th1, 34% Th2, and 26% Th0 ce...

journal_title：Immunology letters

authors： Torbett BE,Laxer JA,Glasebrook AL

更新日期：1990-01-01 00:00:00

abstract：:To monitor genetically-controlled cytokine-producing ability in mice in vitro, we developed a high-density cell culture system, which is preferable for inducing CD4+ T cell-dependent self-priming responses without any antigenic stimulation. When BALB/c spleen cells were cultured at high density (over 1.0 x 10(7) cells...

journal_title：Immunology letters

authors： Sato M,Iwakabe K,Ohta A,Sekimoto M,Kimura S,Nishimura T

更新日期：1999-12-01 00:00:00

abstract：:Using embryonic chickens treated with testosterone propionate, the effects of congenital absence of the bursa of Fabricius determined by the frequency of J chain-positive cells was examined in the spleen, thymus and bone marrow at the embryonic and newly hatched stages. J chain-positive cells in the chicks without bur...

journal_title：Immunology letters

authors： Moriya O,Ichikawa Y

更新日期：1984-01-01 00:00:00

abstract：:Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...

journal_title：Immunology letters

authors： Musset L,Ghillani P,Lunel F,Cacoub P,Cresta P,Frangeul L,Rosenheim M,Preud'homme JL

更新日期：1997-01-01 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...

journal_title：Immunology letters

authors： Muñoz-Fernández MA,Fernández MA,Fresno M

更新日期：1992-06-01 00:00:00

abstract：:Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...

journal_title：Immunology letters

authors： An H,Xu H,Yu Y,Zhang M,Qi R,Yan X,Liu S,Wang W,Guo Z,Qin Z,Cao X

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that play a fundamental role in restrictive host immune response to pathogens, by means of that is a crucial importance for chronic inflammatory disease studies. Therefore, the goal of this study was to measure the correlation of t...

journal_title：Immunology letters

authors： Afkari B,Babaloo Z,Dolati S,Khabazi A,Jadidi-Niaragh F,Talei M,Shanehbandi D,Mahmoudi S,Hazhirkarzar B,Sakhinia E

更新日期：2018-02-01 00:00:00

abstract：:IL-6 mediates its pleiotropic functions through two membrane proteins, a ligand-binding molecule (IL-6 receptor, IL-6R) and a non-ligand-binding signal transducer (gp130). Starting with a previously isolated cDNA clone encoding human gp130, recombinant soluble gp130 (sgp130) lacking the transmembrane and cytoplasmic r...

journal_title：Immunology letters

authors： Yasukawa K,Futatsugi K,Saito T,Yawata H,Narazaki M,Suzuki H,Taga T,Kishimoto T

更新日期：1992-02-01 00:00:00

abstract：:T cells utilize the vascular adhesion molecule E-selectin to enter inflamed skin. T cells identified by the mAb HECA-452 [cutaneous lymphocyte-associated antigen (CLA) T cells] are enriched in E-selectin ligand expressing cells. However, the proportion of CLA(+) T cells reactive with an E-selectin/Fc chimeric construc...

journal_title：Immunology letters

authors： Ni Z,Walcheck B

更新日期：2007-02-15 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate whether the concentrations of serum tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, increased in type 2 diabetes mellitus (T2DM) and type 2 diabetic nephropathy (T2DN) patients. METHODS:The four databases (PubMed, CNKI, WanFang and Chinese-Cqvip) were s...

journal_title：Immunology letters

authors： Chen YL,Qiao YC,Xu Y,Ling W,Pan YH,Huang YC,Geng LJ,Zhao HL,Zhang XX

更新日期：2017-06-01 00:00:00

abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

journal_title：Immunology letters

authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

更新日期：2014-11-01 00:00:00

abstract：:Conventional indirect haemagglutination test was performed in rhesus monkey sera (collected from Plasmodium knowlesi infected animals) with and without prior treatment of sera with 2-mercapto-ethanol (2-ME). Surprisingly, many sera samples showed significant enhancement of final titre with 2-ME. The 2-ME enhancement e...

journal_title：Immunology letters

authors： Ravindran B,Biswas S,Hussain QZ,Chaudhuri SN

更新日期：1984-01-01 00:00:00