Abstract:
:The immunological alterations observed in chronic alcoholic patients may be due to alterations of signal transduction across the lymphocyte membrane. Upon binding of mitogens or antigens to specific plasma membrane receptors, the activation of phospholipase C leads to the hydrolysis of inositol phospholipids, producing inositol phosphates and diacylglycerol. One of the early events in lymphocyte activation is an increase of intracellular calcium concentration, due to both an influx from extracellular fluid and a release from intracellular stores mediated by inositol phosphates. In this study we verified whether the diminished mobilization of intracellular calcium, previously observed in alcoholics, is caused by alteration in phosphoinositide turnover. We evaluated total inositol phosphate production in peripheral blood lymphocytes after anti-CD3 stimulation, comparing control subjects and alcoholic patients. Lymphocyte activation generated inositol phosphates in both controls and alcoholics, but to a different extent, inositol phosphate production being significantly higher in controls than in alcoholics. This reduction in inositol phosphate production could be accounted either to an inhibition of PLC activity or to a modified affinity of phospholipase C for its own substrates, i.e., phosphoinositides, which fatty acid composition has been previously demonstrated to be greatly different in alcoholics in comparison to healthy subjects.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Hrelia S,Celadon M,Bordoni A,Castelli E,Foschi FG,Stefanini GF,Rossi CA,Biagi PLdoi
10.1016/0165-2478(95)00019-2subject
Has Abstractpub_date
1995-05-01 00:00:00pages
63-6issue
1-2eissn
0165-2478issn
1879-0542pii
0165-2478(95)00019-2journal_volume
46pub_type
杂志文章abstract::The present study was conducted to investigate the mode of cell death of bone marrow cells (BMC) treated in vivo or in vitro with gangliosides (DLG) derived from a T cell lymphoma, designated as Dalton's lymphoma (DL). BMC undergoing cell death showed morphological features characteristic to apoptosis such as cell shr...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00156-5
更新日期:2000-04-03 00:00:00
abstract::Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis)...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00243-7
更新日期:2001-10-01 00:00:00
abstract::DNA-dependent RNA polymerase was partially purified from wheat germ extract and tested for inhibition by antinuclear autoantibodies from the sera of patients with connective tissue diseases. The enzyme was inhibited by anti-DNA and by autoantibodies to the nuclear ribonucleoprotein nRNP. Autoantibodies to other ribonu...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90093-7
更新日期:1983-03-01 00:00:00
abstract::A docile substrain of lymphocytic choriomeningitis virus (LCMV) causes a persistent infection in adult C3HeB mice and induces a severe autoimmune hemolytic anemia (AIHA) which is maximal around three weeks post infection (PI). Evaluations of serum immunoglobulin levels of these mice demonstrated grossly elevated IgG2a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90126-9
更新日期:1992-02-15 00:00:00
abstract:OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00071-3
更新日期:2003-08-05 00:00:00
abstract::HIV-1 positive patients generate Nef-specific CTL response, indicating that Nef is a potent immunogen. However, Nef is also known to down regulate the expression of CD4 and MHC-I molecules, thereby protecting virally infected target cells. We compared the immunogenicity of non-functional nef vaccine constructs to wild...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00141-x
更新日期:2003-10-31 00:00:00
abstract::Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90008-c
更新日期:1992-01-01 00:00:00
abstract::T cells recognize with a single receptor both a product of antigens processed by antigen presenting cells (APC1) and a self-marker molecule, encoded by the major histocompatibility complex (MHC, a property termed MHC-restricted recognition of antigen). During their differentiation in the thymus, T cells "learn" what t...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(90)90040-w
更新日期:1990-06-01 00:00:00
abstract::Mouse trisomy 16 (Ts16), an animal model for human Down syndrome (trisomy 21), exhibits severe abnormalities in the development of lymphoid and myeloid cells. Whereas fetal liver cells from diploid mice can be easily immortalized by retroviral transformation with Ab1-MuLV or J2 virus, fetal livers from Ts16 mice conta...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90092-3
更新日期:1992-06-01 00:00:00
abstract:INTRODUCTION:Intrahepatic injection of alloantigen prolongs allograft survival and inhibits T-lymphocyte release of both IL-2 and IFN-gamma but not IL-4. This suggests that intrahepatic processing of antigen lead to a predominance of Th2 cell population with inhibition of Th1 cell type. This study examines the effects ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00322-4
更新日期:2002-04-01 00:00:00
abstract::Natural levels of goat antiphosphorylethanolamine (anti-PE) antibodies decreased after injection of purified human C-reactive protein (CRP). The concentration of anti-CRP antibodies followed a continuous increment from non-detectable levels to a plateau at 80 days after first injection. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90070-3
更新日期:1988-05-01 00:00:00
abstract::T helper17 (Th17) cells have been demonstrated to participate in the pathogenesis of hepatitis B virus (HBV) associated liver damage. However, the contribution of Th17 cells to immune activation and disease aggravation in patients with HBV infection is not fully clear. In this study, we investigated the Th17 cells fre...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/j.imlet.2012.12.001
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Infantile hemangiomas (IHs) are the most common benign tumors of childhood. They are characterized by a unique clinical course with two phases, proliferation and involution, which are followed by regression. The therapy of infantile hemangiomas was revolutionized in 2008 by the introduction of propranolol, h...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.03.005
更新日期:2017-05-01 00:00:00
abstract::Microparticles are recently recognized players of intercellular communication. They are involved in signal transduction, cell activation and apoptosis. Their importance is also suggested in autoimmune diseases such as rheumatoid arthritis and systemic sclerosis. We investigated the role of microparticles in polymyosit...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.12.018
更新日期:2010-02-16 00:00:00
abstract::Dendritic cells (DCs) are highly specialized antigen-presenting cells that play a key role in the initiation and regulation of immune responses. The ability of DCs to process antigens and the outcome of their interaction with T cells are largely dependent on phenotype as well as maturation state of DCs. In this study,...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.05.012
更新日期:2005-11-15 00:00:00
abstract::While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00022-1
更新日期:2003-04-03 00:00:00
abstract::Antibodies reactive with native double stranded DNA are characteristic of the chronic inflammatory disease systemic lupus erythematosus. Native DNA is however, a poor immunogen and the mechanism of anti-DNA antibody production is incompletely understood. Modification of DNA can increase its immunogenicity and in infla...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90237-i
更新日期:1992-10-01 00:00:00
abstract::Genetic or DNA-based immunization, including genomic immunization, has shown to be a viable alternative approach to induce protective immunity against a number of pathogens in several disease models. Here we describe a new method, cDNA expression library immunization (cDELI), based on the use of a large number of cDNA...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00039-x
更新日期:1998-07-01 00:00:00
abstract::As a cytokine adjuvant, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been demonstrated to play central roles in the enhancement of the immune response and protection elicited by experimental vaccines. However, in our previous work, the co-administration of GM-CSF produced untoward effects on the immun...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.08.005
更新日期:2014-11-01 00:00:00
abstract::We examined the alphabeta T cell receptor (TCR) repertoire of naturally occurring CD4+CD25+ regulatory T (Treg) cells isolated from healthy human blood. Three-color FACS analysis demonstrated that the usage of variable region segments of TCRbeta chains by CD4+CD25+ cells did not differ from those of CD4+CD25- cells. C...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.02.011
更新日期:2005-07-15 00:00:00
abstract::Properly balanced cellular responses require both the mutual interactions of soluble factors with cell surface receptors and the crosstalk of intracellular molecules. In particular, immune cells exposed unceasingly to an array of positive and negative stimuli must distinguish between what has to be tolerated and attac...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2017.08.011
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:Previous studies have reported an association between polymorphisms in Il17A and IL17F genes and the prevalence of rheumatoid arthritis (RA) in Caucasian populations. The aim of the current study was to investigate that polymorphisms in both genes may affect RA susceptibility in the Tunisian population and t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2017.01.013
更新日期:2017-03-01 00:00:00
abstract::The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90085-3
更新日期:1984-01-01 00:00:00
abstract::The T cell receptor of gamma delta is normally expressed on a small percentage of peripheral lymphocytes. Although the role of gamma delta T cells in the physiologic immune response is still unknown, there is accumulating evidence that gamma delta T cells may participate in the immune response to mycobacterial and oth...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90105-y
更新日期:1990-08-01 00:00:00
abstract::Blood coagulation and inflammation pathways are linked in many aspects. A number of serum factors involved in coagulation cascades affect directly or indirectly inflammatory responses, whereas proinflammatory cytokines influence blood coagulation pathways. In this work we demonstrated that thrombin is an effective sti...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(99)00015-2
更新日期:1999-04-15 00:00:00
abstract::Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant synthesized in human body. This enzyme promotes immune system function and can be used as a dietary supplement. Rheumatoid arthritis (RA) is an autoimmune disease leading to chronic joint inflammation. RA results in severe destruction of cartilage and disability. Thi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.05.012
更新日期:2015-08-01 00:00:00
abstract::Malaria, a major endemic tropical disease, is caused by the infection of blood cells by Plasmodium protozoa. Most patients control their parasitemia by a not fully understood spleen-dependent mechanism. SDF-1alpha is a chemokine produced by stromal cells such as reticular spleen cells. Nitric oxide (NO) has several im...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.05.001
更新日期:2003-10-31 00:00:00
abstract:BACKGROUND:CD3 and CD19 are the characteristic surface markers of mature T lymphocytes and B lymphocytes of human respectively. A special subset of immune cells that characteristically expressed the surface markers CD19+ of B lymphocytes and CD3+ of T lymphocytes simultaneously (CD19+CD3+ cells, hereinafter referred to...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.01.007
更新日期:2020-04-01 00:00:00
abstract::The contribution of T cell precursors from the thymus and the bone marrow to the pool of intestinal intraepithelial lymphocvtes (IELs) has been studied in a system using donor cells from enhanced-green fluorescent protein (EGFP+ ) transgenic mice a doptively transferred into EGFP- recipient mice. Consistent with previ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(00)00275-3
更新日期:2000-12-01 00:00:00
abstract::An autoreactive T lymphocyte clone, designated as F1C4 was established from an autoimmune mouse strain (NZB/NZW)F1. This clone proliferated in the presence of mitomycin C-treated splenic adherent cells (MMC-SAC) from syngeneic mice. This response was dependent on the numbers of MMC-SAC. The specificity of F1C4 for I-A...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(88)90175-7
更新日期:1988-08-01 00:00:00