Variations of serum IgG subclass levels in hepatitis C virus infection during interferon-alpha therapy.

abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...

journal_title：Immunology letters

authors： Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

更新日期：1994-06-01 00:00:00

abstract：:The physiologically occurring tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), was examined for its effects on guinea pig peritoneal macrophages. Adherent macrophages (møo) were exposed to tuftsin at concentrations ranging from 10(8) to 10(6) M, and the release of oxygen radicals and the arachidonic acid cyclo-oxygenation pro...

journal_title：Immunology letters

authors： Hartung HP,Toyka KV

更新日期：1983-01-01 00:00:00

abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

journal_title：Immunology letters

authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

更新日期：2014-11-01 00:00:00

abstract：:Domain deleted paraproteins are suitable tools to study the interaction between IgG domains and Fc receptor (FcR) binding sites. The effect of the C gamma 2 or C gamma 3 domain deleted paraproteins was compared on antibody dependent cellular cytotoxicity (ADCC) and on FcR mediated rosette formation. The C gamma 2 doma...

journal_title：Immunology letters

authors： Sármay G,Jefferis R,Gergely J

更新日期：1986-06-01 00:00:00

abstract：:Adrenaline has been shown to inhibit the release of tumor necrosis factor (TNF) elicited by lipopolysaccharide (LPS) when tested in vitro on cultured human blood cells and rat macrophages. In this report we have examined the effect of the in vivo administration of adrenaline on TNF serum levels induced by LPS. In agre...

journal_title：Immunology letters

authors： Monastra G,Secchi EF

更新日期：1993-10-01 00:00:00

abstract：:Intravenous infusion of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), induced fatal anaphylactoid reaction in guinea pigs, or reversible thrombocytopenia and leucopenia. These reactions showed a maximal depression of circulating platelet and leucocyte numbers...

journal_title：Immunology letters

authors： Demopoulos CA,Tsabikakis GE,Kapoulas VM

更新日期：1981-08-01 00:00:00

abstract：:The majority of peripheral blood mononuclear cells (PBMC) from acute-phase infectious mononucleosis (IM) patients express high levels of T10 (CD38) and HLA-DR surface antigens, which are markers characteristic of activated T cells. However, Tac antigen (p55) expression on these cells was not detectable by flow cytomet...

journal_title：Immunology letters

authors： Schmidt C,Burman K,Moss DJ,Ryan J,Burrows SR,Misko IS

更新日期：1989-12-01 00:00:00

abstract：:Cell surface molecules are present on several lymphocyte subsets and are differentially expressed during lymphocyte development and activation. Human Leukocyte Differentiation Antigen (HLDA) Workshops have played an essential role in the identification and characterization of the molecules found in the membrane of hem...

journal_title：Immunology letters

authors： Llinàs L,Lázaro A,de Salort J,Matesanz-Isabel J,Sintes J,Engel P

更新日期：2011-01-30 00:00:00

abstract：:Interleukin (IL) 4 is a type 2 cytokine which has a negative immunoregulatory role in human infection. IL-4 suppresses the production of interferon-gamma and enhances IL-10 synthesis. However, the effect of IL-4 on proliferative response of lymphocytes remains to be elucidated. We have previously reported an increase ...

journal_title：Immunology letters

authors： Fan XG,Yakoob J,Fan XJ,Keeling PW

更新日期：1995-11-01 00:00:00

abstract：:Natural anti-cholesterol antibodies (ACHAs) exist in mammalian species, moreover their level sensitively changes in pathological situations, such as atherosclerosis or HIV infection. The conditions of their production and functional role, however, still remained ill defined. Recently we developed IgG3 type monoclonal ...

journal_title：Immunology letters

authors： Izsepi E,Balogh A,Farkas A,Molnar A,Solymos E,Toth EA,Csepanyi-Komi R,Matko J

更新日期：2012-03-30 00:00:00

abstract：:Interleukin-18 (IL-18) gene promoter polymorphism is known as a genetic risk factor for child type 1 diabetes mellitus development. To test the role of IL-18 gene polymorphism in predisposition to adult type 1 diabetes (T1DM) and latent autoimmune diabetes in adults (LADA), we analysed SNPs at position -607 (C/A) and ...

journal_title：Immunology letters

authors： Novota P,Kolostova K,Pinterova D,Novak J,Treslova L,Andel M,Cerna M

更新日期：2005-01-31 00:00:00

abstract：OBJECTIVES:Cytokine production from activated T cells play a pathogenetic role in mucosal lesions of coeliac disease (CD). Active interleukin (IL)-18 is expressed in the small intestinal mucosa in CD but not in healthy controls. IL-18 enhances intercellular adhesion molecule-1 (ICAM-1) expression. We analyzed IL-18 ser...

journal_title：Immunology letters

authors： Merendino RA,Di Pasquale G,Sturniolo GC,Ruello A,Albanese V,Minciullo PL,Di Mauro S,Gangemi S

更新日期：2003-02-03 00:00:00

abstract：:The first step in the clearance of apoptotic cells is chemotactic migration of macrophages towards the apoptotic cells guided by find-me signals provided by the dying cells. Upon sensing the chemotactic signals, macrophages release ATP. ATP is then degraded to ADP, AMP and adenosine to trigger purinergic receptors con...

journal_title：Immunology letters

authors： Joós G,Jákim J,Kiss B,Szamosi R,Papp T,Felszeghy S,Sághy T,Nagy G,Szondy Z

更新日期：2017-03-01 00:00:00

abstract：:In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to ...

journal_title：Immunology letters

authors： Clerici M,Salvi A,Trabattoni D,Lo Caputo S,Semplici F,Biasin M,Ble C,Meacci F,Romeo C,Piconi S,Mazzotta F,Villa ML,Mazzoli S

更新日期：1999-03-01 00:00:00

abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...

journal_title：Immunology letters

authors： Lang K,Drell TL,Niggemann B,Zänker KS,Entschladen F

更新日期：2003-12-15 00:00:00

abstract：:This report describes an immunoradiometric assay for Plasmodium falciparum in infected blood, based on a cross-reacting monoclonal antibody (mAb) raised against P. berghei. In this assay, binding of the mAb to intact P. berghei parasites coated on microtiter plates is inhibited by solubilized P. falciparum infected re...

journal_title：Immunology letters

authors： Pass A,Avidor B,Golenser J,Laskov R,Sulitzeanu D

更新日期：1985-01-01 00:00:00

abstract：:Four murine monoclonal antibodies (mAbs) showing similar reactivity with a cell-wall extract and mannan preparation obtained from Candida albicans were examined for epitope specificity. An enzyme-linked immunosorbent assay (ELISA) was used to determine total mAb binding to extracted cell-wall antigen when each mAb was...

journal_title：Immunology letters

authors： Chaffin WL,Morrow KJ Jr

更新日期：1989-07-01 00:00:00

abstract：:Treatment of purified human C5 with hydrogen peroxide leads to a reduction of functional activity in the classical immune haemolysis assay. The effect of H2O2 is enhanced by traces of iron-EDTA, and becomes even stronger when ascorbic acid is present in addition. The enhancement by iron and protective effects of vario...

journal_title：Immunology letters

authors： von Zabern WV,Hesse D,Nolte R,Haller Y

更新日期：1987-02-01 00:00:00

abstract：:Fc gamma receptors type IIb1 (Fc gammaRIIb1) inhibit B-cell activation when co-ligated with B-cell antigen receptors (BCR) by immune complexes. In murine B-cells the inhibition is mediated by the interaction of the phosphorylated immunoreceptor tyrosine-based inhibitory motif (P-ITIM) of Fc gammaRIIb1 with the SH2 dom...

journal_title：Immunology letters

authors： Sármay G,Koncz G,Gergely J

更新日期：1996-12-01 00:00:00

abstract：:In a previous study we have shown that, in response to electrical stimulation, there is a substantial release of noradrenaline (NA) from the sympathetic nerve terminals of the rat thymus which is of axonal, vesicular origin. In the present study neurochemical evidence was obtained that the release of NA is subject to ...

journal_title：Immunology letters

authors： Haskó G,Elenkov IJ,Vizi ES

更新日期：1995-07-01 00:00:00

abstract：:Work on mast cells and basophils began with their identification by Paul Ehrlich at the end of the 19th century. Mast cells and basophils were immediately perceived as closely linked cells and early nomenclature formulated by Ehrlich himself, i.e., tissue "Mastzellen" and blood "Mastzellen", reflected this unifying vi...

journal_title：Immunology letters

authors： Crivellato E,Nico B,Ribatti D

更新日期：2011-12-30 00:00:00

abstract：:In this study the effect of PHA activation on the phosphatase activity of CD45 has been investigated in human leukemic T-cell lines. It has been found that in vivo activation of the cells with PHA resulted in 2-4-fold increase in enzyme activity. Addition of PHA to the postnuclear supernatant of cell lysates also resu...

journal_title：Immunology letters

authors： Monostori E,Hartyani Z,Ocsovszky I,Hegedus Z,Oravecz T,Kalman M,Ando I

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...

journal_title：Immunology letters

authors： Yen JH,Tsai WC,Chen CJ,Lin CH,Ou TT,Hu CJ,Liu HW

更新日期：2003-08-05 00:00:00

abstract：:It has been considered before that human naive and memory/effector CD4+ T-cells cannot be subdivided solely according to the differential expression of CD45 isoforms. By the lack of expression of CD31 we have identified a subset of CD4+ CD45RA+ CD31- cells which show distinct features of antigen-experienced Th1 cells....

journal_title：Immunology letters

authors： Thiel A,Schmitz J,Miltenyi S,Radbruch A

更新日期：1997-06-01 00:00:00

abstract：:Serum antibodies reactive with intermediate filaments of the cytoskeleton (anti-IF antibodies) are often present in infectious mononucleosis, some other viral diseases, and rheumatoid arthritis. The mechanism of their production is not known, but it is possible that the formation of this and other autoantibodies resul...

journal_title：Immunology letters

authors： Mortazavi-Milani SM,Stierle HE,Holborow EJ

更新日期：1982-10-01 00:00:00

abstract：:Monoclonal antibodies (mAb) reacting with native (TA5, TB12) and denatured (T33, T35) plant toxin mistletoe lectin I (MLI) from Viscum album have been obtained. The interaction between mAbs and native toxin with ML isoforms (MLII, MLIII) has been investigated. An immunological cross-reaction has been shown to take pla...

journal_title：Immunology letters

authors： Tonevitsky AG,Rakhmanova VA,Agapov II,Shamshiev AT,Usacheva EA,Prokoph'ev SA,Denisenko ON,Alekseev YuO,Pfueller U

更新日期：1995-01-01 00:00:00

abstract：:Recent advances in next-generation sequencing have enabled rapid and efficient evaluation of the mutational landscape of cancers. As a result, many cancer-specific neoantigens, which can generate antitumor cytotoxic T-cells inside tumors, have been identified. Previously, we reported a metastatic melanoma case with hi...

journal_title：Immunology letters

authors： Nonomura C,Otsuka M,Kondou R,Iizuka A,Miyata H,Ashizawa T,Sakura N,Yoshikawa S,Kiyohara Y,Ohshima K,Urakami K,Nagashima T,Ohnami S,Kusuhara M,Mitsuya K,Hayashi N,Nakasu Y,Mochizuki T,Yamaguchi K,Akiyama Y

更新日期：2019-04-01 00:00:00

abstract：:CD8 T cells are strongly induced in response to certain strains of vaccinia virus (VACV) and the generation of this population is tightly regulated by two Tumor Necrosis Factor (TNF)/TNFR superfamily members, OX40 (CD134) and CD27. In this study, we examined the role of another member of the TNFR superfamily, 4-1BB (C...

journal_title：Immunology letters

authors： Zhao Y,Croft M

更新日期：2012-01-30 00:00:00

abstract：:This study was to investigate the role of macrophage migration inhibitory factor (MIF) in mouse acute otitis media (AOM), we hypothesize that blocking MIF activity will relieve mouse AOM. A mouse AOM model was constructed by injecting lipopolysaccharide (LPS) into the middle ear of C57BL/6 mice through the tympanic me...

journal_title：Immunology letters

authors： Zhang J,Xu M,Zheng Q,Zhang Y,Ma W,Zhang Z

更新日期：2014-11-01 00:00:00

abstract：:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation ...

journal_title：Immunology letters

authors： Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová E

更新日期：1987-04-01 00:00:00