The use of Fab-Fc recombinant antibodies for studying the mechanism of triggering the effector activities of immunoglobulins.

abstract：:Two cell lines producing monoclonal antibodies have been established from peripheral blood of a negative Rhesus blood donor which has been immunized with positive Rhesus red blood cells. Two monoclonal antibodies Co II 8.8 and Co II 7.12 have been selected. Both are IgG1 antibodies, but recognize different epitopes on...

journal_title：Immunology letters

authors： Paire J,Monestier M,Rigal D,Martel F,Desgranges C

更新日期：1986-09-01 00:00:00

abstract：:Many types of cells in the immune system have been found to produce nitric oxide (NO), which performs multiplex functions. However, in myelin basic protein peptide 68-86 (MBP 68-86)-induced experimental autoimmune encephalomyelitis (EAE) in Lewis rats, we found that elevated NO production was generated from spleen cel...

journal_title：Immunology letters

authors： Xu L,Yang J,Huang Y,van der Meide PH,Levi M,Wahren B,Link H,Xiao B

更新日期：2000-03-01 00:00:00

abstract：:During a pathogenic infection, an inflammatory process is triggered in which several inflammatory mediators, such as cytokines, chemokines, growth factors, complement system components, nitric oxide, and others induce integrity alteration on the endothelial barrier. Chemokines are responsible for regulating leukocyte ...

journal_title：Immunology letters

authors： Cipitelli MDC,Amâncio Paiva I,Badolato-Corrêa J,de-Oliveira-Pinto LM

更新日期：2019-08-01 00:00:00

abstract：:Vogt-Koyanagi-Harada disease is an autoimmune systemic disorder. In Vogt-Koyanagi-Harada disease, inflammatory disorders occur in multiple organs containing melanocytes, including uvea (resulting in acute bilateral panuveitis), skin (resulting in vitiligo and alopecia), central nervous system (resulting in meningitis)...

journal_title：Immunology letters

authors： Yamada K,Senju S,Shinohara T,Nakatsura T,Murata Y,Ishihara M,Nakamura S,Ohno S,Negi A,Nishimura Y

更新日期：2001-10-01 00:00:00

abstract：:Potential endogenous ligands for the cysteine rich domain of the murine mannose receptor (MR) have been detected in marginal zone metallophilic macrophages in spleen and subcapsular sinus macrophages in lymph nodes of naive mice by immunohistochemistry using a Fc chimeric protein. Additional labelling was observed in ...

journal_title：Immunology letters

authors： Martínez-Pomares L,Gordon S

更新日期：1999-01-01 00:00:00

abstract：:Immunization of BALB/c mice (H-2d) with a mixture of major histocompatibility complex (MHC) class I- and MHC class II-restricted synthetic peptides emulsified in incomplete Freund's adjuvant (IFA) induced a high level of specific cytotoxic T lymphocyte (CTL) activity. Peptides 249-260 or 252-260, derived from the circ...

journal_title：Immunology letters

authors： Renggli J,Valmori D,Romero JF,Eberl G,Romero P,Betschart B,Corradin G

更新日期：1995-05-01 00:00:00

abstract：:To examine whether grape seed proanthocyanidin extract (GSPE) which is known to act as an antioxidant has therapeutic effect on collagen-induced arthritis (CIA) in mice, an animal model of rheumatoid arthritis. Mice were treated with an intraperitoneal injection of GSPE (10, 50, or 100 mg/kg) or saline. Clinical, hist...

journal_title：Immunology letters

authors： Cho ML,Heo YJ,Park MK,Oh HJ,Park JS,Woo YJ,Ju JH,Park SH,Kim HY,Min JK

更新日期：2009-06-04 00:00:00

abstract：:We report here that Trichosanthin (Tk), a primary active component isolated from a Chinese traditional medicinal herb, Trichosanthes kirilowii, potently inhibits lymphocyte proliferative response in vitro. We found that Tk treatment increased production of the interleukins IL-4 and IL-10, while production of IL-2 and ...

journal_title：Immunology letters

authors： Zhou X,Yang N,Lu L,Ding Q,Jiao Z,Zhou Y,Chou KY

更新日期：2007-05-15 00:00:00

abstract：:An automated biosensor system designed for measuring molecular interactions in real time and without any labelling of the reactants has been used to study the interaction of two animal viruses (vaccinia virus and poliovirus) and two plant viruses (cowpea mosaic virus and tobacco mosaic virus) with monoclonal antibodie...

journal_title：Immunology letters

authors： Dubs MC,Altschuh D,Van Regenmortel MH

更新日期：1992-01-01 00:00:00

abstract：:In a recent, thought-provoking novel by Elizabeth McCracken (The Giant's House. Avon Books, New York, 1997), two characters discuss love and its impossibilities. One brashly claims to be "immune to love", explaining the concept to his perplexed interlocutor, "...people become immune to love like they become immune to ...

journal_title：Immunology letters

authors： Clerici M,Salvi A,Trabattoni D,Lo Caputo S,Semplici F,Biasin M,Ble C,Meacci F,Romeo C,Piconi S,Mazzotta F,Villa ML,Mazzoli S

更新日期：1999-03-01 00:00:00

abstract：PURPOSE:Benazepril, an angiotensin-converting enzyme (ACE) inhibitor, has been used to treat hypertension, congestive heart failure, and chronic renal failure. However, its biological activity and mechanism of action in inflammation are not fully identified. The present study was designed to determine the in vivo anti-...

journal_title：Immunology letters

authors： Yan SH,Zhao NW,Zhu XX,Wang Q,Wang HD,Fu R,Sun Y,Li QY

更新日期：2013-05-01 00:00:00

abstract：:Lymphocytes obtained from thymus and spleens of 1-6 week old White Leghorn cockerels, untreated or immunized twice with sheep red blood cells (SRBC), were cultured with common T-cell mitogens in serial dilutions and/or different concentrations of bovine prolactin (PRL). [3H]Thymidine incorporation in newly synthesized...

journal_title：Immunology letters

authors： Skwarło-Sońta K

更新日期：1990-06-01 00:00:00

abstract：:Aging is associated to dysfunctional changes in the immune system, a process termed immunosenescence. Elderly individuals usually present chronic low level inflammation, likely as the consequence of continued exposure to antigens combined with poor immune function, increases in production of pro-inflammatory cytokines...

journal_title：Immunology letters

authors： Campos C,Pera A,Lopez-Fernandez I,Alonso C,Tarazona R,Solana R

更新日期：2014-11-01 00:00:00

abstract：:Administration of cyclosporin A (CS-A; 25 mg/kg daily) to rats from the time of immunization with ovalbumin (OVA) in complete Freund's adjuvant abolished the production of anti-OVA antibodies, including IgE. Cyclophosphamide (Cy; 150 mg/kg) given 2 days before immunization also inhibited specific antibody production b...

journal_title：Immunology letters

authors： Thomson AW,Brown PA,Simpson JG,Whiting PH,Davidson RJ

更新日期：1985-01-01 00:00:00

abstract：:Both the sporozoites and the erythrocytic stages can modulate the hepatic phase by cytokines, notably IFN-gamma, TNF and IL-6, either directly or as a result of a cascade of events, and by MHC-restricted and antibody-dependent cell-mediated cytotoxicity. The role played by CD8+ T cells in inducing protective immunity ...

journal_title：Immunology letters

authors： Mazier D,Rénia L,Nussler A,Pied S,Marussig M,Goma J,Grillot D,Miltgen F,Drapier JC,Corradin G

更新日期：1990-08-01 00:00:00

abstract：:The ability of immune checkpoint inhibitors (ICIs) to reactivate the killing function of the immune system to tumor cells has led to long lasting immune response presenting highly promising clinical advances. Recently, immune checkpoint inhibitors related resistance due to the specialized tumor microenvironment has al...

journal_title：Immunology letters

authors： Li Y,Liu J,Gao L,Liu Y,Meng F,Li X,Qin FX

更新日期：2020-04-01 00:00:00

abstract：:HLA-specific antibodies generated by allo-immunization are supposed to be involved in the control of HIV infections by both the neutralizing capacity of HLA-specific antibodies (Abs) and HLA-specific Ab-dependent complement-mediated lysis (CML). We further characterized CML of HIV primary isolates induced by HLA-speci...

journal_title：Immunology letters

authors： Hildgartner A,Wilflingseder D,Gassner C,Dierich MP,Stoiber H,Bánki Z

更新日期：2009-09-22 00:00:00

abstract：:A375 human melanoma cell cultures grown in the presence of TGF beta contained greatly reduced cell numbers and exhibited drastic alterations in cell morphology compared to the control cultures. Preincubation of the cells with the cytokine for only 18 h was sufficient to induce these changes irreversibly. Examination o...

journal_title：Immunology letters

authors： Larisch-Bloch S,Yarom R,Sulitzeanu D

更新日期：1992-07-01 00:00:00

abstract：:A variety of cell types may be involved in the regulation of IgA secretion at the intestinal mucosa. Intestinal epithelial cells (IEC) are known to have the capacity to secrete several cytokines which may exert an important regulatory effect on local immunoglobulin secretion by mucosal B cells. In this study, we have ...

journal_title：Immunology letters

authors： Goodrich ME,McGee DW

更新日期：1999-03-15 00:00:00

abstract：:In addition to its hematopoietic activities, interleukin-3 (IL-3) can modulate macrophage functions. We have studied the production of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor (TNF) by mouse peritoneal macrophages triggered by lipopolysaccharide (LPS) in the presence or absence of IL-3. Int...

journal_title：Immunology letters

authors： Cohen L,David B,Cavaillon JM

更新日期：1991-05-01 00:00:00

abstract：:The binding of nascent human C3b (i.e. the fragment of C3 just after trypsin cleavage) to mouse peritoneal macrophages was demonstrated by immune adherence. Acceptor-bound C3b could be detected longer than 24 h on the cell membrane. The rosette formation and phagocytosis of SRBC coated with anti-SRBC rat IgG was inhib...

journal_title：Immunology letters

authors： Fábry Z,Erdei A,Gergely J

更新日期：1983-06-01 00:00:00

abstract：:Parenteral administration of antigen induces in the earthworms Lumbricus terrestris and Eisenia foetida the formation of antigen-binding protein. Labelled antigen was efficiently digested in the coelomic fluids of both species since the total amount of radioactivity in the coelomic fluids decreased. Antigen internaliz...

journal_title：Immunology letters

authors： Rejnek J,Tucková L,Síma P,Bilej M

更新日期：1993-05-01 00:00:00

abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...

journal_title：Immunology letters

authors： Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

更新日期：1994-06-01 00:00:00

abstract：:Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mR...

journal_title：Immunology letters

authors： Kim JO,Cha HR,Kim ED,Kweon MN

更新日期：2012-09-01 00:00:00

abstract：:As one studies more and more the immune systems of invertebrates their multiplicity and diversity increase. On one hand, the number of different local and systemic innate mechanisms (or cascades of mechanisms) increases with every phylum studied, on the other hand the diversity increases within each system as multiple...

journal_title：Immunology letters

authors： Du Pasquier L

更新日期：2004-03-29 00:00:00

abstract：:To study the interactions between Chlamydia trachomatis (CT) and human immunodeficiency virus (HIV) infections, we examined CT serologies in sequential serum samples of male homosexuals (MHS), followed over a mean period of 4 years. Of the MHS studied, 77 were HIV(-), 18 were HIV(+) and 10 patients seroconverted durin...

journal_title：Immunology letters

authors： Schattner A,Hanuka N,Sarov B,Bentwich Z

更新日期：1994-04-01 00:00:00

abstract：:Th1 and Th2 cytokine response has been confirmed to be correlated with the pathogenesis of HCV infection. The aim of the study is to investigate the Th1 and Th2 cytokine profiles induced by HCV alternate reading frame protein (F protein) in chronic hepatitis C patients. We assessed the immune responses specific to HCV...

journal_title：Immunology letters

authors： Yue M,Deng X,Zhai X,Xu K,Kong J,Zhang J,Zhou Z,Yu X,Xu X,Liu Y,Zhu D,Zhang Y

更新日期：2013-05-01 00:00:00

abstract：:An essential key to pathogenicity in Yersinia is the presence of a 70 kb plasmid (pYV) which encodes a type-III secretion system and several virulence outer proteins whose main function is to enable the bacteria to survive in the host. Thus, a specific immune response is needed in which cytokines are engaged. The aim ...

journal_title：Immunology letters

authors： Monnazzi LG,Carlos IZ,de Medeiros BM

更新日期：2004-06-15 00:00:00

abstract：:House dust mite antigen is a well-known allergen in the pathogenesis of atopic dermatitis (AD), a chronic relapsing inflammatory skin disease. We evaluated the AD model mice sensitized with house dust mite antigen and observed a Th2-dominant immune response. In this experiment, BALB/c mice were sensitized percutaneous...

journal_title：Immunology letters

authors： Santa K,Watanabe K,Nakada T,Kato H,Habu S,Kubota S

更新日期：2003-01-02 00:00:00

abstract：:A murine monoclonal antibody (IgG) has been generated that binds to DNA modified with osmium tetroxide in the presence of 2,2'-bipyridine and does not interact with unmodified DNA. Reactivity of the antibody was tested by gel retardation assay, ELISA, dot-binding assay and immunoblotting. The results obtained suggest ...

journal_title：Immunology letters

authors： Kabakov AE,Podgorodnichenko VK,Poverenny AM

更新日期：1991-09-01 00:00:00