Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells.

abstract：:Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...

journal_title：Immunology letters

authors： Hojo H,Kaneko A,Nanya K,Kayagaki N,Hashimoto Y

更新日期：1994-06-01 00:00:00

abstract：:Myelin basic protein (MBP), is a major component of the central nervous system (CNS) myelin. MBP can stimulate T cells that migrate into the CNS, initiating a cascade of events that result in perivascular infiltration and demyelination. EAE is an inflammatory and demyelinating autoimmune disease of the CNS that serves...

journal_title：Immunology letters

authors： Brenner T,Steinberger I,Soffer D,Beraud E,Ben-Nun A,Lorberboum-Galski H

更新日期：1999-06-01 00:00:00

abstract：:We investigated IgE-mediated allergic responses in a metabolic syndrome model rat strain, SHRSP.Z, which develops obesity and hypertension to cast light on the relationship between metabolic disturbances and allergic responses. IgE-mediated cutaneous anaphylactic responses were severely attenuated in this strain regar...

journal_title：Immunology letters

authors： Sakanaka M,Furuta K,Ichikawa A,Tanaka S

更新日期：2010-01-18 00:00:00

abstract：:Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation. This study aims to measure the expression of soluble ST2 (sST2) and IL-33 in endometriosis. We investigated thirty women with laparoscopic and histopathological confirmed endometriosis and 20 c...

journal_title：Immunology letters

authors： Mbarik M,Kaabachi W,Henidi B,Sassi FH,Hamzaoui K

更新日期：2015-07-01 00:00:00

abstract：:The effect of ageing on thymocyte progenitors in the bone marrow was studied in an in vitro experimental model that permits T lymphocyte development. The model is based on co-culture of BM cells from young and old mice with lymphoid depleted fetal thymus explants. We applied different strategies of thymic colonization...

journal_title：Immunology letters

authors： Globerson A

更新日期：1994-06-01 00:00:00

abstract：:Recent data provide evidence that antigen-specific CD4+ T-cell clones or antigen-activated T-cell lines can kill antigen-presenting cells (APC). We focused our studies on monocytes acting as APC in cultures of T cells freshly isolated from peripheral blood. The presence of monocytes in culture was monitored by their a...

journal_title：Immunology letters

authors： Pryjma J,Zembala M,Baran J,Ernst M,Flad HD

更新日期：1995-06-01 00:00:00

abstract：:Retroplacental blood lymphocytes (RPL) obtained from women without complications at the term delivery were studied for proliferative response to mitogens and surface phenotype and were compared with autologous peripheral blood lymphocytes (PBL). Proliferation of RPL induced by phytohemagglutinin (PHA) was significantl...

journal_title：Immunology letters

authors： Yoshida M,Kanzaki H,Tokushige M,Sato S,Wang HS,Uchida A,Kasakura S,Mori T

更新日期：1988-03-01 00:00:00

abstract：:Callithrix jacchus, the common marmoset, is a small new world primate that is considered effective as an experimental animal model for various human diseases. In this study, we generated monoclonal antibodies (mAbs) against common marmoset lymphocytes for immunological studies on the common marmoset. We established fi...

journal_title：Immunology letters

authors： Ito R,Maekawa S,Kawai K,Suemizu H,Suzuki S,Ishii H,Tanioka Y,Satake M,Yagita H,Habu S,Ito M

更新日期：2008-12-22 00:00:00

abstract：:In the present investigations we aimed to study the effect of Shigella sonnei lipopolysaccharide (LPS) on delayed type hypersensitivity (DTH) to non-bacterial antigen in CBA mice. These experiments showed that intraperitoneal injection of phenol-water extracted LPS and avirulent S. sonnei did not affect the level of D...

journal_title：Immunology letters

authors： Vikström EV

更新日期：2002-01-01 00:00:00

abstract：:Lipopolysaccharide (LPS) is a major component of the outer membrane of Gram-negative bacteria. As such, it signals monocytes, macrophages and neutrophils to up-regulate phagocytic functions and to release pro-inflammatory cytokines. Despite the established role of CD14 as the main LPS receptor, the precise nature of t...

journal_title：Immunology letters

authors： Leon-Ponte M,Kirchhof MG,Sun T,Stephens T,Singh B,Sandhu S,Madrenas J

更新日期：2005-01-15 00:00:00

abstract：:Tuberculosis (TB) is a leading cause of global mortality due to infectious diseases. Expression of cyclooxygenase-2 (COX-2) acts as an important influencing factor favoring bacillary survival during TB infection. In this study, we investigated the Mycobacterium tuberculosis proteins recognized by sera from TB patient ...

journal_title：Immunology letters

authors： Zhao JW,Sun ZQ,Zhang XY,Zhang Y,Liu J,Ye J,Chen CC,Samten B,Wang HH,Guo XK,Zhang SL

更新日期：2014-09-01 00:00:00

abstract：:B cell activating factor belonging to the TNF family (BAFF, also called BLyS, TALL-1, THANK, or zTNF4) is an important survival factor for B cells, and is able to regulate T cell activation. Recently, we have demonstrated that human soluble BAFF (hsBAFF) potently elevates NK cell activity of murine splenic cells in vi...

journal_title：Immunology letters

authors： Zhang W,Wen L,Huang X,Liang J,Gao W,Zhang S,Chen L

更新日期：2008-10-30 00:00:00

abstract：:A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...

journal_title：Immunology letters

authors： Epstein WL,Okamoto M,Suya H,Fukuyama K

更新日期：1986-11-17 00:00:00

abstract：:The protozoan parasite Trypanosoma cruzi is able to replicate in the cytoplasm of primary resident macrophages, but is killed by activated macrophages. Pretreatment of human macrophages with recombinant IFN-gamma and to a lesser extent with TNF-alpha, induced a significant trypanocidal activity. Furthermore, TNF-alpha...

journal_title：Immunology letters

authors： Muñoz-Fernández MA,Fernández MA,Fresno M

更新日期：1992-06-01 00:00:00

abstract：:We have previously reported the production of a series of human monoclonal antibodies reacting with mouse mammary tumor viral antigens as well as the human counterpart HuMTV antigen. Against two of these antibodies (B11 and 4.6/6), anti-idiotypic antibodies were generated, which appeared to be the internal image of vi...

journal_title：Immunology letters

authors： Blank M,Smorodinsky IN,Keydar I,Chaitchik S,Shoenfeld Y

更新日期：1991-04-01 00:00:00

abstract：:Naive CD4 T cells differentiate into functionally distinct T helper (Th) cells subsets or into regulatory T (Treg) cells in response to the cytokine milieu in which they encounter antigen. A recurring theme in post-thymic CD4 T cell differentiation is the cross-regulation of lineage choice by cytokines and transcripti...

journal_title：Immunology letters

authors： Hadjur S,Bruno L,Hertweck A,Cobb BS,Taylor B,Fisher AG,Merkenschlager M

更新日期：2009-01-29 00:00:00

abstract：:A375 human melanoma cell cultures grown in the presence of TGF beta contained greatly reduced cell numbers and exhibited drastic alterations in cell morphology compared to the control cultures. Preincubation of the cells with the cytokine for only 18 h was sufficient to induce these changes irreversibly. Examination o...

journal_title：Immunology letters

authors： Larisch-Bloch S,Yarom R,Sulitzeanu D

更新日期：1992-07-01 00:00:00

abstract：:Dendritic cell (DC)-based tumor vaccine is a promising therapy for malignancies. Recent studies showed greater potency with DC/tumor fusion vaccines against acute myeloid leukemia and melanoma compared with lysate-pulsed DC vaccines. We compared these two vaccine strategies against murine colon cancer and investigated...

journal_title：Immunology letters

authors： Kao JY,Zhang M,Chen CM,Chen JJ

更新日期：2005-11-15 00:00:00

abstract：:Salmonella enterica serovars infect a broad range of mammalian hosts, including humans, causing both gastrointestinal and systemic diseases. Effective immune responses to Salmonella infections depend largely on CD4+ T cell activation by dendritic cells (DCs). Bacteria are internalised by intestinal DCs and respond by ...

journal_title：Immunology letters

authors： Cerny O,Holden DW

更新日期：2019-11-01 00:00:00

abstract：:There has been significant progress in the field of heart transplantation over the last 45 years. Although the role of adaptive immunity in heart allograft rejection has been extensively studied for decades, there is increasing evidence that suggests that the innate immune system also contributes to the development of...

journal_title：Immunology letters

authors： Lv Q,Li C,Mo Y,He L

更新日期：2018-02-01 00:00:00

abstract：:Natural killer (NK) cells and cytotoxic T lymphocytes (CTL), the functional coordination of which are governed by various signal substances, are crucial in the body's defense of tumor and virus-infected cells. We investigated the role of various neurotransmitters and hormones on the regulation of functional parameters...

journal_title：Immunology letters

authors： Lang K,Drell TL,Niggemann B,Zänker KS,Entschladen F

更新日期：2003-12-15 00:00:00

abstract：:Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tes...

journal_title：Immunology letters

authors： Görög G,Laskay T,Petrányi GG

更新日期：1985-01-01 00:00:00

abstract：:African swine fever (ASF) virus has been reported to infect cells of the monocyte family, probably macrophage-like cells, but there is variation in the apparent susceptibility of these cells. We have demonstrated that the phenotype and activity of porcine monocytic cells varies between different isolations and also up...

journal_title：Immunology letters

authors： McCullough KC,Schaffner R,Fraefel W,Kihm U

更新日期：1993-07-01 00:00:00

abstract：:Dendritic cells (DC), the most potent antigen presenting cells (APC), have been shown able to process apoptotic tumor cells and necrotic tumor cells for antigen presentation. Apoptosis and necrosis are the two common final pathways through which the tumors are killed by chemotherapy or radiation therapy. The tumor cel...

journal_title：Immunology letters

authors： Zhu B,Zou L,Cheng X,Lin Z,Duan Y,Wu Y,Zhou F,Chen Z

更新日期：2006-03-15 00:00:00

abstract：:We have reported that a cell line, KML1, obtained from lymph node cells of a 16-week-old female MRL/Mp-lpr/lpr (MRL/1) mouse produces a soluble factor(s) that promotes formation of anti-single-stranded (ss) DNA antibodies by cultures of spleen cells from old MRL/l mice (greater than 16 weeks old). Detailed examination...

journal_title：Immunology letters

authors： Kanai Y,Isonishi S,Katagiri T,Koizumi T,Miura K,Kurosawa Y

更新日期：1990-03-01 00:00:00

abstract：:When the random polymer (Glu, Phe)n was added to primary lymph node T cell cultures from mice immunized with (Glu, Lys, Ala) and other immunogens, significant inhibition of [3H]thymidine incorporation was noted. A similar addition of (Glu, Phe)n to murine T cell lines (Fathman) from the above reacting lymph nodes led ...

journal_title：Immunology letters

authors： Maurer PH,Liu DC,Grun JL

更新日期：1987-12-01 00:00:00

abstract：:The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...

journal_title：Immunology letters

authors： Hoffman SL,Weiss W,Mellouk S,Sedegah M

更新日期：1990-08-01 00:00:00

abstract：:Psoriasis and psoriatic arthritis (PsA) are common diseases associated with considerable morbidity and disability. Their pathophysiology comprises a dysfunctional stromal-immune cell and cytokine network leading to inflammation of skin, entheses and joints. Recent advances in understanding of disease pathogenesis have...

journal_title：Immunology letters

authors： Hueber AJ,McInnes IB

更新日期：2007-12-15 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the selective destruction of the insulin-producing β cells. Research into the pathogenesis of T1D has been hindered by the lack of detection of the autoimmune process during the asymptomatic period and by the inaccessibility to the target tissue. Therefore curre...

journal_title：Immunology letters

authors： Planas R,Pujol-Borrell R,Vives-Pi M

更新日期：2010-10-30 00:00:00

abstract：:Mouse spleen cells were activated with IL2 for 4 days in the presence or absence of paraformaldehyde fixed YAC (PFY) tumor cells (spleen cell: PFY ratio 100:1). Fresh spleen cells had poor expression of Ly49A but the expression was significantly upregulated by IL2 activation. Addition of PFYs resulted in a further boo...

journal_title：Immunology letters

authors： Das A,Saxena RK

更新日期：2001-06-01 00:00:00