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Establishment of human cell lines producing anti-D monoclonal antibodies: identification of Rhesus D antigen.

Abstract：

:Two cell lines producing monoclonal antibodies have been established from peripheral blood of a negative Rhesus blood donor which has been immunized with positive Rhesus red blood cells. Two monoclonal antibodies Co II 8.8 and Co II 7.12 have been selected. Both are IgG1 antibodies, but recognize different epitopes on the Rhesus D antigen, apparently associated with different subunits of the D antigen. Thus the Co II 8.8, like the positive serum, immunoprecipitates an antigen of a relative molecular weight of 33 kDa, while the Co II 7.12 recognizes an antigen of Mr 42 kDa.

journal_name

Immunol Lett

journal_title

Immunology letters

authors

Paire J,Monestier M,Rigal D,Martel F,Desgranges C

doi

10.1016/0165-2478(86)90046-5

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

137-41

issue

3

eissn

0165-2478

issn

1879-0542

pii

0165-2478(86)90046-5

journal_volume

13

pub_type

杂志文章

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