Abstract:
:Administration of human recombinant interleukin-2 (RIL-2) into congenitally athymic (nu/nu) mice carrying subcutaneous transplants of HeLa, HU 609T and T24B human carcinoma cells partially inhibited growth of the human tumor xenografts. In vitro activation of nu/nu spleen cells with human RIL-2 resulted in generation of killer cells showing in the 51Cr cytotoxicity assay similar levels of cytolysis as RIL-2-activated spleen cells from heterozygous (nu/+) mice. The RIL-2-activated (LAK) cells were cytotoxic for a variety of mouse and human tumors, reaching the peak of their cytotoxic activity after 3 days of cultivation in the RIL-2-containing medium. The cytotoxic activity of activated nu/nu spleen cells was significantly reduced by treatment with antibody against glycolipid asialo GM1, the differentiation antigen of natural killer (NK) cells. This finding suggests that in addition to the conventional, asialo GM1- LAK cells, asialo GM1+ activated NK cells participated in the cytotoxicity displayed by the IL-2-activated nu/nu killer spleen cells.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Bubeník J,Kieler J,Tromholt V,Indrová M,Lotzová Edoi
10.1016/0165-2478(87)90013-7subject
Has Abstractpub_date
1987-04-01 00:00:00pages
325-30issue
4eissn
0165-2478issn
1879-0542pii
0165-2478(87)90013-7journal_volume
14pub_type
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journal_title:Immunology letters
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更新日期:1982-01-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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journal_title:Immunology letters
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更新日期:2020-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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更新日期:1991-07-01 00:00:00
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journal_title:Immunology letters
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90087-q
更新日期:1991-09-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2019.02.005
更新日期:2019-11-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00059-e
更新日期:1995-07-01 00:00:00
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更新日期:2007-03-15 00:00:00
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journal_title:Immunology letters
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更新日期:2020-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章,评审
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journal_title:Immunology letters
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更新日期:1995-05-01 00:00:00
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journal_title:Immunology letters
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更新日期:2020-07-01 00:00:00
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journal_title:Immunology letters
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更新日期:2000-12-01 00:00:00
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journal_title:Immunology letters
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Immunology letters
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更新日期:1987-01-01 00:00:00