Abstract:
:Work done in our laboratories, using a murine model, indicates that suppression of host immune responses might be due to secretion of soluble factors by tumor cells. The H238 cells (BALB/c embryonic fibroblasts transformed by UV-inactivated herpes simplex virus Type 2) exhibit progressive tumor growth with subsequent decrease in lymphoproliferation. To further study the suppressive effects of a tumor, H238 conditioned medium (CM) was tested for its ability to block murine and human mitogenic and allogeneic lymphocyte responses. PHA, Con A and LPS were used as mitogens. Lymphoproliferation, in the presence of increasing amounts of H238 CM, resulted in a greater degree of suppression of [3H]thymidine ([3H]Tdr) uptake, in both human and mouse systems. The kinetics of proliferation in the presence of concentrated H238 CM (cCM) showed that depression was evident regardless of the time of cCM addition, thereby affecting it at any stage of the cell cycle. Treatment of H238 cCM using acid (pH 2.3), base (pH 9.6), trypsin (100 micrograms/ml), heat (56 degrees C, 100 degrees C) and freeze-thawing, restored PHA-stimulated lymphoproliferation. Dialysis of H238 cCM showed that the molecular weight of the suppressor lies between 15 and 25 kDa. Northern blot analysis demonstrated the presence of a TGF-beta transcript in H238 cells. Neutralization of the H238 cCM with monoclonal antibody to TGF-beta resulted in complete abrogation of suppressive activity in spleen cell lymphoblastogenesis. These results suggest that TGF-beta appears to be the main inhibitor of immune responses found in this HSV-2-induced murine tumor cell line. Such tumor-induced modulations may contribute to the outcome of immunotherapy in the tumor-bearing host.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Das MR,Gridley DS,Kettering JDdoi
10.1016/0165-2478(91)90087-qsubject
Has Abstractpub_date
1991-09-01 00:00:00pages
37-45issue
1eissn
0165-2478issn
1879-0542pii
0165-2478(91)90087-Qjournal_volume
30pub_type
杂志文章abstract::Crohn's disease and ulcerative colitis, known together as inflammatory bowel disease (IBD), are severe autoimmune disorders now causing gut inflammation and ulceration, among other symptoms, in up to 1 in 250 people worldwide. Incidence and prevalence of IBD have been increasing dramatically over the past several deca...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2014.07.014
更新日期:2014-12-01 00:00:00
abstract::SJL mice develop resistance against tolerance between the 9th and 25th wk of life. This resistance is linked with a loss of suppressor capacity in the thymus. We have shown here that contact photosensitivity (CPS) decreases as a function of age and that this is due to an age-dependent increase in suppressor capacity. ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90102-1
更新日期:1986-03-01 00:00:00
abstract::Toll-like receptors (TLR) are critical in the activation of macrophages by bacterial products. It has been shown that TLR2 and TLR4 mediate lipopolysaccharide (LPS) and lipoproteins signal transduction, respectively. Regulation of TLR2 and TLR4 expression by LPS was considered to be one of the mechanisms to control th...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00010-x
更新日期:2002-05-01 00:00:00
abstract::T cells recognize with a single receptor both a product of antigens processed by antigen presenting cells (APC1) and a self-marker molecule, encoded by the major histocompatibility complex (MHC, a property termed MHC-restricted recognition of antigen). During their differentiation in the thymus, T cells "learn" what t...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(90)90040-w
更新日期:1990-06-01 00:00:00
abstract::Tuberculosis is an infectious disease that affects millions of people worldwide with an annual mortality rate of 1.3 million. The mechanisms contributing to the loss of balance of immune responses and progression to active tuberculosis disease are unknown. Although CD4+ and CD8+ T cells and the cytokines they produce ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.03.009
更新日期:2014-07-01 00:00:00
abstract::Tumor cells have been used as the tumor antigen sources for developing cancer vaccines. Due to their low immunogenicity, tumor antigens are combined with various adjuvants to enhance immunogenicity of cancer vaccines. Among them, a natural killer T cell (NKT)-ligand, α-galactosylceramide (αGC) has been reported as a p...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.10.002
更新日期:2013-11-01 00:00:00
abstract::While the pathophysiology of burn injury is well established in young adults, the factors that contribute to pathogenesis and increased death in elderly burn patients are not defined. The purpose of this study is to determine the effects of burn injury on mesenteric lymph node (MLN) T cell responses in young and aged ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00022-1
更新日期:2003-04-03 00:00:00
abstract::Several recent studies have shown that the antigen receptors (mIgM and mIgD) on normal B cell surfaces are part of larger multimolecular complexes, as each is noncovalently coupled to at least two other proteins whose phosphorylation is inducible upon G protein activation. However, B cell receptor complexes appear to ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90050-x
更新日期:1992-05-01 00:00:00
abstract::Autoimmunity in disease is driven by autoantigen. Cell surface molecules may stimulate autoreactive T-helpers if class II MHC is expressed; special factors may predispose to the ease of class II induction. Soluble autoantigens may be focused by primed B cells and processed for presentation to T cells. Autoantigenicity...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(87)90155-6
更新日期:1987-12-01 00:00:00
abstract::In studying terminal lytic events of sensitized erythrocytes which have reacted with all 9 components of complement, we agree in general with the conclusions of Boyle and Borsos [1] that the cellular intermediate passes through the stages E*bound, E*inserted, and E*doomed. However, we differ with these workers on the ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(81)90095-x
更新日期:1981-04-01 00:00:00
abstract:OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00071-3
更新日期:2003-08-05 00:00:00
abstract::Pretreatment of murine bone marrow-derived macrophages with wheat germ agglutinin (WGA) and concanavalin A (Con A) markedly enhanced the uptake of Staphylococcus aureus H and Escherichia coli 08, respectively. Pretreatment of the respective bacteria with these lectins also greatly increased their uptake by the macroph...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90048-9
更新日期:1986-09-01 00:00:00
abstract::Serum IgG1 levels are selectively increased in patients with chronic hepatitis C virus (HCV) infection. In 15 patients who received interferon (IFN)-alpha therapy, serum levels of immunoglobulin classes and IgG subclasses were measured during treatment and after it was discontinued. In spite of important individual va...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(96)02681-8
更新日期:1997-01-01 00:00:00
abstract::The mechanism of cytolysis by natural killer cells has been shown to involve a soluble lytic factor - the natural killer cytotoxic factor (NKCF). We have investigated the generation of NKCF on exposure of subpopulations of human blood lymphocytes to autologous B lymphocytes and EBV infected B lymphocytes (BEBV), and t...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90096-9
更新日期:1986-03-01 00:00:00
abstract::CBA spleen cells have been stimulated in vitro with A/Jap influenza virus-infected CBA spleen cells to generate a 'primary' cytotoxic lymphocyte (CL) response. The culture conditions were devised to allow the segregation of individual clones of CL and cytotoxicity measured by the lysis of infected or non-infected L-92...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(82)90127-4
更新日期:1982-01-01 00:00:00
abstract::In some animal models of organ transplantation, notably the rat, preoperative administration of donor strain blood may produce long-term allograft survival even in the absence of adjunctive immunosuppressive therapy. The ability of blood transfusion to prevent rejection is highly dependent on the strain combination an...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90213-t
更新日期:1991-07-01 00:00:00
abstract::It has been considered before that human naive and memory/effector CD4+ T-cells cannot be subdivided solely according to the differential expression of CD45 isoforms. By the lack of expression of CD31 we have identified a subset of CD4+ CD45RA+ CD31- cells which show distinct features of antigen-experienced Th1 cells....
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(97)00056-4
更新日期:1997-06-01 00:00:00
abstract::Neuraminidases act as a virulence factors for several pathogens that invade the human body through Peyer's patch M-cells. Because of the structural similarity of Aleuria aurantia lectin (AAL) to neuraminidases, we hypothesized that AAL might also target human M-cells. In an in vitro human M-cell co-culture model signi...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.03.020
更新日期:2005-09-15 00:00:00
abstract::Allogeneic, H-2-incompatible irradiation chimeras (H-2d leads to H-2b) constructed with normal, unmanipulated bone marrow and with marrow-derived factors live long and do not manifest a GvH disease. Their response to primary immunization is deficient but their alloreactivity is normal. This chimeric allotolerance cann...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(83)90003-2
更新日期:1983-04-01 00:00:00
abstract:BACKGROUND:The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs) can down-regulate autoimmunity, but also promote tumor growth. The objective of this study was to examine the levels of AIRE, AchR, and Foxp3 ex...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2014.04.008
更新日期:2014-09-01 00:00:00
abstract::Recombinant and pure "natural" IL-1 and IL-2 were compared with the muramyl dipeptide (MDP) component of Freund's adjuvant for their capacity to enhance the humoral immune response against foot-and-mouth disease (FMD) virus antigen. Using a dose of this antigen which alone did not give a detectable immune response, an...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90008-c
更新日期:1992-01-01 00:00:00
abstract::In transplant rejection, graft versus host or autoimmune diseases T cells are mediating the pathophysiological processes. Compared to unspecific pharmacological immune suppression specific inhibition of those T cells, that are involved in the disease, would be an alternative and attractive approach. T cells are activa...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2009.06.002
更新日期:2009-08-15 00:00:00
abstract::Histamine and putrescine (a precursor of polyamines) are formed by histidine decarboxylase (HDC) and ornithine decarboxylase (ODC), respectively. Within a few hours after injection of a lipopolysaccharide (LPS) into mice, HDC is induced in the liver, spleen, lung and bone marrow, and ODC is induced in the liver, splee...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(92)90086-4
更新日期:1992-06-01 00:00:00
abstract::A direct role for delayed hypersensitivity in organized granuloma formation has been emphasized in the literature, but some clinical and experimental studies have suggested a more complicated relationship. In order to further evaluate T-cell function in cutaneous granulomatous inflammation, hepatic granulomas isolated...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(86)90021-0
更新日期:1986-11-17 00:00:00
abstract::The human matrix metalloproteinases (MMPs) are importantly involved in aneurysm formation. Since the clinical manifestations in Behçet disease (BD) include aneurysm formation among major symptoms, polymorphisms in MMP-9 might be associated with BD susceptibility. The aim of the current case-control study was to invest...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2015.01.005
更新日期:2015-03-01 00:00:00
abstract::In this study, we examined the cytokine production by human peripheral blood mononuclear cells (PBM) from recipients of orthotopic liver transplants which had been stimulated by donor-specific alloantigen. Levels of interleukin (IL)-2, IL-4, interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta produ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00061-3
更新日期:1998-09-01 00:00:00
abstract::Protozoa of the genus Leishmania are intracellular parasites of macrophages and may cause diverse clinical forms of leishmaniasis, including cutaneous, diffuse cutaneous, mucocutaneous and visceral leishmaniasis. Infection with L. major in mice indicates that a protective immune response is achieved when Th1 cells are...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.12.002
更新日期:2006-05-15 00:00:00
abstract::Recently, a newly identified human HERV-K18 like endogenous retrovirus (IDDMK(1,2)22) has been associated to the etiology of type I diabetes (IDDM). Although the exact mechanism remains unclear, it was postulated that the 3' end ORF product of the env gene of IDDMK(1,2)22 would trigger a V beta 7-specific human T cell...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00340-6
更新日期:2002-04-01 00:00:00
abstract::Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4+CD25bri regulatory ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.11.009
更新日期:2017-01-01 00:00:00
abstract::A panel of synthetic peptides representing human lymphocyte antigen (HLA) B8, other class I and class II restricted T cell epitopes and two B cell epitopes, were all able to compete with recognition of a HLA B8 restricted epitope by a cytotoxic T cell clone. Competition was obtained when the competitor peptides were a...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(91)90048-f
更新日期:1991-11-01 00:00:00