Abstract:
:Allogeneic, H-2-incompatible irradiation chimeras (H-2d leads to H-2b) constructed with normal, unmanipulated bone marrow and with marrow-derived factors live long and do not manifest a GvH disease. Their response to primary immunization is deficient but their alloreactivity is normal. This chimeric allotolerance cannot be passively transferred from chimeric donors to normal irradiated recipients. Passive transfer of both donor- or recipient-type immunocompetent T-cells into the chimeric mice does not lead to syngeneic reconstitution, rejection of the engrafted marrow or GvH disease and the mice maintain permanently their chimerism. This new model demonstrates that chimerism is not eradicable in long-lived chimeras reconstituted with unmanipulated bone marrow, and that the bone marrow itself plays a dominant role in maintenance of chimerism.
journal_name
Immunol Lettjournal_title
Immunology lettersauthors
Pierpaoli W,Maestroni GJdoi
10.1016/0165-2478(83)90003-2subject
Has Abstractpub_date
1983-04-01 00:00:00pages
197-202issue
4eissn
0165-2478issn
1879-0542pii
0165-2478(83)90003-2journal_volume
6pub_type
杂志文章abstract::The observation that protective immunity induced by immunization with radiation attenuated Plasmodium berghei and Plasmodium yoelii sporozoites is dependent on CD8+ T lymphocytes in some strains of mice led us to speculate that immunization with sporozoites induces cytotoxic T lymphocytes (CTL) that recognize malaria ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(90)90087-7
更新日期:1990-08-01 00:00:00
abstract::Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multifaceted hematopoietic cytokine and the culture of mouse bone marrow with GM-CSF produces a variety of myeloid cells including granulocytes, macrophages, and dendritic cells. In the present study, we cultured mouse splenocytes with GM-CSF and examined ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.03.003
更新日期:2016-05-01 00:00:00
abstract::Non-Alcoholic Fatty Liver Disease (NALD) is considering a hepatic manifestation of metabolic syndrome. Although the pathogenesis of NALD is not completely understood, insulin resistance and inflammatory cytokines are implicated. Considering that component C5 is a central mediator of inflammation, we investigated the r...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2016.07.014
更新日期:2016-09-01 00:00:00
abstract::Clone C19 derived from a rat bladder cancer cell line BC31ad constitutively released cytotoxic factor RCF. The serum-free C19-conditioned medium was partially purified by DEAE-Sephacel, Sephacryl S-200 and MonoQ-FPLC chromatographies to the specific activity of 6.4 x 10(6) U/mg protein (LM assay). RCF was a 17-kDa pro...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90051-5
更新日期:1994-06-01 00:00:00
abstract::Circulating T follicular helper (cTFH) cells have been demonstrated to be involved in B-cell-mediated alloreactive responses in kidney and liver transplantation; however, whether these cells are involved in acute liver allograft rejection after liver transplantation, and which subsets are involved, remains to be clari...
journal_title:Immunology letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.imlet.2019.03.003
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:To investigate the associations of cytochrome p450 1A1 (CYP1A1) and manganese superoxide dismutase (MnSOD) genes polymorphisms with the susceptibility to AS in Taiwan. METHODS:The polymorphisms of CYP1A1 and MnSOD genes were determined in 70 patients with ankylosing spondylitis (AS) and 93 healthy controls ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(03)00071-3
更新日期:2003-08-05 00:00:00
abstract::Over the last two decades HIV-1 has spread worldwide and has now surpassed malaria as the leading cause of infectious disease mortality in adults (http://www.who.int/infectious-disease-report/pages/ch1text.html). The clinical course and outcome of HIV-1 infection are highly variable among individuals. Most individuals...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(01)00275-9
更新日期:2001-11-01 00:00:00
abstract::The role of the immunomodulator Protein A (PA) (from Staphylococcus aureus, Cowan I strain) in the control of leishmanial infection was studied in experimental animals. Treatment of Leishmania donovani infected hamsters with PA led to a moderate level of reduction of parasite load in their spleen (68%) and liver (46%)...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(98)00102-3
更新日期:1999-02-01 00:00:00
abstract::B cells not only play a pivotal role in humoral immunity, but also are involved in a broad spectrum of immune responses, including antigen presentation and T-cell function regulation. The identification of cell-surface CD molecules derived from a series of Human Leukocyte Differentiation Antigens (HLDA) Workshops has ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2010.09.019
更新日期:2011-01-30 00:00:00
abstract::Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02602-8
更新日期:1996-09-01 00:00:00
abstract::The wide distribution of Borrelia burgdorferi, the spirochete causing Lyme borreliosis, represents a human health hazard in many areas of the world. Vaccination has been proposed as an effective prevention strategy. Vaccination experiments were conducted with preparations of recombinant outer surface protein A (OspA) ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90166-x
更新日期:1994-03-01 00:00:00
abstract::We infected umbilical cord blood lymphocytes (CBL) with EBV in vitro. Analysis of the cell population in 3- and 6-day-old cultures showed a relative increase of B cells and outgrowth of B cells after prolonged culture period. The immunomodulator PSK was added to parallel cultures. In these cultures, B cell growth was ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(01)00330-3
更新日期:2002-03-01 00:00:00
abstract::Atopic dermatitis (AD) and allergic contact dermatitis (ACD) are common skin inflammatory conditions. B and T cells are strongly implicated in allergic contact hypersensitivity (CHS) conditions. Activation of IgD B-cell receptor (BCR) by anti-IgD stimulation depletes mature B cells and modulates T-helper cell type 1/2...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2018.09.008
更新日期:2018-11-01 00:00:00
abstract::The early thymic precursor population of adult mice (low CD4 precursor) has the potential to produce T cells, B cells and dendritic cells if transferred into the appropriate inductive environment of an irradiated recipient. To assess its developmental potential in vitro, this population was isolated and cultured, alon...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)00059-e
更新日期:1995-07-01 00:00:00
abstract::Lck is the principal signal-generating tyrosine kinase of the T cell activation mechanism. We have previously demonstrated that induced Lck activation outside of lipid rafts (LR) results in the rapid translocation of a fraction of Lck to LR. While this translocation predicates the subsequent production of IL-2, the me...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2012.01.001
更新日期:2012-02-29 00:00:00
abstract::Our previous studies had shown that the clinicopathological spectrum in leprosy was associated with discrete T cell subsets in circulation, with tuberculoid patients having antigen-induced Th 1, whereas lepromatous leprosy patients with antigen-specific T cell anergy possessed Th 2 cells. The present study shows that ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(95)02455-7
更新日期:1995-12-01 00:00:00
abstract::Abnormal activation of the transcriptional factor STAT3 (signal transducer and activator of transcription 3) was recently associated with Alzheimer Disease (AD). STAT3 phosphorylation is critical for cytokine secretion linked to neuroinflammation. Moreover, STAT3 may act as a transcriptional regulator of BACE1 (β-APP ...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2020.10.004
更新日期:2020-12-01 00:00:00
abstract::NADPH oxidase 2 is a superoxide-generating enzymatic complex based on the catalytic subunit gp91phox that is also known as Nox2. Initially identified in neutrophils, NADPH oxidase 2 was long considered responsible only for the killing of phagocytized microorganisms. However, advances in knowledge about redox signallin...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2020.02.009
更新日期:2020-05-01 00:00:00
abstract::This paper describes functional and genetic studies on the macrophage resistance gene Lsh/Ity/Bcg first described almost two decades ago. Working in vitro with resident peritoneal, liver (Kupffer cells) and bone marrow derived macrophages from congenic B10 (LshS) and B10.L-LshR mice it has been possible to demonstrate...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/0165-2478(91)90032-6
更新日期:1991-10-01 00:00:00
abstract::The murine pre-B-like cell line, 70Z /3, has been shown to undergo differentiation in response to supernatants derived from concanavalin-A (Con A) stimulated rat spleen cells or ultraviolet light treated P388D1 macrophage cell line. After culture for 24 h with supernatant factors, normally membrane IgM negative 70Z /3...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(84)90085-3
更新日期:1984-01-01 00:00:00
abstract::Dendritic cells (DCs) from cancer patients, as well as tumor-infiltrating DCs, are reported to have suppressed immunostimulatory capacity. One of the major problems in the clinical use of DCs for treating tumors is that the DCs must be autologous ones obtained from patients. Compared with normal DCs (nDCs), flow-cytom...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/s0165-2478(02)00071-8
更新日期:2002-08-01 00:00:00
abstract::Interferon inducible transmembrane protein (IFITM) family genes have been implicated in several cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. We previously showed that the IFITM3 single nucleotide polymorphisms (SNPs) associated with susceptibility...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2013.09.026
更新日期:2013-11-01 00:00:00
abstract::To study the mechanism(s) responsible for the appearance of Epstein-Barr virus (EBV)-induced anti-histone autoantibodies, peripheral blood B lymphocytes from healthy donors were infected with EBV and the resulting lymphoblastoid cell lines were tested for secretion of antibodies reacting with histones. It was found th...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(94)90169-4
更新日期:1994-03-01 00:00:00
abstract::Investigating the functional effects of anti-T cell monoclonal antibodies (obtained through the Second International Workshop on Human Leucocyte Differentiation Antigens), antibodies to the sheep red cell receptor (CD2) were found to block lectin-dependent cytotoxicity. Blocking was seen with all anti-CD2 reagents tes...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(85)90151-8
更新日期:1985-01-01 00:00:00
abstract::Homogeneous IgG fractions were obtained by chromatography of the sera of patients with multiple sclerosis (MS) on Protein G-Sepharose under conditions that remove non-specifically bound proteins. These IgGs contained several chelated metals, the relative amount of which decreases in the order: Fe>or=Ca>Cu>or=Zn>or=Mg>...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2005.10.018
更新日期:2006-02-28 00:00:00
abstract::Growth is coupled to physiological modifications of the immune system which reaches the functional capabilities according to age-related milestones. Few data are available on the circulating immunoglobulin levels and no data exist on total immunoglobulin light chains in infant macaques. Therefore we studied by a nephe...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(96)02522-9
更新日期:1996-05-01 00:00:00
abstract::Parenteral administration of antigen induces in the earthworms Lumbricus terrestris and Eisenia foetida the formation of antigen-binding protein. Labelled antigen was efficiently digested in the coelomic fluids of both species since the total amount of radioactivity in the coelomic fluids decreased. Antigen internaliz...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/0165-2478(93)90044-3
更新日期:1993-05-01 00:00:00
abstract::Tumor cells express a range of antigens including self-antigens (those whose expression is shared by normal host tissue) and non-self antigens (such as those that arise as a result of mutations in normal cellular genes or in the case of some tumors, viral antigens). Immune responses to both types of antigen have been ...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/s0165-2478(02)00240-7
更新日期:2003-01-22 00:00:00
abstract::For more than two decades, chloroquine (CQ) was largely and deliberately used as first choice drug for malaria treatment. However, worldwide increasing cases of resistant strains of Plasmodium have hampered its use. Nevertheless, CQ has recently been tested as adjunct therapy in several inflammatory situations, such a...
journal_title:Immunology letters
pub_type: 杂志文章,评审
doi:10.1016/j.imlet.2013.07.004
更新日期:2013-06-01 00:00:00
abstract::Mature B cells express a single immunoglobulin Fc receptor, FcgammaRIIB, that functions to block downstream signaling by co-aggregated antigen receptors. Co-aggregation of receptors is essential because BCR activated kinases must phosphorylate FcgammaRIIB to recruit SHIP and mediate inhibitory signals. Pre-B cells als...
journal_title:Immunology letters
pub_type: 杂志文章
doi:10.1016/j.imlet.2003.11.028
更新日期:2004-03-29 00:00:00